RU2019110835A - Антитела к pd-1(cd279) - Google Patents
Антитела к pd-1(cd279) Download PDFInfo
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- RU2019110835A RU2019110835A RU2019110835A RU2019110835A RU2019110835A RU 2019110835 A RU2019110835 A RU 2019110835A RU 2019110835 A RU2019110835 A RU 2019110835A RU 2019110835 A RU2019110835 A RU 2019110835A RU 2019110835 A RU2019110835 A RU 2019110835A
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- 102100040678 Programmed cell death protein 1 Human genes 0.000 title claims 13
- 101710089372 Programmed cell death protein 1 Proteins 0.000 title claims 12
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 title claims 7
- 102000048362 human PDCD1 Human genes 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Claims (33)
1. Антитело к PD-1 человека, которое специфически связывает PD-1 человека, имеющий аминокислотную последовательность, соответствующую SEQ ID NO:1, где антитело содержит (i) цепь VH, содержащую три CDR; и (ii) цепь VL, содержащую три CDR, где:
CDR №1 VH представляет собой GYTFTHYGMN (SEQ ID NO:11);
CDR №2 VH представляет собой WVNTYTGEPTYADDFKG (SEQ ID NO:12);
CDR №3 VH представляет собой EGEGLGFGD (SEQ ID NO:13);
CDR №1 VL представляет собой RSSQSIVHSHGDTYLE (SEQ ID NO:14);
CDR №2 VL представляет собой KVSNRFS (SEQ ID NO:15); и
CDR №3 VL представляет собой FQGSHIPVT (SEQ ID NO:16).
2. Антитело к PD-1 человека по п. 1, которое является гуманизированным.
3. Антитело к PD-1 человека по п. 2, которое содержит цепь VH, последовательность которой соответствует SEQ ID NO:36; и цепь VL, последовательность которой соответствует SEQ ID NO:42.
4. Антитело к PD-1 человека по п. 3, которое представляет собой IgG.
5. Антитело к PD-1 человека по п. 4, которое представляет собой IgG1.
6. Антитело к PD-1 человека по п. 5, содержащее вариантный домен CH2, имеющий аминокислотные замены L234A и L235A.
7. Антитело к PD-1 человека по п. 3, содержащее каппа легкую константную область.
8. Антитело к PD-1 человека по п. 3, которое содержит тяжелую цепь, последовательность которой соответствует SEQ ID NO:51 или SEQ ID NO:52, и легкую цепь, последовательность которой соответствует SEQ ID NO:61.
9. Антитело к PD-1 человека по п. 4, которое представляет собой IgG4 и содержит вариантную область Fc, имеющую аминокислотную замену S228P.
10. Нуклеиновая кислота, содержащая нуклеотидную последовательность, кодирующую антитело к PD-1 человека, которое специфически связывает PD-1 человека, имеющий аминокислотную последовательность, соответствующую SEQ ID NO:1, где антитело содержит (i) цепь VH, содержащую три CDR; и (ii) цепь VL, содержащую три CDR, где:
CDR №1 VH представляет собой GYTFTHYGMN (SEQ ID NO:11);
CDR №2 VH представляет собой WVNTYTGEPTYADDFKG (SEQ ID NO:12);
CDR №3 VH представляет собой EGEGLGFGD (SEQ ID NO:13);
CDR №1 VL представляет собой RSSQSIVHSHGDTYLE (SEQ ID NO:14);
CDR №2 VL представляет собой KVSNRFS (SEQ ID NO:15); и
CDR №3 VL представляет собой FQGSHIPVT (SEQ ID NO:16).
11. Способ получения антитела к PD-1 человека, предусматривающий: (a) культивирование клетки-хозяина, сконструированной для экспрессии нуклеиновой кислоты по п. 10, и (b) выделение антитела к PD-1 человека.
12. Способ активации иммунной системы, предусматривающий введение пациенту, нуждающемуся в этом, эффективного количества антитела к PD-1 человека, полученного согласно способу по п. 11.
13. Способ лечения рака, предусматривающий введение пациенту, нуждающемуся в этом, терапевтически эффективного количества антитела к PD-1 человека, где антитело специфически связывает PD-1 человека, имеющий аминокислотную последовательность, соответствующую SEQ ID NO:1, где антитело содержит (i) цепь VH, содержащую три CDR; и (ii) цепь VL, содержащую три CDR, где
CDR №1 VH представляет собой GYTFTHYGMN (SEQ ID NO:11);
CDR №2 VH представляет собой WVNTYTGEPTYADDFKG (SEQ ID NO:12);
CDR №3 VH представляет собой EGEGLGFGD (SEQ ID NO:13);
CDR №1 VL представляет собой RSSQSIVHSHGDTYLE (SEQ ID NO:14);
CDR №2 VL представляет собой KVSNRFS (SEQ ID NO:15); и
CDR №3 VL представляет собой FQGSHIPVT (SEQ ID NO:16).
14. Способ по п. 13, где рак выбран из рака мочевого пузыря, рака молочной железы, рака головы и шеи, рака почки, рака легкого, лимфомы, меланомы и рака желудка.
15. Способ по п. 14, где рак легкого представляет собой немелкоклеточный рак легкого.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662394314P | 2016-09-14 | 2016-09-14 | |
| US62/394,314 | 2016-09-14 | ||
| PCT/US2017/051531 WO2018053106A1 (en) | 2016-09-14 | 2017-09-14 | Anti-pd-1(cd279) antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2019110835A true RU2019110835A (ru) | 2020-10-15 |
| RU2019110835A3 RU2019110835A3 (ru) | 2021-01-26 |
| RU2752562C2 RU2752562C2 (ru) | 2021-07-29 |
Family
ID=59955732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019110835A RU2752562C2 (ru) | 2016-09-14 | 2017-09-14 | Антитела к pd-1(cd279) |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US9914783B1 (ru) |
| EP (2) | EP3512547B1 (ru) |
| JP (1) | JP7079773B2 (ru) |
| KR (2) | KR102561356B1 (ru) |
| CN (1) | CN109789205B (ru) |
| AU (1) | AU2017326329B2 (ru) |
| BR (1) | BR112019004998A2 (ru) |
| CL (2) | CL2019000628A1 (ru) |
| CO (1) | CO2019003154A2 (ru) |
| CR (1) | CR20190199A (ru) |
| CY (1) | CY1123642T1 (ru) |
| DK (1) | DK3512547T3 (ru) |
| DO (1) | DOP2019000056A (ru) |
| EC (1) | ECSP19026178A (ru) |
| ES (1) | ES2837755T3 (ru) |
| HR (1) | HRP20201993T1 (ru) |
| HU (1) | HUE051700T2 (ru) |
| IL (2) | IL265179B2 (ru) |
| LT (1) | LT3512547T (ru) |
| MX (1) | MX2019002946A (ru) |
| MY (1) | MY192158A (ru) |
| PE (1) | PE20191102A1 (ru) |
| PH (1) | PH12019500540A1 (ru) |
| PL (1) | PL3512547T3 (ru) |
| PT (1) | PT3512547T (ru) |
| RS (1) | RS61204B1 (ru) |
| RU (1) | RU2752562C2 (ru) |
| SG (1) | SG10201914120XA (ru) |
| SI (1) | SI3512547T1 (ru) |
| SM (1) | SMT202000691T1 (ru) |
| UA (1) | UA124631C2 (ru) |
| WO (1) | WO2018053106A1 (ru) |
| ZA (1) | ZA201902265B (ru) |
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|---|---|---|---|---|
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| MA42459A (fr) | 2015-07-16 | 2018-05-23 | Bioxcel Therapeutics Inc | Nouvelle approche pour le traitement du cancer par immunomodulation |
| BR112018008891A8 (pt) | 2015-11-03 | 2019-02-26 | Janssen Biotech Inc | anticorpos que se ligam especificamente a pd-1 e tim-3 e seus usos |
| CA3132021C (en) | 2015-11-18 | 2024-03-12 | Merck Sharp & Dohme Corp. | Pd1 and/or lag3 binders |
| RS61204B1 (sr) * | 2016-09-14 | 2021-01-29 | Abbvie Biotherapeutics Inc | Anti-pd-1 antitela |
| JP2019532652A (ja) | 2016-10-26 | 2019-11-14 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 凍結保存腫瘍浸潤リンパ球の再刺激 |
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| JOP20190224A1 (ar) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
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| WO2018226580A2 (en) | 2017-06-05 | 2018-12-13 | Janssen Biotech, Inc. | Antibodies that specifically bind pd-1 and methods of use |
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| US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
| BR112020013848A2 (pt) | 2018-01-08 | 2020-12-01 | Iovance Biotherapeutics, Inc. | métodos para expandir linfócitos infiltrantes de tumor e para tratar um indivíduo com câncer, população de linfócitos infiltrantes de tumor, e, método para avaliar fatores de transcrição |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| CN120919306A (zh) | 2018-02-13 | 2025-11-11 | 默沙东有限责任公司 | 用抗pd-1抗体治疗癌症的方法 |
| US20210130779A1 (en) | 2018-04-27 | 2021-05-06 | Iovance Biotherapeutics, Inc. | Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| US12473532B2 (en) | 2018-05-10 | 2025-11-18 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
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| KR20220032646A (ko) | 2018-12-21 | 2022-03-15 | 오제 이뮈노테라프틱스 | 인간화된 항-인간-pd-1 항체 |
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