RU2785938C2 - Aerosol delivery device and set of parts for it - Google Patents

Abstract

FIELD: tobacco industry.

SUBSTANCE: group of inventions relates to an aerosol delivery device, a case of a channel for the first fluid flow for an aerosol delivery device, and a set of parts for an aerosol delivery device. The aerosol delivery device contains the first aerosol generation unit for generation of the first aerosol from the first aerosol precursor and introduction of the specified first aerosol into the channel for the first fluid flow. The first aerosol is characterized by particle sizes contributing to their penetration in the lungs. The device contains the second aerosol generation unit for generation of the second aerosol from the second aerosol precursor and introduction of the second aerosol into a channel for the second fluid flow. The second aerosol is characterized by particle sizes preventing their penetration in the lungs, the second aerosol is transmitted inside at least one of the oral cavity of a mammal or a nasal cavity of a mammal. The second aerosol contains an active component for activation of at least one of one or several taste buds in the specified oral cavity and one or several olfactory receptors in the specified nasal cavity. The second aerosol generation unit contains Venturi hole for issue and conversion into aerosol of the second aerosol precursor in the second aerosol generation unit, wherein the second aerosol precursor is liquid.

EFFECT: arrangement is provided, in which the second aerosol is formed by the first aerosol flow passing through Venturi hole, which leads to that the second aerosol is captured with the aerosol flow, and the mixture is supplied from the same channel for a fluid flow.

54 cl, 22 dwg

Description

The present application claims priority under GB1715386.7, filed September 22, 2017, the contents and constituent parts of which are incorporated herein by reference for all purposes.

The field of technology to which the present invention relates

The present invention relates to an aerosol delivery device, system and method. In particular, but not exclusively, one or more embodiments in accordance with the present invention relate to the delivery of aerosols containing various active ingredients.

Background of the Invention

Nicotine replacement therapy is for people who want to quit smoking and overcome their addiction to nicotine. One type of device for nicotine replacement therapy is an inhaler or inhaler. It is usually in the form of a plastic cigarette and is used by people who wish to engage in activities associated with the consumption of combustible tobacco - the so-called hand-to-mouth tobacco smoking activities. The inhaler contains a replaceable nicotine cartridge. When the user inhales through the device, the nicotine is dispersed or aerosolized from the cartridge and absorbed through the mucous membranes in the mouth and throat rather than entering the lungs. Nicotine replacement therapies are generally classified as medical products and are regulated by the Medicines for Medical Use Regulations in the United Kingdom.

In addition to passive nicotine delivery devices such as an inhaler, there are active nicotine delivery devices in the form of electronic cigarettes. The inhaled aerosol mist or vapor typically contains nicotine and/or flavoring agents. In use, the user may experience satisfaction and physical sensations similar to those experienced with combustible tobacco products and exhale an aerosol mist or vapor having a similar appearance to the smoke exhaled when using such combustible tobacco products.

The smoking replacement device typically uses thermal and/or ultrasonic agitation to vaporize/convert a solution containing nicotine and/or other flavoring agent, propylene glycol and/or glycerin formulation into an aerosol, mist or vapor for inhalation. One of ordinary skill in the art will recognize that the term "smoking replacement device" as used herein includes, without limitation, electronic nicotine delivery systems (ENDS), electronic cigarettes, e-cigarettes, e-cigars, vaping cigarettes, pipes, cigars, cigarillos, vaporizers and devices of a similar type, which are designed to create an aerosol mist or vapor that is inhaled by the user. Some e-cigarettes are disposable, others are refillable with replaceable and refillable parts.

Smoking replacement devices may resemble a traditional cigarette and are characterized by a cylindrical shape with a mouthpiece at one end through which the user can draw an aerosol, mist or vapor for inhalation. These devices typically have several common components: a power source such as a battery, a reservoir for storing the vaporized liquid (often referred to as e-liquid), an vaporization component such as a heater for spraying, aerosolizing and/or vaporizing the liquid to produce an aerosol, fog or vapor, and a control circuit configured to actuate the evaporative component in response to an activation signal from a switch actuated by the user or configured to detect when the user draws air through the mouthpiece by inhalation.

As an example of a well-known aerosol delivery device, the technical solution disclosed in WO 2016050244 A1, 04/07/2016 can be given. The disadvantages of this solution include non-optimally complex design of the device.

Over the past few years, the popularity and use of smoking replacement devices has increased.

Aspects and embodiments of the present invention have been developed in view of the above.

Brief summary of the present invention

According to a first aspect, an aerosol delivery device is provided, comprising: a first aerosol generating unit for generating a first aerosol from a first aerosol precursor and introducing said first aerosol into a first fluid flow channel, said first aerosol having a particle size that facilitates their penetration into the lungs; a second aerosol generation unit for generating a second aerosol from the second aerosol precursor and introducing the second aerosol into the second fluid flow channel, the second aerosol being sized to prevent entry into the lungs; the second aerosol can be delivered into at least one of the oral cavity of the mammal and the nasal cavity of the mammal, and the second aerosol contains an active ingredient for activating at least one of one or more taste receptors in said oral cavity and one or more olfactory receptors in said nasal cavity .

Preferably, the second aerosol is characterized by at least one of the following: particle sizes that prevent their penetration into the trachea; particle sizes that prevent their penetration into the larynx; particle sizes that prevent their penetration into the laryngopharynx; and particle sizes that prevent their penetration into the oropharynx.

Advantageously, the second aerosol has a mass median aerodynamic particle diameter that is greater than or equal to 15 microns, in particular greater than 30 microns, more particularly greater than 50 microns, even more particularly greater than 60 microns, and even more preferably greater than 70 microns.

Advantageously, the second aerosol is characterized by a maximum mass median aerodynamic particle diameter which is less than 300 microns, in particular less than 200 microns, even more particularly less than 100 microns.

Advantageously, said first aerosol precursor contains components such that the first aerosol contains a lung-deliverable active ingredient.

Advantageously, the first aerosol has a mass median aerodynamic particle diameter that is less than or equal to 10 microns, preferably less than 8 microns, more preferably less than 5 microns, even more preferably less than 1 micron.

Advantageously, said first aerosol generating unit is configured to heat said first aerosol precursor.

Advantageously, said first aerosol generation unit is configured to mix said first aerosol precursor.

Advantageously, said first fluid flow path further receives said first aerosols from the first aerosol inlet of said device.

Advantageously, said first aerosol inlet is configured to supply said first aerosol to said first fluid flow channel.

Advantageously, said second fluid flow channel further receives said second aerosol from the second aerosol inlet of said device.

Advantageously, said second aerosol inlet is configured to supply said second aerosols to said second fluid flow channel.

Advantageously, said channel for the first fluid and said channel for the flow of the second fluid are connected.

Preferably, said channel for the first fluid and said channel for the flow of the second fluid pass next to each other.

Advantageously, said channel for the flow of the second fluid is located along the longitudinal axis of the said channel for the flow of the first fluid.

Advantageously, said first fluid flow path is adjacent to the gas inlet of said device, and said second fluid flow path is adjacent to the aerosol outlet of said device.

Preferably, said second fluid flow path is adjacent to the gas inlet of said device, and said first fluid flow path is adjacent to the aerosol outlet of said device.

Advantageously, said second fluid flow channel is axially aligned with said first fluid flow channel.

Advantageously, said second fluid flow passage is adjacent to said first fluid flow passage in a side-by-side configuration therewith.

Advantageously, said first fluid flow passage is separated from said second fluid flow passage by a wall-like element.

Advantageously, said first fluid flow conduit comprises a first housing restricting said second fluid flow, and said second fluid flow conduit comprises a second housing restricting said second fluid flow, said first housing is intended to receive said first aerosol; and said second housing is intended to receive said second aerosol.

Advantageously, said first housing comprises said first aerosol generating unit and/or said second housing contains said second aerosol generating unit.

Advantageously, said first housing contains a removable module of said delivery device.

Advantageously, said first body contains a plug-in module of said delivery device.

Advantageously, said first body contains a refillable module of said delivery device.

Preferably, said second body contains a removable module of said delivery device.

Preferably, said second body contains a replaceable module of said delivery device.

Advantageously, said second body contains a refillable module of said delivery device.

Preferably, said first aerosol precursor contains nicotine, or a nicotine derivative or nicotine analogue.

Advantageously, said first aerosol precursor comprises a lung-deliverable active ingredient which is a free nicotine salt comprising at least one of the following: nicotine hydrochloride; nicotine dihydrochloride; nicotine monotartrate; nicotine bitartrate; nicotine bitartrate dihydrate; nicotine sulfate; nicotine-zinc chloride monohydrate and nicotine salicylate.

Advantageously, said second aerosol may be delivered to activate at least one of the following: one or more taste buds in said oral cavity; and one or more olfactory receptors in said nasal cavity.

Preferably, said first aerosol generating unit is configured to generate a first aerosol from a first aerosol precursor comprising at least one of the following: glycol; polyglycol and water.

Preferably, said second aerosol generation unit is configured to introduce said second aerosol into said fluid flow channel within a predetermined period of time after said first aerosol generation unit is activated.

Advantageously, said second fluid flow channel comprises at least one baffle configured such that a portion of said second aerosol collides with said baffle.

Advantageously, said aerosol inlet port is configured to introduce a second aerosol with a mass median aerodynamic diameter of the particles preventing their penetration into the lungs.

Preferably, said second aerosol generation unit comprises a Venturi for issuing and aerosolizing the second aerosol precursor in the second aerosol generation unit, the second aerosol precursor being a liquid.

Preferably, said second aerosol generating unit comprises a piezoelectric element for issuing and aerosolizing a second aerosol precursor in the second aerosol generating unit, the second aerosol precursor being a liquid.

Advantageously, said second aerosol generating unit comprises a precursor substrate for the second aerosol precursor, the precursor substrate comprising a hydrophobic surface.

Preferably, said second aerosol generation unit comprises a plurality of capillary tubes configured to draw a second aerosol precursor from the second aerosol precursor reservoir to the free end of the plurality of capillary tubes.

Advantageously, the free end of the plurality of capillary tubes is hydrophobic.

Advantageously, said first aerosol is characterized by a particle size that facilitates its deep penetration into the lungs.

Advantageously, said first aerosol has a mass median aerodynamic particle diameter of less than 2 µm.

Preferably, said second fluid flow conduit terminates in the mouthpiece of the second fluid flow conduit.

Preferably, said first fluid flow channel terminates in the mouthpiece of the first fluid flow channel.

Preferably, said channels for the flow of the first and second fluids terminate in a combined mouthpiece.

Advantageously, said combined mouthpiece comprises separate channels corresponding to said channels for the flow of the first and second fluids, respectively.

Advantageously, said combined channels for the flow of the first and second fluids terminate in the mouthpiece.

Advantageously, said active ingredient comprises a physiologically active ingredient.

According to a second aspect, a first fluid conduit housing is provided, wherein the first fluid conduit housing is for an aerosol delivery device according to the first aspect.

Preferably, the body of the channel for the first fluid contains the specified precursor of the first aerosol.

Preferably, the body of the channel for the first fluid contains the specified unit for generating the first aerosol.

According to a third aspect, a second fluid conduit housing is provided, the second fluid conduit housing being for the aerosol delivery device according to the first aspect.

Preferably, the body of the channel for the second fluid contains the specified precursor of the second aerosol.

Preferably, the body of the channel for the second fluid contains the specified unit for generating the second aerosol.

According to a fourth aspect, a kit of parts is provided, the kits of parts being for the aerosol delivery device according to the first aspect, the kit of parts comprising a first fluid channel housing according to the second aspect and a second fluid flow channel housing according to the third aspect.

Brief description of the figures

One or more specific embodiments in accordance with aspects of the present invention will now be described solely by way of example with reference to the following drawings, in which:

in fig. 1 shows a schematic representation of a heating element for a vaping device;

in fig. 2 shows an image of a device for vaping with a clearomizer;

in fig. 3A is a schematic cross-sectional view of a mouthpiece in accordance with one embodiment of the present invention;

in fig. 3B is a schematic cross-sectional view of the mouthpiece shown in FIG. 3A in a plane perpendicular to the plane of the cross section shown in FIG. 3A;

in fig. 4 is a schematic representation of a mouthpiece according to one embodiment of the present invention showing a piezoelectric aerosol generating unit;

in fig. 5 is a schematic representation of a fragrance element for generating fragrance aerosols in accordance with one embodiment of the present invention;

in fig. 6 is a schematic representation of a fragrance element for generating fragrance aerosols in accordance with one embodiment of the present invention;

in fig. 7 is a schematic representation of a device in accordance with one embodiment of the present invention;

in fig. 8 is a schematic representation of a device in accordance with one embodiment of the present invention;

in fig. 9 is a schematic representation of a device in accordance with one embodiment of the present invention;

in fig. 10 is a schematic representation of a device in accordance with one embodiment of the present invention;

in fig. 11 is a cross-sectional side view of a device in accordance with one embodiment of the present invention;

in fig. 12 is a cross-sectional side view of the vapor release tube of the nicotine delivery system and device shown in FIG. 1 and 2, according to one or more embodiments of the present invention;

in fig. 13 shows a schematic representation of an atomizer;

in fig. 14 is a graphical representation of the change in aerosol size as a function of the viscosity of the liquid precursor;

in fig. 15 shows an image of the formation of an aerosol from a high velocity liquid jet;

in fig. 16 is a schematic representation of the formation of an aerosol from a pressurized fluid exiting an orifice;

in fig. 17 shows a schematic representation of an air atomizer;

in fig. 18 shows a schematic representation of a centrifugal atomizer;

in fig. 19 shows a schematic representation of aerosol formation during ultrasonic atomization;

in fig. 20 shows a schematic representation of a structure for ultrasonic atomization;

in fig. 21 shows a schematic representation of a fixed mesh atomizer; and

in fig. 22 shows a schematic representation of a vibrating mesh atomizer.

Detailed disclosure of the present invention

For a general presentation in Fig. 1 shows a schematic representation of a vaporizer component 1 for a typical e-cigarette. The evaporative component comprises a wick 3, which may be rigid or flexible, impregnated with e-liquid, with a heating coil 5 wrapped around it. In this case, the component as a whole is referred to as a wick and coil heater. During use, an electric current passes through the coil 5, heating it. This heat is transferred to the e-liquid in wick 3, causing it to evaporate.

Smoking replacement devices such as an e-cigarette can be refilled to replace consumed e-liquid. An example of the heating element, e-liquid reservoir, and mouthpiece portions of an e-cigarette 10, known as a clearomizer, is shown in FIG. 2. Mouthpiece 12 can be connected to clean tank 14, which acts as a reservoir for e-liquid. The heating fixture includes a wick 16 which draws e-liquid into heating element 20. Heating element 20 is powered by a battery connected via electrical connection 18. E-liquid drawn into heating element 20 vaporizes and forms an aerosol mist which can be drawn in. into the mouth by a user drawing air through the mouthpiece 12. The airflow is generally introduced through small inlets in or near the electrical connection 18 and through a central airflow fluid passage that passes over or immediately adjacent to the heating element due to whereby the vaporized e-liquid can be entrained in the air stream and drawn through the fluid passage into the mouthpiece 12. Typically, the vapor condenses in the cooler air stream to form an aerosol mist of condensed e-liquid particles. The e-liquid can be flavored. If the user wants to change the flavor, he needs to change the e-liquid in his device, which requires emptying the tank containing the e-liquid and filling it with the e-liquid with the desired flavor. Optionally, the user may use another device, or an interchangeable tank filled with the desired flavoring e-liquid.

The flavoring agent is perceived by the user through taste and/or olfactory receptors located in his oral and nasal cavities. The present inventors have realized that flavor aerosols can penetrate the oral and nasal cavities to deliver the flavor component to the user without penetrating further. However, physiologically active substances such as pharmaceutical compounds and nicotine can be more efficiently delivered through the pulmonary system, in particular through deep penetration into the lungs.

In FIG. 3A shows a schematic of a mouthpiece assembly 30 that can be used to deliver flavor separately from an active ingredient such as nicotine using a vaping device. The mouthpiece 30 includes an open-ended hollow cylindrical section 32 which is configured to receive the mouthpiece or "drip-type" 12 of a vaping unit 34, such as a clearomizer, as shown in FIG. 2 and provide a fluid path. The second hollow cylindrical section 36 with an open end is configured to receive the "flavoring" element 38 and provide a channel for the fluid. The flavor element 38 is a support that supports an aerosol precursor with a flavor component in liquid form, such as "Blueberry" flavor with the trade name FQ CO36 E-FLAVOR BLUEBERRY available from Hertz Flavors GmbH & CO. KG, Reinbeck, Germany. The flavor element 38 includes a flavor component support matrix through which air can be drawn from the "B" side to the "A" side. The airflow passing through the fragrance element 38 causes aerosols from the fragrance component to be formed and entrained in the airflow, which is carried to side A.

The user must place the mouthpiece 30 in their mouth so that side B protrudes from the mouth and draw air towards side A from side B to cause airflow from side B to pass through flavor element 38 and hence draw flavor aerosols into their mouth. The user can activate the vaping device 34 to generate an aerosol mist from the e-liquid precursor in the vaping device by drawing in air on side A of the mouthpiece 30. By activating the vaping device 34 while drawing air through the mouthpiece 30, the user obtains both aerosols from vaping devices containing an active ingredient, and flavoring aerosols from the flavoring element 38.

In FIG. 3B is a schematic view of the mouthpiece 30 from side A. Although the vaping device 34 is shown as located at a distance from the inner wall of the hollow cylinder 32, this is done to clarify the description and clearly depict the relevant components. In practice, the vaping device comes into contact with the mouthpiece 30, typically by means of a sliding friction fit. This is the same for the flavoring element 38 with a hollow cylinder 36.

The aerosols generated in the vaping device 34 are formed by heating the vapor precursor liquid, whereby they typically have a particle size with a mass median aerodynamic diameter less than or equal to 10 microns, preferably less than 8 microns, more preferably less than 5 microns, even more preferably less than 1 micron. Aerosols with this particle size tend to enter the user's lung system. The smaller the particles in the aerosol, the more likely it is to penetrate deeper into the pulmonary system, and the more efficient the transfer of the active ingredient into the user's bloodstream will be. Such deep penetration into the lungs is what is desirable for an active ingredient, but not necessarily for a flavoring ingredient. The flavoring component may enter the oral and nasal cavities of the user to activate taste and/or olfactory receptors, but may not enter the pulmonary system.

The flavoring component is designed such that it typically forms an aerosol with a mass median aerodynamic particle diameter that is greater than or equal to 15 microns, in particular greater than 30 microns, more particularly greater than 50 microns, even more particularly greater than 60 microns, and even more preferably greater than 70 microns. Without wishing to be bound by theory, an aerosol with particles of this size can be formed by drawing liquid droplets from a substrate at ambient temperature of the wearer, such as room temperature, through an air stream passing over the substrate. The particle size of the aerosol formed without heating is generally smaller than the particle size of the aerosol formed as a result of vapor condensation. The particle size of aerosols formed without heating, for example by drawing air through a fluid supporting substrate, can be affected by the ambient temperature, viscosity and/or density of the fluid. However, aerosols formed without heating are generally and most likely to have a significantly larger particle size than aerosols formed by heating. Flavor aerosols can be formed with a maximum mass median aerodynamic particle diameter that is less than 300 microns, in particular less than 200 microns, even more particularly less than 100 microns. This range of mass-median aerodynamic particle diameters results in aerosols whose particles are small enough to be entrained in the airflow caused by the user drawing air through the flavoring element 38 and enter and pass through the mouth and/or nasal cavity to activate taste and/or olfactory receptors.

Briefly, it should be understood that the mass median aerodynamic particle diameter is a statistical measurement of particle/droplet size in an aerosol. That is, the mass median aerodynamic particle diameter represents a quantification of the size of the droplets that together form an aerosol. The mass median aerodynamic particle diameter can be defined as the particle diameter at which 50% of the particles/droplets by mass in the aerosol are greater than the mass median aerodynamic particle diameter, and 50% of the particles/droplets by mass in the aerosol are less than the mass median aerodynamic particle diameter. The expression "aerosol particle size" as used herein refers to the size of the particles/droplets that are contained in a particular aerosol. The size of the particles/droplets in an aerosol can be quantified, for example, by the mass median aerodynamic diameter of the particles.

The particle size of the aerosol generated by the aerosol generating unit may depend on, for example, the temperature of the precursor liquid, the density of the precursor liquid, the viscosity of the precursor liquid, or a combination thereof. The particle size of the aerosol generated by the aerosol generating unit may also depend on the specific parameters and configuration of the aerosol generating device, which will be described in more detail below.

Flavoring element 38 may be formed from any suitable porous material to provide a substrate. For example, it may be formed from a material commonly used as a filter for a cigarette or a substrate material for a Nicorette™ inhaler, i.e. porous polypropylene or polyethylene terephthalate. The liquid flavor component may then be dropped onto the flavor element 38. The substrate of the flavor element 38 may comprise a porous material, wherein the pores of the porous material hold, hold, carry, or store the flavor compound. Optionally or additionally, the porous material may comprise a sintered material such as, for example, BioVyon™ (from Porvair Filtration Group Ltd).

According to the embodiment shown in FIG. 4, the mouthpiece 40 is shaped so that the user can place it in their mouth in a conventional mouthpiece configuration. The tapering fluid flow channel 42 terminates at the mouth end of the piece 40 and communicates with the vaping device receiving cavity 44 through the fluid flow channel 46 . The cavity 58 is configured to accommodate a flavoring compartment 50, in which a flavoring element 54 is located. The flavoring compartment 50 is characterized by the presence of a cavity 52 with an opening 53, the dimensions of which provide for the insertion of a flavoring element 54 into the cavity 52. A coil spring 56 is also located in the cavity 52 A coil spring 56 is located at one end of the cavity 52 on the opposite side of the hole 53.

The flavor element 54 is located in the flavor compartment 50 so that it rests on the coil spring 56. The piezoelectric vibrator 60 is in contact with the end of the flavor element 54 and is powered through an electrical connection 62. The piezoelectric element 60 contains a piezoelectric crystal that can be electrically connected with a power source such as an electric battery through connection 62. The piezoelectric element 60 includes a perforated membrane, the vibration of which is provided by the piezoelectric crystal, or formed by the piezoelectric crystal itself. Due to the presence of perforations in the vibrating membrane, small drops of liquid flavoring component are formed and adsorbed in the flavoring element 54 when the membrane is vibrated. Vibrations typically occur at a frequency in the range of 100 kHz to 2.0 MHz, in particular from 108 kHz to 160 kHz, and more particularly substantially at a frequency of, for example, 108 kHz. Such vibration frequencies can be used to form aerosols of the liquid flavoring component that can be drawn by the airflow from the flavoring element 54 to the end of the mouthpiece 50 and are characterized by the particle size mentioned in the ranges above.

Electrical connection 62 may be connected to a power source via a switch actuated by the user or actuated in response to a pressure drop in fluid passage 42/cavity 58 when the user draws air through mouthpiece 40. Optionally, electrical connection 62 may be connected via a switch on the device. vaping device (SMP), whereby the piezoelectric element 60 is activated when the user activates the vaping device.

Another device configuration that features separate flavor and nicotine aerosol delivery is shown in FIG. 11 and FIG. 12.

For the sake of avoiding ambiguity, in the following description of FIG. 11 and FIG. 12, the term "upstream" defines a position near the point where fluid is drawn into the aerosol outlet tube 168 when the device is in use, i.e. the point from which air containing aerosols is drawn into the tube 168 for releasing aerosol from the environment and/or from the module 162 generating aerosol. The term "downstream" defines the position from the point at which the flavor containing fluid exits flavor element 172. Based on these definitions, any fluid in fluid passage 170 that is "upstream" of flavor element 172 , does not contain any flavor component, and any fluid in the fluid passage that is "downstream" of carrier 172 may contain flavor (depending on whether or not flavor element 172 contains a liquid flavor component and/or flavor connection, and the extent to which the flavor component is drawn into the fluid as it passes through carrier 172).

In FIG. 11 is a schematic side view in cross section of the device 150. As can be seen in FIG. 11, flavor element 172 includes a substrate 174 which, in one or more embodiments, is impregnated with a liquid flavor component and/or flavor compound. Optionally, substrate 174 may comprise a porous material, wherein the pores of the porous material retain the liquid flavor component and/or flavor compound. Also optionally, the porous material may comprise a sintered polymer such as, for example, BioVyon™ (from Porvair Filtration Group Ltd). The porous substrate material 174 is designed to "capillary" or "pull" the nicotine precursor material out of the end portions of the substrate 14 (ie, towards the central portion of the substrate 174). This can prevent leakage of the liquid flavor component from the substrate (and thus from the carrier 172 when the permeable films (not shown in FIGS. 11-12) sealing the flavor element are broken). Thus, the liquid flavor component can be retained in the substrate 174 until the air flow through it (ie, during use) causes the aerosol to form and aerosolizes the flavor from the liquid flavor component.

The evaporation portion 164 of the aerosol generation module 162 includes a reservoir 176 configured to receive the vapor precursor material, an evaporator 178 configured to vaporize the vapor precursor material, and a fluid flow path 180 for delivering aerosols formed from the precursor material. steam, into the passage 170 of the channel for the flow of the fluid tube 168 to release the aerosol.

The vapor precursor material may be in liquid form and may contain one or more of glycol, polyglycol, propylene glycol and water.

The evaporation device 178 includes a chamber (not shown) for holding the vapor precursor material obtained from the reservoir 176 and a heating element (not shown) for heating the vapor precursor material in the chamber.

Vaporizer 178 further includes a tube (not shown) in fluid communication with the chamber and configured to deliver aerosols generated by heating the vapor precursor material in the chamber to the vapor passage 180.

Vaporizer 178 further comprises a control circuit (not shown) activated by the user or actuated by detecting air and/or aerosols being drawn in through aerosol outlet 168, i. when the user puffs or inhales.

The battery compartment 166 of the aerosol generation system 162 includes a battery 182 and a connection 184 for mechanically and electrically connecting the battery compartment 166 to the evaporative portion 164. When the battery compartment 166 and the evaporative portion 164 are connected as shown in FIG. 11, battery 182 is electrically connected to evaporator 178 to supply power to it.

In response to the activation of the control circuit of the evaporator 178, the heating element heats the vapor precursor material in the chamber of the evaporator 178. The steam generated from the heating process forms an aerosol of liquid condensate, which passes through the tube into the passage 180 of the fluid channel of the evaporator 164 This fluid-containing aerosol then passes into the upstream portion of the fluid channel 170 in the form of an aerosol of the aerosol outlet tube 168, passes through the flavor element 172 where the flavor from the substrate 174 is entrained in the aerosol flow, and then exits through downstream section of the channel 170 for fluid in the form of an aerosol for delivery to the user.

This process is shown in Fig. 12, where arrow 186 schematically depicts the flow of aerosol fluid from the aerosol passage of the evaporator portion to the upstream portion of the aerosol fluid passage 170 of the vapor release tube 168, through the flavoring element 172, and then through the downstream portion. channel 170 for fluid in the form of an aerosol for delivery to the user.

In FIG. 12 also schematically depicts the flavor and/or flavor compounds 188 contained in the substrate 174, with the flavor and/or flavor compounds passing from the substrate 174 into the fluid stream 186 in the form of an aerosol, i. involved in the stream 186 aerosol. The flavor and/or flavor compounds in the aerosol stream 186 are designated 190.

In FIG. 5 shows a schematic of another embodiment in which the flavor element 70 provides a support for a liquid flavor component, in which the support is plate-like in structure with a series of platelets 72. An airflow drawn from side B passes through the plate structures and generates an aerosol of the liquid flavor component. , which is entrained in the airflow and carried to side A in the user's mouth. Flavoring element 70 may be located in a mouthpiece 30, such as shown in FIG. 3A and FIG. 3B and described with reference thereto, or a mouthpiece 40 such as that shown in FIG. 4 and described with reference to it.

The flavor element 70 may also be located in the device 150 instead of the flavor element 172 shown in FIG. 11 and FIG. 12.

In FIG. 6 shows a schematic representation of a further embodiment in which the flavoring element 74 is formed as a hollow tubular section characterized by open ended capillary fibers 76 extending from the inner wall 78 of the pipe. The capillary elements may be filled with a liquid flavor component. The flow of air through the tube, shown as a non-limiting example from end B to end A, causes a pressure drop at the free open end of one or more of the capillary elements 76, which causes droplets of liquid flavor component to be drawn from the open end of the capillary elements and entrained in the air. flow from B to A. Optionally, wall 78 may include a liquid flavor component reservoir into which capillary fibers 76 are inserted and/or protrude to draw liquid flavor component from such reservoir to the free end of capillary fibers 76. The reservoir may be a suitable matrix formed of porous material and integrated with the wall, or formed separately from it and inserted into the pipe during the assembly of the fragrance element 74.

The capillary fibers are characterized by a diameter that allows the formation of aerosol droplets with sizes within the ranges indicated above. In general, an open end opening with a diameter approximately equal to the desired median diameter of the aerosol particles to be generated provides for the formation of an aerosol with particles of that median diameter. The exact size of the particles/droplets contained in the aerosol depends, inter alia, on the surface tension and temperature of the liquid flavoring component, as well as on the pressure acting on it. According to the embodiment described, the capillary fibers, or at least their open end, are made of a hydrophobic material for releasing liquid droplets.

According to the embodiment shown schematically in FIG. 7, the respective aerosol generating units are arranged side by side in the device 80. The fragrance aerosol generating unit 82 and the active ingredient aerosol generating unit 84 are shown in a side by side configuration. Air can be drawn into the flavor aerosol generating unit 82 from the outer air hole 86 and into the flavor aerosol generating unit 82 through the air hole 95 . Similarly, air is drawn into the active ingredient generating unit 84 through the outer air hole 88 and into the active ingredient aerosol generating unit through the air hole 97 . The aerosol-containing fluid exits the fragrance aerosol generation unit 82 and the active ingredient aerosol generation unit 84 through outlets 96 and 98, respectively. Outlets 96 and 98 provide fluid communication with mouthpiece 90 through holes 92 and 94. Mouthpiece 90 provides a mixing chamber in which aerosols can be mixed prior to inhalation by a user. The active ingredient aerosol generation unit 84 includes a vapor generation device such as used in conventional vaping devices, which includes an electrically powered heater and a battery for power supply. Details of the heater and battery pack have been omitted from the figure for convenience and clarity of disclosure.

An additional embodiment in accordance with the present invention is schematically depicted in FIG. 8, which shows an apparatus 100 in which the respective aerosol generating units 102/104 and 106 are arranged in a concentric configuration. According to the described embodiment, the fragrance aerosol generating unit 102/104 is described as being in a concentric arrangement around the active component aerosol generating unit 106. Respective reference numerals 102 and 104 designate respective portions of the flavor aerosol generating unit on either side of the active ingredient aerosol generating unit 106 when the device 100 is shown in cross section. The device includes a mouthpiece 108 located at one end. The opening 110 provides fluid communication from the outlets of the aerosol and flavor generating units 102/104 and 106, respectively, to the mouthpiece 108. Air can be drawn into the aerosol generating units through the external air inlets 112, 114 and 116. As depicted, the perforated tube 118 allows air drawn in through the outer air inlets 112, 114, and 116 to be drawn into any of the aerosol generating units to the outlet of the aerosol generating unit, indicated at 119 and 120. In an optional embodiment, the tube 118 is not perforated. and the corresponding airflow is kept separate. Similar to the embodiment shown in FIG. 7, the active ingredient aerosol generation unit 106 includes a generation unit specific to a conventional vaping device.

According to an optional embodiment, the active component aerosol generation unit 106 may be located around the flavor aerosol generation unit 102/104.

In FIG. 9 shows another embodiment in accordance with the present invention, in which the apparatus 130 comprises respectively an active ingredient aerosol generating unit 132 and a fragrance aerosol generating unit 134 arranged in series. The active ingredient aerosol generating unit 132 is in fluid communication with the fragrance aerosol generating unit 134 via a fluid tube 135 . The fluid channel passing through the active ingredient aerosol generating unit 132 and the fragrance aerosol generating unit 134 communicates through the fluid tube 136 with the opening 114 and enters the mouthpiece 138. Air is drawn into the active ingredient aerosol generating unit 132 from the external inlet holes 142 , 144, and 146 for air through the perforations 148. Similar to the embodiment shown in FIG. 7, the active ingredient aerosol generation unit 132 includes a generation unit specific to a conventional vaping device.

According to the embodiment shown schematically in FIG. 10, a similar arrangement is described as shown in FIG. 9, with like parts having the same reference numerals, but the active ingredient aerosol generating unit and the fragrance aerosol generating unit are reversed. Thus, the fragrance aerosol generation unit 134' is located upstream of the active ingredient aerosol generation unit 132'.

In the flavor aerosol generation units according to any of the embodiments disclosed in FIGS. 7-10, flavor element configurations such as those disclosed in FIGS. 3-6 and FIG. 11 and 12. However, any suitable aerosol generation mechanism may be used to generate aerosols in the range given above for flavor aerosols.

For clarity, the active ingredient aerosol generating units in the previously described embodiments are configured to generate aerosols whose particle sizes are conducive to their penetration into the lungs, in particular deep penetration into the lungs, and in general to generate active ingredient aerosols having a mass median aerodynamic diameter particles less than or equal to 10 microns, preferably less than 8 microns, more preferably less than 5 microns, even more preferably less than 1 micron. This is the case when aerosol particles, which are formed from steam condensate, i.e. aerosol mist, for example, as occurs in a typical e-cigarette or vaping device, are likely to be within the specified size ranges, or at least a significant proportion of them are within the specified size ranges. For example, it can reasonably be expected that 50% of the active ingredient aerosol particles are within the specified size ranges. Preferably, a large percentage will be within a predetermined size range, such as 75% or even more. However, lower percentages may be acceptable, such as up to 25% active ingredient aerosol particles within the given size ranges.

Flavor component aerosols can be generated in a variety of ways, some of which are described above. Aerosol generation (sometimes referred to as "spraying") has been described in the technical and scientific literature, and such techniques can be applied, adapted or modified for flavor aerosol generating units and elements using embodiments in accordance with the present invention. The following will provide an overview of aerosolization, as well as techniques and methods for generating aerosols. For the avoidance of ambiguity, references to drops or particles are also references to aerosols, which may contain a drop, such as steam condensate and/or particulate matter.

Aerosols are formed initially as a result of spraying or condensation of steam. Atomization is the process of separating a large volume of fluids into droplets or particles. The process of separating a large volume of fluids into a spray or aerosol which contains particles is usually achieved using a so-called atomizer. Common examples of atomizers include shower sprayers, aerosolized perfumes, and aerosolized hairspray or deodorant. In FIG. 13 shows a schematic representation of a typical atomizer and the particle size range obtained with it.

An aerosol is a collection of moving particles resulting from spraying; For most non-natural spray applications, the aerosol moves particles in a controlled manner and in a controlled direction. Typically, for most everyday applications, an aerosol has a range of particle sizes depending on various internal and environmental parameters, which will be described below.

The drop or particle of the fluid is more or less spherical due to the surface tension of the fluid. Surface tension leads to instability of formations or fluid jets, i. to particle separation and/or spraying. In general, as the temperature of a fluid increases, its surface tension will most often decrease accordingly.

A number of properties and factors affect the size of the droplets or particles and the ability of the fluid to spray after exiting the orifice; these include surface tension, viscosity and density.

Surface Tension: Surface tension tends to stabilize the fluid and prevent it from separating into droplets of particles. Higher surface tension fluids most often form droplets or particles of larger average droplet size or diameter when sprayed.

Viscosity: The viscosity of a fluid has a similar effect on the size or diameter of a droplet or particle formed during spraying as does surface tension. The viscosity of the fluid counteracts agitation, which prevents a large volume of fluid from separating into droplets or particles. Therefore, higher viscosity fluids tend to form droplets or particles of larger average droplet size or diameter when sprayed. In FIG. 14 is a schematic representation of the relationship between viscosity and droplet size when atomization occurs and aerosols are formed.

Density: Density provides the fluid with resistance to acceleration. Therefore, again, higher density fluids are more likely to form droplets or particles of larger average droplet size or diameter when sprayed.

Spray processes

Spray process, i.e. the process that can lead to the formation of aerosols can occur in different ways.

A. Pressure Spray

Also known as airless, airless, hydrostatic, and hydraulic spraying, pressure spraying involves forcing a fluid through a small nozzle or orifice at high pressure, causing the fluid to be expelled at high velocity in a continuous stream or formation. The friction between the fluid and the air separates the flow, which leads first to its separation into fragments, and finally into drops. In FIG. 15 schematically depicts a high velocity water jet 200 that breaks up into droplets 202 in an airless spray system. In such a system, a high-velocity jet of water is emitted from a suitable orifice.

A number of factors affect droplet flow and size, including orifice diameter, environmental conditions (temperature and pressure), and the relative velocity of the fluid and air. In general, the larger the orifice diameter of the nozzle, the larger the average droplet diameter in the spray.

Ambient conditions counteract the spray and tend to separate the fluid flow; this resistance most often partially overcomes the surface tension, viscosity and density of the fluid.

The relative velocity between fluid and air has a large influence on the average droplet diameter in an aerosol. Since the velocity of the fluid discharged through the nozzle opening is pressure dependent, as the pressure of the fluid in the nozzle increases, the average droplet diameter decreases accordingly. Conversely, as the fluid pressure decreases, the velocity decreases and the average droplet diameter increases. In FIG. 16 schematically depicts an airless spray process in which a pressurized fluid is released from a circular orifice into the environment.

B. Air spray

In air atomization, fluid is discharged from nozzle opening 210 at a relatively low velocity and low pressure, and is surrounded by high velocity air 212. Friction between the fluid and air accelerates and separates the fluid flow and results in atomization. Air pressure is the principal source of energy for spraying, and the flow rate of the fluid can be controlled independently of the energy source. Accordingly, air atomization has been applied as a principle technology for atomization in medical inhalation devices. In FIG. 17 schematically depicts such an arrangement with a fluid flow through an orifice in which, when the fluid flow appears, the high velocity air flow surrounds the fluid flow.

C. Centrifugal atomization

In FIG. 18 schematically depicts a rotary or rotary atomizer system 220 (also known as a rotary atomizer). From the nozzle 222, the fluid enters the center of the rotating disc 224 or cone. Centrifugal forces carry the fluid towards the edge of the disk or cone. When it is released from the edge of the disk or cone, the liquid forms jets 226 or sheets, which separate a large volume of liquid into droplets or particles.

At the same rotational speed and at low fluid flow rates, droplets form closer to the edge of the disc than at higher flow rates. The fluid is released from the edge of the disk and moves radially away from the disk in all directions (ie 360°). Accordingly, the droplets may be entrained in the directional airflow or form a funnel, resulting in axial movement of the aerosol.

The flow rate of the fluid entering the rotating disk or cone and the speed of the disk can be controlled independently of each other.

D. Ultrasonic atomization

Ultrasonic atomization is based on an electromechanical device that vibrates at a high frequency. The high speed vibrations cause the fluid to pass over or through the vibrating surface to separate into droplets.

There are a number of types of ultrasonic nebulizers, including ultrasonic wave atomizers and vibrating mesh atomizers.

a. ultrasonic atomizers

A thin layer of liquid is deposited on the resonator surface (typically a resonant surface connected to a piezoelectric element), which then performs mechanical vibrations at a high frequency along direction A. The vibrations result in a standing capillary wave profile characterized by a standing wave length λ when the vibration amplitude exceeds the threshold. When the vibration amplitude increases above the threshold value, the liquid jets separate and the drops come out of the tops/peaks of the capillary waves. In FIG. 19 schematically depicts the operating principles of an ultrasonic atomization system.

As shown schematically in FIG. 20, disk ceramic piezoelectric transducers or resonators convert electrical energy into mechanical energy. The transducers take an electrical input signal in the form of a high frequency signal from a power generator and convert it into a vibration carried out at the same frequency. Two titanium cylinders increase the movement and increase the vibration amplitude of the spray surface.

The nozzle is designed in such a way that the excitation of the piezoelectric crystal located in the transducer leads to the formation of a standing wave along the length of the nozzle. Ultrasonic energy from crystals located along the large diameter of the nozzle body undergoes a staggered transition and amplification as a standing wave as it travels along the length of the nozzle.

Since the wavelength depends on the operating frequency, the dimensions of the nozzle are given by the frequency. In general, high frequency nozzles are smaller, create smaller droplets, and therefore have a lower maximum throughput than nozzles that operate at lower frequencies.

The nozzle is preferably made of titanium due to its good acoustic properties, high tensile strength and excellent corrosion resistance. The liquid enters the spray surface through a supply pipe that runs along the length of the nozzle and absorbs some of the vibration energy, which causes a wave to move in the liquid at the surface. To atomize a liquid, the vibration amplitude of the spray surface must be very carefully controlled. Below the so-called critical amplitude, there is not enough energy to create atomized droplets, and if the amplitude is excessively high, the liquid breaks up and "fragments" of the fluid are ejected (a condition known as "cavitation").

Because ultrasonic atomization is based solely on the liquid being delivered to the atomization surface, the rate at which the liquid is atomized depends solely on the rate at which it is delivered to the surface.

Ultrasonic wave atomizers are particularly well suited for low pressure/low velocity applications and provide an easy to control aerosol spray. Accordingly, since the spraying process is independent of fluid pressure, the volume of liquid sprayed can be controlled by the liquid delivery system to be a couple of microliters or more. In addition, the aerosol spray can be accurately controlled and shaped by entraining the low velocity aerosol spray in the auxiliary airflow to create a spray profile that is so small as to be approximately 1.8 mm wide.

In addition, droplets formed as a result of ultrasonic vibration are characterized by a relatively small average diameter distribution. The median droplet sizes are in the range of 18-68 microns depending on the operating frequency of the nozzle. For example, Sono-tek claims that their ultrasonic spray nozzles can produce a median droplet diameter of approximately 40 microns, with 99.9% of the droplets having a diameter in the range of 5-200 microns.

b. Fixed mesh spraying

In fixed mesh atomizers, a force is applied to the liquid to force it through the fixed mesh, as shown in FIG. 21. An ultrasonic transducer is used to generate vibrations in a liquid and push droplets through a fixed mesh.

c. Vibrating grid spray

Vibrating mesh processes use deformation or vibration of the mesh to force fluid through the mesh, as shown schematically in FIG. 22. Typically, an annular piezoelectric element that is in contact with the mesh is used to create vibrations around the mesh. The openings in the mesh are characterized by a conical structure, with the largest contact cross section of the cone adjacent to the liquid reservoir. The surface of the mesh deforms in the direction of the liquid reservoir, thus pumping and loading liquid into the openings. Deformation of the surface on the other side of the mesh allows drops to be released through the openings.

The size of the droplets and the resulting aerosol depends on the size of the openings in the grid and the physiomechanical properties of the liquid. However, one disadvantage of vibrating mesh devices is that the openings in the mesh can become clogged, in particular with solutions that are too viscous to pass through the mesh.

More details on various techniques for generating aerosols by spraying can be found in the following publications.

"Deposition of Inhaled Particles in the Lungs", Ana Fernandez Tena, Pere Casan Clara; ARCHOVOS DE BRONCONEUMOLGIA, 2012; 48(7) 240-246.

"The mesh nebuliser: a recent technical innovation for aerosol delivery", L. Vecellio; breathe, March 2006, Volume 2, No. 3, pp. 253-260.

"Ultrasonic Atomization Technology for Precise Coatings", Sono-Tek Corporation at http://www.sono-tek.com/ultrasonic-nozzle-technology/and downloaded 23 May 2017.

"High-Frequency Ultrasonic Atomization with Pulsed Excitation", A. Lozano, H. Amaveda, F. Barreras, X. Jorda, M. Lozano; Journal of Fluid Engineering, November 2003, Vol. 125, 941-945.

"Swirl, T-Jet and Vibrating-Mesh Atomizers", M. Eslamian, Nasser Ashgriz; ResearchGate; http://www.researchgate.net/publications/251220009. December 2011.

The techniques, methods, and processes for spraying liquids to generate aerosols described above may be adapted or modified for use in one or more embodiments in accordance with the present invention.

In view of the above description, it will be apparent to a person skilled in the art that various modifications may be made within the scope of the present invention. For example, the coil spring shown in Fig. 4 may be a leaf spring or other elastically deformable component such as a rubber plug.

The terms "fluid", "fluid stream", "air", and "air stream" refer to any suitable fluid composition, including, without limitation, a gas or gas mixture with atomized, vaporized, nebulised, vented, or otherwise gassed. phase or aerosol form of the active ingredient.

The term "active ingredient" includes the terms "physiologically active" or "bioactive" as well as any chemicals or combination of chemicals with the desired properties to improve an inhalable aerosol that is suitable for adsorption upon absorption into media suitable for use in the present invention. In addition, a functional component in non-liquid form, which may be present, for example, in crystalline, powdered or other solid form, can replace the functional component without departing from the scope of the present invention.

In the context of the present invention, any reference to "one embodiment" or "an embodiment" means that a particular element, feature, structure, or characteristic described in connection with an embodiment is included in at least one embodiment. The phrase "according to one embodiment" or the phrase "according to an embodiment" at various places in the specification do not necessarily all refer to the same embodiment.

In the context of the present invention, the terms "comprises", "comprising", "includes", "comprising", "characterized", "characterized" or any other variations thereof are not limiting. For example, a process, method, article, or device that contains a list of elements is not necessarily limited to only those elements, but may include other elements that are not explicitly listed or inherent in such a process, method, article, or device. Also, unless explicitly stated otherwise, "or" refers to an inclusive or non-exclusive or. For example, state A or B is satisfied by any of the following: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and both A and B are true (or present).

In addition, the singular forms are used to describe the plural of the elements and components of the present invention. This is done simply for convenience and for a general understanding of the present invention. This description should be read as including one or at least one element, but the singular also includes the plural, unless it is clear that the opposite is meant.

The scope of this disclosure includes any new feature or combination of features disclosed therein, either explicitly or implicitly, or any generalization thereof, whether it relates to the claimed invention or whether it eliminates any or all of the problems solved by the present invention. Applicant hereby notifies that a new claim may be formulated on these grounds during the consideration of this application or any other additional application derived from this one. In particular, with reference to the appended claims, features from the dependent claims may be combined with features from the independent claims, and features from the corresponding independent claims may be combined in any suitable manner, not just in the specific combinations listed in the claims. .

Claims (59)

1. An aerosol delivery device comprising a first aerosol generating unit for generating a first aerosol from a first aerosol precursor and introducing said first aerosol into a first fluid flow channel, said first aerosol having particle sizes conducive to their penetration into the lungs, a second aerosol generating unit for generating a second aerosol from the second aerosol precursor and introducing the second aerosol into the channel for the flow of the second fluid, the second aerosol being characterized by particle sizes that prevent their penetration into the lungs, the second aerosol is transmitted into at least one of the oral cavity of the mammal and the nasal cavity of the mammal, and the second aerosol contains an active ingredient for activating at least one of one or more taste receptors in said oral cavity and one or more olfactory receptors in said nasal cavity, in which said block the second aerosol generating unit comprises a venturi for issuing and aerosolizing the second aerosol precursor in the second aerosol generating unit, the second aerosol precursor being a liquid. 2. The aerosol delivery device of claim 1, wherein the second aerosol is characterized by at least one of the following: particle sizes that prevent their penetration into the trachea; particle sizes that prevent their penetration into the larynx; particle sizes that prevent their penetration into the laryngopharynx; and particle sizes that prevent their penetration into the oropharynx. 3. An aerosol delivery device according to claim 1 or 2, wherein the second aerosol has a mass median aerodynamic particle diameter that is greater than or equal to 15 μm, in particular greater than 30 μm, more particularly greater than 50 μm, even more particularly greater than 60 μm, and even more preferably greater than 70 µm. 4. An aerosol delivery device according to any one of the preceding claims, wherein the second aerosol has a maximum mass median aerodynamic particle diameter that is less than 300 microns, in particular less than 200 microns, even more specifically less than 100 microns. 5. An aerosol delivery device according to any one of paragraphs. 1-4, wherein said first aerosol precursor contains components such that the first aerosol contains a lung-deliverable active ingredient. 6. The aerosol delivery device of claim 5, wherein the first aerosol has a mass median aerodynamic particle diameter that is less than or equal to 10 µm, preferably less than 8 µm, more preferably less than 5 µm, even more preferably less than 1 µm. 7. An aerosol delivery device according to any one of the preceding claims, wherein said first aerosol generating unit is configured to heat said first aerosol precursor. 8. An aerosol delivery device according to any one of the preceding claims, wherein said first aerosol generating unit is configured to mix said first aerosol precursor. 9. An aerosol delivery device according to any one of the preceding claims, wherein said first fluid flow path further receives said first aerosols from a first aerosol inlet of said device. 10. The aerosol delivery device of claim 9, wherein said first aerosol inlet is configured to deliver said first aerosol to said first fluid flow channel. 11. An aerosol delivery device according to any one of the preceding claims, wherein said second fluid flow path further receives said second aerosol from a second aerosol inlet of said device. 12. The aerosol delivery device of claim 11, wherein said second aerosol inlet is configured to deliver said second aerosols to said second fluid flow channel. 13. An aerosol delivery device according to any one of the preceding claims, wherein said first fluid conduit and said second fluid flow conduit are connected. 14. An aerosol delivery device according to any one of paragraphs. 1-12, in which the specified channel for the first fluid and the specified channel for the flow of the second fluid pass next to each other. 15. The aerosol delivery device of claim 14, wherein said second fluid flow passage is located along a longitudinal axis of said first fluid flow passage. 16. An aerosol delivery device according to claim 14 or 15, wherein said first fluid flow path is adjacent to a gas inlet of said device and said second fluid flow path is adjacent to an aerosol outlet of said device. 17. An aerosol delivery device according to claim 14 or 15, wherein said second fluid flow path is adjacent to a gas inlet of said device and said first fluid flow path is adjacent to an aerosol outlet of said device. 18. The aerosol delivery device of claim 12, wherein said second fluid flow passage is coaxial with said first fluid flow passage. 19. The aerosol delivery device of claim 12, wherein said second fluid flow conduit is adjacent to said first fluid flow conduit in a side-by-side configuration therewith. 20. An aerosol delivery device according to claim 18 or 19, wherein said first fluid flow passage is separated from said second fluid flow passage by a wall-like element. 21. The aerosol delivery device according to claim 20, in which the specified channel for the flow of the first fluid contains a first housing that limits the specified flow of the fluid, and the specified channel for the flow of the second fluid contains a second housing that limits the specified flow of the second fluid, the specified first the housing is designed to receive said first aerosol, and said second housing is designed to receive said second aerosol. 22. The aerosol delivery device of claim 21, wherein said first housing comprises said first aerosol generating unit and/or said second housing comprises said second aerosol generating unit. 23. An aerosol delivery device according to claim 21 or 22, wherein said first housing comprises a removable module of said delivery device. 24. An aerosol delivery device according to any one of paragraphs. 21-23, wherein said first housing contains a plug-in module for said delivery device. 25. An aerosol delivery device according to any one of paragraphs. 21-24, wherein said first body contains a refillable module of said delivery device. 26. An aerosol delivery device according to any one of paragraphs. 21-25, wherein said second body contains a removable module of said delivery device. 27. An aerosol delivery device according to any one of paragraphs. 21-26, wherein said second body contains a plug-in module for said delivery device. 28. An aerosol delivery device according to any one of paragraphs. 21-27, wherein said second body contains a refillable module of said delivery device. 29. An aerosol delivery device according to any one of the preceding claims, wherein said first aerosol precursor contains nicotine or a nicotine derivative or nicotine analogue. 30. The aerosol delivery device of claim 29, wherein said first aerosol precursor comprises a lung-deliverable active ingredient that is a free salt of nicotine, comprising at least one of the following: nicotine hydrochloride; nicotine dihydrochloride; nicotine monotartrate; nicotine bitartrate; nicotine bitartrate dihydrate; nicotine sulfate; nicotine-zinc chloride monohydrate and nicotine salicylate. 31. The aerosol delivery device according to any one of the preceding paragraphs, in which the specified second aerosol is transmitted to activate at least one of the following: one or more taste buds in the specified oral cavity; and one or more olfactory receptors in said nasal cavity. 32. An aerosol delivery device according to any one of the preceding paragraphs, wherein said first aerosol generating unit is configured to generate a first aerosol from a first aerosol precursor comprising at least one of the following: glycol; polyglycol and water. 33. An aerosol delivery device according to any one of the preceding claims, wherein said second aerosol generating unit is configured to introduce said second aerosol into said fluid flow channel within a predetermined period of time after said first aerosol generating unit is activated. 34. An aerosol delivery device according to any one of the preceding claims, wherein said second fluid flow path comprises at least one baffle configured such that a portion of said second aerosol collides with said baffle. 35. An aerosol delivery device according to any one of paragraphs. 11-34, wherein said second aerosol inlet is configured to introduce a second aerosol with a mass median aerodynamic diameter of the particles preventing their entry into the lungs. 36. An aerosol delivery device according to any one of paragraphs. 1-35, wherein said second aerosol generating unit comprises a piezoelectric element for issuing and aerosolizing a second aerosol precursor in the second aerosol generating unit. 37. An aerosol delivery device according to any one of paragraphs. 1-35, wherein said second aerosol generation unit comprises a precursor substrate for the second aerosol precursor, wherein the precursor substrate comprises a hydrophobic surface. 38. An aerosol delivery device according to any one of paragraphs. 1-35, wherein said second aerosol generation unit comprises a plurality of capillary tubes configured to draw a second aerosol precursor from a second aerosol precursor reservoir to a free end of the plurality of capillary tubes. 39. The aerosol delivery device of claim 38, wherein the free end of the plurality of capillary tubes is hydrophobic. 40. An aerosol delivery device according to any one of the preceding claims, wherein said first aerosol has a particle size suitable for deep lung penetration. 41. An aerosol delivery device according to any one of the preceding claims, wherein said first aerosol has a mass median aerodynamic particle diameter of less than 2 microns. 42. An aerosol delivery device according to any one of paragraphs. 29-41, wherein said second fluid flow conduit terminates in the mouthpiece of the second fluid flow conduit. 43. An aerosol delivery device according to any one of paragraphs. 29-42, wherein said first fluid flow conduit terminates in the mouthpiece of the first fluid flow conduit. 44. An aerosol delivery device according to any one of paragraphs. 20-43, in which said channels for the flow of the first and second fluids end in a combined mouthpiece. 45. The aerosol delivery device of claim 44, wherein said combined mouthpiece comprises separate channels corresponding to said first and second fluid flow channels, respectively. 46. Device for aerosol according to any one of paragraphs. 13, 29-42, in which said combined channels for the flow of the first and second fluids end in the mouthpiece. 47. An aerosol delivery device according to any one of the preceding claims, wherein said active ingredient comprises a physiologically active ingredient. 48. A first fluid flow passage housing for an aerosol delivery device according to any one of the preceding claims. 49. The body of the channel for the flow of the first fluid according to p. 48, containing the specified precursor of the first aerosol. 50. The body of the channel for the flow of the first fluid according to p. 48 or 49, containing the specified block generating the first aerosol. 51. The body of the channel for the flow of the second fluid for the aerosol delivery device according to any one of paragraphs. 1–47. 52. A second fluid flow channel body according to claim 51, comprising said second aerosol precursor. 53. The body of the channel for the flow of the second fluid according to p. 51 or 52, containing the specified block generating the second aerosol. 54. A set of parts for the aerosol delivery device according to any one of paragraphs. 1-47, containing the body of the channel for the flow of the first fluid according to any one of paragraphs. 48-50 and the body of the channel for the flow of the second fluid according to any one of paragraphs. 51–53.

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