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RU2019103898A - Method for the prevention of adhesive disease after myomectomy - Google Patents

Method for the prevention of adhesive disease after myomectomy Download PDF

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Publication number
RU2019103898A
RU2019103898A RU2019103898A RU2019103898A RU2019103898A RU 2019103898 A RU2019103898 A RU 2019103898A RU 2019103898 A RU2019103898 A RU 2019103898A RU 2019103898 A RU2019103898 A RU 2019103898A RU 2019103898 A RU2019103898 A RU 2019103898A
Authority
RU
Russia
Prior art keywords
myomectomy
stage
prevention
adhesive disease
injected
Prior art date
Application number
RU2019103898A
Other languages
Russian (ru)
Other versions
RU2019103898A3 (en
RU2730943C2 (en
Inventor
Людмила Владимировна Ткаченко
Наталия Ивановна Свиридова
Регина Робертовна Хохлова
Original Assignee
Федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ВолгГМУ МЗ РФ)
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Application filed by Федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ВолгГМУ МЗ РФ) filed Critical Федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ВолгГМУ МЗ РФ)
Priority to RU2019103898A priority Critical patent/RU2730943C2/en
Publication of RU2019103898A3 publication Critical patent/RU2019103898A3/ru
Publication of RU2019103898A publication Critical patent/RU2019103898A/en
Application granted granted Critical
Publication of RU2730943C2 publication Critical patent/RU2730943C2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (1)

Способ профилактики спаечной болезни после миомэктомии, отличающийся тем, что проводят комплексное трехэтапное воздействие на патогенетические механизмы формирования спаек, при этом на первом этапе за 30-45 мин до операции пациентке внутривенно капельно вводят 1,0 г Транексама в разведении в 200 мл 0,9%-ного раствора хлорида натрия в течение 20-30 мин (за пределами граничных значений интервалов технический результат заявленного изобретения не достигается); на втором этапе после миомэктомии, на область послеоперационного рубца наносится противоспаечный рассасывающийся гель Антиадгезин 5 г; на третьем этапе осуществляется введение антифиброзирующего препарата Лонгидаза в виде вагинальных свечей по одному суппозиторию 1 раз в 3 дня - 10 суппозиториев на курс лечения.A method for the prevention of adhesive disease after myomectomy, characterized in that a complex three-stage effect on the pathogenetic mechanisms of the formation of adhesions is carried out, while at the first stage, 30-45 minutes before the operation, the patient is injected intravenously with 1.0 g of Tranexam at a dilution of 200 ml 0.9 % sodium chloride solution for 20-30 minutes (beyond the boundary values of the intervals, the technical result of the claimed invention is not achieved); at the second stage after myomectomy, antiadhesion absorbable gel Antiadgezin 5 g is applied to the area of the postoperative scar; at the third stage, the antifibrosing drug Longidaza is injected in the form of vaginal suppositories, one suppository 1 every 3 days - 10 suppositories per course of treatment.
RU2019103898A 2019-02-12 2019-02-12 Method for preventing peritoneal adhesions after myomectomy RU2730943C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2019103898A RU2730943C2 (en) 2019-02-12 2019-02-12 Method for preventing peritoneal adhesions after myomectomy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2019103898A RU2730943C2 (en) 2019-02-12 2019-02-12 Method for preventing peritoneal adhesions after myomectomy

Publications (3)

Publication Number Publication Date
RU2019103898A3 RU2019103898A3 (en) 2020-08-12
RU2019103898A true RU2019103898A (en) 2020-08-12
RU2730943C2 RU2730943C2 (en) 2020-08-26

Family

ID=72085158

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2019103898A RU2730943C2 (en) 2019-02-12 2019-02-12 Method for preventing peritoneal adhesions after myomectomy

Country Status (1)

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RU (1) RU2730943C2 (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2386441C1 (en) * 2008-11-14 2010-04-20 Государственное образовательное учреждение высшего профессионального образования "Красноярская государственная медицинская академия имени профессора В.Ф. Войно-Ясенецкого Федерального агентства по здравоохранению и социальному развитию" Method for prevention of adhesive process in peritoneal cavity in obstetric-gynaecologic surgeries
RU2407467C1 (en) * 2009-07-13 2010-12-27 Константин Викторович Пучков Method of laparoscopic myomectomy
UA85231U (en) * 2013-06-03 2013-11-11 Буковинский Государственный Медицинский Университет Мз Украины Method for preventing adhesions following gynecological laparoscopic interventions
RU2563824C2 (en) * 2014-02-20 2015-09-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Астраханская государственная медицинская академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО АГМА Минздрава России) Method for preventing haemorrhage during myomectomy
RU2607590C2 (en) * 2015-06-15 2017-01-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации ГБОУ ВПО ВолгГМУ МЗ РФ Method of treating chronic endometritis
KR20170014143A (en) * 2015-07-29 2017-02-08 (주)메디언스 Composition for Adhesion barrier

Also Published As

Publication number Publication date
RU2019103898A3 (en) 2020-08-12
RU2730943C2 (en) 2020-08-26

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20210213