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PT971913E - Processo para a producao de estatinas semi-sinteticas atraves de novos intermediarios - Google Patents

Processo para a producao de estatinas semi-sinteticas atraves de novos intermediarios

Info

Publication number
PT971913E
PT971913E PT98908031T PT98908031T PT971913E PT 971913 E PT971913 E PT 971913E PT 98908031 T PT98908031 T PT 98908031T PT 98908031 T PT98908031 T PT 98908031T PT 971913 E PT971913 E PT 971913E
Authority
PT
Portugal
Prior art keywords
statines
semi
synthetic
production
new intermediaries
Prior art date
Application number
PT98908031T
Other languages
English (en)
Inventor
Mieke Sibeyn
Ton Rene Vries
Hans Wijnberg
Wijnand Sjourd Faber
Venetka Ivanova Kalkman-Agayn
Original Assignee
Plus Chemicals Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plus Chemicals Bv filed Critical Plus Chemicals Bv
Publication of PT971913E publication Critical patent/PT971913E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30Oxygen atoms, e.g. delta-lactones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574Esters of oxyacids of phosphorus
    • C07F9/65742Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
PT98908031T 1997-01-28 1998-01-27 Processo para a producao de estatinas semi-sinteticas atraves de novos intermediarios PT971913E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97200223 1997-01-28
EP97306809 1997-09-03

Publications (1)

Publication Number Publication Date
PT971913E true PT971913E (pt) 2003-08-29

Family

ID=26146080

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98908031T PT971913E (pt) 1997-01-28 1998-01-27 Processo para a producao de estatinas semi-sinteticas atraves de novos intermediarios

Country Status (16)

Country Link
US (1) US6294680B1 (pt)
EP (2) EP0971913B1 (pt)
JP (1) JP2001508782A (pt)
KR (1) KR100538674B1 (pt)
AR (1) AR011780A1 (pt)
AT (2) ATE237605T1 (pt)
AU (1) AU747219C (pt)
CA (1) CA2278603A1 (pt)
DE (2) DE69813538T2 (pt)
DK (1) DK0971913T3 (pt)
ES (2) ES2197465T3 (pt)
IL (1) IL131044A (pt)
NO (1) NO318146B1 (pt)
NZ (1) NZ336993A (pt)
PT (1) PT971913E (pt)
WO (1) WO1998032751A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0940395A1 (en) * 1998-03-05 1999-09-08 Synthon B.V. Process for producing simvastatin and/or its derivatives
NO991045L (no) 1998-03-05 1999-09-06 Synthon Bv FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater
CA2320163C (en) * 1998-12-10 2008-09-23 Kaneka Corporation Process for producing simvastatin
CO5140104A1 (es) 1999-02-16 2002-03-22 Novartis Ag Derivados de mevinolina y preparacion farmaceuticas que los contienen
KR20010009846A (ko) * 1999-07-14 2001-02-05 구광시 심바스타틴 제조에 유용한 중간체 및 그의 제조방법
WO2001034590A1 (en) * 1999-11-11 2001-05-17 Biocon India Limited Process for manufacturing simvastatin and the novel intermediates
US6573385B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
JP2004505045A (ja) * 2000-07-27 2004-02-19 プラス ケミカルズ ベスローテン フェンノートシャップ 高純度シンバスタチン組成物
NL1017548C2 (nl) 2001-03-09 2002-09-10 Synthon Bv Een lactonisatie proces.
KR20040026705A (ko) 2001-08-16 2004-03-31 테바 파마슈티컬 인더스트리즈 리미티드 스타틴의 칼슘 염 형태의 제조 방법
US6472542B1 (en) 2001-11-29 2002-10-29 Fermic S.A. De C.V. Method for alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin
KR100423892B1 (ko) * 2001-12-03 2004-03-22 씨제이 주식회사 스타틴의 제조에 있어서 새로운 락톤화 방법
SI21187A (sl) 2002-03-26 2003-10-31 Krka, Tovarna Zdravil D.D., Novo Mesto Postopek za pripravo 4-oksitetrahidropiran-2-onov
US6603022B1 (en) 2002-05-10 2003-08-05 Biocon India Limited Process for manufacturing Simvastatin and novel intermediates thereof
CA2515179A1 (en) 2003-02-11 2004-08-26 Ferenc Korodi Process for preparing simvastatin having controlled ranges of simvastatin dimer content
CN101415833B (zh) * 2003-10-21 2012-07-04 维莱尼姆公司 制备新伐他汀及中间体的方法
JP4621451B2 (ja) 2004-08-11 2011-01-26 富士フイルム株式会社 液浸露光用保護膜形成組成物及びそれを用いたパターン形成方法
WO2007030302A2 (en) * 2005-09-01 2007-03-15 Prescient Medical, Inc. Drugs coated on a device to treat vulnerable plaque
WO2007125547A2 (en) 2006-05-03 2007-11-08 Manne Satyanarayana Reddy Novel process for statins and its pharmaceutically acceptable salts thereof
US8404841B2 (en) 2006-10-09 2013-03-26 Msn Laboratories Limited Process for the preparation of statins and their pharmaceutically acceptable salts thereof
EP2387561A4 (en) 2009-01-19 2012-07-25 Msn Lab Ltd IMPROVED PROCESS FOR THE PREPARATION OF HIGH-PURITY (3R, 5S) -7-β-CYCLOPROPYL-4- (4-FLUOROPHENYL) QUINOLIN-3-YL-3,5-DIHYDROXY-6 (E) -HEPTENOIC ACID, INCLUDING ITS PHARMACEUTICALLY ACCEPTABLE SALTS
US8470805B2 (en) * 2009-04-30 2013-06-25 Kaohsiung Medical University Processes for preparing piperazinium salts of KMUP and use thereof
EP2526099B1 (en) 2010-01-18 2016-03-30 MSN Laboratories Limited Improved process for the preparation of amide intermediates and their use thereof
HU229260B1 (en) * 2010-11-29 2013-10-28 Egis Gyogyszergyar Nyrt Process for preparation of rosuvastatin salts
CN110563680A (zh) * 2019-09-10 2019-12-13 山东罗欣药业集团恒欣药业有限公司 一种治疗高脂血症药物的制备方法
CN110483459A (zh) * 2019-09-10 2019-11-22 山东罗欣药业集团恒欣药业有限公司 一种辛伐他汀的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
EP0415488B1 (en) * 1989-08-31 1994-04-20 Merck & Co. Inc. 7-Substituted HMG-COA reductase inhibitors
US5393893A (en) * 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof
EP0940395A1 (en) 1998-03-05 1999-09-08 Synthon B.V. Process for producing simvastatin and/or its derivatives

Also Published As

Publication number Publication date
NO993644L (no) 1999-09-28
US6294680B1 (en) 2001-09-25
DE69834279T2 (de) 2007-01-04
ATE323689T1 (de) 2006-05-15
AU6618398A (en) 1998-08-18
DE69813538D1 (de) 2003-05-22
AU747219C (en) 2003-11-20
ATE237605T1 (de) 2003-05-15
EP1340752A1 (en) 2003-09-03
ES2197465T3 (es) 2004-01-01
ES2266671T3 (es) 2007-03-01
DE69813538T2 (de) 2004-04-01
KR20000070501A (ko) 2000-11-25
DE69834279D1 (de) 2006-05-24
AU747219B2 (en) 2002-05-09
NZ336993A (en) 2000-05-26
JP2001508782A (ja) 2001-07-03
NO318146B1 (no) 2005-02-07
KR100538674B1 (ko) 2005-12-26
EP1340752B1 (en) 2006-04-19
NO993644D0 (no) 1999-07-27
IL131044A (en) 2003-07-31
IL131044A0 (en) 2001-01-28
DK0971913T3 (da) 2003-08-04
CA2278603A1 (en) 1998-07-30
WO1998032751A1 (en) 1998-07-30
EP0971913A1 (en) 2000-01-19
AR011780A1 (es) 2000-09-13
EP0971913B1 (en) 2003-04-16

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