RU2000111472A

RU2000111472A - Aminobutyric Acid Derivatives

Info

Publication number: RU2000111472A
Application number: RU2000111472/04A
Authority: RU
Inventors: Кандзи ТАКАХАСИ; Тсунейуки СУГИУРА
Original assignee: Оно Фармасьютикал Ко. Лтд.
Priority date: 1997-10-09
Filing date: 1998-10-07
Publication date: 2002-02-27

Claims

1. Derived aminobutyric acid of the formula (I)

where R ¹ represents —COOR ¹⁰ , —CONHOR ¹⁰ , —CONHNHR ¹⁰ , - (CH ₂ ) _n SR ⁵⁰ or —YP (OR ⁵¹ ) ₂ ;
R ¹⁰ represents (i) hydrogen, (ii) C1-8 alkyl, (iii) phenyl, (iv) C1-8 alkyl substituted with phenyl or C1-8 alkoxy, or (v) hydroxycarbonyl substituted with phenyl, benzyl or C1- 8 alkyl;
n is 0-3;
R ⁵⁰ represents (i) hydrogen, (ii) C1-8 alkyl, (iii) -COR ⁵² , where R ⁵² is C1-8 alkyl or phenyl; or (iv) -SR ⁵³ , where R ⁵³ is hydrogen, C1-8 alkyl or phenyl;
R ⁵¹ represents hydrogen, C1-8 alkyl or phenyl;
Y represents a single bond, —CH ₂ - or —O—;
each of R ² , R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently is (1) hydrogen, (2) C1-8 alkyl, (3) C2-8 alkenyl, (4) -OR ¹¹ , ( 5) -SR ¹¹ , (6) -NR ¹² R ¹³ , (7) -COR ¹⁴ , (8) Cycle 1, (9) C1-8 alkyl substituted with -OR ¹¹ , -SR ¹¹ , -NR ¹² R ¹³ , —COR ¹⁴ , guanidino or Cycle 1, or (10) C2-8 alkenyl substituted with —OR ¹¹ , —SR ¹¹ , —NR ¹² R ¹³ , —COR ¹⁴ , guanidino or Cycle 1, or R ³ and R ⁴ , taken together represent C1-8 alkylene, R ⁵ and R ⁶ taken together represent C1-8 alkylene, R ³ and R ⁶ taken together represent C1-8 alkylene, R ² and R ³ taken together represent C2 -8 alkylene, R ⁴ and R ⁵ taken together represent C2-8 alkylene or R ⁶ and R ⁷ taken in naturally, C2-8 is alkylene, or R ² is 2-propynyl, and each of R ³ , R ⁴ , R ⁵ , R ⁶ and R ^{7 is} independently (1) hydrogen, (2) C1-8 alkyl, (3 ) C2-8 alkenyl, (4) -OR ¹¹ , (5) -SR ¹¹ , (6) -NR ¹² R ¹³ , (7) -COR ¹⁴ , (8) Cycle 1, (9) C1-8 alkyl, substituted -OR ¹¹ , -SR ¹¹ , -NR ¹² R ¹³ , -COR ¹⁴ , guanidino or Cycle 1, or (10) C2-8 alkenyl, substituted -OR ¹¹ , -SR ¹¹ , -NR ¹² R ¹³ , -COR ¹⁴ , guanidino or Cycle 1, or R ³ and R ⁴ taken together represent C1-8 alkylene, R ⁵ and R ⁶ taken together represent C1-8 alkylene, R ³ and R ⁶ taken together represent C1- 8 alkylene, R ⁴ and R ⁵ taken together represent C2-8 alkylene or R ⁶ and R ⁷ taken together represent C2-8 alkylene;
where Cycle 1 is a carbocyclic or heterocyclic ring, and these carbocyclic ring and heterocyclic ring may be substituted with one or more (i) C1-8 alkyl, (ii) C1-8 alkoxy, (iii) nitro, (iv) guanidino, ( v) amidino, (vi) a halogen atom, (vii) nitrile, (viii) hydroxy, (ix) benzyloxy, (x) -NR ¹⁰¹ R ¹⁰² , where each of R ¹⁰¹ and R ¹⁰² independently represents hydrogen or C1-8 alkyl , (xi) -COOR ¹⁰³ , where R ¹⁰³ is hydrogen or C1-8 alkyl, (xii) trifluoromethyl, (xiii) trifluoromethyloxy, (xiv) phenyl, (xv) phenyl substituted with C1-8 alkyl or C1-8 alkoxy , (xvi) fen hydroxy, (xvii) phenylsulfonyl, (xviii) C1-8 alkyl substituted by phenyl or nitrile, (xix) heterocyclic ring, (xx) keto, and (xxi) C1-8 alkoxy substituted by -CONR ¹⁰⁴ R ^105, wherein each of R ¹⁰⁴ and R ¹⁰⁵ independently represent hydrogen, C1-8 alkyl or phenyl;
R ¹¹ represents (i) hydrogen, (ii) C1-8 alkyl, (iii) Cycle 1 or (iv) -COR ¹⁸ , or C1-8 alkyl substituted with -OR ¹⁵ , -SR ¹⁵ , -NR ¹⁶ R ¹⁷ , -COR ¹⁸ , guanidino or Cycle 1;
R ¹⁵ represents hydrogen, C1-8 alkyl, Cycle 1 or C1-8 alkyl, substituted by cycle 1 or C1-8 alkoxy;
R ¹⁶ represents hydrogen or C1-8 alkyl;
R ¹⁷ represents hydrogen, C1-8 alkyl or —COR ¹⁹ , where R ¹⁹ represents C1-8 alkyl, Cycle 1 or C1-8 alkyl substituted by cycle 1;
R ¹⁸ represents hydroxy, C 1-8 alkyl, C 1-8 alkoxy or -NR ²⁰ R ²¹ where each of R ²⁰ and R ²¹ independently represents hydrogen, C 1-8 alkyl. Cycle 1 or C1-8 alkyl substituted with cycle 1;
R ¹² represents hydrogen, C1-8 alkyl. Cycle 1 or C 1-8 alkyl substituted with cycle 1;
R ¹³ is hydrogen, C1-8 alkyl, Cycle 1, C1-8 alkyl substituted with ring 1, or —COR ²² , where R ²² is C1-8 alkyl. Cycle 1 or C1-8 alkyl substituted with cycle 1;
R ¹⁴ is hydroxy, C1-8 alkyl, C1-8 alkoxy, Cycle 1, C1-8 alkyl substituted by ring 1, or —NR ²³ R ²⁴ , where each of R ²³ and R ²⁴ independently represents (i) hydrogen , (ii) C1-8 alkyl, (iii) Cycle 1 or (iv) C1-8 alkyl substituted with cycle 1 or hydroxy;
(1) R ⁸ represents 1) hydrogen, 2) C1-8 alkyl, 3) C1-8 alkoxycarbonyl, 4) C1-8 alkyl substituted with -OR ²⁶ , -SR ²⁶ , -NR ²⁷ R ²⁸ or -COR ²⁹ or 5) C1-8 alkoxycarbonyl substituted with ring 2 and R ⁹ is

or (2) R ⁸ represents

or

and
R ⁹ represents 1) C1-8 alkyl, 2) C1-8 alkoxy, 3) C1-8 alkoxy, substituted by a ring 2, 4) C1-8 alkyl, substituted -OR ²⁶ , -SR ²⁶ , -NR ²⁷ R ²⁸ , -COR ²⁹ or Cycle 2, or 5)

where Cycle 2 is a carbocyclic ring or heterocyclic and these carbocyclic ring and heterocyclic ring may be substituted with one or more (i) C1-8 alkyl, (ii) C1-8 alkoxy, (iii) nitro, (iv) guanidino, (v ) amidino, (vi) a halogen atom, (vii) nitrile, (viii) hydroxy, (ix) benzyloxy, (x) -NR ²⁰¹ R ²⁰² , where each of R ²⁰¹ and R ²⁰² independently represents hydrogen or C1-8 alkyl , (xi) -COOR ²⁰³ , where R ²⁰³ is hydrogen or C1-8 alkyl, (xii) trifluoromethyl, (xiii) trifluoromethyloxy, (xiv) phenyl, (xv) phenyl substituted with C1-8 alkyl or C1-8 alkoxy , (xvi) enyloxy, (xvii) phenylsulfonyl, (xviii) C1-8 alkyl substituted by phenyl or nitrile, (xix) heterocyclic ring, (xx) keto, and (xxi) C1-8 alkoxy substituted by -CONR ²⁰⁴ R ^205, wherein each of R ²⁰⁴ and R ²⁰⁵ independently represents hydrogen, C1-8 alkyl or phenyl;
R ²⁶ represents hydrogen, C1-8 alkyl, Cycle 2 or C1-8 alkyl, substituted by cycle 2;
R ²⁷ represents hydrogen, C1-8 alkyl, Cycle 2 or C1-8 alkyl, substituted by cycle 2;
R ²⁸ represents hydrogen, C 1-8 alkyl, Cycle 2, C 1-8 alkyl substituted by cycle 2, or -COR ³⁰ , where R ³⁰ represents C 1-8 alkyl, Cycle 2 or C 1-8 alkyl substituted by cycle 2;
R ²⁹ represents hydroxy, C 1-8 alkyl, Cycle 2, C 1-8 alkyl, substituted by cycle 2, or NR ³¹ R ³² , where each of R ³¹ and R ³² independently represents hydrogen, C 1-8 alkyl, Cycle 2 or C1-8 alkyl substituted with ring 2;

represents a carbocyclic or heterocyclic ring;
R ²⁵ represents —EG;
E represents 1) a single bond, 2) -CONR ³³ -, 3) -NR ³³ CO-, 4) -CO-O-, 5) -O-CO-, 6) -NR ³³ -CO-NR ³⁴ -, 7) -CO-CH ₂ -, 8) -CO-, 9) -O-CO-NR ³³ -, 10) -NR ³³ -CO-O-, 11) -O-СО-О-, 12) - CS-NR ³³ -, 13) -NR ³³ -CS-, 14) -CS-O-, 15) -O-CS-, 16) -NR ³³ -CS-R ³⁴ -, 17) -CS-CH ₂ -, 18) -CS-, 19) -O-CS-NR ³³ -, 20) -NR ³³ -CS-O-, 21) -O-CS-O-, 22) -CH ₂ -CH ₂ -, 23) -HC = CH-,

25) -SO ₂ -NR ³³ -, 26) -NR ³³ -SO ₂ -, 27) -SO ₂ -CH ₂ - or 28) -CH ₂ -SO ₂ -;
each of R ³³ and R ³⁴ independently represents hydrogen, C1-8 alkyl, cycle 3 or C1-8 alkyl substituted with cycle 3;
Cycle 3 is a carbocyclic ring or heterocyclic ring, and these carbocyclic ring and heterocyclic ring may be substituted with one or more (i) C1-8 alkyl, (ii) C1-8 alkoxy, (iii) nitro, (iv) guanidino, ( v) amidino, (vi) a halogen atom, (vii) nitrile, (viii) hydroxy, (ix) benzyloxy, (x) -NR ³⁰¹ R ³⁰² , where each of R ³⁰¹ and R ³⁰² independently represents hydrogen or C1-8 alkyl , (xi) -COOR ³⁰³ , where R ³⁰³ is hydrogen or C1-8 alkyl, (xii) trifluoromethyl, (xiii) trifluoromethyloxy, (xiv) phenyl, (xv) phenyl substituted with C1-8 alkyl or C1-8 alkoxy , (xvi) f enyloxy, (xvii) phenylsulfonyl, (xviii) C1-8 alkyl substituted with phenyl or nitrile, (xix) heterocyclic ring, (xx) keto and (xxi) C1-8 alkoxy substituted with -CONR ³⁰⁴ R ³⁰⁵ , where each R ³⁰⁴ and R ³⁰⁵ independently represents hydrogen, C1-8 alkyl or phenyl;
G represents 1) hydrogen, 2) C1-8 alkyl, 3) Cycle 4, 4) -OR ³⁵ , 5) -SR ³⁵ , 6) halogen atom, 7) nitro, 8) nitrile, 9) -NR ³⁶ R ³⁷ 10) —COR ³⁸ , 11) C1-8 alkyl substituted with cycle 4, —OR ³⁵ , —SR ³⁵ , halogen atom, —NR ³⁶ R ³⁷ or —COR ³⁸ ;
where Cycle 4 is a carbocyclic ring or heterocyclic ring, and these carbocyclic ring and heterocyclic ring may be substituted with one or more (i) C1-8 alkyl, (ii) C1-8 alkoxy, (iii) nitro, (iv) guanidino, (v) amidino, (vi) a halogen atom, (vii) nitrile, (viii) hydroxy, (ix) benzyloxy, (x) -NR ⁴⁰¹ R ⁴⁰² , where each of R ⁴⁰¹ and R ⁴⁰² independently represents hydrogen or C1- 8 alkyl, (xi) -COOR ⁴⁰³ , where R ⁴⁰³ is hydrogen or C1-8 alkyl, (xii) trifluoromethyl, (xiii) trifluoromethyloxy, (xiv) phenyl, (xv) phenyl substituted with C1-8 alkyl or C1- 8 alkoc si, (xvi) phenyloxy, (xvii) phenylsulfonyl, (xviii) C1-8 alkyl substituted with phenyl or nitrile, (xix) heterocyclic ring, (xx) keto and (xxi) C1-8 alkoxy substituted with -CONR ⁴⁰⁴ R ⁴⁰⁵ where each of R ⁴⁰⁴ and R ⁴⁰⁵ independently represents hydrogen, C1-8 alkyl or phenyl;
R ³⁵ represents hydrogen, C1-8 alkyl, C1-8 alkoxy, ring 4 or C1-8 alkyl, substituted by cycle 4;
R ³⁶ represents hydrogen, C1-8 alkyl, Cycle 4 or C1-8 alkyl, substituted by cycle 4;
R ³⁷ is hydrogen, C1-8 alkyl, cycle 4, C1-8 alkyl substituted with cycle 4, or —COR ³⁹ , where R ³⁹ is C1-8 alkyl, cycle 4 or C1-8 alkyl substituted with cycle 4;
R ³⁸ is hydroxy, C1-8 alkyl, cycle 4, C1-8 alkyl substituted with cycle 4, or —NR ⁴⁰ R ⁴¹ , where each of R ⁴⁰ and R ^{41 is} independently hydrogen, C1-8 alkyl, Cycle 4 or C1-8 alkyl substituted with ring 4; or —EG, taken together, are C1-4 alkylidene; p is 1-5;
M represents C1-8 alkylene;
J represents a single bond, an oxygen atom, a sulfur atom or —NR ⁴² -, where R ⁴² represents hydrogen or C1-8 alkyl;

can be a double bond when removing hydrogen, when two of R ² , R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ that are not bonded to the same carbon atom and are bonded to adjacent carbon atoms are hydrogens, so condition that

is not a double bond when R ³ and R ⁴ taken together are C1-8 alkylene, R ⁵ and R ⁶ taken together are C1-8 alkylene or R ³ and R ⁶ taken together are C1 -8 alkylene;
or its non-toxic salt.

2. The compound according to claim 1, in which each of R ² , R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently represents (1) hydrogen, (2) C1-8 alkyl, (3) C2-8 alkenyl, (4) -OR ¹¹ , (5) -SR ¹¹ , (6) -NR ¹² R ¹³ , (7) -COR ¹⁴ , (8) Cycle 1, (9) C1-8 alkyl substituted with -OR ¹¹ , -SR ¹¹ , -NR ¹² R ¹³ , -COR ¹⁴ , guanidino or Cycle 1, or (10) C2-8 alkenyl substituted with -OR ¹¹ , -SR ¹¹ , -NR ¹² R ¹³ , -COR ¹⁴ , guanidino or Cycle 1, or R ³ and R ⁴ taken together represent C1-8 alkylene, R ⁵ and R ⁶ taken together represent C1-8 alkylene, R ³ and R ⁶ taken together represent C1-8 alkylene, R ² and R ³ taken together represent C2-8 alkylene, R ⁴ and R ⁵ taken together represent C2-8 alkylene or R ⁶ and R ⁷ taken together represent C2-8 alkylene.

3. The compound according to claim 1, in which R ² represents 2-propynyl, and each of R ³ , R ⁴ , R ⁵ , R ⁶ and R ⁷ independently represents (1) hydrogen, (2) C1-8 alkyl, (3) C2-8 alkenyl, (4) -OR ¹¹ , (5) -SR ¹¹ , (6) -NR ¹² R ¹³ , (7) -COR ¹⁴ , (8) Cycle 1, (9) C1-8 alkyl substituted with —OR ¹¹ , —SR ¹¹ , —NR ¹² R ¹³ , —COR ¹⁴ , guanidino or Cycle 1, or (10) C2-8 alkenyl, substituted with —OR ¹¹ , —SR ¹¹ , —NR ¹² R ¹³ , —COR ¹⁴ , guanidino or Cycle 1, or R ³ and R ⁴ taken together represent C1-8 alkylene, R ⁵ and R ⁶ taken together represent C1-8 alkylene, R ³ and R ⁶ taken together represent C1-8 alkylene, R ⁴ and R ⁵ taken together represent C2-8 alkylene or R ⁶ and R ⁷ taken together, represent C2-8 alkylene.

4. The compound of claim 1, wherein R ¹ is —COOR ¹⁰ .

5. The compound of claim 1, wherein R ¹ is —CONHOR ¹⁰ .

6. The compound of claim 1, wherein R ¹ is —CONHNHR ¹⁰ .

7. The compound of claim 1, wherein R ¹ is - (CH ₂ ) _n SR ⁵⁰ .

8. The compound of claim 1, wherein R ¹ is —YP (OR ⁵¹ ) ₂ .

9. The compound according to claim 2, selected from
(1) 4- (N- (4- (Benzofuran-2-yl) phenylcarbonyl) amino) butyric acid,
(2) 4- (N- (4-Methylphenylcarbonyl) amino) butyric acid,
(3) 4- (N- (4-Butyloxyphenylcarbonyl) amino) butyric acid,
(4) 4- (N- (3-Butyloxyphenylcarbonyl) amino) butyric acid,
(5) 4- [N- [4- (2- (4-Methylphenyl) ethynyl) furan-2-ylcarbonyl] amino] butyric acid,
(6) 4- (N- (4- (Pyrrol-1-yl) phenylcarbonyl) amino) butyric acid,
(7) 4- (N- (trans-4-methylcyclohexylcarbonyl) amino) butyric acid,
(8) 4- (N- (4- (3-Methoxy-1-propinyl) phenylcarbonyl) amino) butyric acid,
(9) 4- (N- (4-Butylphenylcarbonyl) amino) butyric acid,
(10) 4- (N- (Benzofuran-2-ylcarbonyl) amino) butyric acid,
(11) 4- [N- [4- (2- (4-Chlorophenyl) ethenyl) phenylcarbonyl] amino] butyric acid,
(12) 4- [N- [4- (2- (4- (Imidazol-1-yl) phenyl) ethynyl) phenylcarbonyl] amino] butyric acid,
(13) 4- (N- (trans-4-propylcyclohexylcarbonyl) amino) butyric acid,
(14) 4- [N- [4- (2- (4-Methylphenyl) ethynyl) phenylcarbonyl] amino] butyric acid,
(15) 4- [N- [4 - ((4-Bromophenyl) aminosulfonyl) phenylcarbonyl] amino] butyric acid,
(16) 4- [N- (4-Cyclohexylphenylcarbonyl) amino] butyric acid,
(17) 4- [N- [4- (4-Propylphenyl) phenylcarbonyl] amino] butyric acid,
(18) 4- [N- [4- (4-Hydroxyphenyl) phenylcarbonyl] amino] butyric acid,
(19) 4- [N- [4- (4-Chlorophenyl) furan-2-ylcarbonyl] amino] butyric acid,
(20) 4- [N- {4- (4-Heptylphenyl) phenylcarbonyl] amino] butyric acid,
(21) 4- [N- [4- (4-Methoxyphenyl) phenylcarbonyl] amino] butyric acid,
(22) 4- [N- [4- (4-Chlorophenyl) phenylcarbonyl] amino] butyric acid,
(23) 4- [N- (5-Benzyloxyindol-2-ylcarbonyl) amino] butyric acid,
(24) 4- [N- [5- (2- (4-Chlorophenyl) ethenyl) furan-2-ylcarbonyl] amino] butyric acid,
(25) 4- [N- [4- (4-Phenyloxyphenyl) phenylcarbonyl] amino] butyric acid,
(26) 4- (N-Methyl-N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyric acid,
(27) 4- (N- (4- (Benzofuran-2-yl) phenylcarbonyl) amino) -2 (S) -hydroxybutyric acid,
(28) 4- (N- (4- (Benzofuran-2-yl) phenylcarbonyl) amino) -2 (R) -hydroxybutyric acid,
(29) 4- (N- (4- (Benzofuran-2-yl) phenylcarbonyl) amino) -2 (S) -benzyloxymethoxybutyric acid,
(30) 4- (N- (4- (Benzofuran-2-yl) phenylcarbonyl) amino) -2 (R) -benzyloxymethoxybutyric acid,
(31) 4- (N- (4- (2- (4-Chlorophenyl) ethenyl) phenylcarbonyl) amino) -2 (S) -benzyloxymethoxybutyric acid,
(32) 4- (N- (4-Chlorophenylcarbonyl) amino) -2-benzyloxymethoxybutyric acid,
(33) 4- (N- (4-Chlorophenylcarbonyl) amino) -2 - ((N-benzyl-N-methylamino) carbonylmethoxy) butyric acid,
(34) 4- (N- (4-Chlorophenylcarbonyl) amino) -2 - ((N-phenyl-N-methylamino) carbonylmethoxy) butyric acid,
(35) 4- (N- (4-Chlorophenylcarbonyl) amino) -2 - ((N-phenylethyl-N-methylamino) carbonylmethoxy) butyric acid,
(36) 3 (S) -Hydroxy-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyric acid,
(37) 3 (R) -Hydroxy-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyric acid,
(38) 3 (S) -Metoxymethyloxy-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyric acid,
(39) 4- (N- (4- (Benzofuran-2-yl) phenylcarbonyl) amino) -2-butenoic acid,
(40) 3 (R) -Metoxymethyloxy-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyric acid,
(41) 4- (N- (4- (Benzofuran-2-yl) phenylcarbonyl) amino) -3-butenoic acid,
(42) 2-Benzyloxymethyl-4- (N- (4-methylphenylcarbonyl) amino) butyric acid,
(43) 4 (S) -Metylaminocarbonyl-4- (N- (4-methylphenylcarbonyl) amino) butyric acid,
(44) 4 (R) -Metylaminocarbonyl-4- (N- (4-methylphenylcarbonyl) amino) butyric acid,
(45) 4 (S) -Benzylaminocarbonyl-4- (N- (4-methylphenylcarbonyl) amino) butyric acid,
(46) 4 (S) - (4-Hydroxybutyl) aminocarbonyl-4- (N- (4-methylphenylcarbonyl) amino) butyric acid,
(47) 4 (S) -Metoxycarbonyl-4- [N- [4- (4-hydroxy-1-butynyl) phenylcarbonyl] amino] butyric acid,
(48) 4 (S) -tert-Butoxycarbonyl-4- (N- (4-methylphenylcarbonyl) amino) butyric acid,
(49) 4 (S) - (Morpholin-1-yl) carbonyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyric acid,
(50) 4 (S) -hydroxymethyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyric acid,
(51) 4 (S) -Metoxymethyloxymethyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyric acid,
(52) 2 (S) -Benzyl-4 (S) -methoxymethyloxymethyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyric acid,
(53) 2 (S) -Metyl-4 (S) -methoxymethyloxymethyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyric acid,
(54) 2 (S) - (3-Phenyl-2-propenyl) -4 (S) -methoxymethyloxymethyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyric acid,
(55) 2 (S) - (3-Phenylpropyl) -4 (S) -methoxymethyloxymethyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyric acid,
(56) 2 (S) -Metyl-5-ethoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanoic acid,
(57) 2 (S) -Metyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanoic acid,
(58) 2 (S) -Metyl-5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanoic acid,
(59) 2 (S) -allyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanoic acid,
(60) 2 (R) -Metoxymethyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanoic acid,
(61) 2 (R) -Benzyloxymethyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanoic acid,
(62) 2 (3) -Metyl-5- (2-methoxyethoxy) methoxy-4 (S) - [N- (4-cyanophenylcarbonyl) amino] pentanoic acid,
(63) 2 (R) - (2-Methoxyethoxy) methyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanoic acid,
(65) 2 (S) -allyl-5- (2-methoxyethoxy) methoxy-4 (S) - [N- (4-cyanophenylcarbonyl) amino] pentanoic acid,
(66) 2 (S) -Metoxymethyl-5- (2-methoxyethoxy) methoxy-4 (S) - [N- (4-cyanophenylcarbonyl) amino] pentanoic acid,
(69) 2 (R) -Metoxymethyl-5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanoic acid,
(70) 2 (R) -Metoxymethyl-5-ethoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanoic acid,
(71) 2 (R) -Benzyloxymethyl-5- (2-methoxyethoxy) methoxy-4 (S) - [N- (4-cyanophenylcarbonyl) amino] pentanoic acid,
(72) 2 (R) -Benzyloxymethyl-5-ethoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanoic acid,
(73) 2 (R) -Benzyloxymethyl-5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanoic acid,
(74) 2 (S) -allyl-5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanoic acid,
(75) 2 (S) -allyl-5-ethoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanoic acid,
(76) 2 (R) - (2-Methoxyethoxy) methyl-5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanoic acid,
(77) 2 (R) - (2-Methoxyethoxy) methyl-5- (2-methoxyethoxy) methoxy-4 (S) - [N- (4-cyanophenylcarbonyl) amino] pentanoic acid,
(78) 2 (R) - (2-Methoxyethoxy) methyl-5-ethoxymethoxy-4 (3) - [N- (4-chlorophenylcarbonyl) amino] pentanoic acid,
(80) 2 (S) -Metyl-5-ethoxymethoxy-4 (S) - [N-methyl-N- (4-bromophenylcarbonyl) amino] pentanoic acid,
(81) 2 (S) -Metyl-5-ethoxymethoxy-4 (S) - [N-methyl-N- (4-nitrophenylcarbonyl) amino] pentanoic acid,
(82) 2 (S) -Benzyl-4 (S) -tert-butyldimethylsilyloxymethyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyric acid,
(83) 2 (R) -Benzyl-4 (S) -hydroxymethyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyric acid,
(84) 2 (S) -Benzyl-4 (S) -hydroxymethyl-4- (N- (4- (3-methoxy-1-propinyl) phenylcarbonyl) amino) butyric acid,
(85) 2 (S) -Benzyloxy-3 (S) -hydroxy-4- (N- (4- (3-methoxy-1-propinyl) phenylcarbonyl) amino) butyric acid,
(86) 2-Benzyloxy-4- (N- (4- (3-methoxy-1-propynyl) phenylcarbonyl) amino) -2-butenoic acid,
(87) cis-1-carboxymethyl-2- (N- (4- (3-methoxy-1-propinyl) phenylcarbonyl) amino) cyclopentane,
(88) trans-1-carboxymethyl-2- (N- (4- (3-methoxy-1-propinyl) phenylcarbonyl) amino) cyclopentane,
(89) trans-3- (N- (4- (3-Methoxy-1-propinyl) phenylcarbonyl) amino) cyclopentanoic acid,
(90) cis-3- (N- (4- (3-Methoxy-1-propinyl) phenylcarbonyl) amino) cyclopentanoic acid,
(91) trans-2- (N- (4- (3-Methoxy-1-propinyl) phenylcarbonyl) aminomethyl) cyclopentanoic acid,
(92) 2 (R) -allyl-5-ethoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanoic acid,
(93) 5-Methoxy-4 (S) - [N- [4- (4-chlorophenyl) phenylcarbonyl] amino] pentanoic acid,
(94) 2 (S) -Metyl-5-succinimide-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanoic acid,
(95) 2 (S) -Metyl-5-ethoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanoic acid,
(96) 2 (S) -allyl-5-ethoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanoic acid,
(97) 2 (S) -Metyl-5-ethoxymethoxy-4 (S) - [N- [4- (4-cyanophenyl) phenylcarbonyl] amino] pentanoic acid,
and methyl ether, ethyl ether, tert-butyl ether and their non-toxic salts.

10. The compound according to claim 2, selected from
(1) N-Hydroxy-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyramide,
(2) N-Hydroxy-4- (N- (4-methylphenylcarbonyl) amino) butyramide,
(3) N-Hydroxy-4- (N- (4-butyloxyphenylcarbonyl) amino) butyramide,
(4) N-Hydroxy-4- (N- (3-butyloxyphenylcarbonyl) amino) butyramide,
(5) N-Hydroxy-4- [N- [4 - ((4-methylphenyl) ethynyl) furan-2-ylcarbonyl] amino] butyramide,
(6) N-Hydroxy-4- (N- (4- (pyrrol-1-yl) phenylcarbonyl) amino) butyramide,
(7) N-Hydroxy-4- (N- (trans-4-methylcyclohexylcarbonyl) amino) butyramide,
(8) N-Hydroxy-4- (N- (4- (3-methoxy-1-propinyl) phenylcarbonyl) amino) butyramide,
(9) N-Hydroxy-4- (N- (4-butylphenylcarbonyl) amino) butyramide,
(10) N-Hydroxy-4- (N- (benzofuran-2-ylcarbonyl) amino) butyramide,
(11) N-Hydroxy-4- [N- [4- (2- (4-chlorophenyl) ethenyl) phenylcarbonyl] amino] butyramide,
(12) N-Hydroxy-4- [N- [4 - ((4- (imidazol-1-yl) phenyl) ethynyl) phenylcarbonyl] amino] butyramide,
(13) N-Hydroxy-4- (N- (trans-4-propylcyclohexylcarbonyl) amino) butyramide,
(14) N-Hydroxy-4- [N- [4 - ((4-methylphenyl) ethynyl) phenylcarbonyl] amino] butyramide,
(15) N-Hydroxy-4- [N- [4 - ((4-bromophenyl) aminosulfonyl) phenylcarbonyl] amino] butyramide,
(16) N-Hydroxy-4- [N- (4-cyclohexylphenylcarbonyl) amines butyramide,
(17) N-Hydroxy-4- [N- [4- (4-propylphenyl) phenylcarbonyl] amino] butyramide,
(18) N-Hydroxy-4- [N- [4- (4-hydroxyphenyl) phenylcarbonyl] amino] butyramide,
(19) N-Hydroxy-4- [N- [4- (4-chlorophenyl) furan-2-ylcarbonyl] amino] butyramide,
(20) N-Hydroxy-4- [N- [4- (4-heptylphenyl) phenylcarbonyl] amino] butyramide,
(21) N-Hydroxy-4- [N- [4- (4-methoxyphenyl) phenylcarbonyl] amino] butyramide,
(22) N-Hydroxy-4- [N- [4- (4-chlorophenyl) phenylcarbonyl] amino] butyramide,
(23) N-Hydroxy-4- [N- (5-benzyloxyindol-2-ylcarbonyl) amino] butyramide,
(24) N-Hydroxy-4- [N- [5- (2- (4-chlorophenyl) ethenyl) furan-2-yl-carbonyl] amino] butyramide,
(25) N-Hydroxy-4- [N- [4- (4-phenyloxyphenyl) phenylcarbonyl] amino] butyramide,
(26) N-Hydroxy-5- [N- [4- (benzofuran-2-yl) phenylcarbonyl] amino] pentanamide,
(27) N-Hydroxy-6- [N- [4- (Benzofuran-2-yl) phenylcarbonyl] amino] hexanamide,
(28) N-Hydroxy-4- [N - [[(4'-carbamoylmethoxy) biphenyl-4-yl] carbonyl] amino] butyramide,
(29) N-Hydroxy-4- [N- [4- (4-phenylpiperidin-1-yl) phenylcarbonyl] amino] butyramide,
(30) N-Hydroxy-4- [N- [4- [3- (4-chlorophenoxy) -1-propynyl] phenylcarbonyl] amino] butyramide,
(31) N-Hydroxy-4- [N- [4- (3-phenoxy-1-propinyl) phenylcarbonyl] amino] butyramide,
(32) N-Hydroxy-4- [N- [4- (4-methoxyphenoxy) phenylcarbonyl] amino] butyramide,
(33) N-Hydroxy-4- [N- [4- (4-hydroxyphenoxy) phenylcarbonyl] amino] butyramide,
(34) N-Hydroxy-4- [N- [4- (4-phenoxypiperazin-1-yl) phenylcarbonyl] amino] butyramide,
(35) N-Hydroxy-4- [N- [4- (4-phenyl-1,2,5,6-tetrahydropyridin-1-yl) phenylcarbonyl] amino] butyramide,
(36) N-Hydroxy-4- [N- [4- (1-heptinyl) phenylcarbonyl] amino] butyramide,
(37) N-Hydroxy-4- [N- (4-benzyloxyphenylcarbonyl) amino] butyramide,
(38) N-Hydroxy-4- (N-Methyl-N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyramide,
(39) N-Hydroxy-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) -2 (S) -hydroxybutyramide,
(40) N-Hydroxy-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) -2 (R) -hydroxybutyramide,
(41) N-Hydroxy-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) -2 (S) -benzyloxymethoxybutyramide,
(42) N-Hydroxy-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) -2 (R) benzyloxymethoxybutyramide,
(43) N-Hydroxy-4- (N- (4- (2- (4-chlorophenyl) ethenyl) phenylcarbonyl) amino) -2 (S) -benzyloxymethoxybutyramide,
(44) N-Hydroxy-4- (N- (4-chlorophenylcarbonyl) amino) -2-benzyl-hydroxymethoxybutyramide,
(45) N-Hydroxy-4- (N- (4-chlorophenylcarbonyl) amino) -2 - ((N-benzyl-N-methylamino) carbonylmethoxy) butyramide,
(46) N-Hydroxy-4- (N- (4-chlorophenylcarbonyl) amino) -2 - ((N-phenyl-N-methylamino) carbonylmethoxy) butyramide,
(47) N-Hydroxy-4- (N- (4-chlorophenylcarbonyl) amino) -2 - ((N-phenylethyl-N-methylamino) carbonylmethoxy) butyramide,
(48) N-Hydroxy-3 (S) -hydroxy-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyramide,
(49) N-Hydroxy-3 (R) -hydroxy-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyramide,
(50) N-Hydroxy-3 (S) -methoxymethyloxy-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyramide,
(51) N-Hydroxy-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) -2-butenamide,
(52) N-Hydroxy-3 (R) -methoxymethyloxy-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyramide,
(53) N-Hydroxy-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) -3-buteramide,
(54) N-Hydroxy-4- [N- [4- (benzofuran-2-yl) phenylcarbonyl] amino] -3 (S) -benzyloxymethoxybutyramide,
(55) N-Hydroxy-2-benzyloxymethyl-4- (N- (4-methylphenylcarbonyl) amino) butyramide,
(56) N-Hydroxy-2-hydroxymethyl-4- (N- (4-methylphenylcarbonyl) amino) butyramide,
(57) N-Hydroxy-2-hydroxymethyl-4- (N- (4-methylphenylcarbonyl) amino) butyramide,
(58) N-Hydroxy-2-hydroxymethyl-4- (N- (4-methylphenylcarbonyl) amino) butyramide,
(59) N-Hydroxy-4 (S) -melaminocarbonyl-4- (N- (4-methylphenylcarbonyl) amino) butyramide,
(60) N-Hydroxy-4 (R) methylaminocarbonyl-4- (N- (4-methylphenylcarbonyl) amino) butyramide,
(61) N-Hydroxy-4 (S) -benzylaminocarbonyl-4- (N- (4-methylphenylcarbonyl) amino) butyramide,
(62) N-Hydroxy-4 (S) - (4-hydroxybutyl) aminocarbonyl-4- (N- (4-methylphenylcarbonyl) amino) butyramide,
(63) N-Hydroxy-4 (S) -methoxycarbonyl-4- [N- [4- (4-hydroxy-1-butynyl) phenylcarbonyl] amino] butyramide,
(64) N-Hydroxy-4 (R) -carbonyl-4- [N- [4- (3-methoxy-1-propinyl) phenylcarbonyl] amino] butyramide,
(65) N-Hydroxy-4 (S) -carboxy-4- (N- (4-methylphenylcarbonyl) amino) butyramide,
(66) N-Hydroxy-4 (S) - (morpholin-1-yl) carbonyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyramide,
(67) N-Hydroxy-4 (S) -hydroxymethyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyramide,
(68) N-Hydroxy-4 (S) -methoxymethyloxymethyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyramide,
(69) N-Hydroxy-2 (S) -benzyl-4 (S) -methoxymethyloxymethyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyramide,
(70) N-Hydroxy-2 (S) -methyl-4 (S) -methoxymethyloxymethyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyramide,
(71) N-Hydroxy-2 (S) - (3-phenyl-2-propenyl) -4 (S) -methoxymethyloxymethyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyramide,
(72) N-Hydroxy-2 (S) - (3-phenylpropyl) -4 (S) -methoxymethyloxymethyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyramide,
(73) N-Hydroxy-2 (R) -benzyl-4 (S) -hydroxymethyl-4- (N- (4- (benzofuran-2-yl) phenylcarbonyl) amino) butyramide,
(74) N-Hydroxy-2 (S) -benzyl-4 (S) -hydroxymethyl-4- (N- (4- (3-methoxy-1-propynyl) phenylcarbonyl) amino) butyramide,
(75) N-Hydroxy-5-hydroxy-4 (S) - [N- [4- (3-methoxy-1-propinyl) phenylcarbonyl] amino] pentanamide,
(76) N-Hydroxy-5-hydroxy-4 (R) - [N- [4- (3-methoxy-1-propinyl) phenylcarbonyl] amino] pentanamide,
(77) N-Hydroxy-4 (S) - (4-hydroxybutylcarbamoyl) -4- [N- [4- (3-methoxy-1-propynyl) phenylcarbonyl] amino] butyramide,
(78) N-Hydroxy-4 (S) - (3-phenylpropylcarbamoyl) -4- [N- [4- (3-methoxy-1-propynyl) phenylcarbonyl] amino] butyramide,
(79) N-Hydroxy-4 (S) -propylcarbamoyl-4- [N- [4- (3-methoxy-1-propinyl) phenylcarbonyl] amino] butyramide,
(80) N-Hydroxy-4 (S) - (2-hydroxyethylcarbamoyl) -4- [N- [4- (3-methoxy-1-propynyl) phenylcarbonyl] amino] butyramide,
(81) N-Hydroxy-4 (S) - (6-hydroxyhexylcarbamoyl) -4- [N- [4- (3-methoxy-1-propynyl) phenylcarbonyl] amino] butyramide,
(82) N-Hydroxy-4 (S) - [2- (4-methoxyphenyl) ethylcarbamoyl] -4- [N- [4- (3-methoxy-1-propynyl) phenylcarbonyl] amino] butyramide,
(83) N-Hydroxy-4 (S) - (2-morpholinoethylcarbamoyl) -4- [N- [4- (3-methoxy-1-propynyl) phenylcarbonyl] amino] butyramide,
(84) N-Hydroxy-4 (S) - [2- (indol-3-yl) ethylcarbamoyl) -4- [N- [4- (3-methoxy-1-propinyl) phenylcarbonyl] amino] butyramide,
(85) N-Hydroxy-4 (S) - (4-phenylbutylcarbamoyl) -4- [N- [4- (3-methoxy-1-propynyl) phenylcarbonyl] amino] butyramide,
(86) N-Hydroxy-4 (S) - (2-phenylethylcarbamoyl) -4- [N- [4- (3-methoxy-1-propynyl) phenylcarbonyl] amino] butyramide,
(87) N-Hydroxy-4 (S) - [3- (pyrazol-1-yl) propylcarbamoyl] -4- [N- [4- (3-methoxy-1-propynyl) phenylcarbonyl] amino] butyramide,
(88) N-Hydroxy-4 (R) - (3-phenylpropylcarbamoyl) -4- [N- [4- (3-methoxy-1-propynyl) phenylcarbonyl] amino] butyramide,
(89) N-Hydroxy-2- (pyridin-3-yl) methyl-4- (2-phenylethylcarbamoyl) -4- [N- (4-phenoxyphenylcarbonyl) amino] butyramide,
(90) N-Hydroxy-5-methoxymethoxy-4 (S) - [N- [4- (3-methoxy-1-propinyl) phenylcarbonyl] amino] pentanamide,
(91) N-Hydroxy-5-benzyloxymethoxy-4 (S) - [N- [4- (3-methoxy-1-propinyl) phenylcarbonyl] amino] pentanamide,
(92) N-Hydroxy-3- (2-methoxyethoxy) methoxy-4 (S) - [N- [4- (3-phenoxy-1-propynyl) phenylcarbonyl] amino] pentanamide,
(93) N-Hydroxy-5-methoxymethoxy-4 (S) - [N- [4- (3-phenoxy-1-propinyl) phenylcarbonyl] amino] pentanamide,
(94) N-Hydroxy-5-benzyloxymethoxy-4 (S) - [N- [4- (3-phenoxy-1-propinyl) phenylcarbonyl] amino] pentanamide,
(95) N-Hydroxy-5-methoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(96) N-Hydroxy-5-methoxymethoxy-4 (S) - [N- [4- (4-chlorophenyl) phenylcarbonyl] amino] pentanamide,
(97) N-Hydroxy-5-methoxymethoxy-4 (S) - [N- [4- [2- (4-methylphenyl) ethynyl] phenylcarbonyl] amino] pentanamide,
(98) N-Hydroxy-5-methoxymethoxy-4 (S) - [N- [4- [2E- (4-chlorophenyl) ethenyl] phenylcarbonyl] amino] pentanamide,
(99) N-Hydroxy-5-methoxymethoxy-4 (S) - [N- [4- (1-heptinyl) phenylcarbonyl] amino] pentanamide,
(100) N-Hydroxy-5-ethoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(101) N-Hydroxy-5-ethoxymethoxy-4 (S) - [N- (4-methylphenylcarbonyl) amino] pentanamide,
(102) N-Hydroxy-5-methoxymethoxy-4 (R) - [N- [4- (3-methoxy-1-propinyl) phenylcarbonyl] amino] pentanamide,
(103) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- [2- (4-imidazolylphenyl) ethynyl] phenylcarbonyl] amino] pentanamide,
(104) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (4-phenyl-1,2,5,6-tetrahydropyridin-1-yl) phenylcarbonyl] amino] pentanamide,
(105) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(106) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- [2- (4-chlorophenyl) ethenyl] phenylcarbonyl] amino] pentanamide,
(107) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (4-propylphenyl) phenylcarbonyl] amino] pentanamide,
(108) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (benzothiophen-2-yl) phenylcarbonyl] amino] pentanamide,
(109) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (3-methoxyphenoxy) phenylcarbonyl] amino] pentanamide,
(110) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (4-methoxyphenoxy) phenylcarbonyl] amino] pentanamide,
(111) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- (4-benzoylphenylcarbonyl) amino] pentanamide,
(112) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (naphthalen-2-yl) phenylcarbonyl] amino] pentanamide,
(113) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4 - [(4-methoxybiphenyl-4'-yl) oxy] phenylcarbonyl] amino] pentanamide,
(114) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (4-ethoxyphenyl) phenylcarbonyl] amino] pentanamide,
(115) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (4-phenoxyphenyl) phenylcarbonyl] amino] pentanamide,
(116) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (3-cyanomethylphenyl) phenylcarbonyl] amino] pentanamide,
(117) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (biphenyl-4-yl) phenylcarbonyl] amino] pentanamide,
(118) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (3-hydroxyphenoxy) phenylcarbonyl] amino] pentanamide,
(119) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- [2- (4-methylphenyl) ethynyl] phenylcarbonyl] amino] pentanamide,
(120) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (4-hydroxyphenoxy) phenylcarbonyl] amino] pentanamide,
(121) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (4-chlorophenyl) phenylcarbonyl] amino] pentanamide,
(122) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N - [[5- (4-methoxyphenyl) -2-thienyl] carbonyl] amino] pentanamide,
(123) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4 - [(biphenyl-3-yl) oxy] phenylcarbonyl] amino] pentanamide,
(124) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (1-heptinyl) phenylcarbonyl] amino] pentanamide,
(125) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (3-phenoxy-1-propynyl) phenylcarbonyl] amino] pentanamide,
(126) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (4-cyanophenyl) phenylcarbonyl] amino] pentanamide,
(127) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (3-cyanophenyl) phenylcarbonyl] amino] pentanamide,
(128) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- (4-benzylphenylcarbonyl) amino] pentanamide,
(129) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- [2E- (pyridin-4-yl) ethenyl] phenylcarbonyl] amino] pentanamide,
(130) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (benzoxazol-2-yl) phenylcarbonyl] amino] pentanamide,
(131) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (3-ethoxyphenyl) phenylcarbonyl] amino] pentanamide,
(132) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- [4- (4-methylphenylcarbonylamino) phenylcarbonyl] amino] pentanamide,
(133) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N - [[5- [2- (4-methylphenyl) ethynyl] -2-thienyl] carbonyl] amino] pentanamide ,
(134) N-Hydroxy-2 (S) -methyl-5- (2-methoxyethoxy) methoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(135) N-Hydroxy-2 (S) -methyl-5-tert-butylcarbonyloxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(136) N-Hydroxy-2 (S) -methyl-5-benzyloxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(137) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(138) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (4-methylphenylcarbonyl) amino] pentanamide,
(139) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(140) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (adamantylcarbonyl) amino] pentanamide,
(141) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (2-furylcarbonyl) amino] pentanamide,
(142) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N - [(benzothiazol-6-yl) carbonyl] amino] pentanamide,
(143) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (4-fluorophenylcarbonyl) amino] pentanamide,
(144) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N - [(2-bromofuryl-5-yl) carbonyl] amino] pentanamide,
(145) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(146) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanamide,
(147) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (4-cyanophenylcarbonyl) amino] pentanamide,
(148) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- [4- (4-pyridyloxy) phenylcarbonyl] amino] pentanamide,
(149) N-Hydroxy-2 (S) -methyl-5- (2-methoxyethoxy) methoxy-4 (S) - [N- (4-cyanophenylcarbonyl) amino] pentanamide,
(150) N-Hydroxy-2 (S) -methyl-5-methoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(151) N-Hydroxy-2 (S) -methyl-5-benzyloxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(152) N-Hydroxy-2 (S) -methyl-5- (2-methoxyethoxy) methoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(153) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (2-nitrophenylcarbonyl) amino] pentanamide,
(154) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (3-nitrophenylcarbonyl) amino] pentanamide,
(155) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (2-methoxy-4-nitrophenylcarbonyl) amino] pentanamide,
(156) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (3-methoxy-4-nitrophenylcarbonyl) amino] pentanamide,
(157) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (3-hydroxy-4-nitrophenylcarbonyl) amino] pentanamide,
(158) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (4-dihydroboronylphenylcarbonyl) amino] pentanamide,
(159) N-Hydroxy-2 (S) -isobutyl-5-methoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(160) N-Hydroxy-2 (S) -ethyl-5-methoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(161) N-Hydroxy-2 (S) -propyl-5-methoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(162) N-Hydroxy-2 (R) -tert-butoxycarbonylmethyl-5-methoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(163) N-Hydroxy-2 (S) -allyl-5-methoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(164) N-Hydroxy-2 (S) -ethyl-5-ethoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(165) N-Hydroxy-2 (S) -ethyl-5- (2-methoxyethoxy) methoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(166) N-Hydroxy-2 (S) -ethyl-5-tert-butylcarbonyloxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(167) N-Hydroxy-2 (S) -allyl-5-ethoxymethoxy-4 (S) - [N- (4-methylphenylcarbonyl) amino] pentanamide,
(168) N-Hydroxy-2 (S) -allyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(169) N-Hydroxy-2-methylidene-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(171) N-Hydroxy-2 (S) -allyl-5- (2-methoxyethoxy) methoxy-4 (S) - [N- (4-cyanophenylcarbonyl) amino] pentanamide,
(174) N-Hydroxy-2 (S) -allyl-5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanamide,
(175) N-Hydroxy-2 (S) -allyl-5-ethoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(176) N-Hydroxy-2 (R) -dimethylaminomethyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(178) N-Hydroxy-2 (R) -benzyl-5-methoxymethoxy-4 (R) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(179) N-Hydroxy-2 (R) -benzyl-5-methoxymethoxy-4 (R) - [N- [4- (3-phenoxy-1-propynyl) phenylcarbonyl] amino] pentanamide,
(180) N-Hydroxy-2 (R) -methyl-5-ethoxymethoxy-4 (R) - [N- [4- (4-cyanophenyl) phenylcarbonyl] amino] pentanamide,
(181) N-Hydroxy-2 (R) -allyl-5-ethoxymethoxy-4 (R) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(182) N-Hydroxy-2 (R) -methyl-5-ethoxymethoxy-4 (R) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(183) N-Hydroxy-2 (S) -benzyl-5-methoxymethoxy-4 (S) - [N- [4- [2E- (4-chlorophenyl) ethenyl] phenylcarbonyl] amino] pentanamide,
(184) N-Hydroxy-2 (S) - (indol-3-yl) -5-methoxymethoxy-4 (S) - [N- [4- (benzofuran-2-yl) phenylcarbonyl] amino] pentanamide,
(185) N-Hydroxy-2 (S) -benzyl-5-methoxymethoxy-4 (S) - [N- [4- [3- (4-chlorophenoxy-1-propinyl) phenylcarbonyl] amino] pentanamide,
(186) N-Hydroxy-2 (S) -benzyl-5-methoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(187) N-Hydroxy-2 (S) -benzyl-5-methoxymethoxy-4 (S) - [N- [4- (4-phenylpiperidin-1-yl) phenylcarbonyl] amino] pentanamide,
(188) N-Hydroxy-2 (S) -benzyl-5-methoxymethoxy-4 (S) - [N- [4- (6-imidazolyl-1-hexinyl) phenylcarbonyl] amino] pentanamide,
(189) N-Hydroxy-2 (S) - (naphthalen-1-yl) -5-methoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(190) N-Hydroxy-2 (S) - [4- (benzofuran-2-yl) benzyl] -5-methoxymethoxy-4 (S) - [N- (4-iodophenylcarbonyl) amino] pentanamide,
(191) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(192) N-Hydroxy-2 (S) - (4-nitrobenzyl) -5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(193) N-Hydroxy-2 (S) - (indol-3-yl) -5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(194) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N - [(pyridin-4-yl) carbonyl] amino] pentanamide,
(195) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-hydroxyphenylcarbonyl) amino] pentanamide,
(196) N-Hydroxy-2 (S) - (2-nitrobenzyl) -5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(197) N-Hydroxy-2 (S) - (3-nitrobenzyl) -5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(198) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N - [(1-methylpyrrol-2-yl) carbonyl] amino] pentanamide,
(199) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (phenylcarbonyl) amino] pentanamide,
(200) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-ethylphenylcarbonyl) amino] pentanamide,
(201) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-methylphenylcarbonyl) amino] pentanamide,
(202) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(203) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (2,2,3,3-tetramethylcyclopropylcarbonyl) amino] pentanamide,
(204) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-ethoxymethoxy-4 (S) - [N- (4-methylphenylcarbonyl) amino] pentanamide,
(205) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (1-cyclohexenylcarbonyl) amino] pentanamide,
(206) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N [(1-cyclohexen-4-yl) carbonyl] amino] pentanamide,
(207) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-dimethylaminophenylcarbonyl) amino] pentanamide,
(208) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-carbamoylphenylcarbonyl) amino] pentanamide,
(209) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-methoxycarbonylphenylcarbonyl) amino] pentanamide,
(210) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (cyclopentylcarbonyl) amino] pentanamide,
(211) N-Hydroxy-2 (S) - (naphthalen-2-yl) -5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(212) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-trifluoromethylphenylcarbonyl) amino] pentanamide,
(213) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-iodophenylcarbonyl) amino] pentanamide,
(214) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- [4- (2-iodoethynyl) phenylcarbonyl] amino] pentanamide,
(215) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (cycloheptylcarbonyl) amino] pentanamide,
(216) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (2-thienylcarbonyl) amino] pentanamide,
(217) N-Hydroxy-2 (R) - (3,4,4-trimethyl-2,5-dioxoimidazo-lidin-1-yl) methyl-5-ethoxymethoxy-4 (S) - [N- (4- methylphenylcarbonyl) amino] pentanamide,
(218) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N - [(2-bromo-5-thienyl) carbonyl] amino] pentanamide,
(219) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanamide,
(220) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-hydroxymethylphenylcarbonyl) amino] pentanamide,
(221) N-Hydroxy-2 (S) - (benzothiophen-3-yl) -5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(222) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-cyanophenylcarbonyl) amino] pentanamide,
(223) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N - [(1-acetylpiperidin-4-yl) carbonyl] amino] pentanamide,
(224) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N - [(1-methylpiperidin-4-yl) carbonyl] amino] pentanamide,
(225) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-formylphenylcarbonyl) amino] pentanamide,
(226) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(227) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-ethoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(228) N-Hydroxy-2 (S) - (4-methoxybenzyl) -5-ethoxymethoxy-4 (S) - [N- (4-methylphenylcarbonyl) amino] pentanamide,
(229) N-Hydroxy-2 (S) - (2-methoxybenzyl) -5-ethoxymethoxy-4 (S) - [N- (4-methylphenylcarbonyl) amino] pentanamide,
(230) N-Hydroxy-2 (S) - (naphthalen-1-yl) -5-ethoxymethoxy-4 (S) - [N- (4-methylphenylcarbonyl) amino] pentanamide,
(231) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(232) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-methoxycyclohexylcarbonyl) amino] pentanamide,
(233) N-Hydroxy-2 (S) - (benzothiophen-3-yl) -5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanamide,
(234) N-Hydroxy-2 (S) - (benzothiophen-3-yl) -5-ethoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(235) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N - [(2-chloropyridin-5-yl) carbonyl] amino] pentanamide,
(236) N-Hydroxy-2 (S) - (3,5-dimethoxybenzyl) -5-ethoxymethoxy-4 (S) - [N- (4-methylphenylcarbonyl) amino] pentanamide,
(237) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-methylcyclohexylcarbonyl) amino] pentanamide,
(238) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-ethoxymethoxy-4 (S) - [N- (4-cyanophenylcarbonyl) amino] pentanamide,
(239) N-Hydroxy-2 (R) - (3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl) methyl-5-ethoxymethoxy-4 (S) - [N- (trans-4- methylcyclohexylcarbonyl) amino] pentanamide,
(240) N-Hydroxy-2 (R) - (benzofuran-2-yl) -5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(241) N-Hydroxy-2 (S) - (benzothiophen-3-yl) -5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(242) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-cyanophenylcarbonyl) amino] pentanamide,
(243) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-methylidenecyclohexylcarbonyl) amino] pentanamide,
(244) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N - [(1-formylpiperidin-4-yl) carbonyl] amino] pentanamide,
(245) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N - [(1 methyl-1-cyclohexen-4-yl) carbonyl] amino] pentanamide,
(246) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N - [(4-methyl-1-cyclohexenyl) carbonyl] amino] pentanamide,
(247) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-fluorophenylcarbonyl) amino] pentanamide,
(248) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(249) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-hydroxycyclohexylcarbonyl) amino] pentanamide,
(250) N-Hydroxy-2 (S) - (Benzofuran-3-yl) -5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(251) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-ethoxymethoxy-4 (S) - [N- (4-trifluoromethylphenylcarbonyl) amino] pentanamide,
(252) N-Hydroxy-2 (S) - (1-methylindol-3-yl) -5- (2-methoxyethoxy) methoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl; -amino] pentanamide ,
(253) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N - [(1,3-dithian-2-yl) carbonyl] amino] pentanamide,
(254) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanamide,
(255) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-ethoxymethoxy-4 (S) - [N - [(2-bromothiophen-5-yl) carbonyl] amino] pentanamide,
(256) N-Hydroxy-2 (S) - (2-methoxybenzyl) -5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(257) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N - [(2-methylpyridin-5-yl) carbonyl] amino] pentanamide,
(258) N-Hydroxy-2 (S) - (benzofuran-3-yl) -5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(259) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (trans-4-hydroxycyclohexylcarbonyl) amino] pentanamide,
(260) N-Hydroxy-2 (S) - (3-chlorobenzyl) -5-ethoxymethoxy-4 (S) - [N- (4-methylphenylcarbonyl) amino] pentanamide,
(261) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N - [(2-hydroxypyridin-5-yl) carbonyl] amino] pentanamide,
(262) N-Hydroxy-2 (R) - (3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl) methyl-5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanamide,
(263) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-ethoxymethoxy-4 (S) - [N- (4-dimethoxymethylphenylcarbonyl) amino] pentanamide,
(264) N-Hydroxy-2 (S) - (3-trifluoromethyloxybenzyl) -5-ethoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(265) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-ethoxymethoxy-4 (S) - [N- [2-nitrotifen-5-yl) carbonyl] amino] pentanamide,
(266) N-Hydroxy-2 (R) - (benzotriazol-1-yl) methyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(267) N-Hydroxy-2 (R) - (3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl) methyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(268) N-Hydroxy-2 (R) - (3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl) methyl-5-ethoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(269) N-Hydroxy-2 (S) - (3-phenylpropyl) -5-methoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(270) N-Hydroxy-2 (S) - (3-phenylpropyl) -5-methoxymethoxy-4 (S) - [N- [4- [2E- (4-chlorophenyl) ethenyl] phenylcarbonyl] amino] pentanamide,
(271) N-Hydroxy-2 (S) - (3-phenylpropyl) -5-methoxymethoxy-4 (S) - [N- [4- (4-phenyl-1,2,5,6-tetrahydropyridin-1- il) phenylcarbonyl] amino] pentanamide,
(272) N-Hydroxy-2 (S) - (3-phenyl-2-propenyl) -5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(273) N-Hydroxy-2 (S) - (3-phenylpropyl) -5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(274) N-Hydroxy-2 (S) - (2-phenylethyl) -5- (2-methoxyethoxy) methoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(275) N-Hydroxy-2 (S) - (4-phenylbutyl) -5- (2-methoxyethoxy) methoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(276) N-Hydroxy-2 (S) - (3-phenylpropyl) -5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanamide,
(277) N-Hydroxy-2 (S) - (3-phenylpropyl) -5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(278) N-Hydroxy-2 (R) - (2-phenoxyethyl) -5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(279) N-Hydroxy-2 (R) - (2-pyridyl) methyl-5-methoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(280) N-Hydroxy-2 (R) - (2-pyridyl) methyl-5-methoxymethoxy-4 (S) - [N- [4- (benzofuran-2-yl) phenylcarbonyl] amino] pentanamide,
(281) N-Hydroxy-2 (S) - (3-pyridyl) methyl-5-methoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(282) N-Hydroxy-2 (S) - (3-pyridyl) methyl-5-methoxymethoxy-4 (S) - [N- [4- [2- (4-methylphenyl) ethynyl] phenylcarbonyl] amino] pentanamide,
(283) N-Hydroxy-2 (S) - (3-pyridyl) methyl-5-methoxymethoxy-4 (S) - [N- [4- (1-heptinyl) phenylcarbonyl] amino] pentanamide,
(284) N-Hydroxy-2 (S) - (3-pyridyl) Methyl-5-methoxymethoxy-4 (S) - [N- [4- [2E- (4-chlorophenyl) ethenyl] phenylcarbonyl] amino] pentanamide,
(285) N-Hydroxy-2 (S) - (3-pyridyl) methyl-5-methoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(286) N-Hydroxy-2 (S) - (4-pyridyl) methyl-5-methoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(287) N-Hydroxy-2 (R) - (2-pyridyl) methyl-5- (2-methoxyethoxy) methoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(288) N-Hydroxy-2 (S) - (3-pyridyl) methyl-5-ethoxymethoxy-4 (S) - [N- (2-methylphenylcarbonyl) amino] pentanamide,
(289) N-Hydroxy-2 (S) - (3-pyridyl) methyl-5-ethoxymethoxy-4 (S) - [N- (3-methylphenylcarbonyl) amino] pentanamide,
(290) N-Hydroxy-2 (S) - (3-pyridyl) methyl-5-ethoxymethoxy-4 (S) - [N- (4-methylphenylcarbonyl) amino] pentanamide,
(291) N-Hydroxy-2 (S) - (3-pyridyl) methyl-5-ethoxymethoxy-4 (S) - [N- (4-methoxyphenylcarbonyl) amino] pentanamide,
(292) N-Hydroxy-2 (S) - (3-pyridyl) methyl-5-ethoxymethoxy-4 (S) - (N-cyclohexylcarbonylamino) pentanamide,
(293) N-Hydroxy-2 (S) - (3-pyridyl) methyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(294) N-Hydroxy-2 (S) - (3-pyridyl) methyl-5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanamide,
(295) N-Hydroxy-2 (S) - (3-quinolyl) -5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(296) N-Hydroxy-2 (S) -phenylthio-5-methoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(297) N-Hydroxy-2 (S) -phenylthio-5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(298) N-Hydroxy-2 (S) -methylthio-5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(299) N-Hydroxy-2 (S) - (4-pyridyl) thio-5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(300) N-Hydroxy-2 (S) -hydroxy-5-methoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(301) N-Hydroxy-2 (R) -hydroxymethyl-5-ethoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(302) N-Hydroxy-2 (R) -methoxymethyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(303) N-Hydroxy-2 (R) -benzyloxymethyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(304) N-Hydroxy-2 (R) - (2-methoxyethoxy) methyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(305) N-Hydroxy-2 (R) -methoxymethyl-5- (2-methoxyethoxy) methoxy-4 (S) - [N- (4-cyanophenylcarbonyl) amino] pentanamide,
(306) N-Hydroxy-2 (R) -methoxymethyl-5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(307) N-Hydroxy-2 (R) -methoxymethyl-5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanamide,
(308) N-Hydroxy-2 (R) -methoxymethyl-5-ethoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(309) N-Hydroxy-2 (R) -benzyloxymethyl-5- (2-methoxyethoxy) methoxy-4 (S) - [N- (4-cyanophenylcarbonyl) amino] pentanamide,
(310) N-Hydroxy-2 (R) -benzyloxymethyl-5-ethoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(311) N-Hydroxy-2 (R) -benzyloxymethyl-5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanamide,
(312) N-Hydroxy-2 (R) - [2- (3-methoxyphenoxy) ethyl] -5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(313) N-Hydroxy-2 (R) -methoxymethyl-5-ethoxymethoxy-4 (S) - [N - [(2-nitrotifen-5-yl) carbonyl] amino] pentanamide,
(314) N-Hydroxy-2 (R) -methoxymethyl-5-ethoxymethoxy-4 (S) - [N - [(2-bromothiophen-5-yl) carbonyl] amino] pentanamide,
(315) N-Hydroxy-2 (R) - (2-methoxyethoxy) methyl-5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanamide,
(316) N-Hydroxy-2 (R) - (2-methoxyethoxy) methyl-5- (2-methoxyethoxy) methoxy-4 (S) - [N- (4-cyanophenylcarbonyl) amino] pentanamide,
(317) N-Hydroxy-2 (R) - (2-methoxyethoxy) methyl-5-ethoxymethoxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(318) N-Hydroxy-2 (R) -benzyloxymethyl-5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(319) N-Hydroxy-2 (R) - (3-thienyl) methoxymethyl-5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(320) N-Hydroxy-2 (R) - (2-pyridinyl) methyl-5-hydroxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(321) N-Hydroxy-2 (S) -methyl-5-hydroxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(322) N-Hydroxy-2 (S) -methyl-5-hydroxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanamide,
(323) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-hydroxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanamide,
(324) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-hydroxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(325) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-hydroxy-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(326) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-hydroxy-4 (S) - [N - [(2-bromothiophen-5-yl) carbonyl] amino] pentanamide,
(327) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-hydroxy-4 (S) - [N - [(2-nitrotifen-5-yl) carbonyl] amino] pentanamide,
(328) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-hydroxy-4 (S) - [N- (4-cyanophenylcarbonyl) amino] pentanamide,
(329) N-Hydroxy-2 (R) -benzyloxymethyl-5-hydroxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(330) N-Hydroxy-5-methoxymethoxy-4 (S) - [N-methyl-N- [4- (4-chlorophenyl) phenylcarbonyl] amino] pentanamide,
(331) N-Hydroxy-2 (S) - (3-pyridyl) methyl-5-methoxymethoxy-4 (3) - [N-methyl-N- [4- (4-chlorophenyl) phenylcarbonyl] amino] pentanamide,
(332) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N-methyl-N- (4-bromophenylcarbonyl) amino] pentanamide,
(333) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-ethoxymethoxy-4 (3) - [N-methyl-N- (4-bromophenylcarbonyl) amino] pentanamide,
(334) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N-methyl-N- (4-nitrophenylcarbonyl) amino] pentanamide,
(335) N-Hydroxy-2 (S) -methyl-5-benzyloxymethoxy-4 (S) - [N-methyl-N- (4-nitrophenylcarbonyl) amino] pentanamide,
(336) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-hydroxy-4 (S) - [N-methyl-N- (4-chlorophenylcarbonyl) amino] pentanamide,
(337) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-hydroxy-4 (S) - [N-methyl-N- (4-nitrophenylcarbonyl) amino] pentanamide,
(338) N-Hydroxy-2 (S) - (3-methoxybenzyl) -5-hydroxy-4 (S) - [N-methyl-N- (4-bromophenylcarbonyl) amino] pentanamide,
(339) N-Hydroxy-2 (S) -methyl-5-hydroxy-4 (S) - [N-methyl-N- (4-nitrophenylcarbonyl) amino] pentanamide,
(340) N-Hydroxy-2 (S) -benzyl-5-hydroxy-4 (S) - [N-methyl-N- (4-nitrophenylcarbonyl) amino] pentanamide,
(341) N-Hydroxy-2 (S) -methyl-5-hydroxy-4 (S) - [N-methyl-N- (4-bromophenylcarbonyl) amino] pentanamide,
(342) N-Hydroxy-2 (S) -benzyl-5-hydroxy-4 (S) - [N-methyl-N- (4-bromophenylcarbonyl) amino] pentanamide,
(343) N-Hydroxy-2 (S) -methyl-5-hydroxy-4 (S) - [N-methyl-N- (4-chlorophenylcarbonyl) amino] pentanamide,
(344) N-Hydroxy-2 (S) -benzyloxy-3 (S) -hydroxy-4- (N- (4- (3-methoxy-1-propynyl) phenylcarbonyl) amino) butyramide,
(345) N-Hydroxy-2-benzyloxy-4- (N- (4- (3-methoxy-1-propynyl) phenylcarbonyl) amino) -2-buteramide,
(346) cis-1- (N-Hydroxyaminocarbonylmethyl) -2- (N- (4- (3-methoxy-1-propinyl) phenylcarbonyl) amino) cyclopentane,
(347) trans-1- (N-hydroxyaminocarbonylmethyl) -2- (N- (4- (3-methoxy-1-propynyl) phenylcarbonyl) amino) cyclopentane,
(348) trans-1- (N-Hydroxyaminocarbonyl) -3- (N- (4- (3-methoxy-1-propinyl) phenylcarbonyl) amino) cyclopentane,
(349) cis-1- (N-Hydroxyaminocarbonyl) -3- (N- (4- (3-methoxy-1-propinyl) phenylcarbonyl) amino) cyclopentane,
(350) trans-1- (N-Hydroxyaminocarbonyl) -2- (N- (4- (3-methoxy-1-propinyl) phenylcarbonyl) aminomethyl) cyclopentane,
(351) N-Hydroxy-2 (R) -allyl-5-ethoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(352) N-Hydroxy-2 (R) -benzyl-5-methoxymethoxy-4 (S) - [N- [4- (benzofuran-2-yl) phenylcarbonyl] amino] pentanamide,
(353) N-Hydroxy-2 (R) -methyl-5-ethoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(354) N-Hydroxy-2 (R) -methyl-5-ethoxymethoxy-4 (S) - [N- [4- (4-cyanophenyl) phenylcarbonyl] amino] pentanamide,
(355) N-Hydroxy-2 (S) -benzyl-5-methoxymethoxy-4 (R) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(356) N-Hydroxy-2 (S) -benzyl-5-methoxymethoxy-4 (R) - [N- [4- (3-phenoxy-1-propynyl) phenylcarbonyl] amino] pentanamide,
(357) N-Hydroxy-2 (S) - (3-aminobenzyl) -5-ethoxymethoxy-4 (S) - [N- (trans-4-methylcyclohexylcarbonyl) amino] pentanamide,
(358) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-carboxyphenylcarbonyl) amino] pentanamide,
(359) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-aminophenylcarbonyl) amino] pentanamide,
(360) N-Hydroxy-2 (S) -benzyl-5-ethoxymethoxy-4 (S) - [N- (4-piperidylcarbonyl) amino] pentanamide,
(361) N-Hydroxy-2 (S) - (3-hydroxybenzyl) -5-ethoxymethoxy-4 (S) - [N- (4-methylphenylcarbonyl) amino] pentanamide,
(362) N-Hydroxy-2-benzyl-4- [N- [4- (benzofuran-2-yl) phenylcarbonyl] amino] butyramide,
(363) N-Hydroxy-2- (3-phenylpropyl) -4- [N- [4- (benzofuran-2-yl) phenylcarbonyl] amino] butyramide,
(364) N-Hydroxy-2- (2-phenylethyl) -4- [N- [4- (benzofuran-2-yl) phenylcarbonyl] amino] butyramide,
(365) N-Hydroxy-2-benzyl-4- [N- [4- [2E- (4-chlorophenyl) ethenyl] phenylcarbonyl] amino] butyramide,
(366) N-Hydroxy-2-benzyl-4- [N- (4-phenoxyphenylcarbonyl) amino] butyramide,
(367) N-Hydroxy-2- (naphthalen-1-yl) methyl-4- [N- (4-phenoxyphenylcarbonyl) amino] butyramide,
(368) N-Hydroxy-2-isopropyl-4- [N- (4-phenoxyphenylcarbonyl) amino] butyramide,
(369) N-Hydroxy-2-quinolin-4-yl) methyl-4- [N- (4-phenoxyphenylcarbonyl) amino] butyramide,
(370) N-Hydroxy-2- (2-pyridyl) methyl-4- [N- (4-phenoxyphenylcarbonyl) amino] butyramide,
(371) N-Hydroxy-2- (3-pyridyl) methyl-4- [N- (4-phenoxyphenylcarbonyl) amino] butyramide,
(372) N-Hydroxy-2- (naphthalen-2-yl) methyl-4- [N- (4-phenoxyphenylcarbonyl) amino] butyramide,
(373) N-Hydroxy-2- (4-pyridyl) methyl-4- [N- (4-phenoxyphenylcarbonyl) amino] butyramide,
(374) N-Hydroxy-2- (3-methoxybenzyl) -4- [N- (4-phenoxyphenylcarbonyl) amino] butyramide,
(375) N-Hydroxy-2-isobutyl-4- [N- (4-phenoxyphenylcarbonyl) amino] butyramide,
(376) N-Hydroxy-5-methoxy-4 (S) - [N- [4- (4-chlorophenyl) phenylcarbonyl] amino] pentanamide,
(377) N-Hydroxy-2 (S) -methyl-5-succinimide-4 (S) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(378) N-Hydroxy-2 (S) -methyl-5-succinimidoxy-4 (S) - [N-methyl-N- (4-nitrophenylcarbonyl) amino] pentanamide,
(379) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(380) N-Hydroxy-2 (S) -allyl-5-ethoxymethoxy-4 (S) - [N- (4-phenoxyphenylcarbonyl) amino] pentanamide,
(381) N-Hydroxy-2 (S) -methyl-5-ethoxymethoxy-4 (S) - [N- [4- (4-cyanophenyl) phenylcarbonyl] amino] pentanamide, and their non-toxic salts.

11. The compound according to claim 2, selected from
(1) 1-Acetylthio-5-ethoxymethoxy-4- [N- (4-phenoxyphenylcarbonyl) amino] pentane,
(2) 5-Ethoxymethoxy-4- [N- (4-phenoxyphenylcarbonyl) amino] pentantiol,
and their non-toxic salts.

12. The compound of claim 3, selected from
(64) 2 (S) - (2-Propynyl) -5-ethoxymethoxy-4 (S) - [N- (4-nitrophenylcarbonyl) amino] pentanoic acid,
(67) 2 (S) - (2-Propynyl) -5-ethoxymethoxy-4 (S) - [N- (4-bromophenylcarbonyl) amino] pentanoic acid,
(68) 2 (S) - (2-Propynyl) -5-ethoxymethoxy-4 (3) - [N- (4-chlorophenylcarbonyl) amino] pentanoic acid,
(79) 2 (S) - (2-Propynyl) -5- (2-methoxyethoxy) methoxy-4 (3) - [N- (4-cyanophenylcarbonyl) amino] pentanoic acid,
and their non-toxic salts.

13. The compound of claim 3, selected from
(170) N-Hydroxy-2 (3) - (2-propynyl) -5-ethoxymethoxy-4 (3) - [N- (4-nitrophenylcarbonyl) amino] pentanamide,
(172) N-Hydroxy-2 (3) - (2-propynyl) -5-ethoxymethoxy-4 (3) - [N- (4-bromophenylcarbonyl) amino] pentanamide,
(173) N-Hydroxy-2 (3) - (2-propynyl) -5-ethoxymethoxy-4 (3) - [N- (4-chlorophenylcarbonyl) amino] pentanamide,
(177) N-Hydroxy-2 (3) - (2-propynyl) -5- (2-methoxyethoxy) methoxy-4 (3) - [N- (4-cyanophenylcarbonyl) amino] pentanamide,
and their non-toxic salts.

14. An inhibitor of matrix metalloproteinase containing, as an active ingredient, an aminobutyric acid derivative of the formula (I) according to claim 1 or a non-toxic salt thereof.

15. The compound of formula (I) according to claim 1 or its non-toxic salt for the prevention and / or treatment of rheumatoid diseases, epiphyseal osteomyelitis, unusual bone resorption, osteoporosis, periodontosis, interstitial nephritis, arteriosclerosis, emphysema, cirrhosis, corneal injury, metastases, invasion or growth of tumor cells, autoimmune diseases (e.g., Crohn's disease, Sjogren's syndrome), diseases caused by vascular diapedesis or leukocyte infiltration, arterialization, multiple sclerosis, aortic aneurysm or en dometriosis.