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RU2194709C2 - Способы получения производных эстеинасцидина, соединения, промежуточный продукт - Google Patents

Способы получения производных эстеинасцидина, соединения, промежуточный продукт Download PDF

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Publication number
RU2194709C2
RU2194709C2 RU99105564/04A RU99105564A RU2194709C2 RU 2194709 C2 RU2194709 C2 RU 2194709C2 RU 99105564/04 A RU99105564/04 A RU 99105564/04A RU 99105564 A RU99105564 A RU 99105564A RU 2194709 C2 RU2194709 C2 RU 2194709C2
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RU
Russia
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formula
derivative
compound
represented
equiv
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RU99105564/04A
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English (en)
Russian (ru)
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RU99105564A (ru
Inventor
Элиас Дж. Кори
Дэвид Джин
Original Assignee
Президент Энд Феллоуз Оф Гарвард Колледж
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Publication of RU99105564A publication Critical patent/RU99105564A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
RU99105564/04A 1996-09-18 1997-09-17 Способы получения производных эстеинасцидина, соединения, промежуточный продукт RU2194709C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/715,541 1996-09-18
US08/715,541 US5721362A (en) 1996-09-18 1996-09-18 Process for producing ecteinascidin compounds

Publications (2)

Publication Number Publication Date
RU99105564A RU99105564A (ru) 2000-12-27
RU2194709C2 true RU2194709C2 (ru) 2002-12-20

Family

ID=24874473

Family Applications (1)

Application Number Title Priority Date Filing Date
RU99105564/04A RU2194709C2 (ru) 1996-09-18 1997-09-17 Способы получения производных эстеинасцидина, соединения, промежуточный продукт

Country Status (21)

Country Link
US (1) US5721362A (fr)
EP (1) EP0931083B1 (fr)
JP (1) JP4425995B2 (fr)
KR (1) KR100358832B1 (fr)
CN (1) CN1096463C (fr)
AT (1) ATE232868T1 (fr)
AU (1) AU738282B2 (fr)
BR (1) BR9712073B1 (fr)
CA (1) CA2266081C (fr)
CZ (1) CZ299596B6 (fr)
DE (1) DE69719201T2 (fr)
DK (1) DK0931083T3 (fr)
ES (1) ES2192273T3 (fr)
HU (1) HU229407B1 (fr)
IL (2) IL128993A0 (fr)
NO (1) NO325345B1 (fr)
NZ (1) NZ334704A (fr)
PL (1) PL188572B1 (fr)
PT (1) PT931083E (fr)
RU (1) RU2194709C2 (fr)
WO (1) WO1998012198A1 (fr)

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* Cited by examiner, † Cited by third party
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CZ301083B6 (cs) * 1998-04-06 2009-11-04 The Board Of Trustees Of The University Of Illinois Ekteinascidinová sloucenina, farmaceutický prostredek ji obsahující a její použití
CN1195514C (zh) * 1998-05-11 2005-04-06 法马马有限公司 海鞘素 743的代谢物
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) * 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
BG65893B1 (bg) * 1999-05-14 2010-04-30 Pharma Mar S.A. Полусинтетичен метод и нови съединения
GB9918178D0 (en) * 2000-05-15 1999-10-06 Pharma Mar Sa Synthetic methods
EP1254140A4 (fr) 2000-01-19 2003-03-12 Univ Columbia Composes de la serie saframycine-ecteinascidine, utilisations et synthese
US6815544B2 (en) 2000-02-11 2004-11-09 President And Fellows Of Harvard College Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
IL151168A0 (en) * 2000-02-11 2003-04-10 Harvard College Process for producing a pentacyclic compound as an intermediate for the production of ecteinascidin and phthalascidin compounds
US6569859B1 (en) 2000-02-22 2003-05-27 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
DE60111845T2 (de) * 2000-04-12 2006-04-27 Pharma Mar, S.A., Tres Cantos Ecteinaschidin derivate mit antikrebs wirkung
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
US7420051B2 (en) * 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
JP4942900B2 (ja) * 2000-05-15 2012-05-30 ファルマ・マール・ソシエダード・アノニマ エクチナサイジン化合物の製造のための合成方法
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
EP1339713A2 (fr) 2000-11-03 2003-09-03 President And Fellows Of Harvard College Saframycines, analogues et leurs applications
US20040108086A1 (en) * 2000-11-06 2004-06-10 Naoto Takahashi Effective antitumor treatments
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
JP4208469B2 (ja) * 2002-01-29 2009-01-14 独立行政法人科学技術振興機構 エクテナサイジン類の全合成方法、エクテナサイジン類に類縁構造を持つ前記全合成用中間体化合物類、及び該中間体化合物類の合成方法
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
US7183054B2 (en) 2003-06-03 2007-02-27 President And Fellows Of Harvard College Assay for identifying biological targets of polynucleotide-binding compounds
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
SI1689404T1 (sl) * 2003-11-13 2009-02-28 Pharma Mar Sau Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
US20080255132A1 (en) * 2003-11-14 2008-10-16 Eric Rowinsky Combination Therapy Comprising the Use of Et-743 and Paclitaxel for Treating Cancer
US20080293725A1 (en) * 2004-07-09 2008-11-27 Rafael Rosell Costa Prognostic Molecular Markers
CN100396178C (zh) * 2004-08-06 2008-06-25 中国科学院海洋研究所 一种玻璃海鞘的全人工养殖方法及简易型连续投饵装置
JP2008514688A (ja) * 2004-09-29 2008-05-08 ファルマ・マル・エス・アー， ソシエダッド・ユニペルソナル 抗炎症剤としてのエクテイナシジン化合物
HRP20090345T1 (en) * 2004-10-26 2009-08-31 Pharma Mar S.A. Pegylated liposomal doxorubicin in combination with ecteinescidin 743
RS50510B (sr) 2004-10-29 2010-03-02 Pharma Mar S.A., Sociedad Unipersonal Formulacije koje sadrže ekteinascidin i disaharid
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
CN101157929B (zh) * 2007-02-02 2012-05-23 中国科学院上海有机化学研究所 番红霉素的生物合成基因簇
US20100267732A1 (en) * 2007-10-19 2010-10-21 Pharma Mar, S.A. Prognostic Molecular Markers for ET-743 Treatment
CA2800097C (fr) 2010-05-25 2019-01-08 Pharma Mar, S.A. Procede synthetique de fabrication de composes d'exteinascidine et d'intermediaires
KR102452022B1 (ko) 2010-11-12 2022-10-06 파르마 마르 에스.에이. 항종양 알칼로이드를 이용한 병용요법
CN103304478B (zh) * 2013-06-28 2016-04-20 四川大学 一类合成renieramycins型生物碱的中间体及其制备方法
CN104557850B (zh) * 2013-10-29 2019-07-30 江苏盛迪医药有限公司 一种海鞘碱-743中间体的制备方法
CN103709101B (zh) * 2013-12-19 2016-06-29 四川大学 一类renieramycin G的合成中间体及其制备方法
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CN111518110B (zh) 2019-02-01 2023-11-03 博瑞生物医药（苏州）股份有限公司 一种海鞘素化合物及其中间体的制备方法
CN110092802B (zh) * 2019-06-21 2022-01-07 爱斯特（成都）生物制药股份有限公司 一种制备曲贝替定中间体的方法
WO2020261301A1 (fr) * 2019-06-27 2020-12-30 Msn Laboratories Private Limited, R&D Center Procédé amélioré servant à la préparation de polymorphe pur de (1'r,6r,6ar,7r,13s,14s,16r)-5-(acétyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-diméthoxy-4,10,23-triméthylspiro[6,16-(épithiopropanoxyméth ano)-7,13-imino-12h-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'h)-isoquinolin]-19-one
PH12022551216A1 (en) 2019-11-21 2023-07-17 Pharma Mar Sa Methods of treating small cell lung cancer with lurbinectedin formulations
CN114621245A (zh) * 2020-12-11 2022-06-14 江苏恒瑞医药股份有限公司 一种曲贝替定中间体的晶型及其制备方法
US12303506B2 (en) 2022-01-20 2025-05-20 Extrovis Ag Trabectedin composition

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5265663A (en) * 1991-02-14 1993-11-30 Sanwa Shutter Corporation Architectural shutter curtain device
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
DE3923985C1 (fr) * 1989-07-20 1990-06-28 Daimler-Benz Aktiengesellschaft, 7000 Stuttgart, De

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5265663A (en) * 1991-02-14 1993-11-30 Sanwa Shutter Corporation Architectural shutter curtain device
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins

Non-Patent Citations (1)

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Title
МАШКОВСКИЙ М.Д. Лекарственные средства. Харьков: Торсинг, 1998, ч.2, с.263. *

Also Published As

Publication number Publication date
NZ334704A (en) 2000-09-29
JP4425995B2 (ja) 2010-03-03
US5721362A (en) 1998-02-24
DK0931083T3 (da) 2003-05-26
CA2266081A1 (fr) 1998-03-26
PL332206A1 (en) 1999-08-30
BR9712073B1 (pt) 2013-06-18
KR20000036242A (ko) 2000-06-26
IL128993A (en) 2006-06-11
ATE232868T1 (de) 2003-03-15
EP0931083A4 (fr) 2000-05-24
AU738282B2 (en) 2001-09-13
BR9712073A (pt) 2002-01-15
NO991301L (no) 1999-05-14
DE69719201T2 (de) 2003-12-11
DE69719201D1 (de) 2003-03-27
IL128993A0 (en) 2000-02-17
CZ91499A3 (cs) 1999-08-11
CA2266081C (fr) 2006-12-12
PL188572B1 (pl) 2005-02-28
CN1237974A (zh) 1999-12-08
WO1998012198A1 (fr) 1998-03-26
EP0931083A1 (fr) 1999-07-28
EP0931083B1 (fr) 2003-02-19
CZ299596B6 (cs) 2008-09-17
HUP0000068A2 (hu) 2000-06-28
HUP0000068A3 (en) 2001-12-28
CN1096463C (zh) 2002-12-18
ES2192273T3 (es) 2003-10-01
JP2001501196A (ja) 2001-01-30
NO991301D0 (no) 1999-03-17
KR100358832B1 (ko) 2002-11-21
PT931083E (pt) 2003-07-31
AU4420597A (en) 1998-04-14
HU229407B1 (en) 2013-12-30
NO325345B1 (no) 2008-04-07

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