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RU2005126337A - METHOD FOR PRODUCING 1-HEXADECYL-R (-) - 3-OXY-1-ASONIABICYCLO [2.2.2] OCTAN-IMMUNOMODULATOR WITH ANTITUMOR, BACTERIOSTATIC AND ANTI-AGGREGATIVE - Google Patents

METHOD FOR PRODUCING 1-HEXADECYL-R (-) - 3-OXY-1-ASONIABICYCLO [2.2.2] OCTAN-IMMUNOMODULATOR WITH ANTITUMOR, BACTERIOSTATIC AND ANTI-AGGREGATIVE Download PDF

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Publication number
RU2005126337A
RU2005126337A RU2005126337/04A RU2005126337A RU2005126337A RU 2005126337 A RU2005126337 A RU 2005126337A RU 2005126337/04 A RU2005126337/04 A RU 2005126337/04A RU 2005126337 A RU2005126337 A RU 2005126337A RU 2005126337 A RU2005126337 A RU 2005126337A
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RU
Russia
Prior art keywords
hexadecyl
asoniabicyclo
aggregative
octan
immunomodulator
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Application number
RU2005126337/04A
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Russian (ru)
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RU2321589C2 (en
Inventor
Константин Александрович Аникиенко (RU)
Константин Александрович Аникиенко
Дмитрий Игоревич Панков (RU)
Дмитрий Игоревич Панков
Алевтина Сергеевна Полезина (RU)
Алевтина Сергеевна Полезина
Ирина Леонидовна Михалева (RU)
Ирина Леонидовна Михалева
Михаил Валентинович Киселевский (RU)
Михаил Валентинович Киселевский
Наталь Юрьевна Анисимова (RU)
Наталья Юрьевна Анисимова
Федор Витальевич Доненко (RU)
Федор Витальевич Доненко
нский В чеслав Станиславович Добр (RU)
Вячеслав Станиславович Добрянский
ков Виктор Станиславович Пол (RU)
Виктор Станиславович Поляков
Владимир Алексеевич Мельников (RU)
Владимир Алексеевич Мельников
Виктор Алексеевич Петрунин (RU)
Виктор Алексеевич Петрунин
Анатолий Юрьевич Барышников (RU)
Анатолий Юрьевич Барышников
Original Assignee
Федеральное государственное предпри тие Государственный научно-исследовательский институт органической химии и технологии (ФГУП ГосНИИОХТ) (RU)
Федеральное государственное предприятие Государственный научно-исследовательский институт органической химии и технологии (ФГУП ГосНИИОХТ)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Федеральное государственное предпри тие Государственный научно-исследовательский институт органической химии и технологии (ФГУП ГосНИИОХТ) (RU), Федеральное государственное предприятие Государственный научно-исследовательский институт органической химии и технологии (ФГУП ГосНИИОХТ) filed Critical Федеральное государственное предпри тие Государственный научно-исследовательский институт органической химии и технологии (ФГУП ГосНИИОХТ) (RU)
Priority to RU2005126337/04A priority Critical patent/RU2321589C2/en
Publication of RU2005126337A publication Critical patent/RU2005126337A/en
Application granted granted Critical
Publication of RU2321589C2 publication Critical patent/RU2321589C2/en

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Claims (1)

Способ получения бромида 1-гексадецил-R(-)-3-окси-1-азониабицикло[2.2.2]октана,The method of obtaining 1-hexadecyl-R (-) - 3-hydroxy-1-azoniabicyclo [2.2.2] octane bromide,
Figure 00000001
Figure 00000001
 заключающийся в том, что хлорид 1-гексадецил-R(-)-3-окси-1-азониабицикло[2.2.2]октана вводят в реакцию ионного обмена с бромистоводородной кислотой или ее неорганической солью (например, бромидом натрия или бромидом калия) в воде, образующийся продукт фильтруют и очищают перекристаллизацией.consisting in the fact that 1-hexadecyl-R (-) - 3-hydroxy-1-azoniabicyclo [2.2.2] octane chloride is introduced into the ion exchange reaction with hydrobromic acid or its inorganic salt (for example, sodium bromide or potassium bromide) in water, the resulting product is filtered and purified by recrystallization.
RU2005126337/04A 2005-08-19 2005-08-19 Method for preparing 1-hexadecyl-r-(-)-3-hydroxy-1-azoniabicyclo[2.2.2]octane bromide - immunomodulator eliciting antitumor, bacteriostatic and anti-aggregative properties RU2321589C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2005126337/04A RU2321589C2 (en) 2005-08-19 2005-08-19 Method for preparing 1-hexadecyl-r-(-)-3-hydroxy-1-azoniabicyclo[2.2.2]octane bromide - immunomodulator eliciting antitumor, bacteriostatic and anti-aggregative properties

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2005126337/04A RU2321589C2 (en) 2005-08-19 2005-08-19 Method for preparing 1-hexadecyl-r-(-)-3-hydroxy-1-azoniabicyclo[2.2.2]octane bromide - immunomodulator eliciting antitumor, bacteriostatic and anti-aggregative properties

Publications (2)

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RU2005126337A true RU2005126337A (en) 2007-02-27
RU2321589C2 RU2321589C2 (en) 2008-04-10

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2403042C1 (en) * 2009-07-07 2010-11-10 Зубов Дмитрий Львович Medication possessing virulicidal, bactericidal and disinfecting action

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RU2108100C1 (en) * 1993-03-31 1998-04-10 Институт клинической иммунологии СО РАМН Immunomodulating agent
DE19528145A1 (en) * 1995-08-01 1997-02-06 Boehringer Ingelheim Kg New drugs and their use
CN1257903C (en) * 2003-03-21 2006-05-31 嘉事堂药业股份有限公司 Quinic compound containing quaternary ammonium group and its preparation and medicina use

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Effective date: 20100820