RU2128498C1 - Foot gel - Google Patents

Abstract

FIELD: cosmetology, medicine. SUBSTANCE: gel contains the following ingredients, mas.%: chitosan, 1.5-3.0; rutin, 1.0-4.0; ascorbic acid, 1.0-4.0; acetylsalicylic acid, 1.0-5.0; menthol, 0.1-0.3; boric acid, 0.1-0.5; conserving agent, 0.2-1.0; flavor, 0.5-1.0; water, the balance. The gel produces antiinflammatory and soothening effect on skin, improves microcirculation, promotes aching removal and quick resorption of edema and hematomas after trauma. EFFECT: higher efficiency. 3 tbl

Description

 The invention relates to medicine, in particular to cosmetology, and in particular, to means for foot care.

 There are various cosmetic and therapeutic and prophylactic means for the legs, which have anti-inflammatory and deodorizing effects, which improve the exfoliation of keratinized tissues on the feet. Known products contain vegetable oils, emulsifiers, glycerin, vitamins, herbal extracts, as well as preservatives and fragrance [1 - 2].

Known, for example, foot cream [3], containing, wt.%:
Lanolin - 1 - 6
Castor oil - 3 - 7
Monoglycerides - 0.5 - 5
Emulsified wax - 2.5 - 10
Peat Wax Ethanol Extract - 0.5 - 5
Camphor - 0.2 - 2.5
Menthol - 0.1 - 0.3
Cinnamon alcohol - 0.1 - 0.25
Ethyl alcohol - 0.5 - 5
Paraoxybenzoic acid methyl ester - 0.125 - 0.15
Paraoxybenzoic acid propyl ester - 0.04 - 0.05
Fragrance - 0.3 - 1
Distilled Water - Else
The well-known cream has an anti-inflammatory, analgesic effect, helps exfoliate skin cells on the feet. The disadvantages of this method are: the cream weakly relieves foot fatigue, has an insufficient bactericidal and regenerative effect. In addition, the well-known foot cream contains synthetic components that are deficient as preservatives, and the slightly alkaline environment of the cream promotes the development of pathogenic microorganisms.

 Known treatment-and-prophylactic foot gel "Essaen" containing heparin, escin, essential phospholipids, emulsifiers, preservative, alcohol and water [4]. The well-known gel allows you to relieve painful leg fatigue, helps with bruises and sprains, and resolves fresh hematomas. A disadvantage of the known gel is that it contains expensive scarce components, alcohol, which, getting on the mucous membranes, causes burning and itching. In addition, the gel is an imported, inaccessible and expensive tool.

Closest to the claimed gel - the prototype - is a foot cream, [4] containing, wt.%:
Lanolin - 1.5 - 3.0
Castor oil - 3.80 - 8.0
Distilled Monoglycerides - 1.0 - 2.0
Emulsion wax - 2.5 - 4.5
Provitamin coniferous extract - 0.2 - 1.0
Coniferous essential oil (preservative) - 0.1 - 0.5
Water extract of aspen bark - 0.3 - 1.0
Copper derivatives of chlorophyll - 0.3 - 0.7
Camphor - 0.15 - 0.30
Methanol - 0.08 - 0.30
Ethyl alcohol - 0.8 - 4.0
Fragrance - 0.5 - 2.0
Water - Else
The well-known foot cream has exfoliating, nourishing and antiseptic effects on the skin of the legs, helps relieve foot fatigue during use. Essential coniferous oil was used as a preservative in the cream formulation, and copper derivatives of chlorophyll were used as a biostimulant.

 Emulsion wax, distilled monoglycerides, lanolin, castor oil are used as a cream base. Provitamin coniferous concentrate allows you to create a stable emulsion, acting as a structure-forming agent.

 The disadvantages of the known cream is its multicomponent nature, the presence in the formulation of expensive, scarce components, alcohol, which irritates the skin.

 A well-known cream has a weak, insufficiently anti-inflammatory and decongestant effect.

 The technical task of the invention is the creation of funds for the legs, which has anti-inflammatory effect and reduces swelling and fatigue of the legs.

The specified technical problem is achieved by the proposed gel for the feet, containing the following components, wt.%:
Chitosan - 1.5 - 3.0
Rutin - 1.0 - 4.0
Ascorbic acid - 1.0 - 4.0
Acetylsalicylic acid - 1.0 - 5.0
Methanol - 0.1 - 0.3
Boric acid - 0.1 - 0.5
Preservative - 0.2 - 1.0
Fragrance - 0.5 - 1.0
Water - Else
The proposed foot gel has anti-inflammatory and skin softening effects, improves microcirculation, activates metabolic processes in skin cells. The cooling effect of the gel gives a pleasant sensation, which additionally contributes to the disappearance of pain and relieve the feeling of heaviness, freshens tired legs. The active components of the gel favor the rapid absorption of edema and hematomas after injuries. The gel gives a pleasant feeling of coolness in a swollen place and quickly relieves pain.

Characteristics of the components used:
Chitin is one of the most common biopolymers on earth. This is an important component of the exoskeleton of arthropods (insect peel, crustacean shell, etc.). By deacylation of chitin with alkali, chitosan is obtained.

 Cosmetic gel chitosan TU-9158-001-09224959-93 is a polysaccharide of chitosan modified with derivatives of fatty acids. Modification leads to the fact that the gel becomes water-soluble (and not acid-soluble, like regular chitosan). In this form, chitosan retains its immunostimulating properties, as well as the ability to be absorbed by skin cells in the form of carbon raw materials. According to physicochemical and organoleptic properties, it corresponds to gels made on the basis of synthetic polymers (PEG), but differs from them in biostimulating properties inherent in chitosan and the ability to be absorbed by the body's enzymes. The gel is effective in protecting the skin from irritation, in dermatitis, in the treatment of wounds and bedsores.

 The optimal concentration of chitosan in the gel is 1.5 - 3.0%. First, a concentrated gel of 3-5% is prepared, and then diluted with water to the desired concentration of chitosan.

 When using chitosan in a concentration of less than 1.5%, the product acquires a liquid consistency and flows off the skin surface.

 The introduction of tritanose above 3% increases the value of plastic viscosity and creates a too dense texture of the gel, which is poorly smeared on the skin.

 Rutin is an organic compound from the flavonoid group, has vitamin activity (vitamin P group), strengthens the walls of capillaries, regulates their permeability, enhances the effect of ascorbic acid.

 Vitamins Ascorutin (6) are known, which are produced in our country in the form of tablets and dragees and are used to improve the state of blood vessels. They contain rutin and ascorbic acid. However, when administered orally, their action is directed to the body as a whole. The use of an external composition containing these vitamins allows their enhanced effect to be achieved at the place of application. Introduction to the gel composition of rutin at a concentration of 1 - 4% and ascorbic acid at a concentration of 1 - 4% improves microcirculation, activates the metabolic process in the cells. As an antioxidant and cofactor, ascorbic acid stimulates the biosynthesis of glycosaminoglycans, which act as the main plasticizers of the intercellular matrix of the dermis, and thus increase the elasticity and strength of the walls of blood vessels.

 The introduction of ascorbic acid and rutin below the lower and higher upper limits of the specified concentration does not allow to obtain the claimed effect.

 As a component that counteracts platelet aggregation, acetylsalicylic acid in a concentration of 1 - 5% is introduced into the formulation, which helps to reduce blood coagulation in the surface layers of the skin, providing more intensive resorption of hematomas. Acetylsalicylic acid has known anti-inflammatory and analgesic effects.

 The combined effect of all of the above components leads to a visually observed cosmetic improvement in the appearance of the legs and prevents the development of varicose veins.

 As an antiseptic component, which also has a tonic effect, boric acid is introduced in a concentration of 0.1 - 0.5%.

 As a refreshing, cooling and analgesic component, menthol was introduced into the formulation in a concentration of 0.1 - 0.3%.

 As a preservative in the formulation, there is an organic acid selected from the group: sorbic, benzoic or salicylic in a concentration of 0.2 - 1.0%.

 The proposed foot gel is obtained by mechanical mixing at room temperature at 1000 rpm for 30-60 minutes of all constituent components in the indicated concentrations until a homogeneous mass is formed. The finished product is checked for compliance with OST 18-21-81 packaged and packaged.

 Example 1

The enameled reactor with stirrer was loaded, wt.%: Chitosan gel 89.5 (which contains 2% chitosan), rutin 3.0, ascorbic acid 3.0, acetylsalicylic acid 3.0, boric acid 0.3, benzoic acid 0.3, menthol 0.2, perfume 0.7. All were mixed at a speed of 1000 rpm for 30 minutes at 18 - 25 ^o C, Packed in jars and packaged.

 Similarly prepared compositions of gel for the feet with the content of the limit and outside the claimed amounts of the components, examples 1, 2, 4, 5.

 Table 1 shows 5 examples of developed formulations of foot gel, in table 2 - physico-chemical and organoleptic characteristics of the proposed foot gel, the formulation of which corresponds to example 3 of table 1 (all tables are shown at the end of the description).

 From table 2 it can be seen that compositions 1 and 5 have unsatisfactory physicochemical properties, namely, foot gel according to composition 1 has a liquid consistency and quickly drains from the skin surface, and composition 5 has a very dense texture, it is poorly smeared on the skin surface.

 A visual study of the local irritating effect of the gel compositions for the legs was carried out in an experiment on 42 guinea pigs weighing 250 - 270 g by the method of cutaneous applications. Applications were performed daily for 30 days, observing and evaluating local skin changes: color, presence of hyperemia, and edema.

 Observations showed that the proposed foot gel does not have an irritating and allergenic effect on the skin, is quickly absorbed.

 Clinical trials of the gel were carried out on a group of experts of 15 people, consisting of women aged 30 to 45 years, with pain in the legs. Method of applying the gel: it is applied to the skin along the massage lines 2–3 times a day and the organoleptic properties of the latter are determined according to the criteria: removal of painful fatigue, cooling effect, resorption of local puffiness and hematomas, increased skin elasticity according to a 3-point system: yes, a little there is no.

 The test gel had the following composition, wt.%.

Composition X:
Chitosan - 2
Rutin - 2
Ascorbic acid - 2
Acetylsalicylic acid - 3
Menthol - 0.2
Boric acid - 0.3
Benzoic acid - 0.3
Water - Else
For control, a gel was used in which rutin, ascorbic and acetylsalicylic acids (composition Y) and the Indovazin gel standard (composition S) were excluded from the formulation corresponding to composition X. The results are shown in table. 3.

 From table 3 it is seen that the developed gel for the legs has a more pronounced claimed effect than a gel that does not contain active components and gel standard.

 From these tables it follows that the proposed composition of the gel for the feet within the claimed range of components has the best ability to relieve foot fatigue, resolves puffiness and hematomas, has a pleasant cooling effect.

 It is known to use chitosan as a cationic polymer in hair styling products and strengthening hairstyles (7.8). In the proposed gel for the feet, chitosan has a new function as a structurant and moisturize the skin.

 An analysis of well-known scientific, technical and patent sources showed that distinctive features from the prototype were not found together in the known means for the feet.

Thus, the proposed gel in comparison with the prototype allows you to:
- relieve painful leg fatigue,
- improves microcirculation and strengthens the walls of blood vessels,
- prevents platelet aggregation and thereby prevents the development of varicose veins,
- prevents the rapid resorption of hematomas,
- gives a pleasant feeling of coolness in a swollen place,
- absorbed faster, without leaving greasy marks,
- improves skin elasticity, heals microcracks,
- improves the appearance and eliminates cosmetic defects of the legs.

Sources of information
1. Copyright certificate N 1483694 MKI A 61 K 7/00 "Means for foot care"
2. Copyright certificate N 1724242 MKI A 61 K 7/00 "Foot cream"
3. Copyright certificate N 1355284 MKI A 61 K 7/00 "Foot cream"
4. Ronk-Pulenk flyer for Essaen gel
5. Copyright certificate N 1782588 MKI A 61 K 7/00 "Foot cream"
6. M.D. Mashkovsky "Medicines", Moscow, "Medicine", 1993

 7. Application of France N 2597335 MKI A 61 K 7/06 "Cosmetic preparation for hair fixation", publication 23.10.87,

 8. The application of Germany N OS 3632030 MKI A 61 K 7/11 "Means for strengthening hairstyles", publication March 31, 88

Claims (1)

Foot gel containing a base, menthol, preservative, perfume and water, characterized in that it additionally contains rutin, ascorbic acid, acetylsalicylic acid, boric acid, chitosan gel as a base, and benzoic or sorbic as a preservative, or salicylic acid in the following ratio of components, wt.%:
Chitosan - 1.5 - 3.0
Rutin - 1.0 - 4.0
Ascorbic acid - 1.0 - 4.0
Acetylsalicylic acid - 1.0 - 5.0
Menthol - 0.1 - 0.3
Boric acid - 0.1 - 0.5
Preservative - 0.2 - 1.0
Fragrance - 0.5 - 1
Water - Else

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