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PT98475A - Processo para preparacao de derivativos de indole uteis como antagonistas do leucotrieno - Google Patents

Processo para preparacao de derivativos de indole uteis como antagonistas do leucotrieno

Info

Publication number
PT98475A
PT98475A PT98475A PT9847591A PT98475A PT 98475 A PT98475 A PT 98475A PT 98475 A PT98475 A PT 98475A PT 9847591 A PT9847591 A PT 9847591A PT 98475 A PT98475 A PT 98475A
Authority
PT
Portugal
Prior art keywords
alkyl
hydrogen
optionally protected
utilate
preparation
Prior art date
Application number
PT98475A
Other languages
English (en)
Other versions
PT98475B (pt
Inventor
Jeremy Gilmore
Alec Todd
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909016790A external-priority patent/GB9016790D0/en
Priority claimed from GB919107486A external-priority patent/GB9107486D0/en
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of PT98475A publication Critical patent/PT98475A/pt
Publication of PT98475B publication Critical patent/PT98475B/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
PT98475A 1990-07-31 1991-07-29 Processo para preparacao de derivativos de indole uteis como antagonistas do leucotrieno PT98475B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909016790A GB9016790D0 (en) 1990-07-31 1990-07-31 Pharmaceutical compounds
GB919107486A GB9107486D0 (en) 1991-04-09 1991-04-09 Pharmaceutical compounds

Publications (2)

Publication Number Publication Date
PT98475A true PT98475A (pt) 1992-06-30
PT98475B PT98475B (pt) 1997-11-28

Family

ID=26297410

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98475A PT98475B (pt) 1990-07-31 1991-07-29 Processo para preparacao de derivativos de indole uteis como antagonistas do leucotrieno

Country Status (24)

Country Link
EP (1) EP0469833B1 (pt)
JP (1) JP3220191B2 (pt)
KR (1) KR0179985B1 (pt)
CN (1) CN1040108C (pt)
AT (1) ATE184280T1 (pt)
AU (1) AU654140B2 (pt)
CA (1) CA2048096C (pt)
CZ (1) CZ279932B6 (pt)
DE (1) DE69131592T2 (pt)
DK (1) DK0469833T3 (pt)
ES (1) ES2137158T3 (pt)
FI (1) FI102536B (pt)
GR (1) GR3032038T3 (pt)
HU (2) HU213604B (pt)
IE (1) IE912670A1 (pt)
IL (1) IL98990A (pt)
MX (1) MX9100414A (pt)
MY (1) MY131141A (pt)
NO (1) NO300133B1 (pt)
NZ (1) NZ239168A (pt)
PH (1) PH30487A (pt)
PT (1) PT98475B (pt)
SK (1) SK279197B6 (pt)
YU (1) YU47839B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9122590D0 (en) * 1991-10-24 1991-12-04 Lilly Industries Ltd Pharmaceutical compounds
US5273986A (en) * 1992-07-02 1993-12-28 Hoffmann-La Roche Inc. Cycloalkylthiazoles
US5416211A (en) * 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
US5486612A (en) * 1993-12-14 1996-01-23 Eli Lilly And Company N-benzyl dihydroindole LTD4 antagonists
EP0743064A1 (en) * 1995-05-17 1996-11-20 Eli Lilly And Company Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease
US6160120A (en) * 1996-11-19 2000-12-12 Eli Lilly And Company Process for preparing n-benzyl indoles
GB9523948D0 (en) 1995-11-23 1996-01-24 Univ East Anglia Process for preparing n-benzyl indoles
CN101076531A (zh) * 2004-10-12 2007-11-21 解码遗传学公司 用于阻塞性血管疾病的羧酸迫位取代的双环化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8524157D0 (en) * 1984-10-19 1985-11-06 Ici America Inc Heterocyclic amides
MY103259A (en) * 1987-04-15 1993-05-29 Ici America Inc Aliphatic carboxamides
GB8728051D0 (en) * 1987-12-01 1988-01-06 Leo Pharm Prod Ltd Chemical compounds
US4970207A (en) * 1988-07-07 1990-11-13 Fujisawa Pharmaceutical Company, Ltd. Benzodiazepine derivatives

Also Published As

Publication number Publication date
ATE184280T1 (de) 1999-09-15
PT98475B (pt) 1997-11-28
EP0469833A1 (en) 1992-02-05
KR920002582A (ko) 1992-02-28
HU912535D0 (en) 1992-01-28
YU132591A (sh) 1994-01-20
AU8139991A (en) 1992-02-06
IL98990A (en) 1995-06-29
FI913639A0 (fi) 1991-07-30
CA2048096C (en) 2002-09-17
HU213604B (en) 1997-08-28
CA2048096A1 (en) 1992-02-01
MY131141A (en) 2007-07-31
NO300133B1 (no) 1997-04-14
IE912670A1 (en) 1992-02-12
YU47839B (sr) 1996-01-09
CN1040108C (zh) 1998-10-07
JPH06220045A (ja) 1994-08-09
CS238091A3 (en) 1992-03-18
NZ239168A (en) 1993-05-26
NO912963D0 (no) 1991-07-30
DK0469833T3 (da) 1999-12-20
DE69131592D1 (de) 1999-10-14
AU654140B2 (en) 1994-10-27
GR3032038T3 (en) 2000-03-31
ES2137158T3 (es) 1999-12-16
HUT60491A (en) 1992-09-28
CN1061413A (zh) 1992-05-27
SK279197B6 (sk) 1998-07-08
KR0179985B1 (ko) 1999-03-20
FI913639A7 (fi) 1992-02-01
JP3220191B2 (ja) 2001-10-22
IL98990A0 (en) 1992-07-15
FI102536B1 (fi) 1998-12-31
MX9100414A (es) 1992-02-28
CZ279932B6 (cs) 1995-08-16
HU211952A9 (en) 1996-01-29
PH30487A (en) 1997-05-28
EP0469833B1 (en) 1999-09-08
FI102536B (fi) 1998-12-31
DE69131592T2 (de) 2000-01-20
NO912963L (no) 1992-02-03

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920211

FG3A Patent granted, date of granting

Effective date: 19970801

PD3A Change of proprietorship
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040229