RU2015123653A - Гель для ухода за полостью рта, содержащий комплекс цинка и аминокислоты - Google Patents
Гель для ухода за полостью рта, содержащий комплекс цинка и аминокислоты Download PDFInfo
- Publication number
- RU2015123653A RU2015123653A RU2015123653A RU2015123653A RU2015123653A RU 2015123653 A RU2015123653 A RU 2015123653A RU 2015123653 A RU2015123653 A RU 2015123653A RU 2015123653 A RU2015123653 A RU 2015123653A RU 2015123653 A RU2015123653 A RU 2015123653A
- Authority
- RU
- Russia
- Prior art keywords
- dentifrice
- zinc
- amino acid
- source
- complex
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title claims 9
- 239000011701 zinc Substances 0.000 title claims 8
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title claims 6
- 229910052725 zinc Inorganic materials 0.000 title claims 6
- 239000000551 dentifrice Substances 0.000 claims 19
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims 2
- 208000002925 dental caries Diseases 0.000 claims 2
- 210000003298 dental enamel Anatomy 0.000 claims 2
- 230000003628 erosive effect Effects 0.000 claims 2
- 150000004820 halides Chemical class 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- LOFGQZYYARWABM-BYPYZUCNSA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoyl chloride Chemical compound ClC(=O)[C@@H](N)CCCNC(N)=N LOFGQZYYARWABM-BYPYZUCNSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- 239000004909 Moisturizer Substances 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- HFFROHHGHGDACO-JEDNCBNOSA-N [Zn].NCCCC[C@H](N)C(Cl)=O Chemical group [Zn].NCCCC[C@H](N)C(Cl)=O HFFROHHGHGDACO-JEDNCBNOSA-N 0.000 claims 1
- 239000003082 abrasive agent Substances 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 229920006318 anionic polymer Polymers 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000001680 brushing effect Effects 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 210000004268 dentin Anatomy 0.000 claims 1
- 201000002170 dentin sensitivity Diseases 0.000 claims 1
- 150000004683 dihydrates Chemical class 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 208000024693 gingival disease Diseases 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 230000009610 hypersensitivity Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000001333 moisturizer Effects 0.000 claims 1
- 150000004682 monohydrates Chemical class 0.000 claims 1
- -1 oral fresheners Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000002562 thickening agent Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000011787 zinc oxide Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/58—Metal complex; Coordination compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Claims (18)
1. Средство для ухода за зубами, содержащее комплекс цинк-аминокислота-галогенид.
2. Средство для ухода за зубами по п. 1, в котором комплекс цинк-аминокислота-галогенид образуется из предшественников.
3. Средство для ухода за зубами по п. 2, в котором предшественники представляют собой источник ионов цинка, источник аминокислот и источник галогенида.
4. Средство для ухода за зубами по п. 2 или 3, в котором источником галогенидов может быть часть источника ионов цинка, источника аминокислоты или галогенсодержащей кислоты.
5. Средство для ухода за зубами по п. 1, в котором аминокислота выбрана из лизина, глицина и аргинина, в свободной форме или в форме орально приемлемой кислотно-аддитивной соли.
6. Средство для ухода за зубами по п. 1, в котором аминокислота представляет собой основную аминокислоту, в свободной форме или в форме орально приемлемой соли.
7. Средство для ухода за зубами по п. 1, в котором содержание цинка составляет 0,05-4% по массе.
8. Средство для ухода за зубами по п. 1, в котором источник ионов цинка и источник аминокислоты присутствуют в комплексе.
9. Средство для ухода за зубами по п. 1, в котором цинк солюбилизирован, так что гель, по существу, является прозрачным, и которое обеспечивает осаждение цинка при применении и разбавлении слюной и/или полоскании.
10. Средство для ухода за зубами по п. 1, в котором ион цинка и аминокислота образуют комплекс цинка с хлоридом лизина или комплекс цинка с хлоридом аргинина.
11. Средство для ухода за зубами по п. 1, в котором комплекс цинка с аминокислотой представляет собой комплекс цинка с хлоридом лизина, имеющий химическую структуру [Zn(C6H14N2O2)2Cl]+ Cl-, и находится либо в растворе в виде катиона (например [Zn(C6H14N2O2)2Cl]+) и аниона хлорида, либо в форме твердой соли, необязательно в форме моно- или дигидрата.
12. Средство для ухода за зубами по п. 1, дополнительно содержащее эффективное количество источника фторид-ионов.
13. Средство для ухода за зубами по п. 1, содержащее орально приемлемую основу, включающую ингредиенты, выбранные из одного или нескольких абразивных веществ, буферных веществ, увлажнителей, поверхностно-активных веществ, загустителей, полосок или фрагментов из смолы, освежителей для полости рта, вкусовых вещества, ароматизирующих веществ, красящих веществ, антибактериальных веществ, отбеливающих веществ, веществ, которые препятствуют или предотвращают прикрепление бактерий, источников кальция, источников фосфата, орально приемлемых солей калия и анионных полимеров.
14. Средство для ухода за зубами по п. 1, в котором значение pH геля равно от 6 до 8.
15. Средство для ухода за зубами по п. 1, предназначенное для снижения и ослабления кислотной эрозии эмали зубов, чистки зубов, уменьшения биопленки, образуемой бактериями, и зубного налета, уменьшения воспаления десен, подавления развитие кариеса и образования полостей, и/или снижения повышенной чувствительности дентина.
16. Средство для ухода за зубами по п. 1, в котором средство для ухода за зубами представляет собой, по существу, прозрачный гель.
17. Применение источника ионов цинка вместе с аминокислотой в комплексе для получения средства для ухода за зубами.
18. Способ лечения или снижения эрозии зубной эмали, чистки зубов, уменьшения биопленки, образуемой бактериями, и зубного налета, снижения воспаления десен, ингибирования кариеса и образования полостей и/или уменьшения повышенной чувствительности дентина, включающий нанесение средства для ухода за зубами в соответствии с любым из пп. 1-16 на зубы, и необязательно, с последующим полосканием водой или водным раствором, достаточным для инициирования осаждения оксида цинка из геля.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2012/070513 WO2014098824A1 (en) | 2012-12-19 | 2012-12-19 | Oral gel comprising zinc - amino acid complex |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015123653A true RU2015123653A (ru) | 2017-01-25 |
| RU2636226C2 RU2636226C2 (ru) | 2017-11-21 |
Family
ID=47501517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015123653A RU2636226C2 (ru) | 2012-12-19 | 2012-12-19 | Гель для ухода за полостью рта, содержащий комплекс цинка и аминокислоты |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US9763865B2 (ru) |
| EP (1) | EP2934441B1 (ru) |
| KR (1) | KR20150094651A (ru) |
| CN (1) | CN104853723B (ru) |
| AR (1) | AR094075A1 (ru) |
| AU (1) | AU2012397265B2 (ru) |
| BR (1) | BR112015014900B1 (ru) |
| CA (1) | CA2892419C (ru) |
| IL (1) | IL239530A0 (ru) |
| MX (1) | MX368740B (ru) |
| PH (1) | PH12015501436B1 (ru) |
| RU (1) | RU2636226C2 (ru) |
| TW (2) | TWI522120B (ru) |
| WO (1) | WO2014098824A1 (ru) |
| ZA (1) | ZA201503848B (ru) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012397259B2 (en) | 2012-12-19 | 2015-09-17 | Colgate-Palmolive Company | Zinc-lysine complex |
| US9498421B2 (en) | 2012-12-19 | 2016-11-22 | Colgate-Palmolive Company | Two component compositions containing tetrabasic zinc-amino acid halide complexes and cysteine |
| JP5976955B2 (ja) | 2012-12-19 | 2016-08-24 | コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ | 酸化亜鉛およびトリメチルグリシンを含むオーラルケア製品 |
| US20190104741A1 (en) * | 2012-12-19 | 2019-04-11 | Colgate-Palmolive Company | Personal Cleansing Compositions Containing Zinc Amino Acid / Trimethylglycine Halide |
| US9925130B2 (en) | 2012-12-19 | 2018-03-27 | Colgate-Palmolive Company | Composition with zinc amino acid/trimethylglycine halide precursors |
| ES2617492T3 (es) | 2012-12-19 | 2017-06-19 | Colgate-Palmolive Company | Productos antitranspirantes con proteína y sales antitranspirantes |
| WO2014098822A1 (en) | 2012-12-19 | 2014-06-26 | Colgate-Palmolive Company | Zinc amino acid halide mouthwashes |
| US10188112B2 (en) | 2012-12-19 | 2019-01-29 | Colgate-Palmolive Company | Personal cleansing compositions containing zinc amino acid/trimethylglycine halide |
| US9504858B2 (en) | 2012-12-19 | 2016-11-29 | Colgate-Palmolive Company | Zinc amino acid halide complex with cysteine |
| WO2014098813A1 (en) | 2012-12-19 | 2014-06-26 | Colgate-Palmolive Company | Zinc amino acid/trimethylglycine halide |
| EP2934445B1 (en) | 2012-12-19 | 2017-10-04 | Colgate-Palmolive Company | Teeth whitening methods, visually perceptible signals and compositions therefor comprising zinc amino acid halides |
| MX352558B (es) | 2012-12-19 | 2017-11-29 | Colgate Palmolive Co | Composiciones para el cuidado oral que contienen halogenuros de aminoácido de zinc. |
| KR20150097552A (ko) | 2012-12-19 | 2015-08-26 | 콜게이트-파아므올리브캄파니 | 4가염기성 염화아연 및 트리메틸글리신을 포함하는 구강 관리 제품 |
| EP2934442B1 (en) | 2012-12-19 | 2016-11-30 | Colgate-Palmolive Company | Oral care products comprising a tetrabasic zinc - amino acid - halide complex |
| US9675823B2 (en) | 2012-12-19 | 2017-06-13 | Colgate-Palmolive Company | Two component compositions containing zinc amino acid halide complexes and cysteine |
| US9763865B2 (en) * | 2012-12-19 | 2017-09-19 | Colgate-Palmolive Company | Oral gel comprising zinc-amino acid complex |
| US9750670B2 (en) | 2012-12-19 | 2017-09-05 | Colgate-Palmolive Company | Zinc amino acid complex with cysteine |
| US10130571B2 (en) * | 2014-06-18 | 2018-11-20 | Colgate-Palmolive Company | Dentifrice Comprising Zinc-Amino Acid Complex and Phosphates |
| RU2671402C2 (ru) | 2014-06-18 | 2018-10-31 | Колгейт-Палмолив Компани | Синтез комплекса цинка с лизином из хлорида цинка |
| EP3157934B1 (en) | 2014-06-18 | 2018-10-17 | Colgate-Palmolive Company | Low ph synthesis of zinc-lysine complex |
| MX374671B (es) | 2014-12-26 | 2025-03-06 | Colgate Palmolive Co | Complejo de zinc fosfato para el cuidado bucal. |
| RU2690191C2 (ru) | 2014-12-26 | 2019-05-31 | Колгейт-Палмолив Компани | Комплекс фосфата цинка |
| US11213466B2 (en) | 2014-12-26 | 2022-01-04 | Colgate-Palmolive Company | Personal care compositions with zinc phosphate active |
| BR112017012805B1 (pt) | 2014-12-26 | 2020-11-17 | Colgate-Palmolive Company | complexo de polifosfato de zinco solúvel e método de produção de polifosfato de zinco |
| US20170157013A1 (en) * | 2015-12-07 | 2017-06-08 | Colgate-Palmolive Company | Metal Amino Acid Complexes for Bacterial Aggregation |
| AU2016389266B2 (en) | 2016-01-28 | 2021-07-01 | Kimberly-Clark Worldwide, Inc. | Anti-adherent composition against DNA viruses and method of inhibiting the adherence of DNA viruses to a surface |
| KR102627187B1 (ko) | 2016-05-26 | 2024-01-22 | 킴벌리-클라크 월드와이드, 인크. | 유착 방지 조성물 및 표면에 대한 미생물의 유착을 억제하는 방법 |
| US10058493B2 (en) | 2016-12-21 | 2018-08-28 | Colgate-Palmolive Company | Oral care compositions and methods of use |
| US10485742B2 (en) * | 2017-12-01 | 2019-11-26 | Colgate-Palmolive Company | Rheological stabilization through mixed humectant systems in a zinc toothpaste |
| EP3720413B1 (en) | 2017-12-05 | 2025-01-01 | Colgate-Palmolive Company | Zinc/amino acid-functionalized silica |
| CA3082249A1 (en) * | 2017-12-13 | 2019-06-20 | Colgate-Palmolive Company | Dentifrice comprising zinc - amino acid complex |
| EP3723700A1 (en) * | 2017-12-13 | 2020-10-21 | Colgate-Palmolive Company | Zinc-amino acid-tripolyphosphate complexes |
| WO2020086298A1 (en) | 2018-10-24 | 2020-04-30 | Colgate-Palmolive Company | Zinc - amino acid – lauryl sulfate complex with antimicrobial activity |
| EP3880192A1 (en) * | 2018-12-20 | 2021-09-22 | Colgate-Palmolive Company | Oral care composition comprising zinc and an amino acid for treating symptoms of a gastric disorder in the oral cavity |
| CN113226478A (zh) * | 2018-12-21 | 2021-08-06 | 高露洁-棕榄公司 | 锌-精氨酸-卤化物络合物 |
| US11117906B2 (en) | 2018-12-21 | 2021-09-14 | Colgate-Palmolive Company | Methods for synthesizing zinc-lysine-chloride complex |
| US11091502B2 (en) | 2018-12-21 | 2021-08-17 | Colgate-Palmolive Company | Methods for synthesizing zinc-lysine-chloride complex |
| US11229591B2 (en) | 2018-12-21 | 2022-01-25 | Colgate-Palmolive Company | Methods for synthesizing zinc-lysine-chloride complex |
| US12428609B2 (en) * | 2019-11-27 | 2025-09-30 | International Flavors & Fragrances Inc. | Organoleptic compounds |
| EP4084770B1 (en) * | 2019-12-31 | 2023-07-19 | 3M Innovative Properties Company | Aqueous zinc oral care compositions with fluoride |
Family Cites Families (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE735096C (de) | 1940-12-09 | 1943-05-06 | Ig Farbenindustrie Ag | Verfahren zur Herstellung von Sulfonsaeuren |
| US2527686A (en) | 1945-12-26 | 1950-10-31 | Max H Sandberg | Mouthwash |
| US2503280A (en) | 1947-10-24 | 1950-04-11 | Du Pont | Azo catalysts in preparation of sulfonic acids |
| US2507088A (en) | 1948-01-08 | 1950-05-09 | Du Pont | Sulfoxidation process |
| US2893918A (en) | 1957-04-24 | 1959-07-07 | Harold A Abramson | Deodorant composition |
| FR1247957A (fr) | 1958-09-28 | 1960-12-09 | Ajinomoto Kk | Procédé de séparation continue d'aminoacides racémiques |
| US3320174A (en) | 1964-04-20 | 1967-05-16 | Colgate Palmolive Co | Detergent composition |
| US3372188A (en) | 1965-03-12 | 1968-03-05 | Union Oil Co | Sulfoxidation process in the presence of sulfur trioxide |
| US3538230A (en) | 1966-12-05 | 1970-11-03 | Lever Brothers Ltd | Oral compositions containing silica xerogels as cleaning and polishing agents |
| US3678154A (en) | 1968-07-01 | 1972-07-18 | Procter & Gamble | Oral compositions for calculus retardation |
| US3535421A (en) | 1968-07-11 | 1970-10-20 | Procter & Gamble | Oral compositions for calculus retardation |
| US3741911A (en) | 1970-12-21 | 1973-06-26 | Hart Chemical Ltd | Phosphate-free detergent composition |
| US3959458A (en) | 1973-02-09 | 1976-05-25 | The Procter & Gamble Company | Oral compositions for calculus retardation |
| US3937807A (en) | 1973-03-06 | 1976-02-10 | The Procter & Gamble Company | Oral compositions for plaque, caries, and calculus retardation with reduced staining tendencies |
| US3862307A (en) | 1973-04-09 | 1975-01-21 | Procter & Gamble | Dentifrices containing a cationic therapeutic agent and improved silica abrasive |
| US3941818A (en) | 1973-08-20 | 1976-03-02 | Zinpro Corporation | 1:1 Zinc methionine complexes |
| US4039681A (en) * | 1973-08-20 | 1977-08-02 | Zinpro Corporation | Zinc methionine complex for acne treatment |
| US4051234A (en) | 1975-06-06 | 1977-09-27 | The Procter & Gamble Company | Oral compositions for plaque, caries, and calculus retardation with reduced staining tendencies |
| US4340583A (en) | 1979-05-23 | 1982-07-20 | J. M. Huber Corporation | High fluoride compatibility dentifrice abrasives and compositions |
| US4339432A (en) | 1979-06-20 | 1982-07-13 | Lever Brothers Company | Oral mouthwash containing zinc and glycine |
| GB2052978A (en) * | 1979-06-20 | 1981-02-04 | Unilever Ltd | Oral compositions containing zinc salts |
| US4316824A (en) | 1980-06-26 | 1982-02-23 | The Procter & Gamble Company | Liquid detergent composition containing alkyl sulfate and alkyl ethoxylated sulfate |
| JPS57158724A (en) * | 1981-03-26 | 1982-09-30 | Shiseido Co Ltd | Antimicrobial composition |
| US4565693A (en) | 1981-11-09 | 1986-01-21 | Colgate-Palmolive Company | Deodorant composition |
| US4487757A (en) | 1981-12-28 | 1984-12-11 | Colgate-Palmolive Company | Dispensing container of toothpaste which effervesces during toothbrushing |
| IL64700A0 (en) | 1982-01-01 | 1982-03-31 | Binderman Itzhak | Dental care compositions |
| US4885155A (en) | 1982-06-22 | 1989-12-05 | The Procter & Gamble Company | Anticalculus compositions using pyrophosphate salt |
| DE3238118A1 (de) * | 1982-10-14 | 1984-04-19 | Verla-Pharm, Arzneimittelfabrik Apotheker H.J. v. Ehrlich GmbH & Co KG, 8132 Tutzing | Verfahren zur herstellung von komplexverbindungen aus aminodicarbonsaeuren, zweiwertigen metallionen und halogenidionen |
| US4687663B1 (en) | 1983-03-01 | 1997-10-07 | Chesebrough Ponds Usa Co | Dental preparation article and method for storage and delivery thereof |
| GB2179536B (en) | 1984-06-11 | 1988-12-21 | Godfrey Science & Design Inc | Improvement in the flavour of zinc supplements for oral use |
| US4599152A (en) | 1985-05-24 | 1986-07-08 | Albion Laboratories | Pure amino acid chelates |
| US5188821A (en) | 1987-01-30 | 1993-02-23 | Colgate-Palmolive Company | Antibacterial antiplaque oral composition mouthwash or liquid dentifrice |
| US5192531A (en) | 1988-12-29 | 1993-03-09 | Colgate-Palmolive Company | Antibacterial antiplaque oral composition |
| US4866161A (en) | 1987-08-24 | 1989-09-12 | University Of South Alabama | Inhibition of tartar deposition by polyanionic/hydrophobic peptides and derivatives thereof which have a clustered block copolymer structure |
| US5004597A (en) | 1987-09-14 | 1991-04-02 | The Procter & Gamble Company | Oral compositions comprising stannous flouride and stannous gluconate |
| US4842847A (en) | 1987-12-21 | 1989-06-27 | The B. F. Goodrich Company | Dental calculus inhibiting compositions |
| US5061815A (en) | 1988-07-06 | 1991-10-29 | Zinpro Corporation | Metal lysine complexes and method for producing metal lysine complexes |
| US5156845A (en) | 1990-05-04 | 1992-10-20 | Colgate-Palmolive Company | Dry mouth lozenge |
| GB2243775A (en) | 1990-05-09 | 1991-11-13 | Unilever Plc | Oral compositions |
| JPH0578243A (ja) | 1990-12-11 | 1993-03-30 | Shiseido Co Ltd | 鎮痒剤及び鎮痒組成物 |
| GB9107833D0 (en) | 1991-04-12 | 1991-05-29 | Unilever Plc | Treatment of periodontitis |
| US5643559A (en) | 1991-10-30 | 1997-07-01 | Colgate-Palmolive Company | Deodorant compositions comprising inhibitors of odor-producing axillary bacterial exoenzymes |
| US5504055A (en) | 1994-03-15 | 1996-04-02 | J.H. Biotech, Inc. | Metal amino acid chelate |
| US5707679A (en) | 1994-09-30 | 1998-01-13 | Kemin Industries, Inc. | Metal propionates for use as animal feed supplements |
| EP1203575B1 (en) | 1995-05-03 | 2010-09-01 | Unilever N.V. | Clear gel-type dentrifices |
| US5714447A (en) | 1996-01-24 | 1998-02-03 | Church & Dwight Co., Inc. | Deodorant soap or detergent composition containing a zinc compound and a polyamine |
| US5698724A (en) | 1996-04-30 | 1997-12-16 | Zinpro Corporation | Amino acid metal complexes using hydrolyzed protein as the amino acid source and methods re same |
| AU4428397A (en) | 1996-09-20 | 1998-04-14 | Warner-Lambert Company | Oral compositions containing a zinc compound |
| GB9622659D0 (en) | 1996-10-31 | 1997-01-08 | Unilever Plc | Hair treatment composition |
| US5897891A (en) | 1996-11-18 | 1999-04-27 | Godfrey; John C. | Flavorful zinc compositions for oral use incorporating copper |
| FI106923B (fi) | 1997-01-03 | 2001-05-15 | Cultor Ltd Finnsugar Bioproduc | Trimetyyliglysiinin käyttö kehon limakalvojen hygieniaan ja hoitoon tarkoitetuissa valmisteissa |
| US5993784A (en) | 1997-07-24 | 1999-11-30 | Whitehill Oral Technologies | Low foaming therapeutic toothpastes with improved cleaning and abrasion performance |
| DK176196B1 (da) | 1997-10-07 | 2007-01-08 | Ejvind Jersie Pedersen | Mundhygejnepræparat til behandling af halitosis samt anvendelse af et chelat omfattende en metaliondel og en aminosyredel som en komponent i præparatet |
| CN1311628A (zh) | 1998-06-09 | 2001-09-05 | 威廉·J·恩布罗 | 治疗皮肤过敏和感染的方法和组合物 |
| US6169118B1 (en) | 1998-11-12 | 2001-01-02 | Block Drug Company, Inc. | Flavor blend for masking unpleasant taste of zinc compounds |
| US6558710B1 (en) | 1999-06-14 | 2003-05-06 | Helen Rebecca Godfrey | Topical zinc compositions and methods of use |
| US6685920B2 (en) | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| US7164035B2 (en) | 2000-01-07 | 2007-01-16 | Newsome David A | Zinc-monocysteine complex and method of using zinc-cysteine complexes |
| JP3490950B2 (ja) | 2000-03-15 | 2004-01-26 | 三洋電機株式会社 | ２シリンダ型２段圧縮式ロータリーコンプレッサ |
| DE10160933B4 (de) | 2001-12-12 | 2018-06-21 | Evonik Degussa Gmbh | Zubereitungen mit desodorierender Wirkung, enthaltend das Zinksalz der Ricinolsäure und mindestens eine aminofunktionelle Aminosäure |
| US6670494B1 (en) | 2001-12-17 | 2003-12-30 | J H Brotech, Inc. | Method for preparation of metal organic acid chelates |
| US20040033916A1 (en) | 2002-06-28 | 2004-02-19 | Kuzmin Vladimir Semenovich | Disinfecting composition |
| JP2004175790A (ja) | 2002-11-12 | 2004-06-24 | Arita Junichi | α−グルコシダーゼ阻害作用を有する亜鉛含有物 |
| US7022351B2 (en) | 2003-01-14 | 2006-04-04 | Zinpro Corporation | Composition for supplementing animals with solutions of essential metal amino acid complexes |
| US20040198998A1 (en) | 2003-04-04 | 2004-10-07 | Marian Holerca | Glycine-free antiperspirant salts with betaine for enhanced cosmetic products |
| US7270806B2 (en) | 2004-07-27 | 2007-09-18 | Coty S.A. | Liquid stick antiperspirant |
| US7700079B2 (en) | 2005-09-26 | 2010-04-20 | Jamie Collins Doss | Therapeutic soap product with UV protection |
| BRPI0619389A2 (pt) | 2005-11-29 | 2011-10-04 | Procter & Gamble | composição dentifrìcia compreendendo um sistema aglutinante que compreende material de argila hidrofìlica |
| BRPI0622284A2 (pt) | 2006-05-25 | 2011-03-29 | Yiqiang Huang | processo de obtenção de cloreto básico de zinco utilizado como aditivo micronutriente |
| DE102006040302A1 (de) | 2006-08-29 | 2008-03-20 | Henkel Kgaa | Antitranspirant- und Deodorant-Zusammensetzungen mit verbesserter Pflegewirkung |
| EP1935395B1 (en) | 2006-12-20 | 2013-06-05 | Unilever PLC | Oral composition |
| US8247398B2 (en) | 2007-02-17 | 2012-08-21 | Ssv Therapeutics, Inc. | Zinc complexes of natural amino acids for treating elevated copper caused toxicities |
| JP2009084201A (ja) | 2007-09-28 | 2009-04-23 | Riken Koryo Kogyo Kk | パーマネントウェーブ剤用消臭処理剤並びにこれを含有するパーマネントウェーブ剤 |
| CN101172956A (zh) * | 2007-10-26 | 2008-05-07 | 白家强 | 单体赖氨酸锌及再转为赖氨酸锌络合物的制备和用途 |
| US20110229536A1 (en) | 2008-05-12 | 2011-09-22 | Tagra Biotechnologies Ltd. | Compositions for topical application comprising microencapsulated colorants |
| US20100021573A1 (en) | 2008-07-22 | 2010-01-28 | Michael J Gonzalez | Compositions and methods for the prevention of cardiovascular disease |
| JP2010132639A (ja) | 2008-11-10 | 2010-06-17 | Nikko Chemical Co Ltd | Ｄｎａ損傷抑制剤及びマトリックスメタロプロテアーゼ−１産生抑制剤 |
| ES2615281T3 (es) | 2009-06-24 | 2017-06-06 | Charles N.S. Soparkar | Suplementación con cinc para aumentar la capacidad de respuesta al tratamiento con metaloproteasa |
| CN101606639B (zh) | 2009-07-20 | 2012-07-25 | 曹江山 | 一种保育猪浓缩饲料 |
| AU2009353312B2 (en) | 2009-09-30 | 2013-04-04 | Colgate-Palmolive Company | Antiperspirant/deodorant composition |
| PH12012500857A1 (en) | 2009-10-29 | 2012-11-26 | Colgate Palmolive Co | Dentrifice comprising stannous fluoride plus zinc citrate and low levels of water |
| TWI458497B (zh) | 2010-01-13 | 2014-11-01 | Colgate Palmolive Co | 口腔組成物中氧化鋅薄膜之安定化 |
| JP5694506B2 (ja) * | 2010-03-31 | 2015-04-01 | コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ | 口腔ケア組成物 |
| CN103156073B (zh) | 2011-12-13 | 2015-02-18 | 北京东方联鸣科技发展有限公司 | 奶牛产后营养补充剂 |
| CN103535536A (zh) | 2012-07-15 | 2014-01-29 | 新沂市佳威饲料有限公司 | 一种哺乳母猪饲料的配制方法 |
| CA2890537C (en) | 2012-12-05 | 2020-01-21 | Colgate-Palmolive Company | Fluoride-stable zinc containing compositions |
| US20150297500A1 (en) | 2012-12-06 | 2015-10-22 | Colgate-Palmolive Company | Surfactant Systems for Zinc Containing Compositions |
| EP2934445B1 (en) * | 2012-12-19 | 2017-10-04 | Colgate-Palmolive Company | Teeth whitening methods, visually perceptible signals and compositions therefor comprising zinc amino acid halides |
| US9763865B2 (en) * | 2012-12-19 | 2017-09-19 | Colgate-Palmolive Company | Oral gel comprising zinc-amino acid complex |
| MX352558B (es) * | 2012-12-19 | 2017-11-29 | Colgate Palmolive Co | Composiciones para el cuidado oral que contienen halogenuros de aminoácido de zinc. |
| ES2617492T3 (es) | 2012-12-19 | 2017-06-19 | Colgate-Palmolive Company | Productos antitranspirantes con proteína y sales antitranspirantes |
| AU2012397259B2 (en) * | 2012-12-19 | 2015-09-17 | Colgate-Palmolive Company | Zinc-lysine complex |
| WO2014098822A1 (en) * | 2012-12-19 | 2014-06-26 | Colgate-Palmolive Company | Zinc amino acid halide mouthwashes |
| WO2014098813A1 (en) | 2012-12-19 | 2014-06-26 | Colgate-Palmolive Company | Zinc amino acid/trimethylglycine halide |
| WO2014204439A1 (en) | 2013-06-18 | 2014-12-24 | Colgate-Palmolive Company | Zinc amino acid halide complex with cysteine |
| EP2934442B1 (en) | 2012-12-19 | 2016-11-30 | Colgate-Palmolive Company | Oral care products comprising a tetrabasic zinc - amino acid - halide complex |
| KR20150097552A (ko) | 2012-12-19 | 2015-08-26 | 콜게이트-파아므올리브캄파니 | 4가염기성 염화아연 및 트리메틸글리신을 포함하는 구강 관리 제품 |
| JP5976955B2 (ja) | 2012-12-19 | 2016-08-24 | コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ | 酸化亜鉛およびトリメチルグリシンを含むオーラルケア製品 |
| US9675823B2 (en) * | 2012-12-19 | 2017-06-13 | Colgate-Palmolive Company | Two component compositions containing zinc amino acid halide complexes and cysteine |
| US10494589B2 (en) | 2012-12-19 | 2019-12-03 | Colgate-Palmolive Company | Method for indicating time for washing or indicating delivery of antibacterial agent |
| US9925130B2 (en) | 2012-12-19 | 2018-03-27 | Colgate-Palmolive Company | Composition with zinc amino acid/trimethylglycine halide precursors |
| JP6392779B2 (ja) | 2012-12-19 | 2018-09-19 | コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ | システインによる亜鉛アミノ酸錯体 |
| WO2014098821A1 (en) | 2012-12-19 | 2014-06-26 | Colgate-Palmolive Company | Method for indicating time for washing or indicating delivery of antibacterial agent |
| US10130571B2 (en) * | 2014-06-18 | 2018-11-20 | Colgate-Palmolive Company | Dentifrice Comprising Zinc-Amino Acid Complex and Phosphates |
| AU2016377573C1 (en) * | 2015-12-22 | 2019-10-24 | Colgate-Palmolive Company | Oral care compositions comprising zinc amino acid halides |
-
2012
- 2012-12-19 US US14/653,880 patent/US9763865B2/en active Active
- 2012-12-19 MX MX2015007980A patent/MX368740B/es active IP Right Grant
- 2012-12-19 EP EP12809989.2A patent/EP2934441B1/en active Active
- 2012-12-19 KR KR1020157016635A patent/KR20150094651A/ko not_active Withdrawn
- 2012-12-19 BR BR112015014900-6A patent/BR112015014900B1/pt active IP Right Grant
- 2012-12-19 RU RU2015123653A patent/RU2636226C2/ru active
- 2012-12-19 AU AU2012397265A patent/AU2012397265B2/en active Active
- 2012-12-19 PH PH1/2015/501436A patent/PH12015501436B1/en unknown
- 2012-12-19 WO PCT/US2012/070513 patent/WO2014098824A1/en not_active Ceased
- 2012-12-19 CA CA2892419A patent/CA2892419C/en active Active
- 2012-12-19 CN CN201280077876.5A patent/CN104853723B/zh active Active
-
2013
- 2013-11-28 TW TW102143368A patent/TWI522120B/zh not_active IP Right Cessation
- 2013-11-28 TW TW103136089A patent/TW201526919A/zh unknown
- 2013-12-17 AR ARP130104809A patent/AR094075A1/es unknown
-
2015
- 2015-05-28 ZA ZA2015/03848A patent/ZA201503848B/en unknown
- 2015-06-18 IL IL239530A patent/IL239530A0/en unknown
-
2017
- 2017-08-11 US US15/674,557 patent/US10245222B2/en active Active
-
2019
- 2019-02-25 US US16/284,668 patent/US10792236B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX368740B (es) | 2019-10-14 |
| TWI522120B (zh) | 2016-02-21 |
| US10792236B2 (en) | 2020-10-06 |
| EP2934441B1 (en) | 2017-04-26 |
| KR20150094651A (ko) | 2015-08-19 |
| WO2014098824A1 (en) | 2014-06-26 |
| US20190183766A1 (en) | 2019-06-20 |
| PH12015501436A1 (en) | 2015-09-14 |
| BR112015014900B1 (pt) | 2019-05-14 |
| PH12015501436B1 (en) | 2022-07-01 |
| CN104853723A (zh) | 2015-08-19 |
| MX2015007980A (es) | 2015-10-22 |
| TW201526919A (zh) | 2015-07-16 |
| US10245222B2 (en) | 2019-04-02 |
| BR112015014900A2 (pt) | 2017-07-11 |
| US20170340539A1 (en) | 2017-11-30 |
| CA2892419A1 (en) | 2014-06-26 |
| AU2012397265A1 (en) | 2015-06-18 |
| IL239530A0 (en) | 2015-08-31 |
| US20150328110A1 (en) | 2015-11-19 |
| ZA201503848B (en) | 2017-07-26 |
| CA2892419C (en) | 2019-09-17 |
| AR094075A1 (es) | 2015-07-08 |
| US9763865B2 (en) | 2017-09-19 |
| RU2636226C2 (ru) | 2017-11-21 |
| CN104853723B (zh) | 2017-12-08 |
| TW201424762A (zh) | 2014-07-01 |
| EP2934441A1 (en) | 2015-10-28 |
| AU2012397265B2 (en) | 2016-02-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015123653A (ru) | Гель для ухода за полостью рта, содержащий комплекс цинка и аминокислоты | |
| RU2015129106A (ru) | Композиции для ухода за полостью рта, содержащие комплекс цинка с аминокислотой и галогенидом | |
| RU2015123751A (ru) | Ополаскиватель для полости рта с галогенидом цинка-аминокислоты | |
| RU2015123679A (ru) | Продукты для ухода за полостью рта, содержащие комплекс четырехосновной цинк-аминокислота-галогенид | |
| JP2011511795A5 (ru) | ||
| RU2015123707A (ru) | Продукты для ухода за полостью рта, включающие оксид цинка и триметилглицин | |
| RU2016148244A (ru) | Средство для ухода за зубами, содержащее комплекс цинка с аминокислотой и фосфаты | |
| RU2017130866A (ru) | Композиции для ухода за полостью рта и способы их применения | |
| RU2015123748A (ru) | Продукты для ухода за полостью рта, содержащие четырехосновный хлорид цинка и триметилглицин | |
| RU2013111534A (ru) | Средство для ухода за полостью рта, способы его применения и производства | |
| RU2010137324A (ru) | Двухкомпонентный продукт для ухода за ротовой полостью | |
| RU2013124842A (ru) | Средство для ухода за полостью рта и способы его применения и производства | |
| RU2015123704A (ru) | Комплекс цинк-аминокислота-галогенид с цистеином | |
| RU2010137329A (ru) | Продукт для ухода за полостью рта и способы его применения и получения | |
| RU2015126796A (ru) | Композиции, содержащие фосфат цинка | |
| JP2011511067A5 (ru) | ||
| RU2018122670A (ru) | Композиции для ухода за полостью рта, содержащие комплексы цинк-аминокислота-галогенид | |
| RU2013126513A (ru) | Продукт для ухода за полостью рта и способы его применения и получения | |
| JP2014210798A5 (ru) | ||
| RU2013131040A (ru) | Композиции для ухода за полостью рта, содержащие силикат кальция | |
| RU2013126518A (ru) | Продукт для ухода за полостью рта и способы его применения и изготовления | |
| RU2018142540A (ru) | Композиция для ухода за полостью рта | |
| JP2014208652A5 (ru) | ||
| CN102368994B (zh) | 包含氟离子和增稠系统的洁齿剂组合物 | |
| RU2017135563A (ru) | Композиции для ухода за полостью рта |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HE9A | Changing address for correspondence with an applicant |