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RU2271216C2 - Модуляторы ангиогенеза и проницаемости сосудов - Google Patents

Модуляторы ангиогенеза и проницаемости сосудов Download PDF

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Publication number
RU2271216C2
RU2271216C2 RU2002119399/15A RU2002119399A RU2271216C2 RU 2271216 C2 RU2271216 C2 RU 2271216C2 RU 2002119399/15 A RU2002119399/15 A RU 2002119399/15A RU 2002119399 A RU2002119399 A RU 2002119399A RU 2271216 C2 RU2271216 C2 RU 2271216C2
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Russia
Prior art keywords
src
protein
yes
angiogenesis
amino acid
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RU2002119399/15A
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English (en)
Russian (ru)
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RU2002119399A (ru
Inventor
Дэвид А. ЧЕРЕШ (US)
Дэвид А. Череш
Брайан ЭЛИСЕЙРИ (US)
Брайан ЭЛИСЕЙРИ
Роберт ПОЛ (US)
Роберт ПОЛ
Original Assignee
Дзе Скриппс Рисерч Инститьют
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Priority claimed from US09/470,881 external-priority patent/US6685938B1/en
Application filed by Дзе Скриппс Рисерч Инститьют filed Critical Дзе Скриппс Рисерч Инститьют
Publication of RU2002119399A publication Critical patent/RU2002119399A/ru
Application granted granted Critical
Publication of RU2271216C2 publication Critical patent/RU2271216C2/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45Transferases (2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0271Chimeric vertebrates, e.g. comprising exogenous cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Environmental Sciences (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
RU2002119399/15A 1999-12-22 2000-12-22 Модуляторы ангиогенеза и проницаемости сосудов RU2271216C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/470,881 1999-12-22
US09/470,881 US6685938B1 (en) 1998-05-29 1999-12-22 Methods and compositions useful for modulation of angiogenesis and vascular permeability using SRC or Yes tyrosine kinases
US53824800A 2000-03-29 2000-03-29
US09/538,248 2000-03-29

Publications (2)

Publication Number Publication Date
RU2002119399A RU2002119399A (ru) 2004-02-27
RU2271216C2 true RU2271216C2 (ru) 2006-03-10

Family

ID=27043259

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002119399/15A RU2271216C2 (ru) 1999-12-22 2000-12-22 Модуляторы ангиогенеза и проницаемости сосудов

Country Status (19)

Country Link
EP (2) EP1250155B1 (sk)
JP (1) JP2003518077A (sk)
KR (1) KR100813818B1 (sk)
CN (1) CN1434727A (sk)
AT (2) ATE392215T1 (sk)
AU (1) AU781444B2 (sk)
BR (1) BR0016547A (sk)
CA (1) CA2395136A1 (sk)
CZ (1) CZ304320B6 (sk)
DE (1) DE60038631T2 (sk)
DK (2) DK1905457T3 (sk)
ES (2) ES2383763T3 (sk)
HU (1) HU229628B1 (sk)
NO (1) NO20023036L (sk)
PL (1) PL356815A1 (sk)
PT (2) PT1905457E (sk)
RU (1) RU2271216C2 (sk)
SK (1) SK287575B6 (sk)
WO (1) WO2001045751A1 (sk)

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RU2419418C1 (ru) * 2009-11-16 2011-05-27 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Состав для удаления содержимого из атеросклеротических отложений в артериях человека

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US20030130209A1 (en) * 1999-12-22 2003-07-10 Cheresh David A. Method of treatment of myocardial infarction
US7115651B2 (en) 2000-08-25 2006-10-03 Sloan-Kettering Institute For Cancer Research Macrocycles and uses thereof
WO2003079936A1 (en) * 2002-03-18 2003-10-02 Medtronic Ave Inc. Medical devices for delivering anti-proliferative compositions to anatomical sites at risk for restenosis
AU2003281152A1 (en) * 2002-07-12 2004-02-02 Yihai Cao A method for inhibiting vascular permeability and tissue edema
EP1413887A1 (en) * 2002-10-22 2004-04-28 Aventis Pharma S.A. Inhibitors of Src kinase for use in Alzheimer's disease
WO2004056386A2 (en) * 2002-12-19 2004-07-08 To-Bbb Holding B.V. Nucleic acids involved in blood-brain barrier control
GB0307333D0 (en) * 2003-03-29 2003-05-07 Astrazeneca Ab Therapeutic agent
EP2260849A1 (en) * 2004-01-21 2010-12-15 Emory University Compositions and methods of use for tyrosine kinase inhibitors to treat pathogenic infection
US20060094682A1 (en) 2004-10-29 2006-05-04 Odyssey Thera, Inc. Kinase inhibitors for the treatment of diabetes and obesity
US20070148225A1 (en) * 2005-12-23 2007-06-28 Alcon, Inc. PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
IN2013MN00600A (sk) * 2006-05-22 2015-06-12 Univ California
DE602006004196D1 (de) * 2006-06-01 2009-01-22 Cellzome Ag Verfahren zur Identifizierung von mit ZAP-70 wechselwirkenden Molekülen und zur ZAP-70-Reinigung
DE102007037008B4 (de) * 2007-08-06 2015-09-10 Siemens Aktiengesellschaft Diagnosesubstanz zur Anwendung in einem Verfahren zur Bestimmung der Aggressivität eines Prostatatumors
WO2011053048A2 (ko) * 2009-10-29 2011-05-05 연세대학교 산학협력단 신규 혈관누출 차단제
US8557513B2 (en) * 2011-06-27 2013-10-15 Biocrine Ab Methods for treating and/or limiting development of diabetes
US10293023B2 (en) 2013-03-15 2019-05-21 Children's Medical Center Corporation Method of altering vascular permeability and uses thereof
CN105311645B (zh) * 2015-01-23 2018-11-30 中国人民解放军第二军医大学 胚胎fyn相关底物efs在防治肠道病毒71型感染中的应用
CN105288654B (zh) * 2015-01-23 2018-11-30 中国人民解放军第二军医大学 蛋白酪氨酸激酶fyn癌基因在防治肠道病毒71型感染中的应用

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US5766591A (en) * 1994-03-18 1998-06-16 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis
RU97104482A (ru) * 1994-08-26 1999-05-10 Хехст АГ Генная терапия заболеваний сосудов с помощью специфического к клетке и зависимого от клеточного цикла активного вещества
WO1999061590A1 (en) * 1998-05-29 1999-12-02 The Scripps Research Institute Methods and compositions useful for modulation of angiogenesis using tyrosine kinase src

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DE69108716T2 (de) * 1990-01-26 1995-08-17 Washington Research Foundation, Seattle, Wash. Immunreaktivität gegenüber exprimierten aktivierten oncogenen zur diagnose und behandlung von bösartigen geschwülsten.
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RU97104482A (ru) * 1994-08-26 1999-05-10 Хехст АГ Генная терапия заболеваний сосудов с помощью специфического к клетке и зависимого от клеточного цикла активного вещества
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2419418C1 (ru) * 2009-11-16 2011-05-27 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Состав для удаления содержимого из атеросклеротических отложений в артериях человека

Also Published As

Publication number Publication date
WO2001045751A1 (en) 2001-06-28
AU781444B2 (en) 2005-05-26
PT1905457E (pt) 2012-05-25
PL356815A1 (en) 2004-07-12
DK1905457T3 (da) 2012-05-29
DK1250155T3 (da) 2008-08-25
NO20023036D0 (no) 2002-06-21
HUP0203957A2 (hu) 2003-03-28
DE60038631T2 (de) 2009-06-10
NO20023036L (no) 2002-07-22
EP1250155A4 (en) 2003-08-20
RU2002119399A (ru) 2004-02-27
AU2740001A (en) 2001-07-03
ES2383763T3 (es) 2012-06-26
EP1905457B1 (en) 2012-04-18
CA2395136A1 (en) 2001-06-28
DE60038631D1 (de) 2008-05-29
ATE392215T1 (de) 2008-05-15
PT1250155E (pt) 2008-06-06
CZ304320B6 (cs) 2014-03-05
ES2303514T3 (es) 2008-08-16
ATE553782T1 (de) 2012-05-15
JP2003518077A (ja) 2003-06-03
EP1250155B1 (en) 2008-04-16
SK287575B6 (sk) 2011-03-04
HUP0203957A3 (en) 2005-07-28
CN1434727A (zh) 2003-08-06
EP1905457A1 (en) 2008-04-02
KR100813818B1 (ko) 2008-03-17
KR20020063259A (ko) 2002-08-01
HU229628B1 (en) 2014-03-28
EP1250155A1 (en) 2002-10-23
SK8492002A3 (en) 2002-11-06
BR0016547A (pt) 2002-10-29

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Effective date: 20161223