PT99032A - Processo de preparacao de derivados do benzimidazolo e de composicoes farmaceuticas que os contem - Google Patents
Processo de preparacao de derivados do benzimidazolo e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT99032A PT99032A PT99032A PT9903291A PT99032A PT 99032 A PT99032 A PT 99032A PT 99032 A PT99032 A PT 99032A PT 9903291 A PT9903291 A PT 9903291A PT 99032 A PT99032 A PT 99032A
- Authority
- PT
- Portugal
- Prior art keywords
- hydrogen
- pharmaceutical compositions
- compositions containing
- preparation procedure
- benzimidazole derivatives
- Prior art date
Links
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 102000004257 Potassium Channel Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 108020001213 potassium channel Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polyesters Or Polycarbonates (AREA)
- Graft Or Block Polymers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58690090A | 1990-09-24 | 1990-09-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT99032A true PT99032A (pt) | 1993-11-30 |
| PT99032B PT99032B (pt) | 1999-02-26 |
Family
ID=24347548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99032A PT99032B (pt) | 1990-09-24 | 1991-09-24 | Processo de preparacao de derivados do benzimidazolo e de composicoes farmaceuticas que os contem |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0477819B1 (pt) |
| JP (1) | JP3203017B2 (pt) |
| KR (1) | KR100195770B1 (pt) |
| AT (1) | ATE119887T1 (pt) |
| AU (1) | AU635440B2 (pt) |
| CA (1) | CA2052041C (pt) |
| DE (1) | DE69108156T2 (pt) |
| DK (1) | DK0477819T3 (pt) |
| ES (1) | ES2072504T3 (pt) |
| FI (1) | FI103408B1 (pt) |
| IE (1) | IE67133B1 (pt) |
| NO (1) | NO180795C (pt) |
| NZ (1) | NZ239540A (pt) |
| PT (1) | PT99032B (pt) |
| ZA (1) | ZA916805B (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69224448T2 (de) * | 1991-06-24 | 1998-06-10 | Neurosearch As | Imidazol-Verbindungen, Verfahren zu ihrer Herstellung und ihre Anwendung |
| US5158969A (en) * | 1991-08-21 | 1992-10-27 | Neurosearch A/S | Indole derivatives as potassium channel blockers |
| US5232899A (en) * | 1992-06-08 | 1993-08-03 | Imperial Chemical Industries Plc | Benzoxazolinones and their use as herbicides |
| AU5433594A (en) * | 1992-11-19 | 1994-06-08 | Dainippon Pharmaceutical Co. Ltd. | 3,4-dihydro-1-(2-hydroxyphenyl)-2(1h)-quinoxalinone derivative and related compound |
| DK154092D0 (da) * | 1992-12-23 | 1992-12-23 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
| DK28893D0 (da) * | 1993-03-15 | 1993-03-15 | Neurosearch As | Benzimidazole derivater, deres fremstilling og anvendelse |
| DK41193D0 (da) * | 1993-04-07 | 1993-04-07 | Neurosearch As | Ionkanalaabnere |
| US5637470A (en) * | 1994-05-13 | 1997-06-10 | Merck & Co., Inc. | Screening array using cells expressing recombinant α and β subunits of the mammalian large-conductance (maxi-K) potassium channel |
| FR2722190B1 (fr) * | 1994-07-05 | 1996-10-04 | Sanofi Sa | Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant |
| US5565483A (en) * | 1995-06-07 | 1996-10-15 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
| TW504504B (en) * | 1996-11-26 | 2002-10-01 | Bristol Myers Squibb Co | 4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modulators |
| US5893085A (en) * | 1997-06-10 | 1999-04-06 | Phillips; Ronald W. | Dynamic fuzzy logic process for identifying objects in three-dimensional data |
| CA2301549A1 (en) * | 1997-08-28 | 1999-03-04 | Piyasena Hewawasam | 4-aryl-3-aminoquinoline-2-one derivatives as potassium channel modulators |
| AU760250B2 (en) * | 1998-12-04 | 2003-05-08 | Neurosearch A/S | New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents |
| CO5150159A1 (es) * | 1998-12-04 | 2002-04-29 | Bristol Myers Squibb Co | Derivados de 4-arilquinolin-2-ona 3-substituida como moduladores de los canales de potasio |
| JP2005533814A (ja) * | 2002-06-26 | 2005-11-10 | ポセイドン・ファーマスーティカルス・アクティーゼルスカブ | 新規ベンズイミダゾール−２−オン誘導体及びその使用方法 |
| WO2004064835A1 (en) * | 2003-01-17 | 2004-08-05 | Neurosearch A/S | Use of ion channel modulating agents for treating pain |
| ES2222831B2 (es) * | 2003-07-30 | 2006-02-16 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de principio activo que comprende un compuesto 2,5-dihidroxibencenosulfonico y un modulador de los canales de k+. |
| AR050084A1 (es) * | 2004-07-27 | 2006-09-27 | Novartis Ag | Derivados de bencimidazolona como inhibidores de hsp90 |
| JP5313883B2 (ja) * | 2007-04-18 | 2013-10-09 | キッセイ薬品工業株式会社 | 含窒素縮合環誘導体、それを含有する医薬組成物及びその医薬用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH460028A (de) * | 1965-01-22 | 1968-07-31 | Wander Ag Dr A | Verfahren zur Herstellung von Benzimidazolonderivaten |
| FR1561830A (pt) * | 1968-05-08 | 1969-03-28 | ||
| GB1408408A (en) * | 1971-11-24 | 1975-10-01 | Beecham Group Ltd | Benzimidazole derivatives |
| GB1476949A (en) * | 1974-11-20 | 1977-06-16 | Wyeth John & Brother Ltd | Imidazo-1,2-a-benzimidazole and pyrimido-1,2-a-benzimidazole derivatives their preparation and their pharmaceutical compositions |
| CH622009A5 (pt) * | 1976-06-11 | 1981-03-13 | Ciba Geigy Ag | |
| DE3042481A1 (de) * | 1980-11-11 | 1982-06-16 | A. Nattermann & Cie GmbH, 5000 Köln | (omega)-(2-oxo-benzazolinyl)-alkansaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| ES2052544T3 (es) * | 1986-02-03 | 1994-07-16 | Janssen Pharmaceutica Nv | Composiciones anti-histaminicas que contienen n-heterociclil-4-piperidinaminas. |
-
1991
- 1991-08-26 NZ NZ239540A patent/NZ239540A/en not_active IP Right Cessation
- 1991-08-28 ZA ZA916805A patent/ZA916805B/xx unknown
- 1991-08-28 AU AU82767/91A patent/AU635440B2/en not_active Ceased
- 1991-09-11 FI FI914275A patent/FI103408B1/fi not_active IP Right Cessation
- 1991-09-11 IE IE319791A patent/IE67133B1/en not_active IP Right Cessation
- 1991-09-20 JP JP24194691A patent/JP3203017B2/ja not_active Expired - Fee Related
- 1991-09-20 KR KR1019910016522A patent/KR100195770B1/ko not_active Expired - Fee Related
- 1991-09-23 ES ES91116148T patent/ES2072504T3/es not_active Expired - Lifetime
- 1991-09-23 AT AT91116148T patent/ATE119887T1/de not_active IP Right Cessation
- 1991-09-23 EP EP91116148A patent/EP0477819B1/en not_active Expired - Lifetime
- 1991-09-23 DE DE69108156T patent/DE69108156T2/de not_active Expired - Fee Related
- 1991-09-23 DK DK91116148.7T patent/DK0477819T3/da active
- 1991-09-23 CA CA002052041A patent/CA2052041C/en not_active Expired - Fee Related
- 1991-09-23 NO NO913728A patent/NO180795C/no unknown
- 1991-09-24 PT PT99032A patent/PT99032B/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69108156T2 (de) | 1995-07-06 |
| ATE119887T1 (de) | 1995-04-15 |
| EP0477819B1 (en) | 1995-03-15 |
| AU8276791A (en) | 1992-03-26 |
| CA2052041A1 (en) | 1992-03-25 |
| FI103408B (fi) | 1999-06-30 |
| FI103408B1 (fi) | 1999-06-30 |
| CA2052041C (en) | 2002-08-20 |
| NO913728D0 (no) | 1991-09-23 |
| PT99032B (pt) | 1999-02-26 |
| IE67133B1 (en) | 1996-03-06 |
| DE69108156D1 (de) | 1995-04-20 |
| JP3203017B2 (ja) | 2001-08-27 |
| EP0477819A3 (en) | 1992-05-20 |
| NO180795C (no) | 1997-06-25 |
| NO913728L (no) | 1992-03-25 |
| IE913197A1 (en) | 1992-02-25 |
| AU635440B2 (en) | 1993-03-18 |
| NZ239540A (en) | 1993-11-25 |
| FI914275A0 (fi) | 1991-09-11 |
| JPH04305568A (ja) | 1992-10-28 |
| FI914275L (fi) | 1992-03-25 |
| KR100195770B1 (ko) | 1999-06-15 |
| NO180795B (no) | 1997-03-17 |
| ES2072504T3 (es) | 1995-07-16 |
| KR920006327A (ko) | 1992-04-27 |
| DK0477819T3 (da) | 1995-07-17 |
| EP0477819A2 (en) | 1992-04-01 |
| ZA916805B (en) | 1992-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19981111 |
|
| TE3A | Change of address (patent) |
Owner name: NEUROSEARCH A/S Effective date: 19990730 |
|
| PC3A | Transfer or assignment |
Free format text: POSEIDON PHARMACEUTICALS A/S DK Effective date: 20030506 |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20090511 |