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RU2007112288A - COMPOSITION FOR STIMULATING GROWTH AND REGENERATION OF CELLS, AND ALSO WAY OF ITS PRODUCTION - Google Patents

COMPOSITION FOR STIMULATING GROWTH AND REGENERATION OF CELLS, AND ALSO WAY OF ITS PRODUCTION Download PDF

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Publication number
RU2007112288A
RU2007112288A RU2007112288/15A RU2007112288A RU2007112288A RU 2007112288 A RU2007112288 A RU 2007112288A RU 2007112288/15 A RU2007112288/15 A RU 2007112288/15A RU 2007112288 A RU2007112288 A RU 2007112288A RU 2007112288 A RU2007112288 A RU 2007112288A
Authority
RU
Russia
Prior art keywords
composition
cells
regeneration
agent
growth
Prior art date
Application number
RU2007112288/15A
Other languages
Russian (ru)
Inventor
Александр Сергеевич Ботин (RU)
Александр Сергеевич Ботин
Нина Андреевна Онищенко (RU)
Нина Андреевна Онищенко
Андрей Александрович Темнов (RU)
Андрей Александрович Темнов
Original Assignee
Александр Сергеевич Ботин (RU)
Александр Сергеевич Ботин
Нина Андреевна Онищенко (RU)
Нина Андреевна Онищенко
Андрей Александрович Темнов (RU)
Андрей Александрович Темнов
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Александр Сергеевич Ботин (RU), Александр Сергеевич Ботин, Нина Андреевна Онищенко (RU), Нина Андреевна Онищенко, Андрей Александрович Темнов (RU), Андрей Александрович Темнов filed Critical Александр Сергеевич Ботин (RU)
Priority to RU2007112288/15A priority Critical patent/RU2007112288A/en
Priority to PCT/RU2008/000202 priority patent/WO2008121027A1/en
Publication of RU2007112288A publication Critical patent/RU2007112288A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (9)

1. Композиция для стимуляции роста и регенерации клеток органов и тканей при хронических воспалительных и дегенерационных процессах внутренних органов и/или кожных покровов, содержащая лизат лейкоцитов периферической крови и/или стволовых и/или прогениторных клеток костного мозга, полученных от животного которому перед забором клеточного материала наносится острое повреждение внутренних органов и/или кожных покровов, рост и регенерацию которых необходимо простимулировать.1. Composition for stimulating the growth and regeneration of cells of organs and tissues in chronic inflammatory and degenerative processes of internal organs and / or skin, containing a lysate of peripheral blood leukocytes and / or stem and / or progenitor cells of the bone marrow obtained from an animal which before cell collection The material causes acute damage to internal organs and / or skin, the growth and regeneration of which must be stimulated. 2. Композиция по п.1, отличающаяся тем, что клеточный лизат представлен в форме жидкости, в твердой форме, в лиофилизованной форме, в форме порошка, геля или пленки.2. The composition according to claim 1, characterized in that the cell lysate is in the form of a liquid, in solid form, in lyophilized form, in the form of a powder, gel or film. 3. Композиция по п.1, отличающаяся тем, что дополнительно содержит антибиотик, противовоспалительный агент, противовирусный агент, противогрибковый агент, гормон, противоопухолевый агент, анальгетик, анестезирующее средство или любую их комбинацию3. The composition according to claim 1, characterized in that it further comprises an antibiotic, anti-inflammatory agent, antiviral agent, antifungal agent, hormone, antitumor agent, analgesic, anesthetic, or any combination thereof 4. Способ получения композиции для стимуляции роста и регенерации клеток органов и тканей при хронических воспалительных и дегенерационных процессах внутренних органов и/или кожных покровов, включающий4. A method of obtaining a composition for stimulating the growth and regeneration of cells of organs and tissues in chronic inflammatory and degenerative processes of internal organs and / or skin, including а) нанесение животному острого повреждения внутренних органов и/или кожных покровов, рост и регенерацию которых необходимо простимулировать;a) causing acute damage to the animal's internal organs and / or skin, the growth and regeneration of which must be stimulated; б) получение от животного лейкоцитов периферической крови и/или стволовых и/или прогениторных клеток костного мозга;b) obtaining from the animal peripheral blood leukocytes and / or stem and / or progenitor bone marrow cells; в) разрушение клеток с получением клеточного лизата;c) destruction of cells to obtain a cell lysate; г) получение композиции, состоящей из лизата лейкоцитов периферической крови и/или стволовых и/или прогениторных клеток костного мозга,;g) obtaining a composition consisting of a peripheral blood leukocyte lysate and / or stem and / or progenitor bone marrow cells; д) объединение указанной композиции с фармацевтически приемлемым носителем.e) combining said composition with a pharmaceutically acceptable carrier. 5. Способ по п.4, отличающийся тем, что дополнительно производят переработку указанной композиции для получения ее в форме жидкости, твердого продукта, лиофилизированного продукта, порошка, геля или пленки.5. The method according to claim 4, characterized in that it further process the specified composition to obtain it in the form of a liquid, solid product, lyophilized product, powder, gel or film. 6. Способ по п.5, отличающийся тем, что дополнительно производят переработку указанной композиции для увеличения или снижения концентрации одного или нескольких продуктов, содержащихся в данной среде.6. The method according to claim 5, characterized in that it further processes said composition to increase or decrease the concentration of one or more products contained in the medium. 7. Способ по п.4, отличающийся тем, что дополнительно добавляют к указанной композиции антибиотик, противовоспалительный агент, противовирусный агент, противогрибковый агент, гормон, противоопухолевый агент, анальгетик, анестезирующее средство или любой их комбинации.7. The method according to claim 4, characterized in that they additionally add an antibiotic, anti-inflammatory agent, antiviral agent, antifungal agent, hormone, antitumor agent, analgesic, anesthetic, or any combination thereof to the composition. 8. Способ по п.4, отличающийся тем, что разрушение осуществляют с использованием физических методов и/или химических методов.8. The method according to claim 4, characterized in that the destruction is carried out using physical methods and / or chemical methods. 9. Способ по п.8, отличающийся тем, что разрушение клеток осуществляют путем проведения циклов замораживания - оттаивания или обработки суспензии клеток ультразвуком.9. The method according to claim 8, characterized in that the destruction of cells is carried out by conducting cycles of freezing - thawing or sonication of the cell suspension.
RU2007112288/15A 2007-04-03 2007-04-03 COMPOSITION FOR STIMULATING GROWTH AND REGENERATION OF CELLS, AND ALSO WAY OF ITS PRODUCTION RU2007112288A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
RU2007112288/15A RU2007112288A (en) 2007-04-03 2007-04-03 COMPOSITION FOR STIMULATING GROWTH AND REGENERATION OF CELLS, AND ALSO WAY OF ITS PRODUCTION
PCT/RU2008/000202 WO2008121027A1 (en) 2007-04-03 2008-04-02 Growth stimulating and cell regenerating composition and a method for carrying out said method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2007112288/15A RU2007112288A (en) 2007-04-03 2007-04-03 COMPOSITION FOR STIMULATING GROWTH AND REGENERATION OF CELLS, AND ALSO WAY OF ITS PRODUCTION

Publications (1)

Publication Number Publication Date
RU2007112288A true RU2007112288A (en) 2008-10-10

Family

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Application Number Title Priority Date Filing Date
RU2007112288/15A RU2007112288A (en) 2007-04-03 2007-04-03 COMPOSITION FOR STIMULATING GROWTH AND REGENERATION OF CELLS, AND ALSO WAY OF ITS PRODUCTION

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Country Link
RU (1) RU2007112288A (en)
WO (1) WO2008121027A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021509812A (en) * 2018-01-05 2021-04-08 プレートレット バイオジェネシス， インコーポレイテッド Compositions and Methods for Producing Megakaryocytes
WO2020006539A1 (en) 2018-06-29 2020-01-02 Platelet Biogenesis, Inc. Compositions for drug delivery and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60243018A (en) * 1984-05-17 1985-12-03 Yamanouchi Pharmaceut Co Ltd Endogeneous human carcinostatic factor
UA27048C2 (en) * 1993-10-18 2000-02-28 Центр Ембріональних Тканин "Емселл" Medicinal preparation of immunoreplacement activity the basis of cellular suspension and method for treatment of diabetes mellitus by the use of this preparation
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
US20060234375A1 (en) * 2004-09-30 2006-10-19 Doronin Sergey V Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division

Also Published As

Publication number Publication date
WO2008121027A1 (en) 2008-10-09

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FA91 Application withdrawn (on applicant's request)

Effective date: 20081127