RU2070052C1 - Method of treatment of pseudotuberculosis in pigeons - Google Patents

Abstract

FIELD: veterinary. SUBSTANCE: method involves administration of 0.1% sterile aqueous solution of alfalfa plant extract to sick birds (0.5 g per a head per one dose) together with 20% formazin solution (10.0 g per a head) by the following schedule: treatment - 3 days, pause - 3 days, treatment - 3 days, pause - 3 days, treatment - 3 days. Proposed agent is given with drinking water. EFFECT: enhanced effectiveness of treatment.

Description

 The invention relates to methods for treating pseudotuberculosis and may find application in veterinary medicine for the treatment of pseudotuberculosis in birds, for example, pigeons.

 Pseudotuberculosis is an infectious disease of birds caused by Mycoplasma small gram-negative polymorphic cocci. Mycoplasmas are resistant to sulfa drugs, penicillin, but are sensitive to streptomycin, tetracycline antibiotics, tylosin, alkalis. Carboxylic acid and creolin are detrimental to mycoplasma.

 In sick birds shortness of breath, wheezing, coughing are noted, exudate, swelling of the larynx are secreted from the nasal openings. As the disease develops, birds experience diarrhea, weight loss, and egg production.

For the treatment of diseases, morphocycline is used in a dose of 70 mg / kg of plate weight or aerosol 150 200 mg / m ³ ; streptomycin 200 250 mg / kg poultry intramuscularly or 200 250 mg / m ³ aerosol; chloramphenicol - 350 400 mg / m ³ aerosol or 35 50 mg / kg of bird weight orally; fradizin and farmazin in doses of 10 to 20 mg / kg of bird weight; furazolidone, furagin aerosol in a dose of 75 to 100 mg / m ³ or give a dose of 40 to 60 mg / l with drinking water; tilan in a dose of 0.5 g / l with drinking water for 5 days. The interval between courses of treatment is 6-8 days, and when prescribing tilan 3 days.

 For a positive therapeutic effect, accurate adherence to antibiotic delivery times is important. Tilan, farmazin, morphocycline, oleomorphocycline, chloramphenicol, oxytetracycline are given with feed or drinking water (A Brief Guide to Bird Diseases, DA Azimov et al. T: Mehnat, 1986, p. 76 79) Prototype.

 Usually, the disease is complicated by bacterial microflora (Escherichia, Salmonella, etc.) and manifests itself as a mixed infection. For treatment, erythromycin with feed in doses of 0.03 g / kg is used; tylosin with water 35 g per 1000 heads (0.5% concentration) or 1.6 g (800 thousand units) of tylosin per 1 liter of water for 3 to 5 days. In aerosols, oleomorphocycline or kanamycin sulfate is prescribed in doses of 150 to 200 mg ("Veterinary formulation with the basics of therapy and prevention." Reference book. M. Agropromizdat, 1988).

 An object of the invention is to increase the effectiveness of treatment and reduce the treatment time of pseudotuberculosis.

 To solve this problem, sick birds, together with formazine with drinking water, are given an heracond of 50 mg / kg of live weight of the bird.

 The new drug Erakond was developed by the applicant.

Condensed vegetable extract (Herakond) is obtained as follows (application N 4736234 / 30-15, according to which the decision of the examination on the grant of a patent of the Russian Federation was obtained: Pat. N 1839723):
prepare a solution of salts of trace elements based on distilled water vapor condensate, including, for example, Mo 8.0 mg; Ba 10.0 mg; Rv - 20.0 mg; C 1.05 mg; 1.0 mg; Cz 0.5 mg; Zn 20.0 mg; Fe 300.0 mg; Sn 40 mg per 1 kg of plant mass;
the plant mass, for example, alfalfa hay, is crushed and placed in an autoclave;
fill the plant mass with the prepared solution in a ratio of 1: 5 and seal the autoclave;
carry out heating of the pulp to a temperature of 120 ^o C and kept under pressure for 10 minutes;
the primary extract is poured into a storage tank;
re-fill the plant mass with the same solution in the same ratio and seal the autoclave;
carry out heating of the pulp to a temperature of 180 ^o C and kept under pressure for 10 minutes;
the secondary extract is poured into a storage tank;
mix the primary extract with the secondary in the storage tank and evaporate it until a mixture of numerous bubbles appears on the mirror surface;
filter the mixture through a cotton-gauze filter;
the obtained filtrate is placed on a baking sheet covered with a plastic film;
continue to evaporate the extract in an oven at a temperature of 60 ^o With the formation of a resinous mass throughout the thickness of the extract poured onto a baking sheet;
the resulting resinous mass is molded into a lump for future use or storage.

 To use Heraconda to solve the problem, they take the resinous form of Heraconda in the calculation of 50 mg per 1 kg of live weight of the bird, prepare a 0.1% solution, which is used in conjunction with a 20% solution of formazine with drinking water.

 The Trinity Veterinary Institute, together with the Chernoborsky collective farm in the Chelyabinsk region, conducted a study of a method for treating pigeons with pseudotuberculosis by using an extract of plant condensed Heraconda.

 Three groups of pigeons were formed on the basis of analogues taking into account the breed and value of the bird.

 In the first group (dovecote) there were 50 birds, in the second 125, in the third - 100.

 In all three pigeon-groups, before death, the mortality of birds was observed: in the first 6 pigeons fell, in the second 12, in the third 10. In total, 28 pigeons fell from pseudotuberculosis to the experiment.

 Asked drugs at the same time in all 3 groups. In the first group, formazine was given in an amount of 10 g per day, in the second group formazin and heracond (formazine 10 g, heraconda 0.5 g), in the third group heracond in an amount of 0.5 g. The preparations were diluted in water and poured into drinkers. The medications were prescribed for 9 days according to the scheme: 3 days of treatment, then a break of 3 days, again three days of treatment, three days a break and a third time 3 days of treatment. A 0.1% aqueous solution of Heraconda was prepared and poured into drinkers of the second and third groups, an average of 50 mg per 1 kg of live weight of the bird per day. A 20% solution of formazine was prepared (according to the manual), which was poured equally into drinkers of the first and second groups (0.5 L each).

 The results of treatment became visible on the third day of giving drugs. In the second group, deaths stopped, pigeons began to actively take food, began to sit on the floor less, fly more, diarrhea began to disappear.

 In the first and third groups, the sudden death of pigeons was observed in the first days of treatment. The death completely stopped on the 6th day of treatment. The pigeons became lively, the diarrhea disappeared, they began to eat all the food that was given for the day. The treatment results are presented in the table.

 Thus, we can conclude that the second method of treatment is the most effective, in which Heracond (50 mg per 1 kg of live weight of pigeons) and formazin inside with water were used.

Claims (1)

A method for treating pigeon pigeon tuberculosis, including giving a sick bird with drinking water a 20% formazine solution of 10 g per 1 head, characterized in that it additionally sets a 0.1% solution of alfalfa plant extract obtained by treatment with an extractant containing a mixture of trace elements , in the following ratio of components, mg / kg of plant mass:
Mo 8.0
Ba 10.0
Pb 20.0
Co 1.05
V 1.0
Cz 0.5
Zn 200.0;
Fe 300.0
Sn 40.0
in the calculation of 0.5 g per 1 head at a time, and these solutions give the bird according to the scheme: 3 days of treatment, 3 days of a break, again 3 days of treatment, 3 days of a break and then again 3 days of treatment.

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