RU2251424C2 - "carbachthyol" preparation and method for its application - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: the suggested preparation for parturient activity, prophylaxis and therapy of afterbirth delay and puerperal endometritis in cows includes 0.05 g carbacholine, 70 g ichthyol, 5 g crystalline glucose and 1 g phenol/1000 ml distilled water. The method for treating acute puerperal endometritis in cows deals with injection of the above-mentioned preparation at the quantity of 20 ml preheated up to animal's body temperature deeply into gluteal muscles 4-8 times at interval of 24-28 h. The preparation suggested is considered to be of high curative and prophylactic efficiency.

EFFECT: higher efficiency.

2 cl

Description

The invention relates to complex myotonic drugs acting on the uterus with intramuscular administration to cows at the time of delivery and different periods after their completion.

A whole arsenal of myotonic drugs is known, the latter exert their effect only on the smooth muscles of the uterus, causing its contraction. Such a unilateral action often causes negative consequences: overstrain of smooth muscles, uterine contractions, as a rule, short-lived, repeated injections of them can lead to negative effects on the whole body of the female and on the uterus, cause uterine bending, etc. (Yu.M. Serebryakov " Uterine motility and retention of the placenta "// Materials of a scientific-production conference dedicated to the 25th anniversary of the Smolensk Agricultural Institute. - Smolensk, 1999, part 4. P. 280-282).

The problem to which the invention is directed is the development of a comprehensive, cheap myotonic drug that acts as a nonspecific therapy on the smooth muscles of the uterus with a simultaneous effect on the whole body of the female, which increases protective forces and has an anti-inflammatory and desensitizing effect.

The essence of the claimed invention lies in the fact that a comprehensive tool has been belittled with a multilateral positive effect on the mother's body; stimulating labor in cows, even after 1.5-2 hours from the onset of labor, etc.

Composition of the preparation: for the preparation of 1000 ml of the preparation, 0.05 g of carbacholine, 70 g of ichthyol, crystalline glucose 5 g, phenol 1 g, and distilled water 1000 ml are necessary. Carbachthiol is prepared as follows: glucose, phenol and carbacholine are dissolved in 700 ml of distilled water. After complete dissolution of these components, ichthyol is introduced into the solution, poured with water to a volume of 1000 ml and mixed thoroughly, filtered through 3 layers of gauze or towel. Carbakhtiol is packaged in 100, 200, 500 ml in well-washed bottles, which are tightly closed with rubber stoppers and rolled up with aluminum caps.

Vials with the drug are sterilized twice by heating in a water bath for 1 hour after 48 hours to 80 degrees C.

A label is attached to each bottle, which indicates:

name of the manufacturer;

name of the drug;

the amount of the drug in the bottle;

production date (month, year.);

series number;

state control number;

expiration date (month, year.);

storage conditions;

designation of these specifications.

Sterility of carbachthiol is determined according to the "Methodological guidelines" for bacteriological control of the sterility of veterinary biological products and approved by the General Veterinary Administration of the Ministry of Agriculture CCCP July 3, 1980

The manufacturer's laboratory guarantees the compliance of the carbachtiol preparation with the requirements of the technical conditions, provided that the consumer complies with the transportation, storage and use rules for a period of 1 year.

The possibility of the practical use of carbachthiol is confirmed by experiments. With parenteral administration, the drug acts as a nonspecific therapy, increases the body's defenses. It has anti-inflammatory, desensitizing effect, increases tone and enhances contractions of the muscles of the uterus, stomach and intestines, digestive, bronchial, sweat, salivary and lacrimal glands, dilates peripheral vessels, slows the heart rate, narrows the pupil, and reduces intraocular pressure. When applied, it does not cause complications.

Carbakhtiol is used to stimulate labor in cows 1.5-2 hours after the onset of the fetal stage with incomplete opening of the cervical canal (after wedging in the pre-existing parts of the fetus into the birth canal) during mild labor.

To prevent retention of the placenta in cows, 5-6 hours after the end of the stage of fetal hatching, as well as with subinvolution of the uterus, uterine agony and hypotension, hypogastric hypotension, overflow and blockage of the book. When the placenta is retained, carbachthiol can be used twice, with an interval of up to 2-3 hours.

Before use, the drug is heated to the body temperature of the animal in a water bath, a single dose of up to 20 ml is injected deep into the gluteal muscle group at two points, 10 ml on the right and left, after thorough treatment of the skin. If blood flows from the needle after the needle is inserted into the muscle, the needle should be removed and reinserted so that the solution does not enter the bloodstream.

In the treatment of cows with endometritis, carbachthiol is used 4-8 times with an interval of 24-48 hours.

The drug can be used in combination with etiotropic drugs with the exception of novocaine solutions.

Carbachtiol is not used in animals with suspected presence of bezoars, coprostasis, mechanical obstruction of the intestine, respiratory tract disease, heart diseases, for example, traumatic reticulopericarditis, etc. Do not use the drug in pregnant and malnourished animals, with suspected poisoning with hydrocyanic acid and with profuse diarrhea.

In case of forced slaughter, meat is allowed in food without restrictions after stripping the injection site of the drug.

As noted, "Karbakhtiol" is used to stimulate labor in cows. Childbirth in cows consists of three stages: preparatory, hatching, expulsion of the afterbirth.

Often in obstetric practice there are cases of delayed fetal excretion. The reason for the violation of the fetal hatching stage is: poor preparation of the pregnant cow for childbirth, lack of active exercise of cows during the stall period (adynamia), large-fruited, artificial opening of the fetal bladder (amnion), etc.

The use of the drug "Karbakhtiola" to stimulate the stage of fetal excretion.

Extract from the medical history of March 12, 2000, f. Koryuzino, ZAO "Prigorskoye", Smolensky district.

Cow "Spinner", Swiss breed, age 6 years, milk yield in previous lactation 6750 kg.

Amniotic fluid flowed at 15.00; at 19.00 the clinical condition of the animal is satisfactory, but the dynamics of labor are impaired; the pre-existing parts of the fetus - the chest limbs and the head wedged into the pelvic cavity; the limbs protrude from the vulva by 15-17 cm, attempts to stretch the fetus by applying obstetric loops did not bring success. Was introduced "Karbakhtiol", heated in a water bath to an animal's body temperature of 10 ml intramuscularly on the right and left in the gluteal muscles. After 47 minutes, contractions resumed, which were gradually intensified by attempts. 17-20 minutes after the resumption of labor, the presentation of a part of the fetus (limbs and head) safely passed through the pelvic cavity and with the help of 1 livestock breeder, the live calf was removed from the birth canal.

The placenta departed after 5 hours.

Extract from the medical history, 03/18/2000 f. Sinkovo, PSH "Volunteer", Smolensky district.

Cow "Ivushka" of the Swiss breed, age 5 years. In previous lactation, milk yield of 7100 kg.

Childbirth began at 8.30, amniotic fluid diverted at 11.25, the underlying parts of the fetus wedged into the pelvic cavity at 14.00; the chest limbs extend beyond the vulva by 20 cm, the front of the calf’s skull is also in the pelvic cavity, a nasal speculum is visible. At 14.10, "Karbakhtiol" was introduced, 10 ml intramuscularly on the right and left in the gluteal muscles. After 30 minutes, contractions and attempts resumed, at 15.00 the living fetus was spontaneously removed from the birth canal. The placenta departed after 6 hours.

Synthetic hormone oxytocin - 50-60 ED. Was used as stimulation of labor activity in control animals (12 animals), against the background of intravenous administration of a 40% glucose solution - 150-200 ml and calcium gluconate (10% - 100-150 ml) [4].

Treatment of acute purulent-catalytic endometritis.

Extract from the medical history, dated December 20, 1999, the Smolensky farm Smolensky district.

Cow "Lapushka", Swiss breed, age 5 years old, milk yield in the previous lactation 2300 kg. The calving took place on 11/12/1999, the arrest of the afterbirth and its operational separation were observed. An increase in the period of the lochial period was observed, 12/20/1999, with rectal-gynecological examination, purulent-catarrhal endometritis was established. Rectally, the uterus is atonic, the wall is edematous (thickened), does not respond to palpation, when the uterus is pulled into the pelvic cavity, muddy uterine discharge with pieces of pus is observed. When the cow is lying, the uterine secretions flow out in a small pool on the floor behind the animal.

December 24, 1999 Rectally, the uterus, after three injections of Karbakhtiol, is easily circled by hand. With rectal palpation, weak contractions of the uterus are felt. Uterine secretions acquired a mucous character, the amount of purulent mass decreased significantly. The cervical canal is open.

December 28, 1999. After four injections of the uterine preparation, during a rectal examination, an interhornoid groove is almost completely felt in the pelvic cavity, the uterus responds with contractions on palpation, the discharge from the uterus is mucous, a small amount (only mucilage the labia).

After 6 injections of the drug with rectal palpation, the uterus is completely pulled into the pelvic cavity, is easily covered by hand, the uterine wall is elastic. her edema disappeared. Uterine discharge is absent.

Remote research. After treatment, the cow first came to hunting on January 22, 2000, and again on February 12, 2000, May 15. 2000, with a rectal examination, she was found to be pregnant.

For the treatment of catarrhal and purulent-catarrhal endometritis, "Karbakhtiol" was used for more than 1000 cows on the farms of Smolensky, Khislavsky, Pochinkovsky and other areas of the Smolensk region. The cows of the control groups (129 animals) were treated with 7% ichthyol solution in 40% glucose solution, intramuscularly - 20 ml, with an interval of 48 hours, the drug was injected at two points, up to 6-8 times. Moreover, in combination with ichthyol 3-fold, with an interval of 48 hours. ASD-2 (Dorogov's antiseptic stimulator) was injected intramuscularly at a 10% concentration on trivitamine, 10 ml intramuscularly. [thirteen]. Compared to the experimental animals, the control cows had low fertility - 40-50%, although their recovery time was almost the same.

To prevent retention of the placenta, "Karbakhtiol" was administered to cows 6-7 hours after the second stage of labor. Efficiency was 75-87% (213 goals). To control animals (96 animals), the synthetic hormone prostaglandin-estrofan, intramuscularly, was used to prevent retention of the placenta. The effectiveness of the drug was 62-70% [2].

With an increase in the dosage of the drug, signs of hypersalivation, urination, acts of defecation and slight suppression may appear. At the same time, atropine at a dose of 0.1-0.06 g is used subcutaneously as a removal of these phenomena.

The drug has passed extensive production tests, more than 1000 goals. cows in the Smolensk region and the Primorsky Territory of the Russian Federation.

LITERATURE

1. Goncharov V.P., Karpov V.A. Prevention and treatment of histological diseases in cows. - 2nd ed. reslave. - add. - M.: Rosagropromizdat. - 1991 .-- 190 s.

2. Studentov A.P. et al. under the editorship of Nikitina V.Ya. and others. -7th edition, revised. and add. - M .: Kolos, 1999 - p. 48.

3. Ibid., P.309.

4. Ibid., P. 311.

Claims (2)

1. A drug for stimulating labor, preventing and treating retention of the placenta and postpartum endometritis in cows, characterized in that it contains 0.05 g of carbacholine, 70 g of ichthyol, 5 g of crystalline glucose and 1 g of phenol per 1000 ml of distilled water. 2. A method for the treatment of acute postpartum endometritis in cows, characterized in that it includes the administration of the drug according to claim 1 in an amount of 20 ml, preheated to the animal’s body temperature, deep into the gluteal muscles 4-8 times with an interval of 24-48 hours