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RU2004131197A - Устройства для диагностики на основе дифракции - Google Patents

Устройства для диагностики на основе дифракции Download PDF

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Publication number
RU2004131197A
RU2004131197A RU2004131197/13A RU2004131197A RU2004131197A RU 2004131197 A RU2004131197 A RU 2004131197A RU 2004131197/13 A RU2004131197/13 A RU 2004131197/13A RU 2004131197 A RU2004131197 A RU 2004131197A RU 2004131197 A RU2004131197 A RU 2004131197A
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sensitive material
antigens
stencil
specified
biosensor
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RU2004131197/13A
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RU2332672C2 (ru
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Дэвид КОЭН (US)
Дэвид КОЭН
Розанн КЕЙЛОР (US)
Розанн КЕЙЛОР
Кертис СЕЙРИ (US)
Кертис СЕЙРИ
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Кимберли-Кларк Ворлдвайд Инк. (Us)
Кимберли-Кларк Ворлдвайд Инк.
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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Claims (27)

1. Биосенсор, включающий субстратную часть; слой чувствительного материала, в целом равномерно покрывающий сторону указанной субстратной части, причем чувствительный материал специфичен к искомому анализируемому объекту; шаблон активных и неактивных участков указанного чувствительного материала, созданный на указанном слое, причем активные и неактивные участки определяются процессом маскирования, когда на указанную субстратную часть накладывают трафарет таким образом, что открытые участки трафарета определяют неактивные участки указанного чувствительного материала, а участки, экранированные трафаретом, определяют активные участки чувствительного материала; и когда указанный биосенсор контактирует со средой, содержащей указанный искомый анализируемый объект, этот объект связывается с указанным чувствительным материалом в указанных активных участках и создает дифракцию проходящего или отраженного света в виде рисунка дифракции, соответствующего указанным активным участкам.
2. Биосенсор по п.1, в котором указанные неактивные участки указанного чувствительного материала в процессе маскирования облучили источником энергии через трафарет.
3. Биосенсор по п.1, в котором указанный субстрат содержит материал из перечня материалов, включающих пластики, пластики и стекло, покрытые металлом, функционализированные пластики и стекло, кремниевые пластины, стекло и фольгу.
4. Биосенсор по п.1, в котором указанная субстратная часть содержит полимерную пленку, покрытую металлом.
5. Биосенсор по п.4, в котором указанная полимерная пленка представляет собой полиэтилентерефталат.
6. Биосенсор по п.4, в котором указанный металл выбирают из группы, включающей золото, серебро, хром, никель, платину, алюминий, железо, медь, титан, оксид золота, оксид хрома, оксид серебра или цирконий.
7. Биосенсор по п.4, в котором указанный металл является золотом.
8. Биосенсор по п.1, в котором указанный рисунок дифракции видим невооруженным глазом.
9. Биосенсор по п.1, в котором основой указанного чувствительного материала является белок.
10. Биосенсор по п.9, в котором указанный чувствительный материал представляет собой антитело.
11. Биосенсор по п.1, в котором указанную субстратную часть облучают УФ-светом с длиной волны, достаточной для дезактивации указанного чувствительного материала, подвергаемого облучению через указанный трафарет.
12. Биосенсор по п.1, в котором указанный чувствительный материал представляет собой, по крайней мере, один из следующих материалов: антигены, антитела, нуклеотиды, хелатирующие агенты, ферменты, бактерии, дрожжи, грибки, вирусы, бактериальные пили, компоненты бактериальных жгутиков, нуклеиновые кислоты, полисахариды, липиды, белки, углеводы, металлы, гормоны, аптамеры, пептиды и соответствующие рецепторы к этим материалам.
13. Биосенсор по п.1, в котором указанный искомый анализируемый объект представляет собой, по крайней мере, один из следующих объектов: бактерия, дрожжи, грибок, вирус, ревматоидный фактор, антитела IgG, IgM, IgA, IgD и IgE, карциноэмбриональный антиген, антиген стрептококка группы А, вирусные антигены, антигены, ассоциированные с аутоимунным заболеванием, аллергены, опухолевые антигены, антигены стрептококка группы В, антигены ВИЧ I или ВИЧ II, антитела к вирусам; антигены, специфичные к РСВ, антитело, антиген, фермент, гормон, полисахарид, белок, липид, углевод, лекарство, нуклеиновая кислота, Neisseria meningitises групп А, В, С, Y и W подгруппы 135, Streptococcus pneumoniae, E.coli K1, Haemophilus influenza типа А/В, антиген, полученный из микроорганизмов, антигены ПСА и CRP, гаптен, лекарство, допускающее злоупотребление, лекарственное средство, агенты окружающей среды или антигены, специфичные к гепатиту.
14. Способ получения биосенсора, включающий следующие этапы:
формирование слоя чувствительного материала, в целом равномерно покрывающего поверхность субстратной части, причем слой содержит чувствительный материал, специфичный к искомому анализируемому объекту;
установка на субстратную часть трафарета, причем конфигурация трафарета такова, чтобы закрывать, по крайней мере, одну область субстратной части и открывать, по крайней мере, одну прилежащую область;
облучение комбинации субстратной части и трафарета источником энергии, достаточной для дезактивации чувствительного материала в открытых участках трафарета;
удаление трафарета с субстратной части и
получение шаблона активных и неактивных участков чувствительного материала, причем неактивные участки соответствуют открытым участкам трафарета, а активные участки соответствуют закрытым участкам трафарета, таким образом, когда биосенсор приводят в контакт со средой, содержащей искомый анализируемый объект, этот объект связывается с чувствительным материалом в активных участках и создает дифракцию проходящего или отраженного света в виде рисунка дифракции, соответствующего активным участкам.
15. Способ по п.14, в котором субстратную часть выбирают из группы материалов, включающей пластики, пластики и стекло, покрытые металлом, функционализированные пластики и стекло, кремниевые пластины, стекло и фольгу.
16. Способ по п.14, в котором указанная субстратная часть содержит полимерную пленку, покрытую металлом.
17. Способ по п.16, в котором указанная полимерная пленка представляет собой полиэтилентерефталат.
18. Способ по п.16, в котором металл выбирают из группы, включающей золото, серебро, хром, никель, платину, алюминий, железо, медь, титан, оксид золота, оксид хрома, оксид серебра или цирконий.
19. Способ по п.16, в котором металл является золотом.
20. Способ по п.19, включающий покрытие полимерной пленки слоем золота толщиной приблизительно от 1 до 1000 нм.
21. Способ по п.14, в котором рисунок дифракции в активных участках видим невооруженным глазом.
22. Способ по п.14, в котором основой чувствительного материала является белок.
23. Способ по п.22, в котором чувствительный материал представляет собой антитело.
24. Способ по п.14, в котором субстратную часть облучают УФ-светом с длиной волны, достаточной для дезактивации чувствительного материала, подвергаемого облучению через отверстия трафарета.
25. Способ по п.14, в котором чувствительный материал представляет собой, по крайней мере, один из следующих материалов: антигены, антитела, нуклеотиды, хелатирующие агенты, ферменты, бактерии, дрожжи, грибки, вирусы, бактериальные пили, компоненты бактериальных жгутиков, нуклеиновые кислоты, полисахариды, липиды, белки, углеводы, металлы, гормоны, аптамеры, пептиды и соответствующие рецепторы к этим материалам.
26. Способ по п.14, в котором искомый анализируемый объект представляет собой, по крайней мере, один из следующих объектов: бактерия, дрожжи, грибок, вирус, ревматоидный фактор, антитела IgG, IgM, IgA, IgD и IgE, карциноэмбриональный антиген, антиген стрептококка группы А, вирусные антигены, антигены, ассоциированные с аутоимунным заболеванием, аллергены, опухолевые антигены, антигены стрептококка группы В, антигены ВИЧ I или ВИЧ II, антитела к вирусам, антигены, специфичные к РСВ, антитело, антиген, фермент, гормон, полисахарид, белок, липид, углевод, лекарство, нуклеиновая кислота, Neisseria meningitides групп А, В, С, Y и W подгруппы 135, Streptococcus pneumoniae, E.coli K1, Haemophilus influenza типа А/В, антиген, полученный из микроорганизмов, антигены ПСА и CRP, гаптен, лекарство, допускающее злоупотребление, лекарственное средство, агенты окружающей среды или антигены, специфичные к гепатиту.
27. Способ по п.14, также включающий создание множества отверстий в трафарете в нужном порядке, причем эти отверстия определяют рисунок неактивных участков.
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