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RU2008120024A - Способ стимуляции целостности кишечного барьера после родов не через естественные родовые пути - Google Patents

Способ стимуляции целостности кишечного барьера после родов не через естественные родовые пути Download PDF

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Publication number
RU2008120024A
RU2008120024A RU2008120024/13A RU2008120024A RU2008120024A RU 2008120024 A RU2008120024 A RU 2008120024A RU 2008120024/13 A RU2008120024/13 A RU 2008120024/13A RU 2008120024 A RU2008120024 A RU 2008120024A RU 2008120024 A RU2008120024 A RU 2008120024A
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Russia
Prior art keywords
composition
oligosaccharides
group
use according
nucleotide
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RU2008120024/13A
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English (en)
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RU2437581C2 (ru
Inventor
Йоахим ШМИТТ (DE)
Йоахим ШМИТТ
Гюнтер БЕМ (DE)
Гюнтер БЕМ
Кристофер БЕЕРМАНН (DE)
Кристофер БЕЕРМАНН
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Н.В. Нютрисиа (Nl)
Н.В. Нютрисиа
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Application filed by Н.В. Нютрисиа (Nl), Н.В. Нютрисиа filed Critical Н.В. Нютрисиа (Nl)
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Abstract

1. Применение композиции, содержащей ! (i) длинноцепочечную полиненасыщенную жирную кислоту (LC-PUFA); и ! (ii) по меньшей мере, одно, выбранное из группы, состоящей из (а) нуклеотида и (b) предшественника нуклеотида, выбранного из группы, состоящей из нуклеозидов, пуриновых оснований, пиридиновых оснований, рибозы и дезоксирибозы; ! для получения композиции для введения младенцу, рожденному посредством кесарева сечения, для лечения и/или профилактики инфекции, диареи, флегмоны кишечника, аллергии, атопической экземы, астмы, аллергических ринитов и/или аллергических конъюнктивитов, где композиция не является грудным молоком человека. ! 2. Применение композиции, содержащей ! (i) длинноцепочечную полиненасыщенную жирную кислоту (LC-PUFA); и ! (ii) по меньшей мере, одно, выбранное из группы, состоящей из (а) нуклеотида и (b) предшественника нуклеотида, выбранного из группы, состоящей из нуклеозидов, пуриновых оснований, пиридиновых оснований, рибозы и дезоксирибозы; ! для получения композиции для введения младенцу, рожденному посредством кесарева сечения, для улучшения кишечного созревания, уменьшения кишечной проницаемости и/или для лечения нарушений, связанных с кишечным барьером, у младенца, рожденного посредством кесарева сечения, где композиция не является грудным молоком человека. ! 3. Применение по п.1 или 2, в котором композиция дополнительно содержит, по меньшей мере, один неперевариваемый олигосахарид, выбранный из группы, состоящей из фруктанов (включая инулин), фруктоолигосахаридов, неперевариваемых декстринов, галактоолигосахаридов (включая трансгалактоолигосахариды), ксилоолигосахаридов, арабиноолигосахаридов, арабин

Claims (13)

1. Применение композиции, содержащей
(i) длинноцепочечную полиненасыщенную жирную кислоту (LC-PUFA); и
(ii) по меньшей мере, одно, выбранное из группы, состоящей из (а) нуклеотида и (b) предшественника нуклеотида, выбранного из группы, состоящей из нуклеозидов, пуриновых оснований, пиридиновых оснований, рибозы и дезоксирибозы;
для получения композиции для введения младенцу, рожденному посредством кесарева сечения, для лечения и/или профилактики инфекции, диареи, флегмоны кишечника, аллергии, атопической экземы, астмы, аллергических ринитов и/или аллергических конъюнктивитов, где композиция не является грудным молоком человека.
2. Применение композиции, содержащей
(i) длинноцепочечную полиненасыщенную жирную кислоту (LC-PUFA); и
(ii) по меньшей мере, одно, выбранное из группы, состоящей из (а) нуклеотида и (b) предшественника нуклеотида, выбранного из группы, состоящей из нуклеозидов, пуриновых оснований, пиридиновых оснований, рибозы и дезоксирибозы;
для получения композиции для введения младенцу, рожденному посредством кесарева сечения, для улучшения кишечного созревания, уменьшения кишечной проницаемости и/или для лечения нарушений, связанных с кишечным барьером, у младенца, рожденного посредством кесарева сечения, где композиция не является грудным молоком человека.
3. Применение по п.1 или 2, в котором композиция дополнительно содержит, по меньшей мере, один неперевариваемый олигосахарид, выбранный из группы, состоящей из фруктанов (включая инулин), фруктоолигосахаридов, неперевариваемых декстринов, галактоолигосахаридов (включая трансгалактоолигосахариды), ксилоолигосахаридов, арабиноолигосахаридов, арабиногалактоолигосахаридов, глюкоолигосахаридов (включая циклодекстрины и гентиоолигосахариды), хитоолигосахаридов, глюкоманноолигосахаридов, галактоманноолигосахаридов, маннанолигосахаридов, фукоолигосахаридов, галактуроновых олигосахаридов, олигосахаридов гулуроновой кислоты, олигосахаридов маннуроновой кислоты, олигосахаридов идуроновой кислоты, олигосахаридов рибуроновой кислоты, олигосахаридов глюкуроновой кислоты и их смесей.
4. Применение по п.1 или 2, в котором композиция содержит трансгалактоолигосахариды и/или фруктоолигосахариды.
5. Применение по п.1 или 2, в котором композиция содержит олигосахариды галактуроновой кислоты.
6. Применение по п.1 или 2, где LC-PUFA выбран из группы, состоящей из эйкозапентаеновой кислоты, докозагексаеновой кислоты и арахидоновой кислоты.
7. Применение по п.1 или 2, в котором композиция содержит от 0,1 до 15 мас.% LC-PUFA от массы всего жира в композиции.
8. Применение по п.1 или 2, в котором композиция содержит менее чем 3 мас.% LC-PUFA от массы всего жира, находящегося в композиции;
а. омега-3 LC-PUFA ниже 1 мас.% от содержания всего жира;
b. омега-6 LC-PUFA ниже 2 мас.% от содержания всего жира; и
c. содержание арахидоновой кислоты ниже 1 мас.% от содержания всего жира.
9. Применение по п.1 или 2, в котором композиция содержит, по меньшей мере, один нуклеотид, выбранный из группы, состоящей из цитидин-5'-монофосфата, уридин-5'-монофосфата, аденозин-5'-монофосфата, гуанозин-5'-монофосфата, инозин-5'-монофосфата и солей натрия одного из ранее упомянутых нуклеотидов.
10. Применение по п.1 или 2, в котором композиция содержит от 5 до 100 мг нуклеотидов на 100 г сухой массы композиции.
11. Применение по п.1 или 2, в котором композиция дополнительно содержит, по меньшей мере, один бактериальный вид, принадлежащий к роду Bifidobacterium или Lactobacillus.
12. Применение по п.1 или 2, в котором липидный компонент обеспечивает от 5 до 50% всех калорий, белковый компонент обеспечивает от 5 до 50% всех калорий и углеводный компонент обеспечивает от 15 до 90% всех калорий.
13. Применение композиции, приготовленной смешиванием I) пищевого или фармацевтически приемлемого липида; и II) сухой композиции, где сухая композиция II, содержит длинноцепочечную полиненасыщенную жирную кислоту (LC-PUFA); и, по меньшей мере, одно, выбранное из группы, состоящей из (а) нуклеотида и (b) предшественника нуклеотида, выбранного из группы, состоящей из нуклеозидов, пуриновых оснований, пиридиновых оснований, рибозы и дезоксирибозы, для стимуляции развития здоровой кишечной флоры и/или уменьшения кишечных патогенов у младенца, рожденного посредством кесарева сечения.
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