RU2008102835A - Устройство для количественного анализа профиля метаболитов - Google Patents
Устройство для количественного анализа профиля метаболитов Download PDFInfo
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- 239000002207 metabolite Substances 0.000 title claims abstract 11
- 238000004445 quantitative analysis Methods 0.000 title claims abstract 9
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- 239000003814 drug Substances 0.000 claims abstract 10
- 229940079593 drug Drugs 0.000 claims abstract 10
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract 6
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- 239000000203 mixture Substances 0.000 claims abstract 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims abstract 2
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- 238000004949 mass spectrometry Methods 0.000 claims 1
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G01N33/54366—Apparatus specially adapted for solid-phase testing
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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Abstract
1. Вкладыш в составе устройства для количественного анализа профиля лекарственных средств и/или метаболитов в биологическом образце, содержащий (а) подложку, пропитанную (б) по крайней мере одним внутренним стандартом. ! 2. Вкладыш по п.1, в котором носитель содержит сорбент для жидкостей. ! 3. Вкладыш по п.2, в котором материалом сорбента является по крайней мере один материал, такой как целлюлоза, стекловолокно, стеклянные шарики, полиакриламидный гель, пористый пластичный инертный полимер и пористый графит. ! 4. Вкладыш по любому из пп.1-3, в котором внутренний стандарт инкапсулируют в материал покрытия, который защищает внутренний стандарт от деградации и химических реакций перед применением. ! 5. Вкладыш по п.4, в котором материал покрытия включает по крайней мере один полимер, мицеллообразующее соединение, липосомообразующее соединение и полигидроксисоединение. ! 6. Вкладыш по п.5, в котором инкапсулирование включает микроинкапсулирование. ! 7. Вкладыш по п.5 и/или п.6, в котором полимером по настоящему изобретению является гомополимер или сополимер полиалкиленгликоля или их смесь, и/или полигидроксисоединением явлется сорбит и/или глицерин. ! 8. Вкладыш по п.5 и/или п.6, в котором полимером является полиэтиленгликоль (ПЭГ) или пропиленгликоль (ППГ), предпочтительно ПЭГ 1000. ! 9. Вкладыш по п.5 и/или п.6, в котором мицеллообразующим соединением является ПАВ и/или липосомообразующим соединением является фосфолипид, предпочтительно фосфатидилхолин или фосфатидилэтаноламин или их производные. ! 10. Устройство для количественного анализа профиля лекарственных средств и/или метаболитов в биологическом образце, содержащее ! (а) одну
Claims (17)
1. Вкладыш в составе устройства для количественного анализа профиля лекарственных средств и/или метаболитов в биологическом образце, содержащий (а) подложку, пропитанную (б) по крайней мере одним внутренним стандартом.
2. Вкладыш по п.1, в котором носитель содержит сорбент для жидкостей.
3. Вкладыш по п.2, в котором материалом сорбента является по крайней мере один материал, такой как целлюлоза, стекловолокно, стеклянные шарики, полиакриламидный гель, пористый пластичный инертный полимер и пористый графит.
4. Вкладыш по любому из пп.1-3, в котором внутренний стандарт инкапсулируют в материал покрытия, который защищает внутренний стандарт от деградации и химических реакций перед применением.
5. Вкладыш по п.4, в котором материал покрытия включает по крайней мере один полимер, мицеллообразующее соединение, липосомообразующее соединение и полигидроксисоединение.
6. Вкладыш по п.5, в котором инкапсулирование включает микроинкапсулирование.
7. Вкладыш по п.5 и/или п.6, в котором полимером по настоящему изобретению является гомополимер или сополимер полиалкиленгликоля или их смесь, и/или полигидроксисоединением явлется сорбит и/или глицерин.
8. Вкладыш по п.5 и/или п.6, в котором полимером является полиэтиленгликоль (ПЭГ) или пропиленгликоль (ППГ), предпочтительно ПЭГ 1000.
9. Вкладыш по п.5 и/или п.6, в котором мицеллообразующим соединением является ПАВ и/или липосомообразующим соединением является фосфолипид, предпочтительно фосфатидилхолин или фосфатидилэтаноламин или их производные.
10. Устройство для количественного анализа профиля лекарственных средств и/или метаболитов в биологическом образце, содержащее
(а) одну или более лунок (1) и
(б) один или более вкладышей (2) по любому из пп.1-9, расположенных в лунках (1), и
(с) необязательно фиксатор (3) для вкладыша (2) в лунке (1).
11. Устройство по п.10, в котором одна или более лунок (1) в устройстве содержат фильтр (4) для отделения частиц диаметром в несколько мкм, более предпочтительно приблизительно 5 мкм и выходное отверстие (5) для удаления фильтрата.
12. Устройство по п.11, в котором фильтр (4) расположен между вкладышем (2) и выходным отверстием (5).
13. Устройство по п.11 и/или 12, в котором выходное отверстие (5) открывается под действием центробежной силы или при пониженном давлении, предпочтительно менее 500 мбар.
14. Внутренний стандарт для количественного анализа профиля лекарственных средств и/или метаболитов в биологическом образце, и указанный стандарт инкапсулирован, как указано в любом из пп.4-9.
15. Набор для количественного анализа профиля лекарственных средств и/или метаболитов в биологическом образце, включающий устройство, указанное в любом из пп.10-13.
16. Прибор для количественного анализа профилей лекарственных средств и/или метаболитов в биологическом образце, содержащий
(а) ячейку для обработки исследуемых лекарственных средств и/или метаболитов, предназначенных для анализа, которая включает
(а1) автоматизированную систему для обработки жидкостей и
(а2) по крайней мере одно устройство, описанное в любом из пп.10-13, для модификации лекарственных средств и/или метаболитов, присутствующих в образце, и для последующей экстракции производных,
(б) масс-спектрометр для количественного направленного масс-спектрометрического анализа, и
(в) базу данных для хранения результатов анализа.
17. Способ количественного анализа профилей лекарственных средств и/или метаболитов в биологическом образце с использованием вкладыша, описанного в любом из пп.1-9, или устройства, описанного в любом из пп.10-13, или внутреннего стандарта, описанного в п.14, или набора, описанного в п.15, или прибора, описанного в п.16.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69498405P | 2005-06-30 | 2005-06-30 | |
| US69498305P | 2005-06-30 | 2005-06-30 | |
| US60/694,984 | 2005-06-30 | ||
| US60/694,983 | 2005-06-30 |
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| Publication Number | Publication Date |
|---|---|
| RU2008102835A true RU2008102835A (ru) | 2009-08-10 |
| RU2391672C2 RU2391672C2 (ru) | 2010-06-10 |
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| US (2) | US8116983B2 (ru) |
| EP (2) | EP1875401B1 (ru) |
| JP (2) | JP5155160B2 (ru) |
| KR (1) | KR100967573B1 (ru) |
| CN (1) | CN100594501C (ru) |
| AU (1) | AU2006265381B2 (ru) |
| BR (1) | BRPI0613478B8 (ru) |
| CA (2) | CA2608963C (ru) |
| DK (2) | DK1897014T3 (ru) |
| ES (1) | ES2452025T3 (ru) |
| IL (1) | IL187470A (ru) |
| IN (1) | IN2014DN02241A (ru) |
| NO (1) | NO339319B1 (ru) |
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| DE69535669T2 (de) | 1994-05-09 | 2008-12-04 | Oxford Biomedica (Uk) Ltd. | Retrovirale vektoren mit verminderter rekombinationsrate |
| US8969089B2 (en) | 2004-10-12 | 2015-03-03 | Quest Diagnostics Investments, Inc. | Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry |
| WO2007003344A2 (en) * | 2005-06-30 | 2007-01-11 | Biocrates Life Sciences Ag | Device for quantitative analysis of a metabolite profile |
| WO2007130629A1 (en) * | 2006-05-05 | 2007-11-15 | Perkinelmer Las, Inc | Quantitative analysis of surface-derived samples using mass spectrometry |
| EP1923806A1 (en) * | 2006-11-14 | 2008-05-21 | Metanomics GmbH | Fast metabolomic analysis and system therefor |
| US7999084B2 (en) * | 2007-05-16 | 2011-08-16 | Agilent Technologies, Inc. | Devices and methods for reducing matrix effects |
| WO2008145384A1 (en) * | 2007-05-31 | 2008-12-04 | Biocrates Life Sciences Ag | Inflammation and oxidative stress level assay |
| US20100173342A1 (en) * | 2007-05-31 | 2010-07-08 | Weinberger Klaus Michael | Biomarker and Method for Determining an Oxidative Stress Level |
| EP3543691A1 (en) * | 2007-06-29 | 2019-09-25 | Quest Diagnostics Investments Incorporated | Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry |
| US12367163B2 (en) | 2007-06-29 | 2025-07-22 | Quest Diagnostics Investments Llc | Analysis of amino acids in body fluid by liquid chromatography—mass spectrometry |
| WO2009012595A1 (en) * | 2007-07-26 | 2009-01-29 | Phenomenome Discoveries Inc. | Methods for the diagnosis, risk assessment, and monitoring of autism spectrum disorders |
| DE102007043614B3 (de) * | 2007-09-13 | 2008-11-20 | Biocrates Life Sciences Gmbh | Halterung für ein Trägermittel zum Einsetzen in eine zylinderförmige Öffnung |
| EP2208074A4 (en) * | 2007-10-01 | 2010-12-22 | Dh Technologies Dev Pte Ltd | ANALYSIS OF CONJUGATED METABOLIC PRODUCTS OF THE ALCOHOL CONSUMPTION |
| JP2011504596A (ja) * | 2007-11-26 | 2011-02-10 | ウオーターズ・テクノロジーズ・コーポレイシヨン | サンプル中の分析物を定量測定する際に使用するための内部標準および方法 |
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