RU2015150069A3 - - Google Patents
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- Publication number
- RU2015150069A3 RU2015150069A3 RU2015150069A RU2015150069A RU2015150069A3 RU 2015150069 A3 RU2015150069 A3 RU 2015150069A3 RU 2015150069 A RU2015150069 A RU 2015150069A RU 2015150069 A RU2015150069 A RU 2015150069A RU 2015150069 A3 RU2015150069 A3 RU 2015150069A3
- Authority
- RU
- Russia
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361815502P | 2013-04-24 | 2013-04-24 | |
| US61/815,502 | 2013-04-24 | ||
| PCT/US2014/035279 WO2014176415A1 (en) | 2013-04-24 | 2014-04-24 | 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019120236A Division RU2019120236A (ru) | 2013-04-24 | 2014-04-24 | 2,2-дифторопропионамидные производные бардоксолон-метила, полиморфные формы и способы их пременения |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2015150069A RU2015150069A (ru) | 2017-05-29 |
| RU2015150069A3 true RU2015150069A3 (ru) | 2018-03-21 |
| RU2693833C2 RU2693833C2 (ru) | 2019-07-05 |
Family
ID=50842351
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019120236A RU2019120236A (ru) | 2013-04-24 | 2014-04-24 | 2,2-дифторопропионамидные производные бардоксолон-метила, полиморфные формы и способы их пременения |
| RU2015150069A RU2693833C2 (ru) | 2013-04-24 | 2014-04-24 | 2,2-дифторопропионамидные производные бардоксолон-метила, полиморфные формы и способы их применения |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019120236A RU2019120236A (ru) | 2013-04-24 | 2014-04-24 | 2,2-дифторопропионамидные производные бардоксолон-метила, полиморфные формы и способы их пременения |
Country Status (35)
| Country | Link |
|---|---|
| US (5) | US9856286B2 (ru) |
| EP (2) | EP3453715A1 (ru) |
| JP (2) | JP6409050B2 (ru) |
| KR (2) | KR20150144807A (ru) |
| CN (1) | CN105324389B (ru) |
| AR (1) | AR096046A1 (ru) |
| AU (2) | AU2014257072C1 (ru) |
| BR (1) | BR112015027012B1 (ru) |
| CA (1) | CA2909066C (ru) |
| CL (1) | CL2015003135A1 (ru) |
| CR (1) | CR20150620A (ru) |
| CY (1) | CY1120570T1 (ru) |
| DK (1) | DK2989114T3 (ru) |
| DO (1) | DOP2015000263A (ru) |
| EC (1) | ECSP23088864A (ru) |
| ES (1) | ES2683626T3 (ru) |
| HR (1) | HRP20181321T1 (ru) |
| HU (1) | HUE039899T2 (ru) |
| IL (1) | IL242183B (ru) |
| LT (1) | LT2989114T (ru) |
| MX (1) | MX372760B (ru) |
| MY (1) | MY182677A (ru) |
| PE (1) | PE20160006A1 (ru) |
| PH (1) | PH12015502459B1 (ru) |
| PL (1) | PL2989114T3 (ru) |
| PT (1) | PT2989114T (ru) |
| RS (1) | RS57571B1 (ru) |
| RU (2) | RU2019120236A (ru) |
| SG (2) | SG10201805231WA (ru) |
| SI (1) | SI2989114T1 (ru) |
| TW (2) | TWI649330B (ru) |
| UA (1) | UA118348C2 (ru) |
| UY (2) | UY39092A (ru) |
| WO (1) | WO2014176415A1 (ru) |
| ZA (1) | ZA201507481B (ru) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2252283B9 (en) | 2008-01-11 | 2019-03-20 | Reata Pharmaceuticals, Inc. | Synthetic triterpenoids and methods of use in the treatment of disease |
| EA019263B1 (ru) | 2008-04-18 | 2014-02-28 | Ритэ Фамэсутикл, Инк. | Антиоксидативные модуляторы воспаления: производные олеанолевой кислоты с аминовыми и другими модификациями на с-17 |
| NZ588708A (en) | 2008-04-18 | 2012-09-28 | Reata Pharmaceuticals Inc | 2-cyano steroid derivatives including an anti-inflammatory pharmacore |
| ES2634315T3 (es) | 2012-04-27 | 2017-09-27 | Reata Pharmaceuticals, Inc. | Derivados de 2.2-difluoropropionamida de bardoxolona metilo, formas polimórficas y métodos de uso de los mismos |
| US9556222B2 (en) | 2012-06-15 | 2017-01-31 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| US9593074B2 (en) | 2012-09-10 | 2017-03-14 | Reata Pharmaceuticals, Inc. | C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| US9278912B2 (en) | 2012-09-10 | 2016-03-08 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
| TWI649330B (zh) | 2013-04-24 | 2019-02-01 | 艾伯維有限公司 | 甲基巴多索龍之２，２－二氟丙醯胺衍生物、其多晶形及其使用方法 |
| AU2016278040B2 (en) | 2015-06-16 | 2019-07-04 | Nanophagix LLC | Drug delivery and imaging chemical conjugate, formulations and methods of use thereof |
| CN106309451A (zh) * | 2016-08-14 | 2017-01-11 | 吴芊葭 | 一种头孢呋辛酯的药物组合物及其医药用途 |
| CN106279344A (zh) * | 2016-08-14 | 2017-01-04 | 吴芊葭 | 一种从防风中分离的天然化合物及其制备方法、医药应用 |
| NZ753546A (en) | 2016-11-08 | 2022-10-28 | Reata Pharmaceuticals Holdings Llc | Methods of treating alport syndrome using bardoxolone methyl or analogs thereof |
| US20190388407A1 (en) | 2017-02-12 | 2019-12-26 | Aiviva Biopharma, Inc. | Multikinase inhibitors of vegf and tfg beta and uses thereof |
| CN108558985B (zh) * | 2018-05-19 | 2019-06-07 | 河南省科学院高新技术研究中心 | 白桦脂酸衍生物及其合成方法和应用 |
| WO2019246461A1 (en) | 2018-06-20 | 2019-12-26 | Reata Pharmaceuticals, Inc. | Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith |
| AU2019321429B2 (en) * | 2018-08-15 | 2022-12-08 | Aiviva Biopharma, Inc. | Multi-kinase inhibitors of VEGF and TGF beta and uses thereof |
| IL280950B2 (en) | 2018-08-20 | 2023-12-01 | Janssen Pharmaceutica Nv | Inhibitors of keap1-nrf2 protein-protein interaction |
| US20200323882A1 (en) * | 2019-03-15 | 2020-10-15 | University Of Rhode Island Board Of Trustees | Phlip®-mediated targeting of corticosteroids to diseased tissue |
| WO2020226201A1 (ko) * | 2019-05-08 | 2020-11-12 | 경상대학교병원 | 피부 저색소증 예방 또는 치료용 약학적 조성물, 건강기능식품 및 화장료 조성물 |
| JP7695229B2 (ja) | 2019-07-19 | 2025-06-18 | リアタ ファーマシューティカルズ インコーポレイテッド | Ｃ１７極性置換ヘテロ芳香族合成トリテルペノイドおよびその使用方法 |
| US20230111914A1 (en) * | 2019-12-19 | 2023-04-13 | Reata Pharmaceuticals, Inc. | Synthetic triterpenoids with nitrogen-based substituents at c-17 and methods of use thereof |
| EP4259155A1 (en) * | 2020-12-11 | 2023-10-18 | Reata Pharmaceuticals Holdings, LLC | Synthetic triterpenoids for use in therapy |
| US20240140986A1 (en) * | 2021-01-18 | 2024-05-02 | Reata Pharmaceuticals, Inc. | Synthetic ursolic acid derivatives and methods of use thereof |
| CN113197905B (zh) * | 2021-04-23 | 2022-04-19 | 浙江大学 | 三萜类化合物在制备神经母细胞瘤治疗药物中的应用 |
| CN114344308A (zh) * | 2021-12-22 | 2022-04-15 | 山西医科大学第二医院 | 甲基巴多索隆在制备防治骨关节炎的药物中的应用 |
| WO2023132369A1 (ja) | 2022-01-07 | 2023-07-13 | 中外製薬株式会社 | Ｎｒｆ２活性化作用を有する含窒素複素環化合物 |
| EP4349847A1 (en) * | 2022-09-21 | 2024-04-10 | Sicor Società Italiana Corticosteroidi S.r.l. | Process and intermediates for preparation of omaveloxolone and salts thereof |
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| EA019263B1 (ru) | 2008-04-18 | 2014-02-28 | Ритэ Фамэсутикл, Инк. | Антиоксидативные модуляторы воспаления: производные олеанолевой кислоты с аминовыми и другими модификациями на с-17 |
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| NZ588708A (en) | 2008-04-18 | 2012-09-28 | Reata Pharmaceuticals Inc | 2-cyano steroid derivatives including an anti-inflammatory pharmacore |
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| US9278912B2 (en) | 2012-09-10 | 2016-03-08 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
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| US9593074B2 (en) | 2012-09-10 | 2017-03-14 | Reata Pharmaceuticals, Inc. | C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| TWI649330B (zh) | 2013-04-24 | 2019-02-01 | 艾伯維有限公司 | 甲基巴多索龍之２，２－二氟丙醯胺衍生物、其多晶形及其使用方法 |
| TWI716341B (zh) | 2013-08-23 | 2021-01-21 | 美商瑞塔醫藥有限責任公司 | 使用齊墩果酸（ｂａｒｄｏｘｏｌｏｎｅ ｍｅｔｈｙｌ）或其類似物治療和預防內皮功能障礙之方法 |
| MX372772B (es) | 2014-01-24 | 2020-06-29 | Reata Pharmaceuticals Inc | Enonas piridazolilo y pirimidinilo tricíclicas sustituidas con arilo y arilalquilo como moduladores de la inflamación antioxidantes. |
| WO2016130927A1 (en) | 2015-02-12 | 2016-08-18 | Reata Pharmaceuticals, Inc. | Imidazolyl tricyclic enones as antioxidant iflammation modulators |
| EP3353190B1 (en) | 2015-09-23 | 2021-03-17 | Reata Pharmaceuticals, Inc. | C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses |
| NZ753546A (en) | 2016-11-08 | 2022-10-28 | Reata Pharmaceuticals Holdings Llc | Methods of treating alport syndrome using bardoxolone methyl or analogs thereof |
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