RU2013116924A - N1/n2-лактамные ингибиторы ацетил-коа-карбоксилаз - Google Patents
N1/n2-лактамные ингибиторы ацетил-коа-карбоксилаз Download PDFInfo
- Publication number
- RU2013116924A RU2013116924A RU2013116924/04A RU2013116924A RU2013116924A RU 2013116924 A RU2013116924 A RU 2013116924A RU 2013116924/04 A RU2013116924/04 A RU 2013116924/04A RU 2013116924 A RU2013116924 A RU 2013116924A RU 2013116924 A RU2013116924 A RU 2013116924A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- alkyl
- compound
- Prior art date
Links
- 229940121373 acetyl-coa carboxylase inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 16
- 150000003839 salts Chemical class 0.000 claims abstract 14
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims abstract 2
- 239000003085 diluting agent Substances 0.000 claims abstract 2
- 125000005843 halogen group Chemical group 0.000 claims abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims abstract 2
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 2
- 125000001624 naphthyl group Chemical group 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims abstract 2
- 125000001424 substituent group Chemical group 0.000 claims abstract 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
1. Соединение формулы (I)или его фармацевтически приемлемая соль, гдеG представляет собойили;Rпредставляет собой (С-С)алкил или (С-С)циклоалкил;Rпредставляет собой фенил; нафтил; 5-12-членный гетероарил или 8-12-членный конденсированный гетероциклический арил; где каждая группа Rвозможно замещена одним-тремя заместителями, независимо выбранными из (С-С)алкила, (С-С)алкокси, галогено и CONH; иRпредставляет собой водород или (С-С)алкил.2. Соединение по п.1, где Rпредставляет собой изопропил или трет-бутил; или его фармацевтически приемлемая соль.3. Соединение по п.1, где Rпредставляет собой хинолинил или изохинолинил, причем указанный Rвозможно замещен независимо одной-двумя группами метил, метокси или хлоро; или его фармацевтически приемлемая соль.4. Соединение по п.1, где Rпредставляет собой водород.5. Фармацевтическая композиция, содержащая терапевтически эффективное количество соединения по п.1 или его фармацевтически приемлемой соли и фармацевтически приемлемый эксципиент, разбавитель или носитель.6. Соединение по п.1, имеющее структуру,или его фармацевтически приемлемая соль.7. Соединение по п.1, имеющее структуру,или его фармацевтически приемлемая соль.8. Соединение по п.1, имеющее структуру,или его фармацевтически приемлемая соль.
Claims (8)
1. Соединение формулы (I)
или его фармацевтически приемлемая соль, где
G представляет собой
R1 представляет собой (С1-С6)алкил или (С3-С5)циклоалкил;
R2 представляет собой фенил; нафтил; 5-12-членный гетероарил или 8-12-членный конденсированный гетероциклический арил; где каждая группа R2 возможно замещена одним-тремя заместителями, независимо выбранными из (С1-С3)алкила, (С1-С3)алкокси, галогено и CONH2; и
R3 представляет собой водород или (С1-С3)алкил.
2. Соединение по п.1, где R1 представляет собой изопропил или трет-бутил; или его фармацевтически приемлемая соль.
3. Соединение по п.1, где R2 представляет собой хинолинил или изохинолинил, причем указанный R2 возможно замещен независимо одной-двумя группами метил, метокси или хлоро; или его фармацевтически приемлемая соль.
4. Соединение по п.1, где R3 представляет собой водород.
5. Фармацевтическая композиция, содержащая терапевтически эффективное количество соединения по п.1 или его фармацевтически приемлемой соли и фармацевтически приемлемый эксципиент, разбавитель или носитель.
6. Соединение по п.1, имеющее структуру
или его фармацевтически приемлемая соль.
7. Соединение по п.1, имеющее структуру
или его фармацевтически приемлемая соль.
8. Соединение по п.1, имеющее структуру
или его фармацевтически приемлемая соль.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40812710P | 2010-10-29 | 2010-10-29 | |
| US61/408,127 | 2010-10-29 | ||
| US201161531744P | 2011-09-07 | 2011-09-07 | |
| US61/531,744 | 2011-09-07 | ||
| PCT/IB2011/054643 WO2012056372A1 (en) | 2010-10-29 | 2011-10-18 | N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2013116924A true RU2013116924A (ru) | 2014-12-10 |
| RU2540337C2 RU2540337C2 (ru) | 2015-02-10 |
Family
ID=44993633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013116924/04A RU2540337C2 (ru) | 2010-10-29 | 2011-10-18 | N1/N2-ЛАКТАМНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗ |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US8859773B2 (ru) |
| EP (2) | EP2632925B1 (ru) |
| JP (2) | JP5647356B2 (ru) |
| KR (2) | KR101529404B1 (ru) |
| CN (2) | CN103189377B (ru) |
| AR (1) | AR083578A1 (ru) |
| AU (1) | AU2011322117B2 (ru) |
| BR (1) | BR112013010310A2 (ru) |
| CA (1) | CA2815169C (ru) |
| CY (1) | CY1116405T1 (ru) |
| DK (1) | DK2632925T3 (ru) |
| ES (1) | ES2546465T3 (ru) |
| HK (1) | HK1209733A1 (ru) |
| HU (1) | HUE025078T2 (ru) |
| IL (1) | IL225779A0 (ru) |
| MX (1) | MX2013004733A (ru) |
| NZ (1) | NZ609527A (ru) |
| PL (1) | PL2632925T3 (ru) |
| PT (1) | PT2632925E (ru) |
| RU (1) | RU2540337C2 (ru) |
| SG (1) | SG189883A1 (ru) |
| SI (1) | SI2632925T1 (ru) |
| TW (3) | TWI441823B (ru) |
| UY (1) | UY33694A (ru) |
| WO (1) | WO2012056372A1 (ru) |
| ZA (1) | ZA201303882B (ru) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5647356B2 (ja) * | 2010-10-29 | 2014-12-24 | ファイザー・インク | Ｎ１／Ｎ２−ラクタムアセチル−ＣｏＡカルボキシラーゼ阻害剤 |
| CN105073735B (zh) | 2013-02-06 | 2018-08-14 | 拜耳作物科学股份公司 | 作为害虫防治剂的卤素取代的吡唑衍生物 |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| CN103214327A (zh) * | 2013-03-22 | 2013-07-24 | 郑州泰基鸿诺药物科技有限公司 | 一种芳香环或芳杂环三氟甲基酮化合物及其制备方法 |
| CN104230922B (zh) | 2013-06-19 | 2016-12-28 | 中国科学院上海药物研究所 | 一类五元杂环并吡啶类化合物及其制备方法和用途 |
| US20160220557A1 (en) | 2013-09-12 | 2016-08-04 | Pfizer Inc. | Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris |
| EP3089972B1 (de) | 2014-01-03 | 2018-05-16 | Bayer Animal Health GmbH | Neue pyrazolyl-heteroarylamide als schädlingsbekämpfungsmittel |
| CN104844509A (zh) * | 2014-02-14 | 2015-08-19 | 河南工业大学 | 一种条件温和无金属参与的胺基喹啉衍生物的制备方法 |
| KR101731624B1 (ko) * | 2014-07-01 | 2017-05-04 | 광주과학기술원 | 세포 리프로그래밍 유도용 조성물 |
| CN104610143A (zh) * | 2015-02-12 | 2015-05-13 | 佛山市赛维斯医药科技有限公司 | 一种含硝基喹啉结构的葡萄糖激酶活化剂及其用途 |
| AU2016231174B2 (en) | 2015-03-10 | 2020-09-10 | Bayer Animal Health Gmbh | Pyrazolyl-derivatives as pest control agents |
| IL243707A0 (en) | 2016-01-20 | 2016-05-01 | Galmed Res And Dev Ltd | Treatment to regulate the microbiota in the intestine |
| US11197870B2 (en) | 2016-11-10 | 2021-12-14 | Galmed Research And Development Ltd | Treatment for hepatic fibrosis |
| RU2764655C2 (ru) | 2017-03-16 | 2022-01-19 | Цзянсу Хэнжуй Медицин Ко., Лтд. | ПРОИЗВОДНОЕ ГЕТЕРОАРИЛ[4,3-с]ПИРИМИДИН-5-АМИНА, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ЕГО МЕДИЦИНСКИЕ ПРИМЕНЕНИЯ |
| EP3596086A4 (en) * | 2017-03-16 | 2020-12-16 | Celgene CAR LLC | MK2 INHIBITORS, THEIR SYNTHESIS AND THEIR INTERMEDIARIES |
| EP3596083A4 (en) | 2017-03-16 | 2020-12-02 | Celgene CAR LLC | USEFUL HETERARYL COMPOUNDS AS MK2 INHIBITORS |
| KR20190135029A (ko) | 2017-03-30 | 2019-12-05 | 에프. 호프만-라 로슈 아게 | Hpk1의 억제제인 이소퀴놀린 |
| HUE061885T2 (hu) | 2017-11-21 | 2023-08-28 | Pfizer | 4-(4-(4-(1-Izopropil-7-oxo-1,4,6,6,7-tetrahidrospiro[indazol-5,4'-piperidin] -1'-karbonil)-6-metoxipiridin-2-il)-benzoesav kristályos 2-amino-2-(hidroximetil)-propán-1,3-diol sója |
| EP3826722A1 (en) | 2018-07-24 | 2021-06-02 | F. Hoffmann-La Roche AG | Isoquinoline compounds and uses thereof |
| TW202024053A (zh) | 2018-10-02 | 2020-07-01 | 美商建南德克公司 | 異喹啉化合物及其用途 |
| US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
| CN109824669A (zh) * | 2018-12-21 | 2019-05-31 | 西南大学 | 哌啶螺环酒石酸类化合物制备及应用 |
| EP4149917B1 (en) | 2020-05-12 | 2025-07-30 | Merck Sharp & Dohme LLC | Factor xi activation inhibitors |
| WO2021235508A1 (ja) * | 2020-05-21 | 2021-11-25 | 塩野義製薬株式会社 | 脂肪性肝疾患の治療用医薬 |
| EP4284805A1 (en) | 2021-02-01 | 2023-12-06 | Celgene Corporation | Mk2 inhibitors, the synthesis thereof, and intermediates thereto |
| US20230053649A1 (en) * | 2021-06-25 | 2023-02-23 | Cedilla Therapeutics, Inc. | Tead inhibitors and uses thereof |
| CA3263179A1 (en) * | 2022-07-29 | 2024-02-01 | Pfizer Inc | NEW ACC INHIBITORS |
| WO2024213044A1 (en) * | 2023-04-14 | 2024-10-17 | Beijing Double-Crane Runchuang Technology Co., Ltd. | Azacyclo-carbonyl-fused ring derivatives and use thereof |
| WO2025036472A1 (en) * | 2023-08-16 | 2025-02-20 | Pharmaengine, Inc. | Spirocyclic mta-cooperative prmts inhibitor |
| WO2025190395A2 (en) * | 2024-03-14 | 2025-09-18 | Pharmaengine, Inc. | Mta-cooperative prmt5 inhibitor |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2002100A (en) | 1932-06-27 | 1935-05-21 | Smith Sheffield | Shock absorber |
| JPS4925673B1 (ru) * | 1970-05-22 | 1974-07-02 | ||
| DE69837903T2 (de) | 1997-08-11 | 2008-02-14 | Pfizer Products Inc., Groton | Feste pharmazeutische Dispersionen mit erhöhter Bioverfügbarkeit |
| IL157253A0 (en) | 2001-02-28 | 2004-02-19 | Merck & Co Inc | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
| WO2003018586A1 (en) | 2001-08-24 | 2003-03-06 | Pharmacia & Upjohn Company | Substituted-aryl 7-aza[2.2.1]bicycloheptanes for the treatment of disease |
| BR0307874A (pt) | 2002-02-20 | 2004-12-28 | Upjohn Co | Atividade de compostos azabicìclicos com receptor de acetilcolina nicotìnica alfa7 |
| EP1478437B1 (en) | 2002-02-27 | 2005-08-31 | Pfizer Products Inc. | Acc inhibitors |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| JPWO2004092179A1 (ja) | 2003-04-14 | 2006-07-06 | 日本曹達株式会社 | スピロ誘導体、製造法および抗酸化薬 |
| JP2005119987A (ja) | 2003-10-15 | 2005-05-12 | Ajinomoto Co Inc | アシルスルホンアミド誘導体 |
| AU2005247684B2 (en) | 2004-05-12 | 2008-10-23 | Pfizer Products Inc. | Proline derivatives and their use as dipeptidyl peptidase IV inhibitors |
| WO2005113069A2 (en) | 2004-05-14 | 2005-12-01 | Research Development Foundation | Use of circumin and analogues as inhibitors of acc2 |
| UA84208C2 (en) | 2004-05-25 | 2008-09-25 | Пфайзер Продактс Инк. | Tetraazabenzo(e)azulene derivatives and analogs thereof |
| PA8660701A1 (es) | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | Agonistas de pyy y sus usos |
| RU2422446C2 (ru) | 2005-07-19 | 2011-06-27 | Мерк Шарп Энд Домэ Корп. | Производные спирохроманона в качестве ингибиторов ацетил коэнзим а карбоксилазы (асс) |
| US20100160255A1 (en) | 2005-07-29 | 2010-06-24 | Takeda Pharmaceutical Company Limited | Spiro-cyclic compound |
| DE602006019304D1 (de) | 2005-11-18 | 2011-02-10 | Merck Sharp & Dohme | Spirohydantoin-aryl-cgrp-rezeptorantagonisten |
| US8735595B2 (en) | 2006-02-15 | 2014-05-27 | Abbvie Inc. | Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome |
| EP2010520B1 (en) | 2006-04-20 | 2012-09-12 | Pfizer Products Inc. | Heterobicyclic amides for the prevention and treatment of glucokinase-mediated diseases |
| MX2009005604A (es) * | 2006-11-29 | 2009-06-08 | Pfizer Prod Inc | Inhibidores espiro cetona de acetil-coa carboxilasa. |
| PE20081559A1 (es) | 2007-01-12 | 2008-11-20 | Merck & Co Inc | DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA |
| US20100113418A1 (en) * | 2007-02-20 | 2010-05-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| JP5404601B2 (ja) | 2007-04-12 | 2014-02-05 | ファイザー・インク | 新規な３−アミド−ピロロ［３，４−ｃ］ピラゾール−５（１Ｈ，４Ｈ，６Ｈ）カルバルデヒド誘導体 |
| US20090036425A1 (en) | 2007-08-02 | 2009-02-05 | Pfizer Inc | Substituted bicyclolactam compounds |
| US7981904B2 (en) | 2008-03-20 | 2011-07-19 | Takeda Pharmaceutical Company Limited | Acetyl CoA carboxylase inhibitors |
| ES2545231T3 (es) | 2008-05-28 | 2015-09-09 | Pfizer Inc. | Inhibidores de pirazoloespirocetona acetil-CoA carboxilasa |
| WO2009144555A1 (en) * | 2008-05-28 | 2009-12-03 | Pfizer Inc. | Pyrazolospiroketone acetyl-coa carboxylase inhibitors |
| JP5501256B2 (ja) | 2008-07-04 | 2014-05-21 | Ｍｓｄ株式会社 | 新規スピロクロマノンカルボン酸 |
| JP2011528034A (ja) | 2008-07-14 | 2011-11-10 | クロップソリューション，インコーポレイテッド | アセチル−補酵素カルボキシラーゼの修飾因子およびその使用方法 |
| US20110130365A1 (en) | 2008-07-29 | 2011-06-02 | Benbow John W | Fluorinated Heteroaryls |
| MY155418A (en) | 2008-08-28 | 2015-10-15 | Pfizer | Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives |
| WO2010086820A1 (en) | 2009-02-02 | 2010-08-05 | Pfizer Inc. | 4-amino-5-oxo-7, 8-dihydropyrimido [5,4-f] [1,4] oxazepin-6 (5h) -yl) phenyl derivatives, pharmaceutical compositions and uses thereof |
| KR101295937B1 (ko) | 2009-03-11 | 2013-08-14 | 화이자 인코포레이티드 | 글루코카이네이즈 억제제로서 사용되는 벤조푸라닐 유도체 |
| EP2406230A1 (en) | 2009-03-11 | 2012-01-18 | Pfizer Inc. | Substituted indazole amides and their use as glucokinase activators |
| US20120095028A1 (en) | 2009-03-20 | 2012-04-19 | Pfizer Inc. | 3-oxa-7-azabicyclo[3.3.1]nonanes |
| EP2427448A1 (en) | 2009-05-08 | 2012-03-14 | Pfizer Inc. | Gpr 119 modulators |
| CA2759843A1 (en) | 2009-05-08 | 2010-11-10 | Pfizer Inc. | Gpr 119 modulators |
| GEP20135907B (en) | 2009-06-05 | 2013-08-12 | Pfizer | L-(piperidin-4-yl)-pyrazole derivatives as gpr 119 modulators |
| WO2011005611A1 (en) | 2009-07-09 | 2011-01-13 | Merck Sharp & Dohme Corp. | Neuromedin u receptor agonists and uses thereof |
| CA2778886C (en) * | 2009-11-10 | 2014-01-07 | Pfizer Inc. | N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors |
| US20120225900A1 (en) * | 2009-11-10 | 2012-09-06 | Pfizer Inc. | N2-pyrazolospiroketone acetyl-coa carboxylase inhibitors |
| RS55224B1 (sr) | 2010-09-30 | 2017-02-28 | Pfizer | N1-pirazolospiroketon acetil-coa karboksilaza inhibitori |
| JP5647356B2 (ja) * | 2010-10-29 | 2014-12-24 | ファイザー・インク | Ｎ１／Ｎ２−ラクタムアセチル−ＣｏＡカルボキシラーゼ阻害剤 |
-
2011
- 2011-10-18 JP JP2013535549A patent/JP5647356B2/ja not_active Expired - Fee Related
- 2011-10-18 CN CN201180052416.2A patent/CN103189377B/zh not_active Expired - Fee Related
- 2011-10-18 EP EP11784783.0A patent/EP2632925B1/en not_active Not-in-force
- 2011-10-18 KR KR1020137013652A patent/KR101529404B1/ko not_active Expired - Fee Related
- 2011-10-18 CA CA2815169A patent/CA2815169C/en not_active Expired - Fee Related
- 2011-10-18 SG SG2013027446A patent/SG189883A1/en unknown
- 2011-10-18 KR KR20147036653A patent/KR20150006899A/ko not_active Withdrawn
- 2011-10-18 SI SI201130519T patent/SI2632925T1/sl unknown
- 2011-10-18 NZ NZ609527A patent/NZ609527A/en not_active IP Right Cessation
- 2011-10-18 BR BR112013010310A patent/BR112013010310A2/pt not_active IP Right Cessation
- 2011-10-18 RU RU2013116924/04A patent/RU2540337C2/ru not_active IP Right Cessation
- 2011-10-18 PT PT117847830T patent/PT2632925E/pt unknown
- 2011-10-18 EP EP15164071.1A patent/EP2952514A1/en not_active Withdrawn
- 2011-10-18 AU AU2011322117A patent/AU2011322117B2/en not_active Ceased
- 2011-10-18 ES ES11784783.0T patent/ES2546465T3/es active Active
- 2011-10-18 DK DK11784783.0T patent/DK2632925T3/en active
- 2011-10-18 WO PCT/IB2011/054643 patent/WO2012056372A1/en not_active Ceased
- 2011-10-18 CN CN201510087893.2A patent/CN104774205A/zh active Pending
- 2011-10-18 PL PL11784783T patent/PL2632925T3/pl unknown
- 2011-10-18 HU HUE11784783A patent/HUE025078T2/en unknown
- 2011-10-18 MX MX2013004733A patent/MX2013004733A/es unknown
- 2011-10-26 TW TW100138909A patent/TWI441823B/zh not_active IP Right Cessation
- 2011-10-26 TW TW104115757A patent/TW201531472A/zh unknown
- 2011-10-26 TW TW103102453A patent/TWI507406B/zh not_active IP Right Cessation
- 2011-10-27 US US13/282,964 patent/US8859773B2/en active Active
- 2011-10-27 AR ARP110103976A patent/AR083578A1/es unknown
- 2011-10-28 UY UY0001033694A patent/UY33694A/es not_active Application Discontinuation
-
2013
- 2013-04-15 IL IL225779A patent/IL225779A0/en unknown
- 2013-05-28 ZA ZA2013/03882A patent/ZA201303882B/en unknown
-
2014
- 2014-09-26 US US14/497,396 patent/US8993586B2/en active Active
- 2014-11-05 JP JP2014225021A patent/JP2015057416A/ja not_active Withdrawn
-
2015
- 2015-02-13 US US14/621,723 patent/US9181252B2/en active Active
- 2015-06-12 CY CY20151100518T patent/CY1116405T1/el unknown
- 2015-10-22 HK HK15110405.1A patent/HK1209733A1/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2013116924A (ru) | N1/n2-лактамные ингибиторы ацетил-коа-карбоксилаз | |
| JP2013542218A5 (ru) | ||
| ES2521596T3 (es) | Combinación del compuesto GlyT1 con antipsicóticos | |
| EA201690019A1 (ru) | Производное аминотриазина и содержащая его фармацевтическая композиция | |
| AR095311A1 (es) | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante | |
| EA201201378A1 (ru) | Определенные аминопиримидины, композиции на их основе и способы их использования | |
| AR077977A1 (es) | Compuestos y composiciones como inhibidores de cinasa de proteina | |
| JP2013531029A5 (ru) | ||
| EA201201377A1 (ru) | Определенные аминопиридазины, композиции на их основе и способы их использования | |
| JP2013507434A5 (ru) | ||
| EA201170096A1 (ru) | Замещенные производные пиримидона | |
| AR101815A1 (es) | Compuestos y composiciones como inhibidores de quinasa | |
| RU2016135922A (ru) | Терапевтические соединения и композиции | |
| PE20190329A1 (es) | Compuestos moduladores de fxr (nr1h4) | |
| EA201591429A1 (ru) | 2,3-дизамещенные производные 1-ацил-4-амино-1,2,3,4-тетрагидрохинолинов и их применение в качестве ингибиторов бромодомена | |
| EA201591000A1 (ru) | Пирролобензодиазепины | |
| AR089671A1 (es) | 1,4-dihidropirimidinas 4,4-disustituidas y su uso como medicamentos para el tratamiento de la hepatitis b | |
| RU2535347C3 (ru) | Индуцирующие апоптоз средства для лечения злокачественной опухоли и иммунных и аутоиммунных заболеваний | |
| AR095423A1 (es) | 2-azabiciclos sustituidos y su uso como moduladores del receptor de orexina | |
| AR093937A1 (es) | Compuestos quimicos | |
| MX395406B (es) | Compuestos de piperidinobenzodiazepina con actividad antiproliferativa. | |
| EA201171062A1 (ru) | Алкиламидные соединения и их применение | |
| HRP20191482T1 (hr) | 18f-označeni psma ciljani pet reagensi | |
| AR103742A1 (es) | Derivados de trifluorometilpropanamida | |
| PH12022550255A1 (en) | 2-aminoquinazolinone derivative |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20161019 |