RU2019113370A - Комбинация антитела CD19 с ингибитором BCL-2 и пути ее применения - Google Patents
Комбинация антитела CD19 с ингибитором BCL-2 и пути ее применения Download PDFInfo
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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Claims (12)
1. Комбинация, содержащая антитело, специфическое в отношении CD19, где указанное антитело содержит область HCDR1, содержащую последовательность SYVMH (SEQ ID NO: 1), область HCDR2, содержащую последовательность NPYNDG (SEQ ID NO: 2), область HCDR3, содержащую последовательность GTYYYGTRVFDY (SEQ ID NO: 3), область LCDR1, содержащую последовательность RSSKSLQNVNGNTYLY (SEQ ID NO: 4), область LCDR2, содержащую последовательность RMSNLNS (SEQ ID NO: 5), и область LCDR3, содержащую последовательность MQHLEYPIT (SEQ ID NO: 6), и венетоклакс, для применения в лечении неходжкинской лимфомы, хронического лимфоцитарного лейкоза и/или острого лимфобластного лейкоза.
2. Комбинация по п. 1, где антитело характеризуется активностью ADCC.
3. Комбинация по п. 1 или 2, где антитело содержит вариабельный домен тяжелой цепи, содержащий последовательность EVQLVESGGGLVKPGG SLKLSCAASGYTFTSY VMHWVRQAPGKGLEWI GYINPYNDGTKYNEKFQ GRVTISSDKSISTAYMEL SSLRSEDTAMYYCARGT YYYGTRVFDYWGQGT LVTVSS (SEQ ID NO: 10), и вариабельный домен легкой цепи с последовательностью DIVMTQSPATLSLSPGER ATLSCRSSKSLQNVNGN TYLYWFQQKPGQSPQL LIYRMSNLNSGVPDRFS GSGSGTEFTLTISSLEPE DFAVYYCMQHLEYPIT FGAGTKLEIK (SEQ ID NO: 11).
4. Комбинация по любому из предыдущих пунктов, где антитело содержит константный домен тяжелой цепи, содержащий последовательность ASTKGPSVFPLAPSSKS TSGGTAALGCLVKDY FPEPVTVSWNSGALTS GVHTFPAVLQSSGLYS LSSVVTVPSSSLGTQT YICNVNHKPSNTKVD KKVEPKSCDKTHTCP PCPAPELLGGPDVFLF PPKPKDTLMISRTPEV TCVVVDVSHEDPEVQ FNWYVDGVEVHNAK TKPREEQFNSTFRVVS VLTVVHQDWLNGKE YKCKVSNKALPAPEE KTISKTKGQPREPQVY TLPPSREEMTKNQVSL TCLVKGFYPSDIAVE WESNGQPENNYKTTP PMLDSDGSFFLYSKL TVDKSRWQQGNVFS CSVMHEALHNHYTQ KSLSLSPGK(SEQ ID NO: 12).
5. Комбинация по любому из предыдущих пунктов, где антитело содержит константный домен легкой цепи, содержащий последовательность RTVAAPSVFIFPPSDE QLKSGTASVVCLLN NFYPREAKVQWKVD NALQSGNSQESVTEQ DSKDSTYSLSSTLTLS KADYEKHKVYACEV THQGLSSPVT KSFNRGEC (SEQ ID NO: 13).
6. Комбинация по любому из предыдущих пунктов, где указанное антитело, специфическое в отношении CD19, и венетоклакс вводятся отдельно.
7. Комбинация по любому из предыдущих пунктов, где венетоклакс вводится до введения антитела, специфического в отношении CD19.
8. Комбинация по любому из предыдущих пунктов, где указанное антитело, специфическое в отношении CD19, и венетоклакс вводятся одновременно.
9. Комбинация по любому из предыдущих пунктов, где указанное антитело, специфическое в отношении CD19, и венетоклакс вводятся в определенный момент времени, при этом оба лекарственных средства проявляют активность у пациента в одно и то же время.
10. Комбинация по любому из предыдущих пунктов для применения в лечении хронического лимфоцитарного лейкоза.
11. Комбинация по любому из предыдущих пунктов для применения в лечении острого лимфобластного лейкоза.
12. Комбинация по любому из предыдущих пунктов для применения в лечении неходжкинской лимфомы, где неходжкинская лимфома выбрана из группы, состоящей из фолликулярной лимфомы, мелкоклеточной лимфоцитарной лимфомы, лимфомы лимфоидной ткани слизистых оболочек, лимфомы маргинальной зоны, диффузной крупноклеточной В-клеточной лимфомы, лимфомы Беркитта и лимфомы из клеток мантийной зоны.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16196184.2 | 2016-10-28 | ||
| EP16196184 | 2016-10-28 | ||
| PCT/EP2017/077654 WO2018078123A1 (en) | 2016-10-28 | 2017-10-27 | Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2019113370A true RU2019113370A (ru) | 2020-11-30 |
| RU2019113370A3 RU2019113370A3 (ru) | 2021-03-01 |
| RU2756405C2 RU2756405C2 (ru) | 2021-09-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2019113370A RU2756405C2 (ru) | 2016-10-28 | 2017-10-27 | Комбинация антитела CD19 с ингибитором BCL-2 и пути ее применения |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US12358983B2 (ru) |
| EP (2) | EP3532098B1 (ru) |
| JP (3) | JP7094950B2 (ru) |
| KR (2) | KR20230028571A (ru) |
| CN (2) | CN109890418B (ru) |
| AU (2) | AU2017348624B2 (ru) |
| BR (1) | BR112019008244A2 (ru) |
| CA (1) | CA3037246A1 (ru) |
| CY (1) | CY1124648T1 (ru) |
| DK (1) | DK3532098T3 (ru) |
| ES (1) | ES2871574T3 (ru) |
| HR (1) | HRP20210838T1 (ru) |
| HU (1) | HUE054496T2 (ru) |
| IL (3) | IL320372A (ru) |
| LT (1) | LT3532098T (ru) |
| MX (2) | MX2019004942A (ru) |
| NZ (1) | NZ751414A (ru) |
| PL (1) | PL3532098T3 (ru) |
| PT (1) | PT3532098T (ru) |
| RS (1) | RS62036B1 (ru) |
| RU (1) | RU2756405C2 (ru) |
| SG (1) | SG10202104036QA (ru) |
| SI (1) | SI3532098T1 (ru) |
| SM (1) | SMT202100347T1 (ru) |
| WO (1) | WO2018078123A1 (ru) |
| ZA (1) | ZA201903302B (ru) |
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| DK3337506T3 (da) | 2015-08-21 | 2021-09-06 | Morphosys Ag | Kombinationer og anvendelser deraf |
| SG10202104036QA (en) | 2016-10-28 | 2021-05-28 | Morphosys Ag | Combination of anti cd19 antibody with a bcl-2 inhibitor and uses thereof |
| CA3062400A1 (en) | 2017-05-31 | 2018-12-06 | Morphosys Ag | Treatment paradigm for an anti-cd19 antibody and venetoclax combination treatment |
| GB201809746D0 (en) * | 2018-06-14 | 2018-08-01 | Berlin Chemie Ag | Pharmaceutical combinations |
| CA3107085A1 (en) * | 2018-08-31 | 2020-03-05 | Adc Therapeutics Sa | Combination of anti-cd19 antibody-pyrroloenzodiazepine conjugate and ve netoclax |
| KR20200030337A (ko) | 2018-09-12 | 2020-03-20 | 주식회사 녹십자랩셀 | 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물 |
| US20240156863A1 (en) * | 2019-10-31 | 2024-05-16 | Morphosys Ag | Sequential anti-cd19 therapy |
| US20220389104A1 (en) * | 2021-05-28 | 2022-12-08 | Ose Immunotherapeutics | Method for Treating CD127-Positive Cancers by Administering an Anti-CD127 Agent |
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2017
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