RU2019128568A - Жидкая композиция, содержащая прадофлоксацин - Google Patents
Жидкая композиция, содержащая прадофлоксацин Download PDFInfo
- Publication number
- RU2019128568A RU2019128568A RU2019128568A RU2019128568A RU2019128568A RU 2019128568 A RU2019128568 A RU 2019128568A RU 2019128568 A RU2019128568 A RU 2019128568A RU 2019128568 A RU2019128568 A RU 2019128568A RU 2019128568 A RU2019128568 A RU 2019128568A
- Authority
- RU
- Russia
- Prior art keywords
- liquid composition
- acid
- composition according
- antioxidant
- composition containing
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title claims 12
- 239000000203 mixture Substances 0.000 title claims 12
- LZLXHGFNOWILIY-APPDUMDISA-N pradofloxacin Chemical compound C12=C(C#N)C(N3C[C@H]4NCCC[C@H]4C3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 LZLXHGFNOWILIY-APPDUMDISA-N 0.000 title claims 2
- 229960001248 pradofloxacin Drugs 0.000 title claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- 239000003963 antioxidant agent Substances 0.000 claims 5
- 230000003078 antioxidant effect Effects 0.000 claims 5
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims 2
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- 239000000174 gluconic acid Substances 0.000 claims 2
- 235000012208 gluconic acid Nutrition 0.000 claims 2
- 235000012209 glucono delta-lactone Nutrition 0.000 claims 2
- 229960003681 gluconolactone Drugs 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229950006191 gluconic acid Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 229960000448 lactic acid Drugs 0.000 claims 1
- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 229940095574 propionic acid Drugs 0.000 claims 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 229940035024 thioglycerol Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Fats And Perfumes (AREA)
Claims (16)
1. Жидкая композиция, содержащая:
(a) от 1 до 30 % (масс./объем) прадофлоксацина
(b) от 1 до 30 % (масс./объем) кислоты
(c) от 0,01 до 1 % (масс./объем) антиоксиданта, выбранного из лимонной кислоты и тиоглицерина,
(d) в случае необходимости дополнительные фармацевтические вспомогательные вещества и/или добавки
(e) и воду в качестве растворителя.
2. Жидкая композиция по п. 1, причем антиоксидант представляет собой лимонную кислоту.
3. Жидкая композиция по п. 1, причем антиоксидант представляет собой тиоглицерин.
4. Жидкая композиция по п. 1, причем антиоксидант присутствует в концентрации от 0,05 до 0,5 % (масс./объем).
5. Жидкая композиция по п. 4, в которой антиоксидант присутствует в концентрации от 0,05 до 0,3 % (масс./объем).
6. Жидкая композиция по п. 1, причем кислоту выбирают из группы, состоящей из глюконовой кислоты, глюконолактона, метансульфоновой кислоты, молочной кислоты, пропионовой кислоты.
7. Жидкая композиция по п. 6, причем кислота представляет собой глюконовую кислоту или глюконолактон.
8. Жидкая композиция по п. 1, которая представляет собой раствор.
9. Жидкая композиция по любому из пп. 1-8, которая имеет рН от 2 до 5.
10. Жидкая композиция по любому из пп. 1-9 для применения в качестве лекарственного средства, применимого для инъекций.
11. Жидкая композиция по п. 10 для применения в лечении бактериальных инфекций у животных.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17155885.1 | 2017-02-13 | ||
| EP17155885 | 2017-02-13 | ||
| PCT/EP2018/053176 WO2018146194A1 (en) | 2017-02-13 | 2018-02-08 | Liquid composition containing pradofloxacin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2023104607A Division RU2023104607A (ru) | 2017-02-13 | 2018-02-08 | Жидкая композиция, содержащая прадофлоксацин |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2019128568A3 RU2019128568A3 (ru) | 2021-03-15 |
| RU2019128568A true RU2019128568A (ru) | 2021-03-15 |
Family
ID=58043920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019128568A RU2019128568A (ru) | 2017-02-13 | 2018-02-08 | Жидкая композиция, содержащая прадофлоксацин |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US10780168B2 (ru) |
| EP (1) | EP3579820B1 (ru) |
| JP (1) | JP7257322B2 (ru) |
| KR (1) | KR102504435B1 (ru) |
| CN (1) | CN110248643B (ru) |
| AR (1) | AR111032A1 (ru) |
| AU (1) | AU2018217931B2 (ru) |
| BR (1) | BR112019016543A2 (ru) |
| CL (1) | CL2019002283A1 (ru) |
| CO (1) | CO2019008677A2 (ru) |
| CR (1) | CR20190370A (ru) |
| DO (1) | DOP2019000207A (ru) |
| ES (1) | ES2886088T3 (ru) |
| IL (1) | IL268329B (ru) |
| MX (1) | MX387370B (ru) |
| PE (1) | PE20191462A1 (ru) |
| PH (1) | PH12019501946B1 (ru) |
| RU (1) | RU2019128568A (ru) |
| SG (1) | SG11201907073TA (ru) |
| TW (1) | TWI778017B (ru) |
| UA (1) | UA124124C2 (ru) |
| UY (1) | UY37603A (ru) |
| WO (1) | WO2018146194A1 (ru) |
| ZA (1) | ZA201906037B (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE067904T2 (hu) | 2019-02-13 | 2024-11-28 | DEBx Medical Holding BV | Elhalt vagy fertõzött szövetek testfelszíni sérülésekbõl és szájüregbõl történõ eltávolítására alkalmas készítmények |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0868183B1 (en) * | 1995-12-21 | 2002-01-30 | Pfizer Inc. | Injectable quinolone formulations |
| AU715341B2 (en) | 1996-02-23 | 2000-01-20 | Bayer Intellectual Property Gmbh | Possibly substituted 8-cyano-1-cyclopropyl-7-(2,8- diazabicyclo-(4.3.0)-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo- 3-quinolin carboxylic acids and their derivatives |
| ID21415A (id) | 1997-12-05 | 1999-06-10 | Upjohn Co | Senyawa-senyawa antibiotik magnesium quinolon |
| DE19854355A1 (de) | 1998-11-25 | 2000-05-31 | Bayer Ag | Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure |
| DE19854357A1 (de) | 1998-11-25 | 2000-05-31 | Bayer Ag | Semi-Hydrochlorid von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo/4.3.0/ -nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure |
| DE19854356A1 (de) | 1998-11-25 | 2000-05-31 | Bayer Ag | Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure |
| DE19908448A1 (de) | 1999-02-26 | 2000-08-31 | Bayer Ag | Kristallmodifikation D von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo[4.3.0)nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino incarbonsäure |
| JP4373649B2 (ja) | 2002-08-01 | 2009-11-25 | ロート製薬株式会社 | 経口用液剤 |
| DE102004015981A1 (de) | 2004-04-01 | 2005-10-20 | Bayer Healthcare Ag | Neue kirstalline Form von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure |
| CA2566433C (en) | 2004-05-11 | 2013-02-19 | Daiichi Asubio Pharma Co., Ltd. | Therapeutic agent for bh4-responsive hyperphenylalaninemia |
| AU2012202013A1 (en) * | 2004-12-09 | 2012-05-03 | Bayer Intellectual Property Gmbh | Medicament for hygienic application inside the ear |
| DE102005055385A1 (de) * | 2004-12-09 | 2006-06-14 | Bayer Healthcare Ag | Arzneimittel zur hygienischen Applikation im Ohr |
| JP4921750B2 (ja) | 2005-09-14 | 2012-04-25 | 株式会社日本点眼薬研究所 | ピレノキシンまたは薬理学的に許容される塩を含有する懸濁性医薬組成物 |
| DE102006010643A1 (de) * | 2006-03-08 | 2007-09-13 | Bayer Healthcare Aktiengesellschaft | Arzneimittel enthaltend Fluorchinolone |
| DE102006010642A1 (de) | 2006-03-08 | 2007-09-27 | Bayer Healthcare Aktiengesellschaft | Arzneimittelformulierungen, enthaltend Fluorchinolone |
| GB0615108D0 (en) | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel formulations |
| JP5624281B2 (ja) * | 2009-04-21 | 2014-11-12 | 東亜薬品株式会社 | 光安定性に優れたキノロン系抗菌薬含有液体製剤 |
| CN103830240B (zh) * | 2012-11-27 | 2016-07-06 | 洛阳惠中兽药有限公司 | 一种氟喹诺酮药物组合物 |
| CN102988286A (zh) * | 2012-12-13 | 2013-03-27 | 江苏恒丰强生物技术有限公司 | 一种恩诺沙星注射液 |
| CN107072973A (zh) | 2014-09-04 | 2017-08-18 | 劳波索尔制药有限公司 | 含左旋多巴、多巴胺脱羧酶抑制剂和comt抑制剂的药物组合物及其施用方法 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
-
2018
- 2018-02-08 PE PE2019001572A patent/PE20191462A1/es unknown
- 2018-02-08 US US16/484,670 patent/US10780168B2/en active Active
- 2018-02-08 KR KR1020197023567A patent/KR102504435B1/ko active Active
- 2018-02-08 SG SG11201907073TA patent/SG11201907073TA/en unknown
- 2018-02-08 RU RU2019128568A patent/RU2019128568A/ru unknown
- 2018-02-08 CR CR20190370A patent/CR20190370A/es unknown
- 2018-02-08 UA UAA201909560A patent/UA124124C2/uk unknown
- 2018-02-08 BR BR112019016543-6A patent/BR112019016543A2/pt active IP Right Grant
- 2018-02-08 PH PH1/2019/501946A patent/PH12019501946B1/en unknown
- 2018-02-08 AU AU2018217931A patent/AU2018217931B2/en active Active
- 2018-02-08 WO PCT/EP2018/053176 patent/WO2018146194A1/en not_active Ceased
- 2018-02-08 MX MX2019009572A patent/MX387370B/es unknown
- 2018-02-08 JP JP2019543005A patent/JP7257322B2/ja active Active
- 2018-02-08 ES ES18702736T patent/ES2886088T3/es active Active
- 2018-02-08 CN CN201880011402.8A patent/CN110248643B/zh active Active
- 2018-02-08 EP EP18702736.2A patent/EP3579820B1/en active Active
- 2018-02-09 TW TW107104598A patent/TWI778017B/zh active
- 2018-02-09 AR ARP180100319A patent/AR111032A1/es active IP Right Grant
- 2018-02-09 UY UY0001037603A patent/UY37603A/es not_active Application Discontinuation
-
2019
- 2019-07-29 IL IL268329A patent/IL268329B/en unknown
- 2019-08-09 CO CONC2019/0008677A patent/CO2019008677A2/es unknown
- 2019-08-12 CL CL2019002283A patent/CL2019002283A1/es unknown
- 2019-08-13 DO DO2019000207A patent/DOP2019000207A/es unknown
- 2019-09-12 ZA ZA2019/06037A patent/ZA201906037B/en unknown
-
2020
- 2020-08-20 US US16/998,390 patent/US11617792B2/en active Active
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| HE9A | Changing address for correspondence with an applicant |