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RU2001124354A - PNEUMATIC INHALER FOR PREVIOUS APPLICATION OF LIPOSOMAL POWDERS IN THE FORM OF AEROSOL, ALSO SUITABLE FOR THIS POWDER IN THE FORM OF AEROSOL - Google Patents

PNEUMATIC INHALER FOR PREVIOUS APPLICATION OF LIPOSOMAL POWDERS IN THE FORM OF AEROSOL, ALSO SUITABLE FOR THIS POWDER IN THE FORM OF AEROSOL

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Publication number
RU2001124354A
RU2001124354A RU2001124354/14A RU2001124354A RU2001124354A RU 2001124354 A RU2001124354 A RU 2001124354A RU 2001124354/14 A RU2001124354/14 A RU 2001124354/14A RU 2001124354 A RU2001124354 A RU 2001124354A RU 2001124354 A RU2001124354 A RU 2001124354A
Authority
RU
Russia
Prior art keywords
powder
aerosol
liposome
liposomes
nanoparticles
Prior art date
Application number
RU2001124354/14A
Other languages
Russian (ru)
Inventor
Юли Ева ДИДЕРИХС (DE)
Юлия Ева ДИДЕРИХС
Вольфганг КОХ (DE)
Вольфганг Кох
Хуберт ЛЕДДИНГ (DE)
Хуберт ЛЕДДИНГ
Регина РЕШКА (DE)
Регина РЕШКА
Хорст ВИНДТ (DE)
Хорст Виндт
Original Assignee
Макс-Дельбрюк-Центрум Фюр Молекуляре Медицин (De)
Макс-Дельбрюк-Центрум Фюр Молекуляре Медицин
Фраунхофер-Гезелльшафт Цур Фердерунг Дер Ангевандтен Форшунг Е.Ф. (De)
Фраунхофер-Гезелльшафт Цур Фердерунг Дер Ангевандтен Форшунг Е.Ф.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Макс-Дельбрюк-Центрум Фюр Молекуляре Медицин (De), Макс-Дельбрюк-Центрум Фюр Молекуляре Медицин, Фраунхофер-Гезелльшафт Цур Фердерунг Дер Ангевандтен Форшунг Е.Ф. (De), Фраунхофер-Гезелльшафт Цур Фердерунг Дер Ангевандтен Форшунг Е.Ф. filed Critical Макс-Дельбрюк-Центрум Фюр Молекуляре Медицин (De)
Publication of RU2001124354A publication Critical patent/RU2001124354A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/0012—Apparatus for achieving spraying before discharge from the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
    • B05B7/062—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet
    • B05B7/066—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet with an inner liquid outlet surrounded by at least one annular gas outlet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)

Claims (26)

1. Пневматический ингалятор для легочного применения липосомного порошка в виде аэрозоля с контейнером (20) для водной дисперсии липосом, в котором липосомы диспергированы в воде и который через устройство дозирования жидкости (19) связан с распылительным соплом (1) и сушильным блоком (17) в виде распылительной камеры для струйной сушки липосом, к которой примыкает выход (18) в виде мундштука, причем распылительное сопло (1) имеет раздельные каналы подачи (14, 16) для сжатого воздуха и дисперсии липосом, отличающийся тем, что распылительное сопло состоит из корпуса (1) распылителя, который имеет центральное полое пространство (2), в которое концентрически введен инжектор (3), имеющий центральное отверстие (4) для подачи дисперсии липосом и находящийся на регулируемом расстоянии от выходного отверстия (5) корпуса (1) распылителя, и который имеет кольцевое отверстие (6) с выходными отверстиями (7) в полое пространство (2) корпуса (1) распылителя, и что в одной из сторон (8) корпуса (1) распылителя выполнен канал подачи (9) для сжатого воздуха параллельно стенке (10), который примыкает к перпендикулярному ему отверстию (11), которое связано с кольцевым отверстием (6) инжектора (2).1. A pneumatic inhaler for the pulmonary use of a liposome powder in the form of an aerosol with a container (20) for an aqueous dispersion of liposomes, in which the liposomes are dispersed in water and which is connected to a spray nozzle (1) and a drying unit (17) through a liquid metering device (19) in the form of a spray chamber for jet drying of liposomes, to which the outlet (18) adjoins in the form of a mouthpiece, the spray nozzle (1) having separate supply channels (14, 16) for compressed air and dispersion of liposomes, characterized in that the spray nozzle co it comes from the nebulizer body (1), which has a central hollow space (2) into which the injector (3) is concentrically inserted, having a central hole (4) for supplying liposome dispersion and located at an adjustable distance from the outlet (5) of the body (1) ) a spray gun, and which has an annular hole (6) with outlet openings (7) into the hollow space (2) of the spray gun body (1), and that on one side (8) of the spray gun housing (1) there is a feed channel (9) for compressed air parallel to the wall (10), which is adjacent to the perpendicular hole (11), which is connected with the annular hole (6) of the injector (2). 2. Пневматический ингалятор по п.1, отличающийся тем, что сушильный блок (17) имеет полупроницаемые мембраны, которые снабжены сушильным агентом (сиккативом) с наружной стороны.2. A pneumatic inhaler according to claim 1, characterized in that the drying unit (17) has semipermeable membranes that are provided with a drying agent (desiccant) from the outside. 3. Пневматический ингалятор по п.1, отличающийся тем, что в него интегрирован возможный уплотнитель, для отделения генерируемых капель от распыляющего воздуха перед входом в сушильный блок (17).3. A pneumatic inhaler according to claim 1, characterized in that a possible seal is integrated in it, for separating the generated droplets from the atomizing air before entering the drying unit (17). 4. Пневматический ингалятор по п.1, отличающийся тем, что подача сжатого воздуха и подача жидкости выполнены с возможностью независимого друг от друга регулирования.4. The pneumatic inhaler according to claim 1, characterized in that the compressed air supply and fluid supply are made with the possibility of independent regulation from each other. 5. Способ лечения легочных заболеваний, отличающийся тем, что применяют пневматический ингалятор по пп.1-4.5. A method of treating pulmonary diseases, characterized in that a pneumatic inhaler according to claims 1 to 4 is used. 6. Порошок в виде аэрозоля, состоящий из липосом и/или наночастиц и отличающийся отсутствием влаги, отсутствием криопротектора, сферической формой частиц, аморфной или кристаллической структурой и величиной частиц 0,5-10 мкм.6. An aerosol powder consisting of liposomes and / or nanoparticles and characterized by the absence of moisture, the absence of a cryoprotectant, the spherical shape of the particles, the amorphous or crystalline structure and the particle size of 0.5-10 microns. 7. Порошок в виде аэрозоля по п.6 для лечения трахеи и больших бронхов, отличающийся величиной частиц 5-10 мкм.7. The powder in the form of an aerosol according to claim 6 for the treatment of the trachea and large bronchi, characterized by a particle size of 5-10 microns. 8. Порошок в виде аэрозоля по п.6 для лечения трахеи и малых бронхов, отличающийся величиной частиц 3-5 мкм.8. The powder in the form of an aerosol according to claim 6 for the treatment of the trachea and small bronchi, characterized by a particle size of 3-5 microns. 9. Порошок в виде аэрозоля по п.6 для лечения бронхиол и альвеол, отличающийся величиной частиц 0,5-3 мкм.9. The aerosol powder according to claim 6 for the treatment of bronchioles and alveoli, characterized by a particle size of 0.5-3 microns. 10. Порошок в виде аэрозоля, состоящий из липосом и/или наночастиц и приготовленный распылением сжатым воздухом дисперсии липосом и/или наночастиц через сопло для распыления двухкомпонентных материалов при распылительном давлении 1-5 бар и концентрации дисперсии 0,2-1%.10. An aerosol powder consisting of liposomes and / or nanoparticles and prepared by spraying compressed liposome dispersions and / or nanoparticles through a nozzle for spraying two-component materials at a spray pressure of 1-5 bar and a dispersion concentration of 0.2-1%. 11. Порошок в виде аэрозоля по пп.6-10, отличающийся тем, что он содержит активное вещество.11. A powder in the form of an aerosol according to claims 6-10, characterized in that it contains an active substance. 12. Порошок в виде аэрозоля по п.11, отличающийся тем, что он содержит активное вещество для лечения заболеваний дыхательных путей.12. The powder in the form of an aerosol according to claim 11, characterized in that it contains an active substance for the treatment of respiratory diseases. 13. Липосомный порошок в виде аэрозоля, содержащий фосфолипиды, холестерин, природный или искусственный легочный сурфактант или катионные амфифилы, а также активное вещество.13. Liposome powder in the form of an aerosol containing phospholipids, cholesterol, natural or artificial pulmonary surfactant or cationic amphiphiles, as well as the active substance. 14. Липосомный порошок в виде аэрозоля, содержащий большие мультиламеллярные везикулы (MLV) или маленькие одноламеллярные везикулы (SUV) в качестве липосом.14. Liposome powder in the form of an aerosol containing large multilamellar vesicles (MLV) or small unicamellar vesicles (SUV) as liposomes. 15. Липосомный порошок в виде аэрозоля, содержащий гидрированный фосфатидилхолин сои и холестерин в молярном соотношении 1:0,25, а также SUV, полученные обработкой ультразвуком.15. Liposome powder in the form of an aerosol containing hydrogenated soy phosphatidylcholine and cholesterol in a molar ratio of 1: 0.25, as well as SUVs obtained by sonication. 16. Липосомный порошок в виде аэрозоля, содержащий гидрированный фосфатидилхолин сои и холестерин в молярном соотношении 1:0,25, а также MLV, полученные гомогенизацией.16. Liposome powder in the form of an aerosol containing hydrogenated soy phosphatidylcholine and cholesterol in a molar ratio of 1: 0.25, as well as MLV obtained by homogenization. 17. Липосомный порошок в виде аэрозоля, содержащий гидрированный фосфатидилхолин сои, холестерин и полиэтиленгликоль в молярном соотношении 1:1:0,1, а также MLV, полученные встряхиванием диспергированных липидных пленок.17. Liposome powder in the form of an aerosol containing hydrogenated soy phosphatidylcholine, cholesterol and polyethylene glycol in a molar ratio of 1: 1: 0.1, as well as MLV obtained by shaking dispersed lipid films. 18. Липосомный порошок в виде аэрозоля, содержащий гидрированный фосфатидилхолин сои, холестерин и полиэтиленгликоль в молярном соотношении 1:1:0,1, а также SUV, полученные обработкой ультразвуком.18. Liposome powder in the form of an aerosol containing hydrogenated soy phosphatidylcholine, cholesterol and polyethylene glycol in a molar ratio of 1: 1: 0.1, as well as SUVs obtained by sonication. 19. Липосомный порошок в виде аэрозоля, содержащий фосфатидилхолин и холестерин в молярном соотношении 1:0,5, загруженные 5,6-карбоксифлуоресцеином, а также SUV, полученные обработкой ультразвуком.19. Liposome powder in the form of an aerosol containing phosphatidylcholine and cholesterol in a molar ratio of 1: 0.5, loaded with 5,6-carboxyfluorescein, as well as SUVs obtained by sonication. 20. Липосомный порошок в виде аэрозоля, содержащий DAC-Chol и DOPE в весовом соотношении 2:3.20. Liposome powder in the form of an aerosol containing DAC-Chol and DOPE in a weight ratio of 2: 3. 21. Липосомный порошок в виде аэрозоля, содержащий DAC-Chol и DOPE в весовом соотношении 2:3 в комплексе с сульфатом протамина.21. Liposome powder in the form of an aerosol containing DAC-Chol and DOPE in a weight ratio of 2: 3 in combination with protamine sulfate. 22. Липосомный порошок в виде аэрозоля, содержащий DAC-Chol и DOPE в весовом соотношении 2:3 в комплексе с поли-L-лизином.22. Liposome powder in the form of an aerosol containing DAC-Chol and DOPE in a weight ratio of 2: 3 in combination with poly-L-lysine. 23. Порошок из наночастиц в виде аэрозоля, состоящий исключительно из кристаллов активного вещества.23. A powder of nanoparticles in the form of an aerosol, consisting solely of crystals of the active substance. 24. Порошок из наночастиц в виде аэрозоля, состоящий из нагруженных активным веществом полимерных частиц.24. A powder of nanoparticles in the form of an aerosol, consisting of polymer particles loaded with the active substance. 25. Порошок из наночастиц в виде аэрозоля по п.24, отличающийся тем, что в качестве полимеров применяют полиметакрилат, полицианоакрилат, полигликолат, полилактат, поливинилпирролидон, поливинилацетат, альгинат, желатин, отдельно или в вариабельных соотношениях смешивания.25. The aerosolized nanoparticle powder of claim 24, wherein polymers are polymethacrylate, polycyanoacrylate, polyglycolate, polylactate, polyvinylpyrrolidone, polyvinyl acetate, alginate, gelatin, separately or in variable mixing ratios. 26. Порошок в виде аэрозоля по п.6, отличающийся тем, что липосомы или наночастицы являются поверхностно-модифицированными, например, полиэтиленгликолем, плазма- или сурфактант-ассоциированными белками или фрагментами антител.26. The aerosol powder according to claim 6, characterized in that the liposomes or nanoparticles are surface-modified, for example, polyethylene glycol, plasma or surfactant-associated proteins or antibody fragments.
RU2001124354/14A 1999-02-03 2000-02-03 PNEUMATIC INHALER FOR PREVIOUS APPLICATION OF LIPOSOMAL POWDERS IN THE FORM OF AEROSOL, ALSO SUITABLE FOR THIS POWDER IN THE FORM OF AEROSOL RU2001124354A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19905285.9 1999-02-03
DE19905285 1999-02-03
DE19954107 1999-11-02
DE19954107.8 1999-11-02

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RU2001124354A true RU2001124354A (en) 2003-06-20

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EP (1) EP1148905A2 (en)
JP (1) JP2002538855A (en)
KR (1) KR20010101991A (en)
CN (1) CN1338956A (en)
AU (1) AU3416400A (en)
CA (1) CA2361807A1 (en)
DE (1) DE10004860A1 (en)
HU (1) HUP0105445A2 (en)
PL (1) PL349885A1 (en)
RU (1) RU2001124354A (en)
SK (1) SK10942001A3 (en)
WO (1) WO2000045878A2 (en)

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MXPA01012533A (en) 1999-06-05 2003-10-14 Innovata Biomed Ltd Delivery system.
GB9920839D0 (en) 1999-09-04 1999-11-10 Innovata Biomed Ltd Inhaler
DE10112167C2 (en) 2001-03-12 2003-02-13 Bionorica Ag Process for the gentle extraction of dry extracts
GB0128148D0 (en) 2001-11-23 2002-01-16 Innovata Biomed Ltd Assembly
US6900317B2 (en) 2002-02-19 2005-05-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Salts of the CGRP antagonist BIBN4096 and inhalable powdered medicaments containing them
GB0219815D0 (en) * 2002-08-24 2002-10-02 Accentus Plc Preparation of small crystals
US6883517B2 (en) * 2002-09-30 2005-04-26 Asaf Halamish Downdraft nebulizer
US7459146B2 (en) * 2003-05-30 2008-12-02 3M Innovative Properties Company Stabilized aerosol dispersions
EP1744800B1 (en) 2004-04-21 2016-06-22 Innovata Biomed Limited Inhaler
KR100682334B1 (en) * 2006-07-14 2007-02-16 (주)지에프씨 Apparatus for producing particulate lecithin wax composition
WO2010098430A1 (en) * 2009-02-26 2010-09-02 日本エー・シー・ピー株式会社 Gas mist inhaler
AU2012306504B2 (en) 2011-09-06 2015-08-20 Nicoventures Trading Limited Heating smokeable material
US20140053839A1 (en) * 2011-11-04 2014-02-27 Acp Japan Co., Ltd. Gas mist inhaler
KR101373981B1 (en) * 2012-07-24 2014-03-12 한국화학연구원 Nebulizer
KR101313993B1 (en) * 2012-07-24 2013-10-01 한국화학연구원 Nebulizer
GB201217067D0 (en) 2012-09-25 2012-11-07 British American Tobacco Co Heating smokable material
GB201311620D0 (en) 2013-06-28 2013-08-14 British American Tobacco Co Devices Comprising a Heat Source Material and Activation Chambers for the Same
GB201500582D0 (en) 2015-01-14 2015-02-25 British American Tobacco Co Apparatus for heating or cooling a material contained therein
GB201415381D0 (en) * 2014-08-29 2014-10-15 Algipharma As Inhalable powder formulations of alginate oligomers
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US20170055575A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Material for use with apparatus for heating smokable material
US20170055584A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Article for use with apparatus for heating smokable material
US20170119046A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Apparatus for Heating Smokable Material
US20170119047A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Article for Use with Apparatus for Heating Smokable Material
BR112018071191A2 (en) * 2016-04-15 2019-02-12 Kaer Biotherapeutics Corporation injector for the generation of a fluid and gas and method for the generation of an aerosol from a fluid and gas by operating an injector
GB201817868D0 (en) * 2018-11-01 2018-12-19 Nicoventures Trading Ltd Aerosolised formulation
CN111514418B (en) * 2019-06-12 2022-01-14 中南大学湘雅二医院 Self-suction nasal powder material feeding device
CN115155832A (en) * 2022-07-04 2022-10-11 浙江泰林医学工程有限公司 Self-suction type small-flow micro-fog spray head

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166476B1 (en) * 1984-05-28 1989-05-03 MALLINCKRODT, INC.(a Missouri corporation) Aerosol generator-inhalator
US5209821A (en) * 1985-05-09 1993-05-11 Purdue Research Foundation Apparatus for removing volatiles from, or dehydrating, liquid products
DE3686025T2 (en) 1985-05-22 1993-01-07 Liposome Technology Inc METHOD AND SYSTEM FOR INHALING LIPOSOMES.
DE4438292C2 (en) * 1994-10-26 1999-07-22 Pari Gmbh Dose-accurate aerosol generation for inhalation therapy
GB2321419B (en) * 1997-01-27 2001-02-07 Medic Aid Ltd Atomizer

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AU3416400A (en) 2000-08-25
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