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RU2002117244A - A method for the diagnosis of individual sensitivity of the brain to ischemia - Google Patents

A method for the diagnosis of individual sensitivity of the brain to ischemia

Info

Publication number
RU2002117244A
RU2002117244A RU2002117244/15A RU2002117244A RU2002117244A RU 2002117244 A RU2002117244 A RU 2002117244A RU 2002117244/15 A RU2002117244/15 A RU 2002117244/15A RU 2002117244 A RU2002117244 A RU 2002117244A RU 2002117244 A RU2002117244 A RU 2002117244A
Authority
RU
Russia
Prior art keywords
ischemia
brain
diagnosis
individual sensitivity
gene
Prior art date
Application number
RU2002117244/15A
Other languages
Russian (ru)
Other versions
RU2239836C2 (en
Inventor
Вероника Игоревна Скворцова
Светлана Андреевна Лимборска
Светлана Андреевна Лимборская
Евгени Александровна Кольцова
Евгения Александровна Кольцова
Петр Андреевич Сломинский
Ирма Мухамедовна Шетова
Тать на Викторовна Тупицына
Татьяна Викторовна Тупицына
Original Assignee
Российский государственный медицинский университет
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Российский государственный медицинский университет filed Critical Российский государственный медицинский университет
Priority to RU2002117244/15A priority Critical patent/RU2239836C2/en
Publication of RU2002117244A publication Critical patent/RU2002117244A/en
Application granted granted Critical
Publication of RU2239836C2 publication Critical patent/RU2239836C2/en

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Claims (1)

Способ диагностики индивидуальной чувствительности головного мозга к ишемии, отличающийся тем, что при наличии у обследуемого генотипа -/+(О/R) гена р53, определяемого по аллельному полиморфизму в сайте узнавания рестриктазы Bam HI RFLP в 5 экзоне этого гена, с вероятностью более 75% прогнозируют возможность крупноочагового (более 90 см3) ишемического поражения мозга в случае нарушения его кровоснабжения при минимальной вероятности возникновения мелкоочаговых (до 40 см3) инфарктов.A method for diagnosing the individual sensitivity of the brain to ischemia, characterized in that if the examined genotype contains - / + (O / R) p53 gene, determined by allelic polymorphism in the Bam HI RFLP restriction enzyme recognition site in exon 5 of this gene, with a probability of more than 75 % predict the possibility of large-focal (more than 90 cm 3 ) ischemic brain damage in case of a violation of its blood supply with a minimum likelihood of small focal (up to 40 cm 3 ) heart attacks.
RU2002117244/15A 2002-06-28 2002-06-28 Method for diagnosing individual brain sensitivity to ischemia RU2239836C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2002117244/15A RU2239836C2 (en) 2002-06-28 2002-06-28 Method for diagnosing individual brain sensitivity to ischemia

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2002117244/15A RU2239836C2 (en) 2002-06-28 2002-06-28 Method for diagnosing individual brain sensitivity to ischemia

Publications (2)

Publication Number Publication Date
RU2002117244A true RU2002117244A (en) 2004-01-20
RU2239836C2 RU2239836C2 (en) 2004-11-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002117244/15A RU2239836C2 (en) 2002-06-28 2002-06-28 Method for diagnosing individual brain sensitivity to ischemia

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RU (1) RU2239836C2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2266545C1 (en) * 2004-06-01 2005-12-20 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия Министерства Здравоохранения Российской Федерации" Method for diagnosing atherothrombotic ischemic stroke subtype

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2123704C1 (en) * 1995-03-21 1998-12-20 Евгений Иванович Гусев Method of diagnosing acute cerebral ischemia
RU2140306C1 (en) * 1998-05-29 1999-10-27 Московский областной научно-исследовательский клинический институт Method of diagnosis and prophylactic treatment of insult

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2266545C1 (en) * 2004-06-01 2005-12-20 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия Министерства Здравоохранения Российской Федерации" Method for diagnosing atherothrombotic ischemic stroke subtype

Also Published As

Publication number Publication date
RU2239836C2 (en) 2004-11-10

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Legal Events

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20050629