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RU2008110078A - Анализы и способы применения биомаркеров - Google Patents

Анализы и способы применения биомаркеров Download PDF

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Publication number
RU2008110078A
RU2008110078A RU2008110078/15A RU2008110078A RU2008110078A RU 2008110078 A RU2008110078 A RU 2008110078A RU 2008110078/15 A RU2008110078/15 A RU 2008110078/15A RU 2008110078 A RU2008110078 A RU 2008110078A RU 2008110078 A RU2008110078 A RU 2008110078A
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Russia
Prior art keywords
tissue
expression
cells
galnac
cancer
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RU2008110078/15A
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English (en)
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RU2409817C2 (ru
Inventor
Клаус В. ВАГНЕР (US)
Клаус В. ВАГНЕР
Ави Дж. АШКЕНАЗИ (US)
Ави Дж. АШКЕНАЗИ
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Дженентек, Инк. (Us)
Дженентек, Инк.
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Publication of RU2409817C2 publication Critical patent/RU2409817C2/ru

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Abstract

1. Способ предсказания чувствительности образца ткани или клеток млекопитающего к антителам рецепторов клеточной смерти, включающий стадии: ! получения образца ткани или клеток млекопитающего; ! исследования образца ткани или клеток с целью выявления экспрессии GalNac-T14, причем экспрессия указанного GalNac-T14 позволяет предсказать, что указанный образец ткани или клеток чувствителен к индуцирующей апоптоз активности антител рецепторов клеточной смерти. ! 2. Способ по п.1, в котором указанную экспрессию GalNac-T14 исследуют, определяя экспрессию мРНК GalNac-T14. ! 3. Способ по п.1, в котором указанную экспрессию GalNac-T14 исследуют методами иммуногистохимии. ! 4. Способ по п.1, дополнительно включающий стадию исследования экспрессии рецепторов DR4, DR5, DcR1 или DcR2 в указанном образце ткани или клеток. ! 5. Способ по п.1, в котором образец ткани или клеток содержит раковую ткань или клетки. ! 6. Способ по п.5, в котором указанные раковые клетки представляют собой клетки или ткань раковых опухолей поджелудочной железы, лимфомы, немелкоклеточного рака легких, рака толстой кишки, колоректального рака, меланомы или хондросаркомы. ! 7. Способ по п.1, в котором указанные антитела рецепторов клеточной смерти представляют собой агонистические анти-DR4 или анти-DR5 антитела. ! 8. Способ индуцирования апоптоза в образце ткани или клеток млекопитающего, включающий стадии: ! получения образца ткани или клеток млекопитающего; ! исследования образца ткани или клеток с целью выявления экспрессии GalNac-T14 и, при выявлении такой экспрессии, последующего воздействия на указанный образец ткани или клеток эффективного количества антител рецепторов клеточной смерти. ! 9. Спо�

Claims (24)

1. Способ предсказания чувствительности образца ткани или клеток млекопитающего к антителам рецепторов клеточной смерти, включающий стадии:
получения образца ткани или клеток млекопитающего;
исследования образца ткани или клеток с целью выявления экспрессии GalNac-T14, причем экспрессия указанного GalNac-T14 позволяет предсказать, что указанный образец ткани или клеток чувствителен к индуцирующей апоптоз активности антител рецепторов клеточной смерти.
2. Способ по п.1, в котором указанную экспрессию GalNac-T14 исследуют, определяя экспрессию мРНК GalNac-T14.
3. Способ по п.1, в котором указанную экспрессию GalNac-T14 исследуют методами иммуногистохимии.
4. Способ по п.1, дополнительно включающий стадию исследования экспрессии рецепторов DR4, DR5, DcR1 или DcR2 в указанном образце ткани или клеток.
5. Способ по п.1, в котором образец ткани или клеток содержит раковую ткань или клетки.
6. Способ по п.5, в котором указанные раковые клетки представляют собой клетки или ткань раковых опухолей поджелудочной железы, лимфомы, немелкоклеточного рака легких, рака толстой кишки, колоректального рака, меланомы или хондросаркомы.
7. Способ по п.1, в котором указанные антитела рецепторов клеточной смерти представляют собой агонистические анти-DR4 или анти-DR5 антитела.
8. Способ индуцирования апоптоза в образце ткани или клеток млекопитающего, включающий стадии:
получения образца ткани или клеток млекопитающего;
исследования образца ткани или клеток с целью выявления экспрессии GalNac-T14 и, при выявлении такой экспрессии, последующего воздействия на указанный образец ткани или клеток эффективного количества антител рецепторов клеточной смерти.
9. Способ по п.8, в котором указанную экспрессию GalNac-T14 исследуют, определяя экспрессию мРНК GalNac-T14.
10. Способ по п.8, в котором указанную экспрессию GalNac-T14 исследуют методами иммуногистохимии.
11. Способ по п.8, дополнительно включающий стадию исследования экспрессии рецепторов DR4, DR5, DcR1 или DcR2 в указанном образце ткани или клеток.
12. Способ по п.8, в котором указанный образец ткани или клеток содержит раковую ткань или клетки.
13. Способ по п.12, в котором указанные раковые клетки представляют собой клетки или ткань раковых опухолей поджелудочной железы, лимфомы, немелкоклеточного рака легких, рака толстой кишки, колоректального рака, меланомы или хондросаркомы.
14. Способ по п.8, в котором указанные клетки подвергают воздействию эффективного количества агонистических антител DR4 или DR5.
15. Способ по п.14, в котором указанные клетки подвергают воздействию эффективного количества агонистических антител DR5, которые связываются с рецептором DR5, показанным на фиг.3A.
16. Способ лечения заболевания, например, связанного с нарушением иммунитета, или рака, у млекопитающего, включающий стадии:
получения образца ткани или клеток от указанного млекопитающего;
исследования образца ткани или клеток с целью выявления экспрессии GalNac-T14 и, при выявлении такой экспрессии, последующего введения указанному млекопитающему эффективного количества антител рецепторов клеточной смерти.
17. Способ по п.16, в котором указанную экспрессию GalNac-T14 исследуют, определяя экспрессию мРНК GalNac-T14.
18. Способ по п.16, в котором указанную экспрессию GalNac-T14 исследуют методами иммуногистохимии.
19. Способ по п.16, дополнительно включающий стадию исследования экспрессии рецепторов DR4, DR5, DcR1 или DcR2 в указанной ткани или клетках.
20. Способ по п.16, в котором образец ткани или клеток содержит раковую ткань или клетки.
21. Способ по п.20, в котором указанные раковые клетки или ткань представляют собой клетки или ткань раковых опухолей поджелудочной железы, лимфомы, немелкоклеточного рака легких, рака толстой кишки, колоректального рака, меланомы или хондросаркомы.
22. Способ по п.16, в котором указанному млекопитающему вводят эффективное количество анти-DR4 или анти-DR5 антител.
23. Способ по п.22, в котором указанному млекопитающему также вводят химиотерапевтическое средство (средства) или назначают лучевую терапию.
24. Способ по п.22, в котором указанному млекопитающему также вводят цитокин, цитотоксический агент или ингибитор клеточного роста.
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