RU2241465C1 - Method for increasing inspecific body resistance to delivery act in pregnant women - Google Patents

Abstract

FIELD: medicine, obstetrics.

SUBSTANCE: one should apply inhalations with air-ozone mixture at ozone concentration being 25-35 mcg/cu. m for 15-20 min at repeating the procedure every other day, up to 3 seances before delivery. The present innovation favors the stabilization of arterial pressure values, increased functional erythrocytic activity, improved rheological blood characteristics that, in its turn, provides necessary level of transplacental transfusion, and this leads to improved state of babies both during delivery and at birth. It, also, provides decreased frequency of postnatal period complications.

EFFECT: higher efficiency.

8 ex, 1 tbl

Description

The invention relates to medicine and can be used in obstetrics to increase the nonspecific resistance of a pregnant woman with pathology of the cardiovascular system (neurocirculatory dystonia, hypertension) to the birth certificate.

The problem of diseases of the cardiovascular system in pregnant women is currently extremely urgent for the reason that in the structure of both extragenital morbidity in pregnant women and maternal mortality, the priority belongs to the pathology of the circulatory system.

One of the most unfavorable (critical) periods, even for a physiologically proceeding pregnancy, is: 1) the birth act due to an increase in hemodynamic stress, especially in the second stage of labor; 2) the first 28-48 hours of the postpartum period (puerperal period), when the entire "pregnancy building" is rapidly destroyed, which requires the mobilization of adaptive and adaptive mechanisms of the puerperal.

But if in healthy pregnant women, due to the functional sufficient reserves of the cardiovascular system, these changes do not represent a danger, then in pregnant women who previously had even a favorable course of the disease of the circulatory system, they often acquire an aggressive character.

The basics of increasing the body's stress resistance should include influencing metabolic processes in the functional initial state of the body or at the earliest possible time after exposure in order to stimulate the body's adaptive capabilities and orient the metabolism in the most economical way to reduce the “cost” of adaptation.

A known method of treating discirculatory encephalopathy (RF patent No. 2139061, application form 20.02.95, publ. 10.10.99, IPC A 61 K 33/00, A. A. Smirnov, A. V. Gustov, K. N. Kontorshchikova. Method treatment of discirculatory encephalopathy), which consists in the fact that for the treatment of vascular diseases of the nervous system, the traditional course of therapy is supplemented by introducing into the body an ozone-oxygen mixture by intravenous drip of 200.0 ml of physiological solution containing 4-6 mg / l of ozone daily for 5 days. However, this method has several disadvantages: it requires complex technical equipment for ozonation of physiological saline; requires invasive intervention; requires a significant amount of time.

The closest in technical essence and the achieved positive effect is a method of increasing non-specific resistance (RF patent No. 2147445, application. 04/01/1997, publ. 04/20/2000, IPC A 61 M 16/00. Yu. Yu. Byalovsky, V.N. Abrosimov, SVVikulin. A way to increase non-specific resistance). The method is carried out in the form of presentation of inspiratory non-threshold resistive respiratory loads of 11-28 cm of water. Art. / (hp), supplied within 3 minutes, with exercise cycles carried out every 20 minutes for 3 hours a day, and the course of treatment is carried out for 10-14 days. However, this method has several disadvantages: individual selection of a resistor (channel lumen) in the range of 11-28 cm of water is required. Art. / (hp); subjective patient intolerance to the resistor is possible, which requires a decrease in load to 7 cm of water. Art. / (hp), however, the effect of increasing non-specific resistance is reduced; it takes a lot of time.

The task to which the invention is directed is to simplify, reduce side effects while increasing the nonspecific resistance of the pregnant woman with pathology of the cardiovascular system (neurocirculatory dystonia, hypertension) to the birth certificate.

The problem is solved in that, in addition to the traditional methods of therapy, they affect the pregnant woman’s body with an external factor in the form of inhalation with an air-ozone mixture with an ozone concentration of 25-35 μg / m ³ for 15-25 minutes, with the procedure being repeated every other day, up to three sessions before childbirth.

The method is as follows. An ozonizer is placed in the inhalation room. When it reaches an ozone concentration of 25-35 μg / m ³ (the calculation is carried out according to the performance of the ozonizer, its operating time and the volume of the room), the pregnant woman is placed in the room where she is for 15-25 minutes. The procedure is repeated every other day until 3 sessions before childbirth.

The increase in the adaptive potency of the pregnant woman is evidenced by changes in the biochemical parameters of the blood of the pregnant woman (a decrease in the bound fractions of water in whole blood, a decrease in the content of non-erythrocyte hemoglobin), a stabilization of the blood pressure in the labor, a decrease in the frequency of complications in labor, an improvement in the condition of children at birth, and a decrease in the frequency of complications of the postpartum period .

The table shows examples of the proposed method and the results of its implementation.

Example 1. Pregnant woman K., 21 years old with a diagnosis of “Pregnancy 38-39 weeks, mixed-type neurocirculatory dystonia, chronic fetal hypoxia of the fetus, fetal development retardation syndrome, complicated obstetric and gynecological history”. Fluctuations in blood pressure within: systolic - from 80 to 115 mm RT. st .; diastolic - from 50 to 70 mm RT. Art. A course of 3 inhalations every other day was carried out with an air-ozone mixture with an ozone concentration of 35 μg / m ³ and the duration of each session was 25 minutes. For this, an ozonizer is placed in the inhalation room. When it reaches an ozone concentration of 35 μg / m ³ (the calculation is carried out according to the performance of the ozonizer, its operating time and the volume of the room), the pregnant woman is placed in the room where she is for 25 minutes. The procedure is repeated every other day until 3 sessions before childbirth.

Example 2. Pregnant V., 27 years old, with a diagnosis of "Pregnancy 38-39 weeks, neurocirculatory dystonia of the hypertonic type, chronic intrauterine hypoxia of the fetus." It was carried out analogously to example 1, with the exception of the concentration of 25 μg / m ³ and the exposure time of 15 minutes

Example 3. Pregnant I., 32 years old with a diagnosis of "Pregnancy 39 weeks, neurocirculatory dystonia of a mixed type, placental insufficiency, complicated obstetric and gynecological history." It was carried out analogously to example 1, with the exception of the concentration of 30 μg / m ³ and the exposure time of 20 minutes

Example 4. Pregnant M., 22 years old with a diagnosis of "Pregnancy 38-39 weeks, mixed-type neurocirculatory dystonia, fetoplacental insufficiency." It was carried out analogously to example 1, with the exception of the concentration of 10 μg / m ³ and the exposure time of 25 minutes

Example 5. Inhalation with an air-ozone mixture with an ozone concentration of 40 μg / m ³ and an exposure time of 25 minutes is not possible due to the high risk of its toxic effects on a pregnant woman.

Example 6. Pregnant N., 24 years old with a diagnosis of "Pregnancy 38 weeks, neurocirculatory dystonia of a mixed type, placental insufficiency, complicated obstetric and gynecological history." It was carried out analogously to example 1, except for a concentration of 35 μg / m ³ and an exposure time of 10 minutes.

Example 7. Pregnant T., 25 years old with a diagnosis of "Pregnancy 39 weeks, neurocirculatory dystonia of the hypertonic type, placental insufficiency, complicated obstetric and gynecological history." It was carried out analogously to example 1, with the exception of the concentration of 35 μg / m ³ and the exposure time of 30 minutes

Example 8. B., 26 years old, with a diagnosis of "Pregnancy 38-39 weeks, neurocirculatory dystonia of the hypertonic type, placental insufficiency, chronic fetal hypoxia." Blood pressure indicators ranged from: systolic - from 120 to 145 mm RT. st .; diastolic - from 70 to 95 mm RT. Art. Conducted a course of traditional therapy. Inhalation of the air-ozone mixture is not carried out. The indicators of the bound fractions of the whole blood water were: bound blood water 55.75%; bound extracellular water 23.42%; bound intracellular water 32.33%; erythrocyte bound water 17.39%. The duration of labor is 7 hours 30 minutes. By periods: 1 period - 6 hours 50 minutes; 2 period - 30 minutes; 3 period - 10 minutes. In childbirth, there were sharp fluctuations in hemodynamic parameters (in the 1st period, systolic blood pressure was 120-135 mm Hg, diastolic blood pressure was 70-90 mm Hg). A newborn male was born, weighing 3600 g, length 50 cm, Apgar score for 1 min - 7b., 5 min - 8b., Neonatologist considered the condition as satisfactory by the doctor, during examination of clinical signs of pathology was not established. In the postpartum period, a lochiometer was diagnosed. The woman was discharged on the 9th day from the maternity hospital home in satisfactory condition.

As can be seen from their tables, the best results were achieved with an ozone concentration of 25-35 μg / m ³ and an inhalation session duration of 15-25 minutes. If the air-ozone mixture contains a lower concentration of ozone or the session time is shorter, then the effect of a positive clinical effect was not achieved. If the air-ozone mixture contains a high concentration of ozone - the risk of toxic effects of ozone on the body is high, if the session time increases more than 25 minutes, then a positive effect was not achieved.

Changes in the biochemical parameters of the blood of pregnant women indicate an increase in the adaptive potency of the pregnant woman: a decrease in the bound fractions of water in whole blood (bound blood water, bound extracellular water, bound intracellular water, bound red blood cell water); decrease in the content of non-erythrocyte hemoglobin. Physiologically more beneficial for the body, if the water is represented mainly by extracellular fluid, its mobile part. The observed changes indicate an increase in the functional activity of the mother erythrocytes, a change in their volume and energy potential, which improves the rheological characteristics of the blood and provides the necessary level of transplacental transfusion.

This method was tested on 26 pregnant women on the basis of the maternity hospital of the emergency hospital No. 1 named after N.A.Semashko, Rostov-on-Don.

Clinically, in the study group, the indicators of blood pressure in all women in labor are stabilized in childbirth; the percentage of complications of the birth act is reduced in relation to the control group: the development of anomalies of labor activity (by 40%); asphyxia of the newborn (0 cases); pathology of the postpartum period (0 cases). The development of complications during inhalation with an air-ozone mixture is not observed.

Thus, the proposed method for increasing the nonspecific resistance of a pregnant woman’s body to the birth certificate excludes the development of a side effect, does not require special equipment, ozonizers are produced by industry.

Claims (1)

A way to increase the nonspecific resistance of a pregnant woman’s body to the birth act, which consists in exposing the woman to an external factor, characterized in that inhalation with an air-ozone mixture with an ozone concentration of 25-35 μg / m ³ for 15-20 minutes is used as an external factor with the repetition of the procedure every other day, up to 3 sessions before childbirth.