[go: up one dir, main page]

RU2018101473A - Депо-препарат, содержащий сложный эфир лимонной кислоты - Google Patents

Депо-препарат, содержащий сложный эфир лимонной кислоты Download PDF

Info

Publication number
RU2018101473A
RU2018101473A RU2018101473A RU2018101473A RU2018101473A RU 2018101473 A RU2018101473 A RU 2018101473A RU 2018101473 A RU2018101473 A RU 2018101473A RU 2018101473 A RU2018101473 A RU 2018101473A RU 2018101473 A RU2018101473 A RU 2018101473A
Authority
RU
Russia
Prior art keywords
depot composition
composition according
trialkyl citrate
citrate
depot
Prior art date
Application number
RU2018101473A
Other languages
English (en)
Other versions
RU2018101473A3 (ru
RU2749952C2 (ru
Inventor
Тацуя Миязаки
Кендзи МАСАКИ
Кёхей ТАКАХАСИ
Кацухито ЯМАДА
Original Assignee
Сантэн Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сантэн Фармасьютикал Ко., Лтд. filed Critical Сантэн Фармасьютикал Ко., Лтд.
Publication of RU2018101473A publication Critical patent/RU2018101473A/ru
Publication of RU2018101473A3 publication Critical patent/RU2018101473A3/ru
Application granted granted Critical
Publication of RU2749952C2 publication Critical patent/RU2749952C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (22)

1. Депо-композиция, содержащая триалкилцитрат и/или ацетилтриалкилцитрат, где алкильные группы, которыми обладает каждый из триалкилцитрата и ацетилтриалкилцитрата, являются одинаковыми или разными и имеют число атомов углерода от 3 до 5.
2. Депо-композиция по п. 1, где число атомов углерода алкильной группы составляет 4.
3. Депо-композиция по п. 1, где триалкилцитрат представляет собой три-н-бутилцитрат, и ацетилтриалкилцитрат представляет собой ацетил-три-н-бутилцитрат.
4. Депо-композиция по п. 1, дополнительно содержащая лекарственное средство.
5. Депо-композиция по п. 4, где лекарственное средство представляет собой соединение формулы (1) или его соль:
[Химическая структура 1]
Figure 00000001
,
где R1 означает атом водорода, атом галогена, гидроксильную группу, С1-6алкильную группу, C1-6алкильную группу, замещенную одним или более атомами галогена, С1-6алкоксильную группу или C1-6алкоксильную группу, замещенную одним или более атомами галогена; и
R2 означает атом водорода, C1-6алкильную группу, С1-6алкилкарбонильную группу или C1-6алкилкарбонильную группу, замещенную одной или более гидроксильными группами.
6. Депо-композиция по п. 5, где соединение формулы (1) представляет собой 2-[[[2-[(гидроксиацетил)амино]-4-пиридинил]метил]тио]-N-[4-(трифторметокси)фенил]-3-пиридинкарбоксамид или его соль.
7. Депо-композиция по п. 4, где лекарственное средство представляет собой изопропил-(6-{[4-(пиразол-1-ил)бензил](пиридин-3-илсульфонил)аминометил}пиридин-2-иламино)ацетат или его соль.
8. Депо-композиция по п. 4, где лекарственное средство представляет собой непафенак, дексаметазон, индометацин, диклофенак натрия, левофлоксацин, INCB28050, циклоспорин А, тимолола малеат, флуоцинолона ацетонид, триамцинолона ацетонид, будесонид, олопатадин, латанопрост, изопропил-(6-{[4-(пиразол-1-ил)бензил](пиридин-3-илсульфонил)аминометил}пиридин-2-иламино)ацетат, 2-[[[2-[(гидроксиацетил)-амино]-4-пиридинил]метил]тио]-N-[4-(трифторметокси)фенил]-3-пиридинкарбоксамид или сиролимус.
9. Депо-композиция по п. 4, содержащая от 0,001 до 30% (масс./масс.) лекарственного средства.
10. Депо-композиция по п. 1, содержащая по меньшей мере 0,1% (масс./масс.) триалкилцитрата и/или ацетилтриалкилцитрата.
11. Депо-композиция по любому из пп. 1-10 для глазного местного введения.
12. Депо-композиция по п. 11 для интравитреального введения, субконъюнктивального введения или интракамерального введения.
13. Депо-композиция по любому из пп. 1-10 для предупреждения и/или лечения глазного заболевания.
14. Способ образования депо, включающий приведение жидкой композиции, содержащей триалкилцитрат и/или ацетилтриалкилцитрат, в контакт с водой, фосфатным буферным раствором, жидкостью организма или имитированной жидкостью организма,
где алкильные группы, которыми обладает каждый из триалкилцитрата и ацетилтриалкилцитрата, являются одинаковыми или разными и имеют число атомов углерода от 3 до 5.
15. Способ предупреждения и/или лечения глазного заболевания, включающий введение депо-композиции по любому из пп. 1-10 пациенту, который нуждается в предупреждении и/или лечении глазного заболевания.
16. Способ по п. 15, при котором осуществляют глазное местное введение депо-композиции.
17. Способ по п. 15 или 16, при котором депо-композицию вводят интравитреально, интракамерально или субконъюнктивально.
RU2018101473A 2015-07-01 2016-06-30 Депо-препарат, содержащий сложный эфир лимонной кислоты RU2749952C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015133040 2015-07-01
JP2015-133040 2015-07-01
PCT/JP2016/069522 WO2017002941A1 (ja) 2015-07-01 2016-06-30 クエン酸エステルを含有するデポ剤

Publications (3)

Publication Number Publication Date
RU2018101473A true RU2018101473A (ru) 2019-08-01
RU2018101473A3 RU2018101473A3 (ru) 2019-11-15
RU2749952C2 RU2749952C2 (ru) 2021-06-21

Family

ID=57607818

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018101473A RU2749952C2 (ru) 2015-07-01 2016-06-30 Депо-препарат, содержащий сложный эфир лимонной кислоты

Country Status (11)

Country Link
US (1) US20180185489A1 (ru)
EP (1) EP3318280A4 (ru)
JP (1) JP6872322B2 (ru)
KR (1) KR20180023945A (ru)
CN (1) CN107708738B (ru)
AR (1) AR105215A1 (ru)
CA (1) CA2991015A1 (ru)
HK (1) HK1249443A1 (ru)
RU (1) RU2749952C2 (ru)
TW (1) TWI755356B (ru)
WO (1) WO2017002941A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201810618QA (en) 2016-06-30 2019-01-30 Durect Corp Depot formulations
US10682340B2 (en) 2016-06-30 2020-06-16 Durect Corporation Depot formulations
JP2020059652A (ja) * 2016-12-26 2020-04-16 参天製薬株式会社 タフルプロストとクエン酸エステルとを含有するデポ剤
US20200121652A1 (en) 2017-06-16 2020-04-23 The Doshisha Compounds having caspase inhibitory activity, pharmaceutical agent containing said compounds and for treating or preventing corneal endothelial symptoms, disorders, or diseases, and application of said pharmaceutical agent
US11433090B2 (en) 2017-06-16 2022-09-06 The Doshisha mTOR-inhibitor-containing medicine for treating or preventing ophthalmic symptoms, disorders, or diseases, and application thereof
US10940144B2 (en) 2017-09-29 2021-03-09 Santen Pharmaceutical Co., Ltd. Drug containing pyridylaminoacetic acid compound
WO2019124487A1 (ja) 2017-12-21 2019-06-27 参天製薬株式会社 オミデネパグの組合せ
TWI842692B (zh) 2017-12-28 2024-05-21 日商參天製藥股份有限公司 含有吡啶基胺乙酸化合物之醫藥製劑

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4738851A (en) * 1985-09-27 1988-04-19 University Of Iowa Research Foundation, Inc. Controlled release ophthalmic gel formulation
CA2413157A1 (en) * 2000-06-28 2002-01-03 Atul J. Shukla Biodegradable vehicles and delivery systems of biologically active substances
US6960346B2 (en) * 2002-05-09 2005-11-01 University Of Tennessee Research Foundation Vehicles for delivery of biologically active substances
US20050281879A1 (en) * 2003-11-14 2005-12-22 Guohua Chen Excipients in drug delivery vehicles
US9993558B2 (en) * 2004-10-01 2018-06-12 Ramscor, Inc. Sustained release eye drop formulations
US20090239891A1 (en) * 2006-03-01 2009-09-24 Shukla Atul J Sustained Release Dosage Forms of Analgesic Medications
EA200970067A1 (ru) * 2006-07-28 2009-08-28 Пфайзер Продактс Инк. Агонисты ep2
US8974814B2 (en) * 2007-11-12 2015-03-10 California Institute Of Technology Layered drug delivery polymer monofilament fibers
WO2010068281A2 (en) * 2008-12-11 2010-06-17 Massachusetts Institute Of Technology Contact lens drug delivery device
US8501800B2 (en) * 2009-03-05 2013-08-06 Insite Vision Incorporated Controlled-release ophthalmic vehicles
JP5300033B2 (ja) * 2009-03-30 2013-09-25 宇部興産株式会社 緑内障の治療又は予防のための医薬組成物
JP6339011B2 (ja) * 2011-06-10 2018-06-06 ラムスコール インコーポレイテッド 眼へのタンパク質の送出のための持続放出性製剤及びその調製方法
US9289428B2 (en) * 2011-06-10 2016-03-22 Ramscor, Inc. Conveniently injectable or implantable sustained-release antioxidant formulations for therapies of ocular maladies or cancer
CN102429862B (zh) * 2011-11-29 2013-05-01 江苏德达医药科技有限公司 一种聚维酮碘眼用缓释滴眼液
JP2014019650A (ja) * 2012-07-13 2014-02-03 Santen Pharmaceut Co Ltd スルホンアミド化合物とタフルプロストの組み合わせ
KR102074020B1 (ko) * 2012-07-13 2020-02-05 산텐 세이야꾸 가부시키가이샤 술폰아미드 화합물의 조합
US9339496B2 (en) * 2012-07-13 2016-05-17 Santen Pharmaceutical Co., Ltd. Composition for treating or preventing glaucoma comprising a sulfonamide compound, and a beta-receptor antagonist
US20140018350A1 (en) * 2012-07-13 2014-01-16 Asahi Glass Co., Ltd. Combination of sulfonamide compound and tafluprost
MY163236A (en) * 2013-09-20 2017-08-30 Santen Pharmaceutical Co Ltd Polyethylene glycol-containing composition
EA031734B1 (ru) * 2014-01-10 2019-02-28 Сантен Фармасьютикал Ко., Лтд. Фармацевтический препарат, содержащий соединение пиридиламиноуксусной кислоты

Also Published As

Publication number Publication date
US20180185489A1 (en) 2018-07-05
RU2018101473A3 (ru) 2019-11-15
EP3318280A4 (en) 2018-08-22
WO2017002941A1 (ja) 2017-01-05
TWI755356B (zh) 2022-02-21
RU2749952C2 (ru) 2021-06-21
JP2017014209A (ja) 2017-01-19
TW201705988A (zh) 2017-02-16
AR105215A1 (es) 2017-09-13
EP3318280A1 (en) 2018-05-09
CN107708738B (zh) 2022-03-25
HK1249443A1 (en) 2018-11-02
JP6872322B2 (ja) 2021-05-19
CN107708738A (zh) 2018-02-16
KR20180023945A (ko) 2018-03-07
CA2991015A1 (en) 2017-01-05

Similar Documents

Publication Publication Date Title
RU2018101473A (ru) Депо-препарат, содержащий сложный эфир лимонной кислоты
CN105307498B (zh) 用于治疗眼病的组合物、制剂和方法
CN103370326B (zh) 作为趋化因子受体调节剂的磷衍生物
RU2017127135A (ru) Терапевтическое средство против рака желчных протоков
JP2014500295A5 (ru)
JP2016515561A5 (ru)
JP2016505637A5 (ru)
RU2017116196A (ru) 2-амино-6-(дифторметил)-5,5-дифтор-6-фенил-3,4,5,6-тетрагидропиридины как ингибиторы васе1
RU2013149174A (ru) Новое имидазооксазиновое соединение или его соль
RU2012116877A (ru) Соединения 2-пиридона, применяемые в качестве ингибиторов нейтрофильной эластазы
RU2019141734A (ru) Терапевтические соединения и композиции и способы их применения
JP2016027060A5 (ru)
JP2018528273A5 (ru)
PH12016501357A1 (en) Pharmaceutical preparation containing pyridylamino acetic acid compound
JP2016510326A5 (ru)
CA3224013A1 (en) Combination therapy of inhibitors of c-c chemokine receptor type 9 (ccr9) and anti-alha4beta7 integrin blocking antibodies
JP6749962B2 (ja) 網脈絡膜障害の抑制剤
JP2018522927A5 (ru)
RU2018106498A (ru) Производные 5-(N-конденсированный трициклический арил-тетрагидроизохинолин-6-ил) пиридин-3-ил-уксусной кислоты в качестве ингибиторов репликации вируса иммунодефицита человека
WO2018005801A3 (en) Novel non-systemic tgr5 agonists
RU2017128880A (ru) Производные (r)-2-метил-пиперазина в качестве модуляторов cxcr3 рецептора
JP2015083565A5 (ru)
JP2018525447A5 (ru)
JP2016512501A5 (ru)
JP2015521598A5 (ru)