RU2120296C1 - Method of treatment of patients with lichen ruber planus of mouth cavity mucosa - Google Patents

Abstract

FIELD: medicine, stomatology. SUBSTANCE: method proposes clamine (by 2 tablets, twice per a day) or phytolone (by 50-60 drops, 2-3 times per a day) for 1-1.5 month as biologically active substances for treatment. Drugs are used in combination with laminaria extract, natural coniferous complex or Carotineli-M as applications (for 15-20 min every day, 2-3 courses at 2 weeks interval). EFFECT: enhanced therapeutic effectiveness of method. 2 cl, 2 ex, 2 tbl

Description

 The invention relates to medicine, namely to dentistry.

 A known method of treating red lichen (CPL) of the oral mucosa (MOP) using normalization of metabolic processes in the body and epithelium of the oral mucosa of biologically active substances (BAS) for general treatment (vitamins A, E, C multivitamins), and for the local - the application of oil solutions of vitamins A, E, carotoline, rosehip oil, sea buckthorn, etc. ("Diseases of the oral mucosa: Textbook. Edited by L.M. Lukins. - N. Novgorod: NGMI , 1993, p. 73 - 77).

 The disadvantages of this method are the low effectiveness of treatment, long periods of epithelialization of erosion and the elimination of inflammatory phenomena in complicated forms of CPL, short periods of remission of the disease.

 The aim of the invention is to increase the effectiveness of treatment by reducing the time of epithelialization of erosion and the elimination of inflammatory phenomena and lengthening periods of remission of the disease.

 This goal is achieved by the fact that the complex treatment includes natural biologically active substances: preparations "Klamin" and "Fitolon", and for local treatment of the oral cavity use kelp extract, natural coniferous complex or "Carotinoli-M".

 "Klamin" (TU 9350-001-11152173-93) and "Fitolon" (TU-29199-010-13189938-92) are therapeutic and prophylactic food additives, the basis of which is a substance from sea kale (kelp) containing vital components necessary for the human body: micro and macro elements, mono-, di- and triglycerides of fatty acids, chlorophyll and its derivatives, carotenoids (beta and gamma-carotenes), plant sterols, ascorbic acid, mannitol, amino acids, including essential ones .

 "Klamin" is available in the form of tablets containing dietary fiber (sorbent). "Fitolon" - in the form of alcohol tincture. Unlike synthetic vitamin preparations, Klamin and Phytolon contain a wider range of biologically active substances with a synergistic effect.

 "Klamin" and "Fitolon" improve metabolic processes in the body, have oncoprotective, antioxidant and immunostimulating properties.

 Laminarine extract contains amino acids, proteins, polysaccharides, trace elements, small concentrations of chlorophyll derivatives and carotenoids (TU 15-02-444-84).

 Natural coniferous complex (NHC) contains chlorophyll derivatives, carotenoids, tocopherol, vitamin C, sterols, fatty acids (TU 6491-13189938-008-92).

 "Carotinoli-M" - a multivitamin preparation obtained from some species of commercial fish, contains fat-soluble vitamins (A, D, E, K), beta-carotene, over 22 unsaturated fatty acids and other biologically active substances (TU 64-03-92) .

 These drugs improve trophism, microcirculation and metabolic processes in the tissues, accelerate their healing in lesions.

 The method is as follows. In the general treatment include "Klamin" 2 tablets. 2 times a day or "Fitolon" 50-60 drops 2 - 3 times a day, one hour after eating. The duration of the course of treatment is 1 - 1.5 months. To obtain a lasting result, 2 to 3 courses are required with interruptions of 2 weeks. Every six months, preventive treatment courses of the same duration are carried out.

 For local treatment, kelp extract is used in a dilution of 1: 10 with water, NHC on glycerol 1:10 and Carotinoli-M with the addition of olive oil in a ratio of 1: 2, 1: 3 in the form of applications on the affected areas of MOP for 15-20 min, 1-2 - 3 times a day.

 Despite the generality of the mechanisms of their action, kelp extract has great anti-inflammatory, necrolytic and epithelizing properties and is used for exudative-hyperemic and erosive-ulcerative forms of CPL, and NHC and Karotinoli-M are used for all forms of CPL and as a combined method after treatment of complicated forms of kelp extract as agents with a more pronounced antiproliferative effect.

 The proposed method was the treatment of 57 patients with CPR SOPR. The duration of observation during and after treatment was 2 years. Biochemical examination of patients revealed various deviations in the protein composition of the blood, cholesterol, beta-lipoproteins and impaired glucose tolerance. After treatment, in most cases (81.5%), normalization of the main indicators of protein, lipid and carbohydrate metabolism was observed.

 The results are presented in table. 12.

 Positive results in treatment were achieved in 87% of patients.

 The terms of epithelialization of erosion in the erosive-ulcerative form of CPL averaged 8.1 days. The duration of remission increased with mild and moderate forms of the disease to 1.5 - 2 years, and in severe cases - up to 7 - 8 months.

 When treating in a known manner, a positive effect was obtained in 55% of cases, the duration of epithelization was 14.2 days, remission in mild and moderate course lasted from 7 months. up to 1 year, with severe course - 2-3 months.

 We give specific examples of the implementation of the treatment method in clinical practice.

 Example 1. Patient K., 66 years old. Diagnosis: CPL, erosive-ulcerative form. Complains of pain in the mouth while eating. Disease duration - 5 months.

 Objectively: the mucous membrane of the cheeks is edematous, hyperemic. Against this background, extensive rashes of hyperkeratotic papules are determined. On the mucous membrane of the left cheek, erosion is determined in a size of 1.0 x 1.5 cm.

 Data of biochemical research before treatment: total protein 61 g / l, albumin-globulin coefficient - 0.82, total cholesterol - 7.8 mmol / l, beta-lipoproteins - 7.6 g / l, glycemic coefficient - 1.72, post-glycemic coefficient - 1.4.

 Treatment of concomitant pathology was carried out by appropriate specialists.

 Inside, motherwort tincture and Klamin were prescribed according to the scheme. In the oral cavity, applications were performed with kelp extract for 15 to 20 minutes, 2 times a day. Edema and hyperemia disappeared on day 3, erosion epithelized on day 6. Then applied daily applications with natural coniferous complex for a month.

 After treatment, subjective sensations were absent.

 Objectively: the mucous membrane of the oral cavity is pale pink, there is a significant reduction in the eruptive elements. Biochemical parameters after treatment: total protein - 68 g / l, albumin-globulin coefficient - 1.29, cholesterol 6.8 mmol / l, beta-lipoproteins - 5.5 g / l, glycemic coefficient 1.42, post-glycemic coefficient - 1.02.

 Example 2. Patient A., 67 years old. Diagnosis: CPL, erosive-ulcerative form. Complaints of pain in the oral cavity while talking and eating. The duration of the disease is 4 years. The last exacerbation occurred 2 months ago.

 Objectively: extensive papular eruptions in various parts of the CRS, especially on the dorsal-lateral surfaces of the tongue. The mucous membrane of the affected areas is edematous and hyperemic, on the dorsal-lateral surface of the tongue, erosion is determined on the left side, covered with fibrinous coating, 1.5x2.5 cm in size. Before treatment, treatment was performed for a month: inside Aevit and application of rosehip oil. No effect was observed.

 Data of biochemical research before treatment: total protein 60 g / l, albumin-globulin coefficient - 0.91, total cholesterol - 7.1 mmol / l, beta-lipoproteins - 8.2 g / l, glycemic coefficient - 1.68, post-glycemic coefficient of 1.52.

 Conducted 3 courses of treatment "Fitolon" according to the scheme. Topically, the application "Carotinoli-M" 1 - 2 times a day. Epithelization of erosion occurred on day 9.

 At the end of treatment, the disappearance of inflammatory phenomena, partial regression of papules, especially on the lateral surfaces of the tongue, was observed.

 Data from a biochemical study after treatment: total protein - 66 g / l, albumin-globulin coefficient - 1.34, total cholesterol - 6.5 mmol / l, beta-lipoproteins - 6.0 g / l, glycemic coefficient - 1.50 , post-glycemic coefficient of 1.21.

 Thus, the proposed method for the treatment of lichen planus of the oral mucosa contributes, in comparison with the known method, a higher therapeutic effect, reducing the time of epithelialization of erosion by 1.7 times, lengthening the periods of remission by almost 2 times against the background of normalization of the main indicators of protein, lipid and carbohydrate metabolism.

Claims (1)

 A method for the treatment of lichen planus of the oral mucosa by the use of biologically active substances, characterized in that Clamin, 2 tablets, is used as biologically active substances. 2 times a day or Fitolon 50-60 drops 2-3 times a day for 1-1.5 months and application to the affected areas of the oral mucosa of the extract of kelp, natural coniferous complex or Carotinoli-M for 15-20 minutes daily with 2 - 3 courses with breaks of 2 weeks.

Images