RU2000121C1 - Agent for wound treatment - Google Patents

Abstract

The invention relates to the field of medicine and is intended for the treatment of wounds in combined radiation-traumatic injury. The purpose of the invention is to increase the effectiveness of the treatment of wounds in radiation-traumatic injury. For this, the product contains a copolymer of vinyl alcohol with vinyl acetate and vinyl glutarate (BC-VA-VG) and a chitin-chitosan complex (hitat) from the biomass of mycelial fungi in the ratio of the high parts of BC-VA-VG - 90-10 . hitat - 10-90. The proposed tool provides purification of the wound from purulent necrotic masses, as well as salts of heavy metals and radionuclides and prevents their migration into the bloodstream. 2 tab.

Description

The invention relates to medicine and is intended for the treatment of wounds with combined radiation-traumatic injury.

A wound healing agent is known which is a film of a polymer synthetic material (Aseplen film). Aseplen film is designed to close a wound in order to protect it from infection and injury.

However, it does not have the ability to sufficiently absorb wound fluid and is absolutely ineffective in injuries associated with radiation damage.

The closest to the proposed tool in technical essence is a powdery draining sorbent

based on a copolymer of vinyl alcohol with vinyl acetate and vinyl glutarate (BC-VA-VG). possessing the ability to absorb wound fluid, ensures the outflow of microbial flora and metabolites from the wound, relieves inflammation and relieves swelling, has a prolonged draining effect, hemostatic effect, stimulates microcirculation in the wound, and has a beneficial effect on local immune processes in the wound.

However, this tool is completely ineffective in combined radiation-traumatic injury.

Vinyl alcohol copolymer with; i-nyl acetate acetate and vinyl glutarate of the general formula

u o o o o

go

about

- (sn / -snIsng-C1-Op

0

1

CH

OH

(sn2

CH

0

OH

CH3

I

0

1

(-CH2-CH) - (CH2-CH) m- (CH2-Cr-Op

where n m + p 30-125;

m-25-125;

p is 0-22 or

P / (p + m) 0-0.2.

The aim of the invention is to provide a draining sorbent with an effective therapeutic effect in the treatment of wounds from radiation (radiation) damage.

The goal is achieved by the fact that the (hydrophilic) water-absorbing sorbent from a cross-linked synthetic polymer (polyvinyl alcohol or its copolymers with Wii-acetate, vinyl glutarate) is combined in a composition with a natural cross-linked polymer from the polysaccharide class (chitosan, hitate, chitin) with a ratio of components 9: 1 -1: 9 parts by weight

The compositions of this invention are prepared by adding a crosslinked polysaccharide (chitate) to an aqueous solution of a synthetic polymer (PVA) followed by crosslinking the synthetic polymer with glutaraldehyde at an appropriate pH, grinding the resulting hydrogel in an aqueous medium, dehydrating the powder in an organic solvent, filtering and drying the finished product.

The proposed composition differs from the prototype (Gelevin) in that it has the ability not only to absorb wound fluid, drain the wound and ensure the outflow of microflora, but also has a pronounced therapeutic effect in treating wounds from radiation damage due to the selective sorption of radioactive nuclides (see table 2).

When the resulting composition is applied to the wound, it swells in the wound exudate, due to which the wound is cleansed of purulent-necrotic masses, the edema is removed, and relief is eliminated

5

0

5

0

5

0

5

0

5

nor, improvement of microcirculation in the wound and at the same time sorption of heavy and radioactive metal ions from the wound by chitates and prevention of their migration into the bloodstream and underlying tissues. The presence of a double therapeutic effect contributes to the rapid cleansing and healing of wounds with radiation damage.

Example 1. To 90 g of an aqueous PVA solution with a polymer concentration of 5% (MM 60-80 thousand)), 0.5 g of chitate powder was added. 0.735 g of a solution of glutaraldehyde with a concentration of 24.5% and hydrochloric acid to pH 1-2. The mixture was stirred and allowed to stand for 20 hours at, ° 5 ° C. The resulting hydrogel is ground in an aqueous phase in a stirred reactor to a suspension, the ground mass is washed with water to a neutral pH, filtered from the liquid phase and dried.

The water absorption capacity of the resulting composition was 17.0 g / g in saline, 16.1 g / g. sorption of heavy metals (see table 2).

Examples 2-5 are similar to example 1.

Example b. 0.5 g of chitate powder, 0.735 g of glutaraldehyde solution with a concentration of 24.5% are added to 90 g of an aqueous solution of a BC-VA copolymer (content of VA units of 22 mol%) with a polymer concentration of 5% (MM 60 thousand). and hydrochloric acid to a pH of 1-2. The mixture is stirred and allowed to stand at 25 ° C for 25 hours. The resulting hydrogel is crushed in an aqueous or aqueous ethanol medium in a stirred reactor until suspension, the crushed mass is neutralized with mineral acid, washed with water, filtered from the liquid phase and dispersed in ethanol or acetone. The separated powder is filtered off and dried.

Water absorption of the composition 21 g / g; in saline, 19.0 g / g; sorption of heavy metal ions see table 2.

Examples 7-9 are similar to example 6.

The data for examples 1-8 are presented in table 1.

Claims (1)

The claims A water-absorbing polymer treatment for wounds, characterized in that. in order to increase the efficiency of wound treatment in radiation-traumatic injuries, it contains a copolymer of vinyl alcohol with vinyl acetate and vinyl glutarate (BC-VA-HH) and a chitin-chitosan complex (heath) from mycelial fungi biomass in the following ratio, parts by weight . BC-VA-VG10-90 Hit10-90