RU2019113370A3 - - Google Patents
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- RU2019113370A3 RU2019113370A3 RU2019113370A RU2019113370A RU2019113370A3 RU 2019113370 A3 RU2019113370 A3 RU 2019113370A3 RU 2019113370 A RU2019113370 A RU 2019113370A RU 2019113370 A RU2019113370 A RU 2019113370A RU 2019113370 A3 RU2019113370 A3 RU 2019113370A3
- Authority
- RU
- Russia
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16196184 | 2016-10-28 | ||
| EP16196184.2 | 2016-10-28 | ||
| PCT/EP2017/077654 WO2018078123A1 (en) | 2016-10-28 | 2017-10-27 | Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2019113370A RU2019113370A (ru) | 2020-11-30 |
| RU2019113370A3 true RU2019113370A3 (ru) | 2021-03-01 |
| RU2756405C2 RU2756405C2 (ru) | 2021-09-30 |
Family
ID=57218739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019113370A RU2756405C2 (ru) | 2016-10-28 | 2017-10-27 | Комбинация антитела CD19 с ингибитором BCL-2 и пути ее применения |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US12358983B2 (ru) |
| EP (2) | EP3903821A1 (ru) |
| JP (3) | JP7094950B2 (ru) |
| KR (2) | KR102500868B1 (ru) |
| CN (2) | CN118045175A (ru) |
| AU (2) | AU2017348624B2 (ru) |
| BR (1) | BR112019008244A2 (ru) |
| CA (1) | CA3037246A1 (ru) |
| CY (1) | CY1124648T1 (ru) |
| DK (1) | DK3532098T3 (ru) |
| ES (1) | ES2871574T3 (ru) |
| HR (1) | HRP20210838T1 (ru) |
| HU (1) | HUE054496T2 (ru) |
| IL (3) | IL320372A (ru) |
| LT (1) | LT3532098T (ru) |
| MX (2) | MX2019004942A (ru) |
| NZ (1) | NZ751414A (ru) |
| PL (1) | PL3532098T3 (ru) |
| PT (1) | PT3532098T (ru) |
| RS (1) | RS62036B1 (ru) |
| RU (1) | RU2756405C2 (ru) |
| SG (1) | SG10202104036QA (ru) |
| SI (1) | SI3532098T1 (ru) |
| SM (1) | SMT202100347T1 (ru) |
| WO (1) | WO2018078123A1 (ru) |
| ZA (1) | ZA201903302B (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3337506T3 (pl) | 2015-08-21 | 2022-01-03 | Morphosys Ag | Kombinacje i ich zastosowania |
| ES2871574T3 (es) | 2016-10-28 | 2021-10-29 | Morphosys Ag | Combinación de anticuerpo anti CD19 con un inhibidor de BCL-2 y usos de la misma |
| MX2019014330A (es) * | 2017-05-31 | 2020-02-05 | Morphosys Ag | Paradigma de tratamiento para un tratamiento de combinacion de anticuerpo anti-cd19 y venetoclax. |
| GB201809746D0 (en) * | 2018-06-14 | 2018-08-01 | Berlin Chemie Ag | Pharmaceutical combinations |
| WO2020043878A1 (en) * | 2018-08-31 | 2020-03-05 | Adc Therapeutics Sa | Combination therapy |
| EP4051317A1 (en) * | 2019-10-31 | 2022-09-07 | MorphoSys AG | Sequential anti-cd19 therapy |
| US20220389104A1 (en) * | 2021-05-28 | 2022-12-08 | Ose Immunotherapeutics | Method for Treating CD127-Positive Cancers by Administering an Anti-CD127 Agent |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS60500673A (ja) | 1983-03-08 | 1985-05-09 | コモンウエルス セラム ラボラトリ−ズ コミツシヨン | 抗原活性を有するアミノ酸配列 |
| US5686072A (en) | 1992-06-17 | 1997-11-11 | Board Of Regents, The University Of Texas | Epitope-specific monoclonal antibodies and immunotoxins and uses thereof |
| US20020058029A1 (en) | 2000-09-18 | 2002-05-16 | Nabil Hanna | Combination therapy for treatment of autoimmune diseases using B cell depleting/immunoregulatory antibody combination |
| US7771951B2 (en) | 2001-12-03 | 2010-08-10 | Amgen Fremont Inc. | Antibody categorization based on binding characteristics |
| CA2534639C (en) | 2003-07-31 | 2013-07-30 | Immunomedics, Inc. | Anti-cd19 antibodies |
| US7902338B2 (en) | 2003-07-31 | 2011-03-08 | Immunomedics, Inc. | Anti-CD19 antibodies |
| WO2007002223A2 (en) | 2005-06-20 | 2007-01-04 | Medarex, Inc. | Cd19 antibodies and their uses |
| PT2270050E (pt) | 2005-12-30 | 2013-09-12 | Merck Patent Gmbh | Anticorpos anti-cd19 com imunogenicidade reduzida |
| CA2658557C (en) | 2006-08-14 | 2015-12-01 | Xencor, Inc. | Optimized antibodies that target cd19 |
| US7798471B2 (en) | 2006-08-15 | 2010-09-21 | Hydralift Amclyde, Inc. | Direct acting single sheave active/passive heave compensator |
| DK2066349T3 (da) | 2006-09-08 | 2012-07-09 | Medimmune Llc | Humaniseret anti-cd19-antistoffer og anvendelse heraf i behandling af tumorer, transplantation og autoimmune sygdomme |
| PL2529622T3 (pl) | 2006-09-22 | 2018-07-31 | Pharmacyclics Llc | Inhibitory kinazy tyrozynowej brutona |
| EP2708557A1 (en) * | 2007-05-30 | 2014-03-19 | Xencor, Inc. | Method and compositions for inhibiting CD32B expressing cells |
| AU2008311815B2 (en) | 2007-10-19 | 2014-02-06 | Seagen Inc. | CD19 binding agents and uses thereof |
| US20100128586A1 (en) | 2008-11-25 | 2010-05-27 | Mediatek Inc. | Method and apparatus for accessing data from disc with linking area |
| BRPI1005984A2 (pt) | 2009-02-23 | 2016-10-04 | Glenmark Pharmaceuticals Sa | anticorpo humanizado ou fragmento do mesmo que se liga ao cd19 humano, acido nucleico isolado, vetor, célula hospedeira, método para produzir um anticorpo humanizado ou fragmento do mesmo que se liga à cd12 humano, composição, imunoconjugado, uso de um anticorpo humanizado ou fragmento do mesmo, artigo de manufatura e kit |
| US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| AU2010263272C1 (en) | 2009-06-24 | 2016-02-11 | The Feinstein Institute For Medical Research | Method for treating chronic lymphocytic leukemia |
| WO2011147834A1 (en) | 2010-05-26 | 2011-12-01 | Roche Glycart Ag | Antibodies against cd19 and uses thereof |
| MX387728B (es) | 2010-06-03 | 2025-03-18 | Pharmacyclics Llc | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
| EP2409712A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile |
| EP2409993A1 (en) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anti-CD19 antibody having ADCC function with improved glycosylation profile |
| US8543911B2 (en) | 2011-01-18 | 2013-09-24 | Apple Inc. | Ordering document content based on reading flow |
| EP2524929A1 (en) | 2011-05-17 | 2012-11-21 | Sanofi | Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms |
| KR20140071368A (ko) | 2011-08-16 | 2014-06-11 | 모르포시스 아게 | 항ｃｄ19 항체 및 퓨린 유사체를 이용한 병용 요법 |
| KR102115203B1 (ko) | 2011-08-16 | 2020-05-28 | 모르포시스 아게 | 항-cd19 항체 및 질소 머스타드를 사용한 조합 요법 |
| CN105793251B (zh) * | 2013-12-05 | 2018-10-12 | 豪夫迈·罗氏有限公司 | 具有亲电子官能性的杂芳基吡啶酮和氮杂-吡啶酮化合物 |
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| EP3129470B1 (en) * | 2014-04-07 | 2021-04-07 | Novartis Ag | Treatment of cancer using anti-cd19 chimeric antigen receptor |
| CN106794231A (zh) | 2014-06-16 | 2017-05-31 | 赞科股份有限公司 | 用于慢性淋巴细胞性白血病（cll）的治疗 |
| CN117427091A (zh) | 2014-10-20 | 2024-01-23 | 朱诺治疗学股份有限公司 | 用于过继细胞治疗中的给药的组合物和方法 |
| JP2018506533A (ja) * | 2015-02-12 | 2018-03-08 | シアトル ジェネティックス， インコーポレイテッド | Ｃｄ１９−ａｄｃ及びビンクリスチンを使用する組み合わせ療法 |
| PL3302550T3 (pl) | 2015-05-26 | 2020-02-28 | Morphosys Ag | Kombinacja przeciwciała anty-cd19 i inhibitora kinazy tyrozynowej brutona i jej zastosowania |
| HRP20191585T1 (hr) | 2015-05-26 | 2019-11-29 | Hoffmann La Roche | Kombinirana terapija protutijela anti cd20 s inhibitorima bcl-2 i mdm2 |
| AU2016288246A1 (en) | 2015-07-02 | 2018-02-01 | Celgene Corporation | Combination therapy for treatment of hematological cancers and solid tumors |
| PL3337506T3 (pl) | 2015-08-21 | 2022-01-03 | Morphosys Ag | Kombinacje i ich zastosowania |
| LT3916392T (lt) | 2016-05-30 | 2024-08-26 | Incyte Corporation | Pacientų gydymo anti-cd19 terapinės naudos prognozavimo būdai |
| DK3475303T3 (da) | 2016-06-27 | 2021-05-31 | Morphosys Ag | Anti-cd19-antistofformuleringer |
| ES2871574T3 (es) | 2016-10-28 | 2021-10-29 | Morphosys Ag | Combinación de anticuerpo anti CD19 con un inhibidor de BCL-2 y usos de la misma |
| MX2019014330A (es) | 2017-05-31 | 2020-02-05 | Morphosys Ag | Paradigma de tratamiento para un tratamiento de combinacion de anticuerpo anti-cd19 y venetoclax. |
| US20210292410A1 (en) | 2017-12-07 | 2021-09-23 | Morphosys Ag | Treatment paradigm for an anti-cd19 antibody and venetoclax combination treatment |
| KR20200030337A (ko) | 2018-09-12 | 2020-03-20 | 주식회사 녹십자랩셀 | 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물 |
| EA202193024A1 (ru) | 2019-05-03 | 2022-02-09 | МорфоСис АГ | Анти-cd19-терапия у пациентов с ограниченным числом естественных клеток-киллеров |
| MX2022005031A (es) | 2019-10-31 | 2022-07-27 | Morphosys Ag | Terapia anti cumulo de diferenciacion 19(cd19) en combinacion con lenalidomida para el tratamiento de leucemias o linfomas. |
| EP4051317A1 (en) | 2019-10-31 | 2022-09-07 | MorphoSys AG | Sequential anti-cd19 therapy |
| MX2022005033A (es) | 2019-10-31 | 2022-09-09 | Morphosys Ag | Terapia combinada antitumoral que comprende un anticuerpo anti grupo de diferenciación 19 (cd19) y linfocitos t gamma delta. |
| TW202216193A (zh) | 2020-06-22 | 2022-05-01 | 德商莫菲西斯公司 | 包含抗CD19抗體及阻斷SIRPα-CD47先天免疫檢查點之多肽之抗腫瘤組合療法 |
| MX2023006538A (es) | 2020-12-04 | 2023-08-08 | Morphosys Ag | Terapia combinada de anticuerpo anti cúmulo de diferenciación 19 (cd19). |
| US20230357392A1 (en) | 2021-12-22 | 2023-11-09 | Morphosys Ag | Treatment Paradigm for an Anti-CD19 Antibody Therapy |
-
2017
- 2017-10-27 ES ES17797564T patent/ES2871574T3/es active Active
- 2017-10-27 WO PCT/EP2017/077654 patent/WO2018078123A1/en not_active Ceased
- 2017-10-27 LT LTEP17797564.6T patent/LT3532098T/lt unknown
- 2017-10-27 IL IL320372A patent/IL320372A/en unknown
- 2017-10-27 AU AU2017348624A patent/AU2017348624B2/en active Active
- 2017-10-27 IL IL266216A patent/IL266216B2/en unknown
- 2017-10-27 HR HRP20210838TT patent/HRP20210838T1/hr unknown
- 2017-10-27 JP JP2019522273A patent/JP7094950B2/ja active Active
- 2017-10-27 HU HUE17797564A patent/HUE054496T2/hu unknown
- 2017-10-27 KR KR1020197012532A patent/KR102500868B1/ko active Active
- 2017-10-27 BR BR112019008244A patent/BR112019008244A2/pt unknown
- 2017-10-27 MX MX2019004942A patent/MX2019004942A/es unknown
- 2017-10-27 SM SM20210347T patent/SMT202100347T1/it unknown
- 2017-10-27 CN CN202410183851.8A patent/CN118045175A/zh active Pending
- 2017-10-27 US US16/342,645 patent/US12358983B2/en active Active
- 2017-10-27 PL PL17797564T patent/PL3532098T3/pl unknown
- 2017-10-27 IL IL301786A patent/IL301786B2/en unknown
- 2017-10-27 SG SG10202104036QA patent/SG10202104036QA/en unknown
- 2017-10-27 PT PT177975646T patent/PT3532098T/pt unknown
- 2017-10-27 DK DK17797564.6T patent/DK3532098T3/da active
- 2017-10-27 CN CN201780067047.1A patent/CN109890418B/zh active Active
- 2017-10-27 CA CA3037246A patent/CA3037246A1/en active Pending
- 2017-10-27 KR KR1020237005018A patent/KR20230028571A/ko not_active Ceased
- 2017-10-27 SI SI201730811T patent/SI3532098T1/sl unknown
- 2017-10-27 RS RS20210792A patent/RS62036B1/sr unknown
- 2017-10-27 EP EP21165598.0A patent/EP3903821A1/en active Pending
- 2017-10-27 EP EP17797564.6A patent/EP3532098B1/en active Active
- 2017-10-27 RU RU2019113370A patent/RU2756405C2/ru active
- 2017-10-27 NZ NZ751414A patent/NZ751414A/en unknown
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2019
- 2019-04-26 MX MX2022016270A patent/MX2022016270A/es unknown
- 2019-05-24 ZA ZA2019/03302A patent/ZA201903302B/en unknown
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2021
- 2021-06-10 CY CY20211100512T patent/CY1124648T1/el unknown
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2022
- 2022-06-22 JP JP2022100006A patent/JP2022137089A/ja active Pending
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2024
- 2024-08-01 JP JP2024125584A patent/JP2024167208A/ja active Pending
- 2024-12-23 AU AU2024287178A patent/AU2024287178A1/en active Pending