RO72596B - Procedeu pentru prepararea unor derivati de acid tiazolidincarboxilic, tiazancarboxilic sau morfolincarboxilic - Google Patents
Procedeu pentru prepararea unor derivati de acid tiazolidincarboxilic, tiazancarboxilic sau morfolincarboxilicInfo
- Publication number
- RO72596B RO72596B RO92287A RO9228777A RO72596B RO 72596 B RO72596 B RO 72596B RO 92287 A RO92287 A RO 92287A RO 9228777 A RO9228777 A RO 9228777A RO 72596 B RO72596 B RO 72596B
- Authority
- RO
- Romania
- Prior art keywords
- acid
- group
- preparation
- tiazolidincarboxylic
- tiazancarboxylic
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- -1 mercaptomethyl group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- STUHQDIOZQUPGP-UHFFFAOYSA-N morpholin-4-ium-4-carboxylate Chemical class OC(=O)N1CCOCC1 STUHQDIOZQUPGP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- ULSZVNJBVJWEJE-UHFFFAOYSA-N thiazolidine-2-carboxylic acid Chemical compound OC(=O)C1NCCS1 ULSZVNJBVJWEJE-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Procedeu pentru prepararea unor derivati de acid tiazolidincarboxilic, tiazancarboxilic sau morfolincarboxilic cu formula din pag.1 a descrierii, în care X reprezinta un atom de oxigen, de sulf, o grupa SO sau SO2, R reprezinta un atom de hidrogen sau o grupa acetil, R1 reprezinta un atom de hidrogen sau o grupa metil, R2 reprezinta un atom de hidrogen, o grupa metil sau etil, R3 reprezinta un atom de hidrogen, o grupa metil, mercaptometil sau acetiltiometril, m are valoarea 2 si n valoarea 1, cînd X este oxigen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74728176A | 1976-12-03 | 1976-12-03 | |
| US83610777A | 1977-09-23 | 1977-09-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO72596B true RO72596B (ro) | 1983-07-30 |
| RO72596A RO72596A (ro) | 1983-08-03 |
Family
ID=27114718
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO7799106A RO78013A (ro) | 1976-12-03 | 1977-12-02 | Procedeu pentru prepararea unor derivati de acid tiazolidincarboxilictiazoncarboxilic sau morfolincarboxilic |
| RO7792287A RO72596A (ro) | 1976-12-03 | 1977-12-02 | Procedeu pentru prepararea unor derivati de acid tiazolidincarboxilictiazancarboxilic sau morfolincarboxilic |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO7799106A RO78013A (ro) | 1976-12-03 | 1977-12-02 | Procedeu pentru prepararea unor derivati de acid tiazolidincarboxilictiazoncarboxilic sau morfolincarboxilic |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS5382778A (ro) |
| AR (1) | AR220689A1 (ro) |
| AT (1) | AT363467B (ro) |
| AU (1) | AU518147B2 (ro) |
| BG (1) | BG32269A3 (ro) |
| CA (1) | CA1146940A (ro) |
| CH (1) | CH634062A5 (ro) |
| DD (1) | DD133798A5 (ro) |
| DE (1) | DE2752719C2 (ro) |
| DK (1) | DK152494C (ro) |
| EG (1) | EG13037A (ro) |
| ES (1) | ES464555A1 (ro) |
| FI (1) | FI67378C (ro) |
| FR (1) | FR2372817A1 (ro) |
| GB (1) | GB1578940A (ro) |
| GR (1) | GR72453B (ro) |
| HK (1) | HK55881A (ro) |
| IE (1) | IE46169B1 (ro) |
| IL (1) | IL53352A0 (ro) |
| IN (1) | IN146945B (ro) |
| IT (1) | IT1092179B (ro) |
| NL (3) | NL171055C (ro) |
| NO (1) | NO148416C (ro) |
| NZ (1) | NZ185800A (ro) |
| PT (1) | PT67352B (ro) |
| RO (2) | RO78013A (ro) |
| SE (1) | SE441267B (ro) |
| YU (1) | YU41823B (ro) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1105731B (it) * | 1977-06-29 | 1985-11-04 | Yoshitomi Pharmaceutical | Composti di tiazolidina |
| JPS5455565A (en) * | 1977-10-06 | 1979-05-02 | Santen Pharmaceut Co Ltd | Novel thiazolidine derivative |
| AU528115B2 (en) * | 1978-04-08 | 1983-04-14 | Santen Pharmaceutical Co. Ltd. | Antihypertensive 4-thiazolidine/carboxylic acids |
| JPS557255A (en) * | 1978-07-03 | 1980-01-19 | Santen Pharmaceut Co Ltd | Thiazolidine derivative |
| JPS5531022A (en) * | 1978-08-24 | 1980-03-05 | Yoshitomi Pharmaceut Ind Ltd | Hydroxamic acid derivative and its preparation |
| GR73585B (ro) * | 1978-09-11 | 1984-03-26 | Univ Miami | |
| JPS5540622A (en) * | 1978-09-14 | 1980-03-22 | Santen Pharmaceut Co Ltd | Hypotensive agent |
| JPS5829950B2 (ja) * | 1978-10-05 | 1983-06-25 | ウェルファイド株式会社 | 環状イミノカルボン酸誘導体およびその塩類 |
| JPS5562060A (en) * | 1978-10-31 | 1980-05-10 | Santen Pharmaceut Co Ltd | Sulfur-containing compound |
| US4483861A (en) * | 1978-10-31 | 1984-11-20 | Santen Pharmaceutical Co., Ltd. | Antihypertensive sulfur-containing compounds |
| JPS55124757A (en) * | 1979-03-17 | 1980-09-26 | Santen Pharmaceut Co Ltd | Sulfur-containing compound |
| US4347371A (en) * | 1978-12-30 | 1982-08-31 | Santen Pharmaceutical Co., Ltd. | Disulfide compounds |
| JPS565415A (en) * | 1979-06-26 | 1981-01-20 | Santen Pharmaceut Co Ltd | Ester-type hypotensor |
| JPS5683483A (en) * | 1979-12-13 | 1981-07-08 | Santen Pharmaceut Co Ltd | Thiazolidine compound |
| JPS56139455A (en) * | 1980-04-02 | 1981-10-30 | Santen Pharmaceut Co Ltd | Sulfur-containing acylaminoacid |
| DE3152643A1 (de) * | 1980-12-29 | 1982-12-16 | Santen Pharmaceutical Co Ltd | Heterocyclic 5-membered ring compounds |
| JPH0662529B2 (ja) * | 1984-07-13 | 1994-08-17 | 三共株式会社 | アミノ酸誘導体 |
| CA1277663C (en) * | 1985-02-04 | 1990-12-11 | Richard A. Mueller | Heterocyclic amides |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2446100C3 (de) * | 1974-09-26 | 1982-01-14 | Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren | Phenoxyalkancarbonsäureamide von Thiazolidincarbonsäuren, Verfahren zu ihrer Herstellung und Arzneimittel |
| AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
-
1977
- 1977-11-07 AU AU30379/77A patent/AU518147B2/en not_active Expired
- 1977-11-10 IL IL53352A patent/IL53352A0/xx not_active IP Right Cessation
- 1977-11-14 GR GR54804A patent/GR72453B/el unknown
- 1977-11-21 CA CA000291351A patent/CA1146940A/en not_active Expired
- 1977-11-25 IE IE2397/77A patent/IE46169B1/en not_active IP Right Cessation
- 1977-11-25 DE DE2752719A patent/DE2752719C2/de not_active Expired
- 1977-11-28 GB GB49420/77A patent/GB1578940A/en not_active Expired
- 1977-11-28 IN IN418/DEL/77A patent/IN146945B/en unknown
- 1977-11-28 NZ NZ185800A patent/NZ185800A/xx unknown
- 1977-11-29 ES ES464555A patent/ES464555A1/es not_active Expired
- 1977-11-29 FR FR7735940A patent/FR2372817A1/fr active Granted
- 1977-11-30 AR AR270203A patent/AR220689A1/es active
- 1977-11-30 AT AT0857677A patent/AT363467B/de not_active IP Right Cessation
- 1977-12-01 FI FI773640A patent/FI67378C/fi not_active IP Right Cessation
- 1977-12-01 NL NLAANVRAGE7713274,A patent/NL171055C/xx not_active IP Right Cessation
- 1977-12-01 YU YU2837/77A patent/YU41823B/xx unknown
- 1977-12-02 IT IT52051/77A patent/IT1092179B/it active
- 1977-12-02 NO NO774126A patent/NO148416C/no unknown
- 1977-12-02 DK DK538277A patent/DK152494C/da not_active IP Right Cessation
- 1977-12-02 DD DD7700202373A patent/DD133798A5/xx unknown
- 1977-12-02 BG BG037941A patent/BG32269A3/xx unknown
- 1977-12-02 PT PT67352A patent/PT67352B/pt unknown
- 1977-12-02 RO RO7799106A patent/RO78013A/ro unknown
- 1977-12-02 RO RO7792287A patent/RO72596A/ro unknown
- 1977-12-02 CH CH1480077A patent/CH634062A5/de not_active IP Right Cessation
- 1977-12-02 SE SE7713722A patent/SE441267B/xx not_active IP Right Cessation
- 1977-12-03 JP JP14651877A patent/JPS5382778A/ja active Granted
- 1977-12-03 EG EG668/77A patent/EG13037A/xx active
-
1981
- 1981-11-12 HK HK558/81A patent/HK55881A/xx unknown
-
1982
- 1982-03-19 NL NL8201145A patent/NL8201145A/nl not_active Application Discontinuation
- 1982-03-19 NL NL8201146A patent/NL8201146A/nl not_active Application Discontinuation
Also Published As
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