RU2015148496A - 4-Phenylpyrrolidinone-2 derivative containing its composition with nootropic activity, a method for their preparation and a method for the treatment or prevention of disorders of the nerve system - Google Patents
4-Phenylpyrrolidinone-2 derivative containing its composition with nootropic activity, a method for their preparation and a method for the treatment or prevention of disorders of the nerve system Download PDFInfo
- Publication number
- RU2015148496A RU2015148496A RU2015148496A RU2015148496A RU2015148496A RU 2015148496 A RU2015148496 A RU 2015148496A RU 2015148496 A RU2015148496 A RU 2015148496A RU 2015148496 A RU2015148496 A RU 2015148496A RU 2015148496 A RU2015148496 A RU 2015148496A
- Authority
- RU
- Russia
- Prior art keywords
- composition
- potassium taurate
- disorders
- nootropic activity
- prevention
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 5
- 230000001777 nootropic effect Effects 0.000 title claims abstract 5
- 230000002265 prevention Effects 0.000 title claims abstract 3
- 210000005036 nerve Anatomy 0.000 title 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract 6
- IMYBWPUHVYRSJG-UHFFFAOYSA-M potassium;2-aminoethanesulfonate Chemical compound [K+].NCCS([O-])(=O)=O IMYBWPUHVYRSJG-UHFFFAOYSA-M 0.000 claims abstract 6
- FKRSNIDTANUROA-UHFFFAOYSA-N O=C1N(CC(C1)C1=CC=CC=C1)CC(=O)O.C(=O)(OCC)OC Chemical compound O=C1N(CC(C1)C1=CC=CC=C1)CC(=O)O.C(=O)(OCC)OC FKRSNIDTANUROA-UHFFFAOYSA-N 0.000 claims abstract 4
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 4
- 231100000053 low toxicity Toxicity 0.000 claims abstract 4
- 210000000653 nervous system Anatomy 0.000 claims abstract 4
- 229940104261 taurate Drugs 0.000 claims abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 4
- HOJZEMQCQRPLQQ-UHFFFAOYSA-N 4-phenylpyrrolidin-2-one Chemical compound C1NC(=O)CC1C1=CC=CC=C1 HOJZEMQCQRPLQQ-UHFFFAOYSA-N 0.000 claims abstract 2
- VEUUMBGHMNQHGO-UHFFFAOYSA-N ethyl chloroacetate Chemical compound CCOC(=O)CCl VEUUMBGHMNQHGO-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1. 1-[(4-фенил-2-пирролидон-1-ил)ацетил]таурат калия формулыобладающий ноотропной активностью и низкой токсичностью.2. Композиция для лечения и профилактики нарушений нервной системы, обладающая ноотропной активностью и низкой токсичностью, содержащая соединение по п 1, а также таурат калия и воду и характеризующаяся формулой.3. Композиция по п. 2, в которой мольное отношение 1-[(4-фенил-2-пирролидон-1-ил)ацетил]таурата калия, таурата калия и воды составляет 1:1:1.4. Способ получения соединения по п.1 и композиции по п.2, предусматривающийа) обработку 4-фенилпирролидона-2 избытком гранулированного KOH в ДМСО при нагревании, а затем избытком этилхлорацетата с получением карбэтоксиметилового эфира (2-оксо-4-фенилпирролидино)уксусной кислоты; иб) осуществление реакции карбэтоксиметилового эфира (2-оксо-4-фенилпирролидино)уксусной кислоты с тауратом калия.5. Способ лечения или профилактики нарушений нервной системы, предусматривающий введение нуждающемуся в этом пациенту терапевтически или профилактически эффективного количества композиции по п. 2.1.1 - [(4-phenyl-2-pyrrolidon-1-yl) acetyl] potassium taurate of the formula possessing nootropic activity and low toxicity. 2. A composition for the treatment and prevention of disorders of the nervous system, having nootropic activity and low toxicity, containing a compound according to claim 1, as well as potassium taurate and water and characterized by the formula. 3. The composition of claim 2, wherein the molar ratio of 1 - [(4-phenyl-2-pyrrolidon-1-yl) acetyl] potassium taurate, potassium taurate and water is 1: 1: 1.4. A method for producing a compound according to claim 1 and a composition according to claim 2, comprising: treating 4-phenylpyrrolidone-2 with an excess of granular KOH in DMSO by heating, and then with an excess of ethyl chloroacetate to give carbethoxymethyl ether (2-oxo-4-phenylpyrrolidino) acetic acid; ib) the reaction of carbethoxymethyl ether (2-oxo-4-phenylpyrrolidino) acetic acid with potassium taurate. 5. A method of treating or preventing disorders of the nervous system, comprising administering to a patient in need thereof a therapeutically or prophylactically effective amount of a composition according to claim 2.
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2015148496A RU2611623C2 (en) | 2015-11-11 | 2015-11-11 | 4-phenyl pyrrolidinone-2 derivative, nootropic composition thereof, method for producing thereof and method preventive treatment of nervous system disorders |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2015148496A RU2611623C2 (en) | 2015-11-11 | 2015-11-11 | 4-phenyl pyrrolidinone-2 derivative, nootropic composition thereof, method for producing thereof and method preventive treatment of nervous system disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015148496A true RU2015148496A (en) | 2016-05-10 |
| RU2611623C2 RU2611623C2 (en) | 2017-02-28 |
Family
ID=55959683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015148496A RU2611623C2 (en) | 2015-11-11 | 2015-11-11 | 4-phenyl pyrrolidinone-2 derivative, nootropic composition thereof, method for producing thereof and method preventive treatment of nervous system disorders |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2611623C2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2748419C2 (en) * | 2017-02-20 | 2021-05-25 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" | Derivatives of 4-phenylpyrrolidone with anticonvulsant and nootropic activity as means of treating epilepsy and paroxysmal conditions |
| CN119504517A (en) * | 2025-01-22 | 2025-02-25 | 浙江天启生化股份有限公司 | A kind of preparation method of magnesium acetyl taurate |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2741910C2 (en) * | 2019-07-09 | 2021-01-29 | Государственное бюджетное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации | Compounds having anti-ischemic, antianginal, cytoprotective properties, a method for production thereof and use thereof, a method of treating a neurodegenerative disease, a method of treating a psychic disorder |
| RU2711655C1 (en) * | 2019-09-13 | 2020-01-20 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский национальный исследовательский медицинский университет имени Н.И. Пирогова" Министерства здравоохранения Российской Федерации | Method for large-scale synthesis of potassium salt of 2-[2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamido]ethane sulphonic acid |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2437659C1 (en) * | 2010-11-12 | 2011-12-27 | Государственное образовательное учреждение высшего профессионального образования "Российский государственный педагогический университет им. А.И. Герцена" (РГПУ им. А.И. Герцена) | Medication possessing antidepressive, anxiolytic and nootropic action |
| RU2440981C1 (en) * | 2010-11-12 | 2012-01-27 | Государственное образовательное учреждение высшего профессионального образования "Российский государственный педагогический университет им. А.И. Герцена" (РГПУ им. А.И. Герцена) | Phenylhydrazide (4-phenyl-2-pyrrolidon-1-yl)-acetic acid, having nootropic, antidepressant and anxiolytic activity |
| RU2524651C1 (en) * | 2013-06-20 | 2014-07-27 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Pharmaceutical composition in form of solution for injection and method for production thereof |
-
2015
- 2015-11-11 RU RU2015148496A patent/RU2611623C2/en active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2748419C2 (en) * | 2017-02-20 | 2021-05-25 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" | Derivatives of 4-phenylpyrrolidone with anticonvulsant and nootropic activity as means of treating epilepsy and paroxysmal conditions |
| CN119504517A (en) * | 2025-01-22 | 2025-02-25 | 浙江天启生化股份有限公司 | A kind of preparation method of magnesium acetyl taurate |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2611623C2 (en) | 2017-02-28 |
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