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RU2011152596A - Полимерные наночастицы, покрытые оксидом магнитного металла, и их применение - Google Patents

Полимерные наночастицы, покрытые оксидом магнитного металла, и их применение Download PDF

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RU2011152596A
RU2011152596A RU2011152596/15A RU2011152596A RU2011152596A RU 2011152596 A RU2011152596 A RU 2011152596A RU 2011152596/15 A RU2011152596/15 A RU 2011152596/15A RU 2011152596 A RU2011152596 A RU 2011152596A RU 2011152596 A RU2011152596 A RU 2011152596A
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nanoparticle
agent
active agent
specified
peptide
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Шломо МАРДЖЕЛ
Бенни ПЕРЛШТЕЙН
Чая БРОУДИ
Том Миккелсен
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Бар-Илан Юниверсити
Генри Форд Хоспитал
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Abstract

1. Наночастица, содержащая полимер, хелатирующий металл, оксид магнитного металла и, по меньшей мере, одно активное средство, ковалентно связанное с указанным полимером.2. Наночастица по п.1, где указанный полимер, хелатирующий металл, представляет собой желатин, полиметиленимин, хитозан или полилизин.3. Наночастица по п.1, где указанный оксид магнитного металла представляет собой оксид железа или феррит, происходящий из оксида железа.4. Наночастица по п.3, где указанный оксид железа представляет собой магнетит, оксимагнетит или их смесь.5. Наночастица по п.1, где указанное, по меньшей мере, одно активное средство представляет собой флуоресцентный краситель, контрастное средство, пептид или пептидомиметик, полипептид, антифолатное лекарственное средство, антибиотик, противовоспалительное средство, химиотерапевтическое средство антрациклинового ряда или любую их комбинацию.6. Наночастица по п.5, где указанный флуоресцентный краситель представляет собой родамин или флуоресцеин.7. Наночастица по п.5, где указанный пептид или пептидомиметик представляют собой циклический RGD (cRGD) или ациклический RGD.8. Наночастица по п.5, где указанный полипептид представляет собой родственный TNF лиганд, индуцирующий апоптоз (TRAIL), или интерлейкин-12 (IL-12).9. Наночастица по п.5, где указанное антифолатное лекарственное средство представляет собой метатрексат.10. Наночастица по п.5, где указанное химиотерапевтическое средство антрациклинового ряда представляет собой доксорубицин.11. Наночастица по п.1, дополнительно включающая, по меньшей мере, одно дополнительное активное средство, связанное с внешней поверхностью указанной наночастицы.12. На�

Claims (27)

1. Наночастица, содержащая полимер, хелатирующий металл, оксид магнитного металла и, по меньшей мере, одно активное средство, ковалентно связанное с указанным полимером.
2. Наночастица по п.1, где указанный полимер, хелатирующий металл, представляет собой желатин, полиметиленимин, хитозан или полилизин.
3. Наночастица по п.1, где указанный оксид магнитного металла представляет собой оксид железа или феррит, происходящий из оксида железа.
4. Наночастица по п.3, где указанный оксид железа представляет собой магнетит, оксимагнетит или их смесь.
5. Наночастица по п.1, где указанное, по меньшей мере, одно активное средство представляет собой флуоресцентный краситель, контрастное средство, пептид или пептидомиметик, полипептид, антифолатное лекарственное средство, антибиотик, противовоспалительное средство, химиотерапевтическое средство антрациклинового ряда или любую их комбинацию.
6. Наночастица по п.5, где указанный флуоресцентный краситель представляет собой родамин или флуоресцеин.
7. Наночастица по п.5, где указанный пептид или пептидомиметик представляют собой циклический RGD (cRGD) или ациклический RGD.
8. Наночастица по п.5, где указанный полипептид представляет собой родственный TNF лиганд, индуцирующий апоптоз (TRAIL), или интерлейкин-12 (IL-12).
9. Наночастица по п.5, где указанное антифолатное лекарственное средство представляет собой метатрексат.
10. Наночастица по п.5, где указанное химиотерапевтическое средство антрациклинового ряда представляет собой доксорубицин.
11. Наночастица по п.1, дополнительно включающая, по меньшей мере, одно дополнительное активное средство, связанное с внешней поверхностью указанной наночастицы.
12. Наночастица по п.11, где указанное, по меньшей мере, одно дополнительное активное средство ковалентно связано с внешней поверхностью наночастицы через линкер.
13. Наночастица по п.12, где указанный линкер происходит из полисахарида, белка, пептида, полиамина, полиэтиленгликоля, акрилоилхлорида, дивинилсульфона (DVS), дикарбонилимидазола, этиленгликоль-бис(сульфосукцинимидилсукцината), N-гидроксисульфосукцинимидного эфира m-малеимидобензойной кислоты или любой их комбинации.
14. Наночастица по п.11, где указанное, по меньшей мере, одно дополнительное активное средство, связанное с внешней поверхностью наночастицы, представляет собой флуоресцентный краситель, контрастное средство, пептид или пептидомиметик, полипептид, антифолатное лекарственное средство, антибиотик, противовоспалительное средство, химиотерапевтическое средство антрациклинового ряда или любую их комбинацию.
15. Наночастица по п.14, где указанный пептид или пептидомиметик представляют собой циклический RGD (cRGD) или ациклический RGD.
16. Наночастица по п.14, где указанный полипептид представляет собой цитокин, фермент, антитело или гормон.
17. Наночастица по п.16, где указанное антитело представляет собой Bevacizumab (торговое наименование: Авастин) или Infliximab (торговое наименование: Ремикад).
18. Наночастица по п.14, где указанный полипептид представляет собой родственный TNF лиганд, индуцирующий апоптоз (TRAIL), или интерлейкин-12 (IL-12).
19. Фармацевтическая композиция, содержащая наночастицу по п.1 и фармацевтически приемлемый носитель.
20. Применение наночастицы по п.1 для обнаружения опухоли у индивидуума, где TRAIL, пептид cRGD, IL-12, доксорубицин, метотрексат или любая их комбинация связаны с внешней поверхностью наночастицы, а контрастное средство или флуоресцентный краситель ковалентно связаны с указанным полимером.
21. Применение наночастицы по п.11 для индуцирования апоптоза, аутофагии или обоих в раковой клетке, где указанноеЮ по меньшей мере, одно активное средство представляет собой TRAIL, пептид cRGD, IL-12, доксорубицин, метотрексат, Bevacizumab или любую их комбинацию, и где указанная раковая клетка представляет собой глиомную клетку, раковую стволовую клетку, клетку карциномы шейки матки, клетку карциномы мочевого пузыря, клетку рака молочной железы, клетку рака яичника или клетку рака легкого.
22. Применение по п.21, где указанное индуцирование апоптоза, аутофагии или обоих в раковой клетке представляет собой лечение пациента, страдающего глиомой, карциномой шейки матки, карциномой мочевого пузыря, раком молочной железы, раком яичника или раком легкого.
23. Применение по п.21, дополнительно включающее стадию приведения указанной клетки в контакт с ингибитором протеосомы.
24. Применение по п.21, дополнительно включающее стадию γ-облучения указанной клетки.
25. Применение наночастицы по п.1 для применения рентгеновской визуализации или магнитно-резонансной визуализации (МРТ) к субъекту, где указанное активное средство представляет собой контрастное средство.
26. Применение наночастицы по п.1 для обнаружения воспаления у субъекта, где указанный оксид магнитного металла представляет собой оксид железа или феррит, а указанное, по меньшей мере, одно активное средство представляет собой флуоресцентный краситель или контрастное средство.
27. Применение наночастицы по п.1 для лечения воспаления у субъекта, где указанный оксид магнитного металла представляет собой оксид железа, а указанное, по меньшей мере, одно активное средство представляет собой противовоспалительное средство.
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Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101678090B (zh) 2007-03-07 2012-04-11 乌第有限合伙公司 用于预防和治疗自身免疫病的组合物和方法
EP2591804A3 (en) 2007-09-24 2014-04-16 Bar-Ilan University Polymer nanoparticles coated by magnetic metal oxide and uses thereof
EP2277544A1 (en) * 2009-07-08 2011-01-26 Nelica Ciobanu Biocompatible magnetic nano-clusters containing iron oxide respectively iron oxide - boron with primary use in magnetic drug targeting and boron neutron capture therapy
US9259485B2 (en) 2009-07-30 2016-02-16 Fujifilm Corporation Kidney-imaging agent comprising recombinant gelatin
CN101642579B (zh) * 2009-08-14 2013-10-23 江苏大学 壳聚糖修饰顺磁性金属离子磁共振成像对比剂的制备方法
JPWO2011083845A1 (ja) * 2010-01-08 2013-05-16 富士フイルム株式会社 腫瘍部位に対する標的化剤
US9273398B2 (en) * 2010-01-16 2016-03-01 Nanoridge Materials, Inc. Metallized nanotubes
WO2011128896A1 (en) * 2010-04-12 2011-10-20 Ramot At Tel-Aviv University Ltd. Iron oxide nanoparticles for use in treating non-infectious inflammatory disorders
US20110301456A1 (en) * 2010-06-07 2011-12-08 Malignext Targeting Technologies, Inc. Tissue Marking for Lesion Removal
CN101890173B (zh) * 2010-07-16 2012-05-23 江苏大学 磁性水溶性壳聚糖磁共振成像对比剂的制备方法
CN107441628B (zh) 2010-08-27 2020-06-19 斯巴卡有限公司 用于靶向热调节的组合物和方法
US9572880B2 (en) 2010-08-27 2017-02-21 Sienna Biopharmaceuticals, Inc. Ultrasound delivery of nanoparticles
WO2012033531A1 (en) * 2010-09-10 2012-03-15 Kent State University Nanoparticles based on gadolinium coordination polymers as highly sensitive t1 mri contrast agents
US9511151B2 (en) 2010-11-12 2016-12-06 Uti Limited Partnership Compositions and methods for the prevention and treatment of cancer
EP2646818A4 (en) * 2010-11-30 2016-09-21 Univ Illinois SILICANANOPARTIKELKONJUGATE
GB201204579D0 (en) 2012-03-15 2012-05-02 Univ Nottingham Trent Coating metal oxide particles
US10988516B2 (en) 2012-03-26 2021-04-27 Uti Limited Partnership Methods and compositions for treating inflammation
WO2013146694A1 (ja) * 2012-03-28 2013-10-03 コニカミノルタ株式会社 生体物質の検出方法
WO2014006254A1 (es) 2012-07-03 2014-01-09 Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii Nanopartículas recubiertas de gelatina
CN104822412B (zh) 2012-10-11 2018-05-01 纳诺康波西克斯公司 银纳米片组合物及方法
US9603948B2 (en) 2012-10-11 2017-03-28 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
EP2931367A4 (en) * 2012-12-14 2016-06-15 Medivation Technologies Inc MAGNETIC RETENTION OF REGENERATING CELLS FOR WOUND REPAIR
EP2942064B1 (en) 2013-01-04 2022-09-07 Inventera Pharmaceuticals Inc. Mri contrast agent including t1 contrast material coated on surface of nanoparticle support
WO2014130736A1 (en) 2013-02-20 2014-08-28 Sloan-Kettering Institute For Cancer Research Wide field raman imaging apparatus and associated methods
BR112015026019A2 (pt) 2013-04-11 2017-07-25 Brigham & Womens Hospital Inc métodos e composições de tratamento de doenças autoimunes
BR112015029144A2 (pt) 2013-05-24 2017-07-25 Univ Danmarks Tekniske formulações de gel para guiar radioterapia
JP6452704B2 (ja) * 2013-09-09 2019-01-16 ラボ − オン − ア − ビード エービー 磁性粒子の製造
SG11201603487YA (en) 2013-11-04 2016-05-30 Uti Limited Partnership Methods and compositions for sustained immunotherapy
WO2015134620A1 (en) * 2014-03-04 2015-09-11 Memorial Sloan Kettering Cancer Center Applying mechanical force by remote-controlled rotation
US10912947B2 (en) 2014-03-04 2021-02-09 Memorial Sloan Kettering Cancer Center Systems and methods for treatment of disease via application of mechanical force by controlled rotation of nanoparticles inside cells
US10688202B2 (en) 2014-07-28 2020-06-23 Memorial Sloan-Kettering Cancer Center Metal(loid) chalcogen nanoparticles as universal binders for medical isotopes
EP3220887A1 (en) 2014-11-21 2017-09-27 Technical University of Denmark Gel formulations for local drug release
DE102014019388A1 (de) * 2014-12-29 2016-06-30 Susanne Wagner Arzneimittel auf der Basis von Maghämit zur gleichzeitigen Reduzierung der gastrointestinalen Natriumresorption und Phosphatresorption
WO2016198932A2 (en) 2015-05-06 2016-12-15 Uti Limited Partnership Nanoparticle compositions for sustained therapy
CA2990223A1 (en) 2015-07-01 2017-01-05 Memorial Sloan Kettering Cancer Center Anisotropic particles, methods and uses thereof
KR101748120B1 (ko) * 2015-07-13 2017-06-16 서울대학교산학협력단 나노입자-유리체 기반 단백질 복합체를 유효성분으로 포함하는 혈관신생억제용 조성물 및 이의 용도
CA2995372C (en) * 2015-08-13 2023-10-24 Northeastern University Biomaterials for combined radiotherapy and immunotherapy of cancer
CN106902395B (zh) * 2015-12-22 2020-04-07 先健科技(深圳)有限公司 可吸收铁基合金植入医疗器械
KR20170097510A (ko) 2016-02-18 2017-08-28 연세대학교 산학협력단 T1 mri 조영제로서의 나노입자의 분산 안정도를 증가시키는 방법 및 t1 mri 조영제 나노입자
CN105854019A (zh) * 2016-05-06 2016-08-17 暨南大学 Il-27的受体激活剂在制备治疗肥胖症及其并发症产品中的应用
JP7246930B2 (ja) * 2016-05-18 2023-03-28 モデルナティエックス インコーポレイテッド インターロイキン－１２（ｉｌ１２）をコードするポリヌクレオチドおよびその使用
JP2018019686A (ja) * 2016-07-20 2018-02-08 コニカミノルタ株式会社 ゼラチン粒子、ゼラチン粒子の製造方法、ゼラチン粒子内包細胞、ゼラチン粒子内包細胞の製造方法、および細胞構造体
CN106344539B (zh) * 2016-08-25 2019-01-29 湖北大学 一种多功能靶向纳米胶囊抗癌药物的制备方法
US20180207293A1 (en) * 2017-01-25 2018-07-26 2C Tech Corp. Nanoparticles for sustained ophthalmic drug delivery and methods of use
CN108926719B (zh) 2017-05-25 2020-09-01 北京格瑞特森生物医药科技有限公司 用c(RGD-ACP-K)修饰的长循环脂质体
EP3708191A4 (en) * 2017-11-06 2020-11-25 Konica Minolta, Inc. COMPOSITE PARTICLES FOR IMAGING, PROCESS FOR THE PRODUCTION OF COMPOSITE PARTICLES, CELLS, CELLULAR STRUCTURE AND MIXED DISPERSION
JP7217473B2 (ja) * 2017-11-06 2023-02-03 コニカミノルタ株式会社 ハイドロゲル粒子およびその製造方法、ハイドロゲル粒子を内包する細胞または細胞構造体、ハイドロゲル粒子を用いた細胞活性の評価方法、並びにハイドロゲル粒子の徐放性製剤としての使用
US12397038B2 (en) 2017-11-29 2025-08-26 Uti Limited Partnership Ubiquitous antigens for treatment of autoimmune or inflammatory diseases
WO2019108838A1 (en) * 2017-11-29 2019-06-06 The Regents Of The University Of California Cross-linked fluorescent supramolecular nanoparticles and method of making
EP3781613A1 (en) 2018-04-18 2021-02-24 SHPP Global Technologies B.V. Magnetic nanoparticles embedded in polymer microparticles
US20220031605A1 (en) * 2018-09-26 2022-02-03 Ege Universitesi Targeted drug delivery system to be used in treating osteomyelitis
KR102187362B1 (ko) * 2018-12-26 2020-12-07 서울대학교산학협력단 페로토시스를 통한 암세포의 선택적 사멸을 위한 나노 입자, 이의 제조 방법 및 이의 용도
WO2020174476A1 (en) * 2019-02-28 2020-09-03 Hadasit Medical Research Services And Development Ltd. Targeted magnetic vehicles and method of using the same
US20200400656A1 (en) * 2019-06-21 2020-12-24 Stemcell Technologies Canada Inc. Particle assemblies, methods of making and use
WO2024073558A2 (en) * 2022-09-30 2024-04-04 Ohio State Innovation Foundation Compositions and methods of use thereof
JPWO2025013818A1 (ru) * 2023-07-10 2025-01-16

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582956A (en) * 1976-07-30 1981-01-21 Ici Ltd Composite magnetic particles
DK130991D0 (da) 1991-07-04 1991-07-04 Immunodex K S Polymere konjugater
IL104734A0 (en) 1993-02-15 1993-06-10 Univ Bar Ilan Bioactive conjugates of cellulose with amino compounds
US6998116B1 (en) * 1996-01-09 2006-02-14 Genentech, Inc. Apo-2 ligand
US5834121A (en) 1996-01-16 1998-11-10 Solid Phase Sciences Corp. Composite magnetic beads
IL118848A0 (en) 1996-07-14 1996-10-31 Univ Bar Ilan Method for preparing bioactive polymers
EP1088315B1 (en) 1998-05-26 2003-06-25 Bar-Ilan University Nucleation and growth of magnetic metal oxide nanoparticles and its use
DE60117556T2 (de) * 2000-06-21 2006-11-02 Bioarray Solutions Ltd. Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
AU2001273413A1 (en) * 2000-07-12 2002-01-21 Immunex Corporation Method for treating cancer using an interleukin- 4 antagonist
US6997863B2 (en) * 2001-07-25 2006-02-14 Triton Biosystems, Inc. Thermotherapy via targeted delivery of nanoscale magnetic particles
DE10144252A1 (de) * 2001-08-31 2003-03-27 Fraunhofer Ges Forschung Nanopartikel mit daran immobilisiertem biologisch aktivem TNF
JP2005521640A (ja) 2001-11-13 2005-07-21 ジェネンテック・インコーポレーテッド Ａｐｏ−２リガンド／ＴＲＡＩＬ製剤
US20050129769A1 (en) * 2002-06-03 2005-06-16 Barry Stephen E. Polymeric articles for carrying therapeutic agents
EP1531868A2 (en) 2002-06-03 2005-05-25 Alnis Biosciences, Inc. Therapeutic agent-containing polymeric nanoarticles
EP2500032A1 (en) 2002-06-24 2012-09-19 Genentech, Inc. APO-2 ligand/trail variants and uses thereof
US7550282B2 (en) 2002-11-20 2009-06-23 Bar-Ilan University Biological glue based on thrombin-conjugated nanoparticles
JP2006514096A (ja) 2002-11-27 2006-04-27 アイアールエム・リミテッド・ライアビリティ・カンパニー 癌細胞においてアポトーシスを誘導するための方法および組成物
WO2005017539A2 (en) 2003-08-14 2005-02-24 The General Hospital Corporation Imaging pathology
CN1879065A (zh) * 2003-09-12 2006-12-13 弗尔克斯破产财产公司 用于生物活性剂的定位传递的包含磁性成分和生物相容性聚合物的可磁靶向颗粒
US20050090732A1 (en) * 2003-10-28 2005-04-28 Triton Biosystems, Inc. Therapy via targeted delivery of nanoscale particles
EP1710255A4 (en) * 2003-12-12 2008-09-24 Chugai Pharmaceutical Co Ltd MODIFIED ANTIBODIES RECOGNIZING A TRIMER OR LARGER RECEPTOR
AU2005209318B2 (en) 2004-01-28 2010-02-11 Cytimmune Sciences, Inc. Functionalized colloidal metal compositions and methods
KR100617769B1 (ko) * 2004-03-24 2006-08-28 삼성전자주식회사 채널 부호화 장치 및 방법
US20050226911A1 (en) 2004-04-13 2005-10-13 Bringley Joseph F Article for inhibiting microbial growth in physiological fluids
AU2005282397A1 (en) * 2004-09-08 2006-03-16 Genentech, Inc. Methods of using death receptor ligands and CD20 antibodies
WO2006106513A2 (en) 2005-04-05 2006-10-12 Bar-Ilan University New core and core-shell nanoparticles containing iodine for x-ray imaging
EP1968649A4 (en) * 2005-12-20 2012-12-19 Fujifilm Corp NANOPARTICLES OF PROTEINS AND THEIR USE
EP2591804A3 (en) 2007-09-24 2014-04-16 Bar-Ilan University Polymer nanoparticles coated by magnetic metal oxide and uses thereof

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