RU2006133168A - MEDICINAL FORMULATION FOR INHIBITING REPRODUCTION OF HUMAN IMMUNODEFICIENCY VIRUS - Google Patents
MEDICINAL FORMULATION FOR INHIBITING REPRODUCTION OF HUMAN IMMUNODEFICIENCY VIRUS Download PDFInfo
- Publication number
- RU2006133168A RU2006133168A RU2006133168/15A RU2006133168A RU2006133168A RU 2006133168 A RU2006133168 A RU 2006133168A RU 2006133168/15 A RU2006133168/15 A RU 2006133168/15A RU 2006133168 A RU2006133168 A RU 2006133168A RU 2006133168 A RU2006133168 A RU 2006133168A
- Authority
- RU
- Russia
- Prior art keywords
- glycyrrhizic acid
- immunodeficiency virus
- human immunodeficiency
- medicinal formulation
- trinicotinates
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 5
- 241000725303 Human immunodeficiency virus Species 0.000 title claims abstract 3
- 230000002401 inhibitory effect Effects 0.000 title claims abstract 3
- 238000009472 formulation Methods 0.000 title 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims abstract 8
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical class O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract 8
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims abstract 4
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims abstract 4
- 229960004949 glycyrrhizic acid Drugs 0.000 claims abstract 4
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000001685 glycyrrhizic acid Substances 0.000 claims abstract 4
- 235000019410 glycyrrhizin Nutrition 0.000 claims abstract 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims abstract 4
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Лекарственный состав для ингибирования репродукции вируса иммунодефицита человека, включающий производные глицирризиновой кислоты, отличающийся тем, что он дополнительно содержит карбонат натрия, а в качестве производных глицирризиновой кислоты он содержит ди- и/или триникотинаты глицирризиновой кислоты, имеющие общую формулу:где R - этоили Н, причем два и/или три из названных R - этопричем массовое соотношение в составе ди- и/или триникотинатов глицирризиновой кислоты и карбоната натрия находится в интервале от 1:1 до 1:3.A medicinal composition for inhibiting the reproduction of the human immunodeficiency virus, including derivatives of glycyrrhizic acid, characterized in that it additionally contains sodium carbonate, and as derivatives of glycyrrhizic acid, it contains di- and / or trinicotinates of glycyrrhizic acid, having the general formula: where R is or H moreover, two and / or three of the above-mentioned R - this is the mass ratio in the composition of di- and / or trinicotinates of glycyrrhizic acid and sodium carbonate is in the range from 1: 1 to 1: 3.
Claims (1)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2006133168/15A RU2365374C2 (en) | 2006-09-18 | 2006-09-18 | Medicinal compound for inhibition of human immunodeficiency virus reproduction |
| PCT/RU2006/000573 WO2008035998A1 (en) | 2006-09-18 | 2006-11-02 | Medicinal composition for inhibiting propagation of human immunodeficiency virus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2006133168/15A RU2365374C2 (en) | 2006-09-18 | 2006-09-18 | Medicinal compound for inhibition of human immunodeficiency virus reproduction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006133168A true RU2006133168A (en) | 2008-03-27 |
| RU2365374C2 RU2365374C2 (en) | 2009-08-27 |
Family
ID=39200740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006133168/15A RU2365374C2 (en) | 2006-09-18 | 2006-09-18 | Medicinal compound for inhibition of human immunodeficiency virus reproduction |
Country Status (2)
| Country | Link |
|---|---|
| RU (1) | RU2365374C2 (en) |
| WO (1) | WO2008035998A1 (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1625882A1 (en) * | 1988-10-04 | 1991-02-07 | Институт химии Башкирского научного центра Уральского отделения АН СССР | Method of obtaning glycopeptides of glycyrrihisic acid |
| RU2024546C1 (en) * | 1991-03-04 | 1994-12-15 | Институт органической химии УНЦ РАН | β-GLYCYRRHIZIC ACID GLYCOPEPTIDE WITH L-GLUTAMIC ACID DIBUTYL ETHER SHOWING ANTI-AIDS-ACTIVITY |
| RU2272631C2 (en) * | 2004-04-20 | 2006-03-27 | Государственный научный центр вирусологии и биотехнологии "Вектор" (ГНЦ ВБ "Вектор") | Synergetic composition for inhibition of hiv |
-
2006
- 2006-09-18 RU RU2006133168/15A patent/RU2365374C2/en not_active IP Right Cessation
- 2006-11-02 WO PCT/RU2006/000573 patent/WO2008035998A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| RU2365374C2 (en) | 2009-08-27 |
| WO2008035998A1 (en) | 2008-03-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZ9A | Application not withdrawn (correction of the notice of withdrawal) |
Effective date: 20080718 |
|
| PC4A | Invention patent assignment |
Effective date: 20100727 |
|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20100919 |
|
| NF4A | Reinstatement of patent |
Effective date: 20130420 |
|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20160919 |