RU2008117550A - MODIFICATION OF ALBUMIN WITH SOVIALS AS A METHOD OF INCREASING ITS STABILITY FOR THE PRODUCTION OF PHARMACEUTICAL BIOLOGICAL PRODUCT ALBUMIN IN COMPLEX WITH GENTAMICIN OR STIMADEN - Google Patents
MODIFICATION OF ALBUMIN WITH SOVIALS AS A METHOD OF INCREASING ITS STABILITY FOR THE PRODUCTION OF PHARMACEUTICAL BIOLOGICAL PRODUCT ALBUMIN IN COMPLEX WITH GENTAMICIN OR STIMADEN Download PDFInfo
- Publication number
- RU2008117550A RU2008117550A RU2008117550/15A RU2008117550A RU2008117550A RU 2008117550 A RU2008117550 A RU 2008117550A RU 2008117550/15 A RU2008117550/15 A RU 2008117550/15A RU 2008117550 A RU2008117550 A RU 2008117550A RU 2008117550 A RU2008117550 A RU 2008117550A
- Authority
- RU
- Russia
- Prior art keywords
- albumin
- stimaden
- gentamicin
- production
- sovial
- Prior art date
Links
- 102000009027 Albumins Human genes 0.000 title claims abstract 10
- 108010088751 Albumins Proteins 0.000 title claims abstract 10
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 title claims abstract 5
- 229930182566 Gentamicin Natural products 0.000 title claims abstract 5
- 229960002518 gentamicin Drugs 0.000 title claims abstract 5
- 238000004519 manufacturing process Methods 0.000 title claims abstract 5
- 238000000034 method Methods 0.000 title claims abstract 5
- 238000012986 modification Methods 0.000 title 1
- 230000004048 modification Effects 0.000 title 1
- 230000002779 inactivation Effects 0.000 claims abstract 4
- 102000004169 proteins and genes Human genes 0.000 claims abstract 4
- 108090000623 proteins and genes Proteins 0.000 claims abstract 4
- 230000009286 beneficial effect Effects 0.000 claims abstract 2
- 230000003115 biocidal effect Effects 0.000 claims abstract 2
- 229960000074 biopharmaceutical Drugs 0.000 claims abstract 2
- 238000007385 chemical modification Methods 0.000 claims abstract 2
- 230000002519 immonomodulatory effect Effects 0.000 claims abstract 2
- 230000007246 mechanism Effects 0.000 claims abstract 2
- 238000006068 polycondensation reaction Methods 0.000 claims abstract 2
- 230000001105 regulatory effect Effects 0.000 claims abstract 2
- 230000006641 stabilisation Effects 0.000 claims abstract 2
- 238000011105 stabilization Methods 0.000 claims abstract 2
- 230000000087 stabilizing effect Effects 0.000 claims abstract 2
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1. Способ стабилизации альбумина для изготовления на его основе фармацевтических биопрепаратов с дополнительным антибиотическим (гентамицин) или иммуномодулирующим (стимаден) механизмами действия путем модификации белка совиалем, отличающийся тем, что полезный эффект достигается за счет принципа химической модификации, при этом стабилизацию осуществляют в реакции поликонденсации из расчета 3-5 моль совиаля на 1 моль альбумина, вследствие чего модифицированные формы белка выдерживают регламентный режим термоинактивации в присутствии гентамицина или стимадена, предусмотренный технологией производства альбуминовых биопрепаратов. ! 2. Способ по п.1, отличающийся тем, что модифицированные конструкции альбумина выдерживают режим термоинактивации при 60°C в течение 20 ч.1. A method of stabilizing albumin for the manufacture of pharmaceutical biologics based on it with additional antibiotic (gentamicin) or immunomodulating (stimaden) mechanisms of action by modifying the protein with sovial, characterized in that the beneficial effect is achieved due to the principle of chemical modification, while stabilization is carried out in the polycondensation reaction based on 3-5 mol of sovial per 1 mol of albumin, as a result of which the modified forms of the protein withstand the regulatory regime of thermal inactivation in the presence of gentamicin or stimaden, provided by the technology for the production of albumin biological products. ! 2. The method according to claim 1, characterized in that the modified albumin constructs withstand heat inactivation at 60 ° C for 20 hours
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2008117550/15A RU2414237C2 (en) | 2008-04-30 | 2008-04-30 | Sovialem albumin modification as method for stability enhancement for preparing pharmaceutical biological preparation of albimun in complex with gentamycin or stimaden |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2008117550/15A RU2414237C2 (en) | 2008-04-30 | 2008-04-30 | Sovialem albumin modification as method for stability enhancement for preparing pharmaceutical biological preparation of albimun in complex with gentamycin or stimaden |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008117550A true RU2008117550A (en) | 2009-11-10 |
| RU2414237C2 RU2414237C2 (en) | 2011-03-20 |
Family
ID=41354378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008117550/15A RU2414237C2 (en) | 2008-04-30 | 2008-04-30 | Sovialem albumin modification as method for stability enhancement for preparing pharmaceutical biological preparation of albimun in complex with gentamycin or stimaden |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2414237C2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2480235C2 (en) * | 2011-07-29 | 2013-04-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования (ФГБОУ ВПО) "Удмуртский государственный университет" | Method of increasing of albumin thermal stability when modifying it with metal-carbon nanostructures |
| AR095398A1 (en) | 2013-03-13 | 2015-10-14 | Genentech Inc | FORMULATIONS WITH REDUCED OXIDATION |
| LT2968467T (en) * | 2013-03-13 | 2020-08-25 | F. Hoffmann-La Roche Ag | Formulations with reduced oxidation |
| US10653779B2 (en) | 2013-03-13 | 2020-05-19 | Genentech, Inc. | Formulations with reduced oxidation |
| RU2659032C1 (en) * | 2017-04-26 | 2018-06-27 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Удмуртский государственный университет" | Method of gentamycin modification with vinylpirrolidone copolymer with acryoline diagetalum |
-
2008
- 2008-04-30 RU RU2008117550/15A patent/RU2414237C2/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2414237C2 (en) | 2011-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20140501 |