RU2129005C1 - Species for thyroid function recovery - Google Patents

Abstract

FIELD: medicine, endocrinology, phytotherapy. SUBSTANCE: invention relates to agents of plant origin for recovery of thyroid function. Species has rice, celandine, plantain and thuja taken at the definite ratio. Species can be used in different medicinal forms: decoction, tablets, capsules. EFFECT: enhanced therapeutic effect of an agent. 4 cl, 5 ex

Description

 The invention relates to the field of therapeutic nutrition and medicine and can be used as a component of drug therapy as a nutritional supplement for diseases of the thyroid gland.

 There are known pharmacological preparations traditionally used to treat thyroid diseases - thyroidin (thyroxine) (1), mercazolil (2).

 However, they have a number of adverse side effects on the body, namely: thyroidin is contraindicated in thyrotoxicosis, diabetes mellitus, severe forms of coronary insufficiency; mercazolil may cause the development of leukopenia, impaired renal function, etc.

 Surgical methods of treating thyroid diseases are also possible, although it is known that removal of the thyroid gland with thyrotoxicosis can lead to undesirable consequences, as the patient goes from a state of thyrotoxicosis to a state of hypothyroidism. In addition, with surgical intervention, the following are possible: damage to the nerve-N.RECURENS and further loss of voice; damage to the parathyroid glands and the appearance of persistent seizures.

 It should be noted that to date, there are no known drug collections from natural products that are used as a component of drug therapy as a food supplement for thyroid diseases. Therefore, our efforts were aimed at finding a treatment for thyroid diseases with medicinal herbs that would remove the effects of thyrotoxicosis, but would not allow the reverse phenomena to develop in the form of hypothyroidism, that is, they would lead to an actually euthyroid state.

 The problem to which the claimed invention is directed is to create a composition that is a mixture of natural products, one of which is taken as the basis, and the other are active substances of plant origin, while their combination creates synergism in obtaining a therapeutic effect.

This problem is solved by creating a collection, which is a composition of rice, which is taken for the base, plantain, thuja and celandine roots, which are active substances of plant origin, with the following weight ratio:
Rice - 3
Plantain Plantado mayor L. - 1
Thuja Thuja occidentales - 2
Celandine Roots Chelidonium maids - 0.8
The combination of substances in these ratios creates synergism due to the biochemical characteristics of each of the components. Studies have shown that the presence of thuja acids in the final product (the active substance of thuja) promotes the production of thyroid hormone, while thuya acids prevent the development of nodular (tumor) growths in the thyroid gland. Alkaloids (chelidonin, homochelidonin, chelerythrin, methoxychelidonin, oxyheledonin, sanguatorin, protonin α-allocryptonin, β-allocryptonin, spartein, etc.) contained in the celandine help to relieve the excited state from impulses received from hypothyroidism: reduce tachycardia, vegetative-vascular stratification, reduce pulse pressure, reduce the phenomena of exophthalmos, tone the muscles of the eyeballs.

 In the process of research it was found that the presence in the final product of the indican glycoside aucubin contained in the plantain, helps to restore impaired metabolic processes (protein fat, water, vitamin, etc.) due to its participation in the Krebs cycle. Such substances as carotene, ascorbic acid (up to 42.2 mg%), vitamin K, flavoniside, beckon, sorbitol, organic acids (citric, oleic), also found in plantain, restore the vitamin balance in the body. It should be noted that rice (its shell structure) has the properties of an antioxidant, therefore, its presence as a powerful adsorbent in the final product when interacting with other substances helps to compensate for the products of impaired metabolism and to reduce the effects of toxicosis.

 The collection is prepared as follows.

 Rice grains are ground to a particle size of 1-3 mm. Plantain leaves and thuja shoots (previously dried) are crushed into a coarse powder with a particle size of 1-3 mm. Celandine roots (pre-dried) are also ground to a particle size of 1-3 mm. The components are mixed in the ratios indicated in the claims to a homogeneous state.

 The final product is the sum of biologically active substances in the form of a hygroscopic amorphous powder of light coffee color. The yield of the final product depends on the quality of the feedstock and is 85 - 87% of the amount of feedstock.

 The collection is non-toxic and meets the medical and biological requirements and sanitary standards for the quality of food raw materials and food products approved by the USSR Ministry of Health on 01.08.89 N 5061.

 According to the claimed invention for the use of the collection in the form of an aqueous solution, the collection additionally contains 16 weight parts of water. An aqueous solution of collection is obtained as follows: the components are mixed in the ratio indicated in the claims to a homogeneous state and diluted with distilled water to 1 liter, and then once subjected to heat treatment to the boiling point of water.

 In the course of the study it was found that the use of collection in different doses causes an improvement in the condition of thyroid gland diseases.

 Studies have shown that the most optimal concentration of the final product in water is 1:16. With a change in concentration, the desired therapeutic effect is not achieved.

 According to the claimed invention for the use of the collection as capsules, one capsule contains 0.65 mg of the final product in the form of a dry concentrate and 1/10 part of the gelatin. It is recommended to use capsules of 1-2 pcs., 2-3 times a day after meals.

 According to the claimed invention, for the use of the collection as tablets, one tablet contains 0.5 mg of the final product in the form of a dry concentrate. It is recommended to use tablets of 1-3 pcs., 2-3 times a day after meals.

 Clinical examples of the use of collection.

 Example 1

 Patient E. Koroleva, 31 years old. Sick since 1992, the diagnosis of diffuse non-toxic goiter. The clinic of the disease is confirmed by a biochemical blood test: cholesterol 4 mm / l; Ultrasound - a cyst of the right lobe. Prescribed treatment: thyroxine 1 tablet 3 times a day. A year later (1993), against the background of thyroxine treatment, the diagnosis was made - diffuse toxic goiter. Objectively, when examining, all the signs of the classic picture of a basic disease were noted: severe tachycardia (PL 120-180 beats per minute), sweating, 2nd stage meriotoxicosis, itchy skin, an increase in basal metabolic rate by 60%.

 In the second half of 1993, thyroxine was canceled, mercazolil was prescribed 6 tablets per day. After treatment, the condition did not improve clinically.

 In February 1994, the patient began taking collection as a dietary supplement, with the exception of drug treatment. Objectively, in May 1994, examination revealed the absence of tachycardia (PL 65-70 beats per minute), sweating, irritability disappeared, but the enlargement of the thyroid gland still remained. Thyrotoxicosis phenomena completely disappeared after six months. In December 1995, she gave birth to a healthy baby.

 Example 2. Patient O. Augustow, 54 years old.

 Sick since 1994, the diagnosis is diffuse non-toxic goiter with nodularity. Consulted jointly by surgeon and endocrinologist, surgery is proposed. She refused the operation.

 For four months I received an aqueous solution of the collection of 1 tablespoon per day 3 times after a meal, with the exception of drug treatment. Objectively, during the ultrasound examination it was noted: the disappearance of the phenomena of diffuse non-toxic goiter with nodularity.

 Example 3. Patient I. Samoilova, 53 years old.

Sick since 1986, diagnosis - diffuse knobby goiter 1.2 cm (on scan). In 1996, he was diagnosed with autoimmune thyroiditis. A course of treatment is prescribed - thyroxine in increasing dosage. Objectively noted in the study of thyroid hormones TSH ₃ - 1.6; TTG ₄ - 107.5; cholesterol 7.2 mm / l; the level of β-lipoproteins is 55 units.

 For six months I received a collection of 1 tablespoon per day 3 times after a meal with the exception of drug treatment. Objectively, during the ultrasound examination it was noted: the disappearance of the phenomena of diffuse knobby goiter; cholesterol 5.6 mm / l; the level of β-lipoproteins decreased to 35 units.

 Example 4. Patient L. Klokova, 62 years old.

 Sick since 1990, the diagnosis is diffuse toxic goiter, with nodules on the right. Objectively, before surgery, the level of β-lipoproteins is 42 units; cholesterol 5.8 mm / l. Subtotal thyroid resection was performed, leaving 4 g of tissue at the upper pole on the right. Histologically - autoimmune thyroiditis. During the year, the patient's condition was satisfactory, after which deterioration occurred: the patient periodically experienced hypothyroidism and hyperthyroidism. Pulse pressure remained high (BP 200/110); cholesterol 5.9 mm / l; the level of β-lipoproteins is 40 units.

 For 1.5 years (with short interruptions) I received a collection of 1 tablespoon per day 3 times after a meal with the exception of drug treatment. Objectively, the euthyroid state of cholesterol is 4.5 mm / l; the level of β-lipoproteins 32 units. The patient has been observed for the past three years - a stable condition (euthyroid).

 Example 5

 Patient E. Ovechkina, 28 years old. It was operated on in 1994 for diffuse goiter. The postoperative course of the disease is not smooth, exophthalmos continued to grow and disturb the patient.

 For four months I received a collection of 1 tablespoon per day 3 times after a meal, with the exception of drug treatment. In 1995 she gave birth to a healthy baby. Currently, the condition is normal.

 Thus, as can be seen from the examples, a pronounced positive result of treatment by the claimed collection was obtained in all patients with thyroid diseases. In control patients receiving traditional treatment methods, a pronounced positive result was noted in only 60% of cases.

Sources of information
1. Mashkovsky M.D. Medicines - M .: Medicine, 1988, t. 1, ch. 7, p. 549.

 2. Mashkovsky M.D. Medicines - M .: Medicine, 1988, t. 1, ch. 7, p. 552.6

Claims (4)

 1. A collection for restoring the function of the thyroid gland, which is a mixture of natural products, one of which serves as the basis, and the other are active substances of plant origin, characterized in that it contains rice as the basis, and celandine roots, plantain and thuja as active substances with the following mass ratios of components: 3: 0.8: 1: 2.  2. The collection according to claim 1, characterized in that the aqueous collection solution contains raw materials and water in a ratio of 1: 16.  3. The collection according to claim 1, characterized in that when used in the form of capsules, it contains 0.65 mg of active substance per capsule.  4. The collection according to claim 1, characterized in that when using it in the form of tablets, it contains 0.5 mg of active substance per tablet.