RU2002115720A - Устройства и способ для отбора проб биологической жидкости и измерения анализируемого вещества - Google Patents
Устройства и способ для отбора проб биологической жидкости и измерения анализируемого вещества Download PDFInfo
- Publication number
- RU2002115720A RU2002115720A RU2002115720/14A RU2002115720A RU2002115720A RU 2002115720 A RU2002115720 A RU 2002115720A RU 2002115720/14 A RU2002115720/14 A RU 2002115720/14A RU 2002115720 A RU2002115720 A RU 2002115720A RU 2002115720 A RU2002115720 A RU 2002115720A
- Authority
- RU
- Russia
- Prior art keywords
- biological fluid
- layer
- sampling
- skin
- analyte
- Prior art date
Links
- 239000013060 biological fluid Substances 0.000 title claims 21
- 239000012491 analyte Substances 0.000 title claims 10
- 238000005070 sampling Methods 0.000 title claims 10
- 238000000034 method Methods 0.000 title claims 5
- 239000004020 conductor Substances 0.000 claims 8
- 239000012530 fluid Substances 0.000 claims 5
- 239000011148 porous material Substances 0.000 claims 5
- 239000011159 matrix material Substances 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000004891 communication Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Optics & Photonics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Claims (10)
1. Устройство для отбора проб биологической жидкости и измерения концентрации анализируемого вещества, содержащее по меньшей мере один прокалывающий кожу элемент, содержащий отверстие для доступа биологической жидкости, гальванический элемент для измерения концентрации анализируемого вещества в биологической жидкости, содержащий по меньшей мере один пористый электрод, среду передачи жидкости, сообщающуюся по жидкости с упомянутым по меньшей мере одним прокалывающим элементом и по меньшей мере одним пористым электродом, причем среда передачи жидкости предназначена для передачи биологической жидкости, находящейся в отверстии для доступа по меньшей мере одного прокалывающего элемента, в гальванический элемент.
2. Устройство по п.1, отличающееся тем, что среда передачи жидкости содержит слой гидрофильного пористого материала.
3. Устройство по п.2, отличающееся тем, что слой гидрофильного пористого материала содержит дистальную часть, связанную с прокалывающим элементом, и проксимальную часть, находящуюся рядом с по меньшей мере одним пористым электродом, при этом проксимальная часть имеет большую пористость, чем дистальная часть.
4. Устройство для отбора проб биологической жидкости и измерения концентрации анализируемого вещества, содержащее матрицу микроигл, каждая из которых имеет отверстие для доступа, слой пористого материала над матрицей микроигл, первый слой проводящего материала над слоем пористого материала, при этом первый слой проводящего материала выполнен пористым, причем отверстие для доступа, слой пористого материала и первый слой проводящего материала образуют путь передачи жидкости, второй слой проводящего материала, при этом первый слой проводящего материала и второй слой проводящего материала расположены на расстоянии друг от друга и биологическая жидкость, находящаяся в отверстиях для доступа, переходит в пространство между первым и вторым слоями проводящего материала.
5. Сенсорное устройство для анализируемого вещества, содержащее гальванический элемент, содержащий по меньшей мере один пористый электрод, среду передачи жидкости, находящуюся снаружи рядом с упомянутым по меньшей мере одним пористым электродом.
6. Система для отбор проб биологической жидкости из кожи пациента и измерения целевого анализируемого вещества в биологической жидкости, содержащая по меньшей мере одно устройство для отбора проб биологической жидкости по п.1, средство управления, электрически связанное с по меньшей мере одним устройством, при этом средство управления содержит средство для направления электрического входного сигнала к устройству для отбора проб биологической жидкости и приема электрического выходного сигнала из устройства для отбора проб биологической жидкости, программно-реализованный алгоритм, для вычисления и определения концентрации целевого анализируемого вещества в биологической пробе после приема электрического выходного сигнала.
7. Способ анализа биологической жидкости в коже пациента и определения концентрации целевого анализируемого вещества, содержащегося в ней, заключающийся в том, что используют по меньшей мере одну микроиглу, содержащую открытый дистальный конец, вводят по меньшей мере одну микроиглу в кожу на заданную глубину, втягивают биологическую жидкость, присутствующую у открытого дистального конца под действием капиллярных сил, передают отобранную биологическую жидкость через проводящий материал в измерительную камеру.
8. Способ по п.7, отличающийся тем, что дополнительно осуществляют химическую реакцию отобранной биологической жидкости с выбранным реагентом в измерительной камере, подают первый сигнал в измерительную камеру, принимают второй сигнал из измерительной камеры, при этом второй электрический сигнал представляет собой концентрацию анализируемого вещества в отобранной биологической жидкости.
9. Способ по п.7, отличающийся тем, что дополнительно втягивают отобранную биологическую жидкость, присутствующую в измерительной камере, под действием капиллярных сил, передают отобранную биологическую жидкость через второй проводящий материал.
10. Способ отбора проб биологической жидкости из кожи пациента и измерения концентрации содержащихся в ней одного или более целевых анализируемых веществ, заключающийся в том, что используют систему для отбора проб биологической жидкости из кожи пациента и измерения анализируемого вещества по п.6, содержащую первое сенсорное устройство, подключенное к средству управления, прикладывают сенсорное устройство к коже пациента, при этом осуществляют отбор пробы биологической жидкости пациента и измеряют концентрацию одного или нескольких целевых анализируемых веществ в ней, извлекают сенсорное устройство из кожи пациента, извлекают указанное сенсорное устройство из средства управления, подсоединяют второе сенсорное устройство к средству управления, повторяют описанные выше операции для выполнения требуемого количества отборов проб и измерений.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/879,146 | 2001-06-12 | ||
| US09/879,146 US6837988B2 (en) | 2001-06-12 | 2001-06-12 | Biological fluid sampling and analyte measurement devices and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2002115720A true RU2002115720A (ru) | 2004-01-20 |
Family
ID=25373515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002115720/14A RU2002115720A (ru) | 2001-06-12 | 2002-06-11 | Устройства и способ для отбора проб биологической жидкости и измерения анализируемого вещества |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US6837988B2 (ru) |
| EP (1) | EP1266608B1 (ru) |
| JP (1) | JP2003038467A (ru) |
| KR (1) | KR20020094901A (ru) |
| CN (1) | CN1273830C (ru) |
| AR (1) | AR034377A1 (ru) |
| AT (1) | ATE336942T1 (ru) |
| AU (1) | AU784526B2 (ru) |
| CA (1) | CA2389833A1 (ru) |
| CZ (1) | CZ20022022A3 (ru) |
| DE (1) | DE60214087T2 (ru) |
| DK (1) | DK1266608T3 (ru) |
| ES (1) | ES2271193T3 (ru) |
| HK (1) | HK1049951B (ru) |
| IL (2) | IL173339A0 (ru) |
| MX (1) | MXPA02005614A (ru) |
| PL (1) | PL354421A1 (ru) |
| RU (1) | RU2002115720A (ru) |
| TW (1) | TWI234450B (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2674083C2 (ru) * | 2013-03-12 | 2018-12-04 | Кориум Интернэшнл, Инк. | Аппликаторы с микровыступами |
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- 2002-05-29 AU AU44453/02A patent/AU784526B2/en not_active Ceased
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- 2002-06-06 MX MXPA02005614A patent/MXPA02005614A/es unknown
- 2002-06-06 AR ARP020102117A patent/AR034377A1/es unknown
- 2002-06-07 CA CA002389833A patent/CA2389833A1/en not_active Abandoned
- 2002-06-10 TW TW091112470A patent/TWI234450B/zh not_active IP Right Cessation
- 2002-06-10 CZ CZ20022022A patent/CZ20022022A3/cs unknown
- 2002-06-11 DE DE60214087T patent/DE60214087T2/de not_active Expired - Lifetime
- 2002-06-11 EP EP02254050A patent/EP1266608B1/en not_active Expired - Lifetime
- 2002-06-11 RU RU2002115720/14A patent/RU2002115720A/ru not_active Application Discontinuation
- 2002-06-11 AT AT02254050T patent/ATE336942T1/de not_active IP Right Cessation
- 2002-06-11 KR KR1020020032674A patent/KR20020094901A/ko not_active Withdrawn
- 2002-06-11 PL PL02354421A patent/PL354421A1/xx not_active Application Discontinuation
- 2002-06-11 JP JP2002170487A patent/JP2003038467A/ja active Pending
- 2002-06-11 CN CNB021243123A patent/CN1273830C/zh not_active Expired - Fee Related
- 2002-06-11 DK DK02254050T patent/DK1266608T3/da active
- 2002-06-11 ES ES02254050T patent/ES2271193T3/es not_active Expired - Lifetime
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- 2003-03-20 HK HK03102055.5A patent/HK1049951B/en not_active IP Right Cessation
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2674083C2 (ru) * | 2013-03-12 | 2018-12-04 | Кориум Интернэшнл, Инк. | Аппликаторы с микровыступами |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60214087D1 (de) | 2006-10-05 |
| MXPA02005614A (es) | 2004-09-10 |
| EP1266608A2 (en) | 2002-12-18 |
| AU784526B2 (en) | 2006-04-27 |
| IL173339A0 (en) | 2006-06-11 |
| AU4445302A (en) | 2002-12-19 |
| US6837988B2 (en) | 2005-01-04 |
| US20020185384A1 (en) | 2002-12-12 |
| AR034377A1 (es) | 2004-02-18 |
| HK1049951A1 (en) | 2003-06-06 |
| CN1437022A (zh) | 2003-08-20 |
| CZ20022022A3 (cs) | 2003-12-17 |
| IL150038A (en) | 2006-09-05 |
| EP1266608A3 (en) | 2004-08-04 |
| DE60214087T2 (de) | 2007-02-15 |
| ATE336942T1 (de) | 2006-09-15 |
| PL354421A1 (en) | 2002-12-16 |
| JP2003038467A (ja) | 2003-02-12 |
| TWI234450B (en) | 2005-06-21 |
| US20040217018A1 (en) | 2004-11-04 |
| KR20020094901A (ko) | 2002-12-18 |
| IL150038A0 (en) | 2002-12-01 |
| CA2389833A1 (en) | 2002-12-12 |
| ES2271193T3 (es) | 2007-04-16 |
| EP1266608B1 (en) | 2006-08-23 |
| DK1266608T3 (da) | 2006-11-13 |
| HK1049951B (en) | 2007-01-26 |
| CN1273830C (zh) | 2006-09-06 |
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