RU2167877C2 - Производные конденсированных полициклических гетероциклических соединений и способ их получения - Google Patents
Производные конденсированных полициклических гетероциклических соединений и способ их получения Download PDFInfo
- Publication number
- RU2167877C2 RU2167877C2 RU97121851/04A RU97121851A RU2167877C2 RU 2167877 C2 RU2167877 C2 RU 2167877C2 RU 97121851/04 A RU97121851/04 A RU 97121851/04A RU 97121851 A RU97121851 A RU 97121851A RU 2167877 C2 RU2167877 C2 RU 2167877C2
- Authority
- RU
- Russia
- Prior art keywords
- ring
- group
- optionally substituted
- compound
- oxo
- Prior art date
Links
- 0 *C(C(C1C2C3CCCCC2CC2C1CCCCC2)[O-])C3=C Chemical compound *C(C(C1C2C3CCCCC2CC2C1CCCCC2)[O-])C3=C 0.000 description 8
- GAWVXGDSDZWDGH-UHFFFAOYSA-N C(C=C1)Sc(nc2)c1cc2C1=Cc2ccccc2SC1 Chemical compound C(C=C1)Sc(nc2)c1cc2C1=Cc2ccccc2SC1 GAWVXGDSDZWDGH-UHFFFAOYSA-N 0.000 description 1
- YYLLYRWIXOEJBH-UHFFFAOYSA-N C(C=Cc1c2)Oc1ccc2C(C1)=COc2c1cccc2 Chemical compound C(C=Cc1c2)Oc1ccc2C(C1)=COc2c1cccc2 YYLLYRWIXOEJBH-UHFFFAOYSA-N 0.000 description 1
- ZHULDJMXFBTZHH-UHFFFAOYSA-N C1NC=Cc(cc2)c1cc2N(C1)C=Cc2c1cccc2 Chemical compound C1NC=Cc(cc2)c1cc2N(C1)C=Cc2c1cccc2 ZHULDJMXFBTZHH-UHFFFAOYSA-N 0.000 description 1
- ZMZIREOYBXDHMD-UHFFFAOYSA-N C1c(cc(cn2)C3=CSc4ccccc4C3)c2SC=C1 Chemical compound C1c(cc(cn2)C3=CSc4ccccc4C3)c2SC=C1 ZMZIREOYBXDHMD-UHFFFAOYSA-N 0.000 description 1
- BBMJHIBGGPNXAR-UHFFFAOYSA-N CC(C(C(c1c2c(cccc3)c3cc1)C1=C2[I]=CC=C11)=O)C1=O Chemical compound CC(C(C(c1c2c(cccc3)c3cc1)C1=C2[I]=CC=C11)=O)C1=O BBMJHIBGGPNXAR-UHFFFAOYSA-N 0.000 description 1
- JNKZYMXRAQJMRC-UHFFFAOYSA-N CC(C(C1c2c3cccc2-c2c1ccc1c2cccc1)=O)C3=O Chemical compound CC(C(C1c2c3cccc2-c2c1ccc1c2cccc1)=O)C3=O JNKZYMXRAQJMRC-UHFFFAOYSA-N 0.000 description 1
- NRGHIDMFFKECSK-UHFFFAOYSA-N CN(CCC(C(C1c2c3cccc2-c2c1ccc1c2CCCC1=O)=O)C3=O)CC=C Chemical compound CN(CCC(C(C1c2c3cccc2-c2c1ccc1c2CCCC1=O)=O)C3=O)CC=C NRGHIDMFFKECSK-UHFFFAOYSA-N 0.000 description 1
- HOQZWHMBSZXLJB-UHFFFAOYSA-N N=C(C=COc1c2)c1ccc2C(Oc1ccncc11)=CC1=N Chemical compound N=C(C=COc1c2)c1ccc2C(Oc1ccncc11)=CC1=N HOQZWHMBSZXLJB-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7/133992 | 1995-05-31 | ||
| JP13399295 | 1995-05-31 | ||
| JP7/309195 | 1995-11-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU97121851A RU97121851A (ru) | 1999-10-27 |
| RU2167877C2 true RU2167877C2 (ru) | 2001-05-27 |
Family
ID=15117861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97121851/04A RU2167877C2 (ru) | 1995-05-31 | 1996-05-31 | Производные конденсированных полициклических гетероциклических соединений и способ их получения |
Country Status (3)
| Country | Link |
|---|---|
| CA (1) | CA2220509C (fr) |
| RU (1) | RU2167877C2 (fr) |
| WO (1) | WO1996038446A1 (fr) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2266906C1 (ru) * | 2004-04-29 | 2005-12-27 | Общество с ограниченной ответственностью "Исследовательский Институт Химического Разнообразия" (ООО "Исследовательский Институт Химического Разнообразия") | Анелированные карбамоилазагетероциклы, способы их получения (варианты), фармацевтическая композиция, фокусированная библиотека |
| RU2389730C2 (ru) * | 2005-01-10 | 2010-05-20 | Тиботек Фармасьютикалз Лтд. | 1,5,6-замещенные 2-оксо-3-циано-1,6а-диазатетрагидрофлуорантены |
| RU2393162C2 (ru) * | 2008-09-12 | 2010-06-27 | Государственное образовательное учреждение высшего профессионального образования САНКТ-ПЕТЕРБУРГСКАЯ ГОСУДАРСТВЕННАЯ ХИМИКО-ФАРМАЦЕВТИЧЕСКАЯ АКАДЕМИЯ (ГОУ ВПО СПХФА Росздрава) | ЗАМЕЩЕННЫЕ 2Н,8Н-1,4-ДИОКСА-9b-АЗАФЕНАЛЕН-2,8-ДИОНЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
| RU2507204C2 (ru) * | 2009-08-31 | 2014-02-20 | Мерк Шарп И Доум Корп. | Положительные аллостерические модуляторы м1-рецепторов на основе пираниларилметилбензохиназолинона |
| RU2520966C2 (ru) * | 2009-02-25 | 2014-06-27 | Дайити Санкио Компани, Лимитед | Производное трициклического пиразолопиримидина |
| RU2527451C2 (ru) * | 2008-12-11 | 2014-08-27 | Вайв Хелткер Компани | Синтез карбамоилпиридоновых ингибиторов интегразы вич и промежуточных соединений |
| US9260418B2 (en) | 2009-08-31 | 2016-02-16 | Merck Sharp & Dohme Corp. | Pyranyl aryl methyl benzoquinolinone M1 receptor positive allosteric modulators |
| RU2591194C2 (ru) * | 2010-04-22 | 2016-07-10 | Интра-Селлулар Терапиз, Инк. | Органические соединения |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101541811B (zh) * | 2006-09-19 | 2014-07-09 | 第一三共株式会社 | 吡唑并嘧啶衍生物 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB912289A (en) * | 1959-06-09 | 1962-12-05 | Geigy Ag J R | New basic ethers and processes for their production |
| US3962438A (en) * | 1975-01-07 | 1976-06-08 | Smithkline Corporation | Anti-arthritic 1H-pyrimido-(5,4,3-kl)phenothiazine-1,3(2H)-diones and 1-thiones |
| WO1992000281A1 (fr) * | 1990-06-26 | 1992-01-09 | Research Corporation Technologies, Inc. | Agents anticancereux a base de 1,2-dihydro-3h-dibenzisoquinoline-1,3-diones |
-
1996
- 1996-05-31 CA CA002220509A patent/CA2220509C/fr not_active Expired - Fee Related
- 1996-05-31 RU RU97121851/04A patent/RU2167877C2/ru not_active IP Right Cessation
- 1996-05-31 WO PCT/JP1996/001487 patent/WO1996038446A1/fr not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB912289A (en) * | 1959-06-09 | 1962-12-05 | Geigy Ag J R | New basic ethers and processes for their production |
| US3962438A (en) * | 1975-01-07 | 1976-06-08 | Smithkline Corporation | Anti-arthritic 1H-pyrimido-(5,4,3-kl)phenothiazine-1,3(2H)-diones and 1-thiones |
| WO1992000281A1 (fr) * | 1990-06-26 | 1992-01-09 | Research Corporation Technologies, Inc. | Agents anticancereux a base de 1,2-dihydro-3h-dibenzisoquinoline-1,3-diones |
Non-Patent Citations (1)
| Title |
|---|
| ANTONINI IPPOLITO ET ALL. "Synthesis of (dialkylamino)alkyl disubsubstituted pyrimido[5,6,1-de]acridines" J.Med.Chem, 1995, v.38. № 17, р.3282-3286. * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2266906C1 (ru) * | 2004-04-29 | 2005-12-27 | Общество с ограниченной ответственностью "Исследовательский Институт Химического Разнообразия" (ООО "Исследовательский Институт Химического Разнообразия") | Анелированные карбамоилазагетероциклы, способы их получения (варианты), фармацевтическая композиция, фокусированная библиотека |
| RU2389730C2 (ru) * | 2005-01-10 | 2010-05-20 | Тиботек Фармасьютикалз Лтд. | 1,5,6-замещенные 2-оксо-3-циано-1,6а-диазатетрагидрофлуорантены |
| RU2393162C2 (ru) * | 2008-09-12 | 2010-06-27 | Государственное образовательное учреждение высшего профессионального образования САНКТ-ПЕТЕРБУРГСКАЯ ГОСУДАРСТВЕННАЯ ХИМИКО-ФАРМАЦЕВТИЧЕСКАЯ АКАДЕМИЯ (ГОУ ВПО СПХФА Росздрава) | ЗАМЕЩЕННЫЕ 2Н,8Н-1,4-ДИОКСА-9b-АЗАФЕНАЛЕН-2,8-ДИОНЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
| RU2527451C2 (ru) * | 2008-12-11 | 2014-08-27 | Вайв Хелткер Компани | Синтез карбамоилпиридоновых ингибиторов интегразы вич и промежуточных соединений |
| RU2520966C2 (ru) * | 2009-02-25 | 2014-06-27 | Дайити Санкио Компани, Лимитед | Производное трициклического пиразолопиримидина |
| RU2507204C2 (ru) * | 2009-08-31 | 2014-02-20 | Мерк Шарп И Доум Корп. | Положительные аллостерические модуляторы м1-рецепторов на основе пираниларилметилбензохиназолинона |
| US8846702B2 (en) | 2009-08-31 | 2014-09-30 | Merck Sharp & Dohme Corp. | Pyranyl aryl methyl benzoquinazolinone M1 receptor positive allosteric modulators |
| US9260418B2 (en) | 2009-08-31 | 2016-02-16 | Merck Sharp & Dohme Corp. | Pyranyl aryl methyl benzoquinolinone M1 receptor positive allosteric modulators |
| RU2591194C2 (ru) * | 2010-04-22 | 2016-07-10 | Интра-Селлулар Терапиз, Инк. | Органические соединения |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2220509A1 (fr) | 1996-12-05 |
| WO1996038446A1 (fr) | 1996-12-05 |
| CA2220509C (fr) | 2005-07-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4776842B2 (ja) | 異性体の縮合ピロロカルバゾール類およびイソインドロン類 | |
| US5223625A (en) | Annelated indolo [3,2,-C]lactams | |
| KR20030070590A (ko) | 세로토닌 효능제 및 길항제로서 치환된 피롤로퀴놀린 및피리도퀴놀린 | |
| JPS5942678B2 (ja) | 四環式化合物及びその製法 | |
| JP2002543080A (ja) | ５−ｈｔ受容体リガンドとしての四環系アゼピノインドール化合物 | |
| JPH01190680A (ja) | インドール誘導体およびその製造方法 | |
| EP0319429B1 (fr) | Dérivés de la 9-(acylamino)tétrahydroacridine et agents pour l'amélioration de la mémoire les contenant comme ingrédient | |
| AU4376897A (en) | Novel indole-2,3-dione-3-oxime derivatives | |
| RU2167877C2 (ru) | Производные конденсированных полициклических гетероциклических соединений и способ их получения | |
| EP0831094B1 (fr) | Derives heterocycliques polycycliques fusionnes | |
| JP2001503759A (ja) | ５Ｈ―ピロロ［２，１―ｃ］［１，４］ベンゾジアゼピンの３―カルボキサミド誘導体 | |
| KR100243514B1 (ko) | 피롤로아제핀 유도체 | |
| EP0491814B1 (fr) | Derives d'imidazoquinazoline tetracycliques, leur preparation et compositions pharmaceutiques | |
| US5198437A (en) | 1,7-annelated indolecarboxylic acid esters and amides | |
| JP3992306B2 (ja) | 縮合多環式ヘテロ環誘導体 | |
| US4547501A (en) | Method of using [1,2,4]triazolo[4,3-a]quinoxaline-4-amine derivatives as antidepressant and antifatigue agents | |
| WO2010007248A2 (fr) | Nouveaux derives tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| CA1118423A (fr) | Derives de la 7- et de la 8-aza-indolo-isoquinoline | |
| US6583150B1 (en) | Pharmaceutical composition based on polyaromatic compounds | |
| JP3818549B2 (ja) | 縮合四環式ヘテロ環誘導体 | |
| EP0115920A2 (fr) | Dérivés de pyrazino(2',3'-3,4)pyrido(1,2-A)indole | |
| KR830000603B1 (ko) | 이소퀴놀린 유도체의 제조방법 | |
| US3480637A (en) | 3,3-bis(carbo-lower-alkoxy)indolo(2,3-a)quinolizinium salts | |
| JP3027599B2 (ja) | 新規なイソインドール誘導体およびその塩 | |
| JP2006507280A (ja) | 新規置換〔１，４〕ベンゾジオキシノ〔２，３−ｅ〕イソインドール誘導体、それらの製造方法、及びそれらを含有する医薬組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC4A | Invention patent assignment |
Effective date: 20100727 |
|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20120601 |