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RU2018146479A3 - - Google Patents

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Publication number
RU2018146479A3
RU2018146479A3 RU2018146479A RU2018146479A RU2018146479A3 RU 2018146479 A3 RU2018146479 A3 RU 2018146479A3 RU 2018146479 A RU2018146479 A RU 2018146479A RU 2018146479 A RU2018146479 A RU 2018146479A RU 2018146479 A3 RU2018146479 A3 RU 2018146479A3
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RU
Russia
Application number
RU2018146479A
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RU2748731C2 (ru
RU2018146479A (ru
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Publication of RU2018146479A publication Critical patent/RU2018146479A/ru
Publication of RU2018146479A3 publication Critical patent/RU2018146479A3/ru
Application granted granted Critical
Publication of RU2748731C2 publication Critical patent/RU2748731C2/ru

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
RU2018146479A 2016-07-07 2017-07-06 Комбинация, содержащая антагонист ep4 и ингибитор иммунных контрольных точек RU2748731C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662359504P 2016-07-07 2016-07-07
US62/359,504 2016-07-07
PCT/JP2017/024753 WO2018008711A1 (ja) 2016-07-07 2017-07-06 Ep4拮抗薬と免疫チェックポイント阻害薬を含んでなる組み合わせ

Publications (3)

Publication Number Publication Date
RU2018146479A RU2018146479A (ru) 2020-08-07
RU2018146479A3 true RU2018146479A3 (ru) 2020-11-23
RU2748731C2 RU2748731C2 (ru) 2021-05-31

Family

ID=60912958

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018146479A RU2748731C2 (ru) 2016-07-07 2017-07-06 Комбинация, содержащая антагонист ep4 и ингибитор иммунных контрольных точек

Country Status (21)

Country Link
US (1) US11065226B2 (ru)
EP (1) EP3482760B1 (ru)
JP (2) JP6323629B1 (ru)
KR (1) KR102473601B1 (ru)
CN (1) CN109475520B (ru)
AU (1) AU2017292522B2 (ru)
CA (1) CA3029611A1 (ru)
DK (1) DK3482760T3 (ru)
ES (1) ES2900306T3 (ru)
HU (1) HUE057799T2 (ru)
IL (1) IL264063B (ru)
MX (1) MX385428B (ru)
MY (1) MY197673A (ru)
PH (1) PH12019500002B1 (ru)
PL (1) PL3482760T3 (ru)
PT (1) PT3482760T (ru)
RU (1) RU2748731C2 (ru)
SG (1) SG11201811591UA (ru)
TW (2) TWI805255B (ru)
WO (1) WO2018008711A1 (ru)
ZA (1) ZA201900060B (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3255624B2 (ja) 1998-07-03 2002-02-12 日本電信電話株式会社 コネクタプラグおよび光コネクタ
HUE052969T2 (hu) * 2015-01-09 2021-05-28 Ono Pharmaceutical Co Triciklusos spiro vegyület
JP7264060B2 (ja) * 2017-04-18 2023-04-25 テンペスト セラピューティクス,インク. 二環式化合物および癌の処置におけるそれらの使用
JP7159007B2 (ja) 2017-11-01 2022-10-24 小野薬品工業株式会社 脳腫瘍の治療のための医薬
CA3090485C (en) * 2018-02-05 2024-01-16 Shenzhen Ionova Life Science Co., Ltd. Heterobicyclic carboxylic acids for treating cancer or inflammatory diseases
CN110156674A (zh) * 2018-02-13 2019-08-23 中国科学院上海有机化学研究所 一种作为吲哚胺-2,3-双加氧酶抑制剂的螺环化合物
US10973834B2 (en) * 2018-04-16 2021-04-13 Arrys Therapeutics, Inc. EP4 inhibitors and use thereof
JP7361713B2 (ja) 2018-04-17 2023-10-16 テンペスト セラピューティクス,インク. 二環式カルボキサミドおよびその使用方法
WO2020014465A1 (en) 2018-07-11 2020-01-16 Arrys Therapeutics, Inc. Polymorphic compounds and uses thereof
EP3722319A1 (en) * 2019-04-09 2020-10-14 Rottapharm Biotech S.r.l. Pharmaceutical combination of an ep4 antagonist and immune checkpoint inhibitors for the treatment of tumours
WO2020242773A1 (en) * 2019-05-31 2020-12-03 Clear Creek Bio, Inc. Methods of promoting differentiation of myeloid-derived suppressor cells using inhibitors of dihydroorotate dehydrogenase
CN110386941A (zh) * 2019-08-15 2019-10-29 上海邦耀生物科技有限公司 Ep4受体拮抗剂和pd-1抑制剂联合用于癌症的治疗
IL294196A (en) * 2019-12-25 2022-08-01 Nippon Shinyaku Co Ltd Antitumor drug for use in combination with immune checkpoint inhibitor
EP4117665A4 (en) * 2020-03-10 2024-04-17 Emory University METHODS OF TREATING CANCER WITH CHECKPOINT INHIBITORS IN COMBINATION WITH PURINE-CLIPPING ENZYMES
EP4245301A4 (en) * 2020-11-13 2024-08-21 ONO Pharmaceutical Co., Ltd. TREATMENT OF CANCER BY COMBINED USE OF AN EP4 ANTAGONIST AND AN IMMUNE CHECKPOINT INHIBITOR
CN114790186A (zh) * 2021-01-25 2022-07-26 武汉人福创新药物研发中心有限公司 作为ep4拮抗剂的稠环化合物及其制备方法和用途
CN117377656A (zh) * 2021-05-28 2024-01-09 南京明德新药研发有限公司 苯并螺杂环衍生物及其应用
US20250002448A1 (en) * 2021-09-21 2025-01-02 Merck Sharp & Dohme Llc Allosteric modulators of nicotinic acetylcholine receptors
WO2023198060A1 (zh) * 2022-04-12 2023-10-19 正大天晴药业集团股份有限公司 蛋白酶体抑制剂与抗pd-1抗体的药物组合

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1071648A2 (en) 1998-03-13 2001-01-31 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
US6211197B1 (en) 1998-10-07 2001-04-03 Merck Frosst Canada & Co. Prostaglandin receptor ligands
EP1312601A4 (en) 2000-08-22 2005-09-21 Ono Pharmaceutical Co CARBOXYLENE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND MEDICAMENTS CONTAINING THEM AS AN ACTIVE SUBSTANCE
US7491748B2 (en) 2001-08-09 2009-02-17 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
CN101622230B (zh) 2007-02-26 2012-08-22 默克弗罗斯特加拿大有限公司 作为ep4受体拮抗剂的吲哚和二氢吲哚环丙基酰胺衍生物
US20150004175A1 (en) 2011-12-13 2015-01-01 Yale University Compositions and Methods for Reducing CTL Exhaustion
CN106572993B (zh) * 2014-05-23 2019-07-16 卫材R&D管理有限公司 Ep4拮抗剂在制备治疗癌症的药物中的应用
HUE052969T2 (hu) * 2015-01-09 2021-05-28 Ono Pharmaceutical Co Triciklusos spiro vegyület

Also Published As

Publication number Publication date
EP3482760B1 (en) 2021-11-10
IL264063A (en) 2019-01-31
US11065226B2 (en) 2021-07-20
US20190255013A1 (en) 2019-08-22
NZ749540A (en) 2024-09-27
DK3482760T3 (da) 2022-01-03
JP2018100297A (ja) 2018-06-28
RU2748731C2 (ru) 2021-05-31
IL264063B (en) 2022-02-01
PH12019500002B1 (en) 2024-06-28
KR20190026736A (ko) 2019-03-13
AU2017292522A1 (en) 2019-01-17
BR112019000243A2 (pt) 2019-04-16
PH12019500002A1 (en) 2019-10-21
CA3029611A1 (en) 2018-01-11
HUE057799T2 (hu) 2022-06-28
CN109475520B (zh) 2021-05-14
PL3482760T3 (pl) 2022-02-07
TW202224675A (zh) 2022-07-01
WO2018008711A1 (ja) 2018-01-11
PT3482760T (pt) 2021-12-15
KR102473601B1 (ko) 2022-12-01
EP3482760A4 (en) 2019-07-10
SG11201811591UA (en) 2019-01-30
JP7020218B2 (ja) 2022-02-16
MX385428B (es) 2025-03-04
MX2018015567A (es) 2019-06-06
TW201806593A (zh) 2018-03-01
JPWO2018008711A1 (ja) 2018-07-05
EP3482760A1 (en) 2019-05-15
AU2017292522A9 (en) 2019-01-31
RU2018146479A (ru) 2020-08-07
JP6323629B1 (ja) 2018-05-16
TWI805255B (zh) 2023-06-11
MY197673A (en) 2023-07-03
ZA201900060B (en) 2019-09-25
CN109475520A (zh) 2019-03-15
ES2900306T3 (es) 2022-03-16
TWI795362B (zh) 2023-03-11
AU2017292522B2 (en) 2022-10-13

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