PT94925A - Processo para a preparacao de derivados de tiazol e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de derivados de tiazol e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT94925A PT94925A PT94925A PT9492590A PT94925A PT 94925 A PT94925 A PT 94925A PT 94925 A PT94925 A PT 94925A PT 9492590 A PT9492590 A PT 9492590A PT 94925 A PT94925 A PT 94925A
- Authority
- PT
- Portugal
- Prior art keywords
- preparation
- pharmaceutical compositions
- alkyl
- hydroxy
- halogen
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- -1 nitro, amino Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898918045A GB8918045D0 (en) | 1989-08-07 | 1989-08-07 | Thiazole derivatives,processes for production thereof and pharmaceutical compositions comprising the same |
| GB909003930A GB9003930D0 (en) | 1990-02-21 | 1990-02-21 | Thiazole derivatives,processes for production thereof and pharmaceutical compositions comprising the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT94925A true PT94925A (pt) | 1991-04-18 |
| PT94925B PT94925B (pt) | 1997-04-30 |
Family
ID=26295715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT94925A PT94925B (pt) | 1989-08-07 | 1990-08-06 | Processo para a preparacao de derivados de tiazol e de composicoes farmaceuticas que os contem |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0412404B1 (pt) |
| JP (1) | JPH0368567A (pt) |
| KR (1) | KR910004582A (pt) |
| CN (1) | CN1027370C (pt) |
| AT (1) | ATE133667T1 (pt) |
| AU (1) | AU635758B2 (pt) |
| CA (1) | CA2022731A1 (pt) |
| DE (1) | DE69025104T2 (pt) |
| DK (1) | DK0412404T3 (pt) |
| ES (1) | ES2082805T3 (pt) |
| FI (1) | FI96857C (pt) |
| GR (1) | GR3019009T3 (pt) |
| HK (1) | HK151596A (pt) |
| HU (2) | HUT57752A (pt) |
| IE (1) | IE902679A1 (pt) |
| IL (1) | IL95281A (pt) |
| NO (1) | NO179638C (pt) |
| PH (1) | PH26766A (pt) |
| PT (1) | PT94925B (pt) |
| RU (2) | RU2010026C1 (pt) |
| TW (1) | TW205041B (pt) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU644281B2 (en) * | 1991-04-24 | 1993-12-02 | Sumitomo Pharmaceuticals Company, Limited | Novel thiazole derivatives |
| FR2677021B1 (fr) * | 1991-05-31 | 1993-10-01 | Upsa Laboratoires | Nouveaux derives de thiazole antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant. |
| DE4119756A1 (de) * | 1991-06-15 | 1992-12-17 | Basf Ag | Aminoalkylsubstituierte 5-mercaptothiazole, ihre herstellung und verwendung |
| AT402926B (de) * | 1994-12-05 | 1997-09-25 | Hafslund Nycomed Pharma | Heterocyclische amide, verfahren zu ihrer herstellung und verwendung |
| IL117620A0 (en) * | 1995-03-27 | 1996-07-23 | Fujisawa Pharmaceutical Co | Heterocyclic compounds processes for the preparation thereof and pharmaceutical compositions containing the same |
| TW513418B (en) * | 1996-07-31 | 2002-12-11 | Otsuka Pharma Co Ltd | Thiazole derivatives, their production and use |
| US6262096B1 (en) | 1997-11-12 | 2001-07-17 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
| IT1299198B1 (it) * | 1998-03-05 | 2000-02-29 | Nicox Sa | Sali nitrati di farmaci antiulcera |
| US6414156B2 (en) | 1998-10-21 | 2002-07-02 | Bristol-Myers Squibb Company | Process for preparing azacycloalkanoylaminothiazoles |
| US6214852B1 (en) | 1998-10-21 | 2001-04-10 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
| GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| EP2308833A3 (en) | 1999-04-15 | 2011-09-28 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| US6515004B1 (en) | 1999-12-15 | 2003-02-04 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
| US6392053B2 (en) | 1999-12-15 | 2002-05-21 | Bristol-Myers Squibb Company | Process for preparing arylacetylaminothiazoles |
| US6716995B2 (en) | 2000-08-17 | 2004-04-06 | Lumera Corporation | Design and synthesis of advanced NLO materials for electro-optic applications |
| HUP0303538A2 (hu) | 2000-12-21 | 2005-02-28 | Bristol-Myers Squibb Co. | Tirozin kinázok Tec családjának tiazolil-vegyület inhibitorai és ezeket tartalmazó gyógyszerkészítmények |
| EP1724270A3 (en) | 2001-07-19 | 2007-01-03 | Pfizer Italia S.r.l. | Phenylacetamido-thiazole derivatives, process for their preparation and their use as antitumor agents |
| CN1319967C (zh) | 2002-01-18 | 2007-06-06 | 安斯泰来制药有限公司 | 2－酰基氨基噻唑衍生物或其盐 |
| CN1835948B (zh) * | 2003-07-17 | 2010-05-26 | 安斯泰来制药有限公司 | 2-酰基氨基噻唑衍生物或其盐 |
| JP4774995B2 (ja) * | 2005-01-12 | 2011-09-21 | アステラス製薬株式会社 | アシルアミノチアゾール誘導体を有効成分とする医薬組成物 |
| US8841334B2 (en) | 2006-05-31 | 2014-09-23 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
| ES2645995T3 (es) | 2006-05-31 | 2017-12-11 | Abbvie Inc. | Compuestos como ligandos del receptor cannabinoide y sus usos |
| CN101454302A (zh) | 2006-05-31 | 2009-06-10 | 艾博特公司 | 用作大麻素受体配位体的噻唑化合物及其用途 |
| US7985768B2 (en) | 2006-08-31 | 2011-07-26 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
| US7868038B2 (en) | 2006-08-31 | 2011-01-11 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
| US7875640B2 (en) | 2007-03-28 | 2011-01-25 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
| US7872033B2 (en) | 2007-04-17 | 2011-01-18 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
| CN101711253A (zh) | 2007-05-18 | 2010-05-19 | 雅培制药有限公司 | 用作大麻素受体配体的新化合物 |
| US9193713B2 (en) | 2007-10-12 | 2015-11-24 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| TWI437986B (zh) * | 2008-01-31 | 2014-05-21 | R Tech Ueno Ltd | 噻唑衍生物及使用該衍生物作為ｖａｐ－１抑制劑之用途 |
| CA2716857A1 (en) | 2008-03-11 | 2009-09-17 | Teodozyi Kolasa | Novel compounds as cannabinoid receptor ligands |
| US8846730B2 (en) | 2008-09-08 | 2014-09-30 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| EP2428507B1 (en) | 2008-09-16 | 2015-10-21 | AbbVie Bahamas Ltd. | Cannabinoid receptor ligands |
| PA8854001A1 (es) | 2008-12-16 | 2010-07-27 | Abbott Lab | Compuestos novedosos como ligandos de receptores de canabinoides |
| CN101768155B (zh) * | 2008-12-30 | 2012-09-05 | 天津药物研究院 | 一类含(氨甲基-五元芳香杂环-4-羰基)-吡咯烷-2-羧酸的衍生物、其制备方法和用途 |
| CN101768130B (zh) * | 2008-12-30 | 2012-07-04 | 天津药物研究院 | 含氨甲基五元芳香杂环4-羧酸类衍生物、其制备方法和用途 |
| CN104151262B (zh) * | 2014-07-07 | 2016-02-24 | 浙江大学 | 4,5-二取代-2-氨基噻唑化合物及其制备方法 |
| CN104163802B (zh) * | 2014-07-08 | 2016-04-27 | 浙江大学 | 2-氨基噻唑-4-甲酸乙酯的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB951885A (en) * | 1961-05-13 | 1964-03-11 | Sankyo Co | A new process for the preparation of thiazole compounds |
| US4649146A (en) * | 1983-01-31 | 1987-03-10 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole derivatives and pharmaceutical composition comprising the same |
-
1990
- 1990-07-16 TW TW079105854A patent/TW205041B/zh active
- 1990-07-19 PH PH40861A patent/PH26766A/en unknown
- 1990-07-23 IE IE267990A patent/IE902679A1/en unknown
- 1990-07-31 AT AT90114628T patent/ATE133667T1/de not_active IP Right Cessation
- 1990-07-31 EP EP90114628A patent/EP0412404B1/en not_active Expired - Lifetime
- 1990-07-31 DE DE69025104T patent/DE69025104T2/de not_active Expired - Fee Related
- 1990-07-31 AU AU60045/90A patent/AU635758B2/en not_active Ceased
- 1990-07-31 DK DK90114628.2T patent/DK0412404T3/da active
- 1990-07-31 ES ES90114628T patent/ES2082805T3/es not_active Expired - Lifetime
- 1990-08-03 IL IL9528190A patent/IL95281A/en not_active IP Right Cessation
- 1990-08-06 KR KR1019900012081A patent/KR910004582A/ko not_active Ceased
- 1990-08-06 HU HU904912A patent/HUT57752A/hu unknown
- 1990-08-06 PT PT94925A patent/PT94925B/pt not_active IP Right Cessation
- 1990-08-06 NO NO903438A patent/NO179638C/no unknown
- 1990-08-06 CA CA002022731A patent/CA2022731A1/en not_active Abandoned
- 1990-08-06 CN CN90106739A patent/CN1027370C/zh not_active Expired - Fee Related
- 1990-08-06 JP JP2208833A patent/JPH0368567A/ja active Pending
- 1990-08-06 FI FI903879A patent/FI96857C/fi not_active IP Right Cessation
- 1990-08-06 RU SU904830691A patent/RU2010026C1/ru active
-
1991
- 1991-11-22 RU SU915010232A patent/RU2048468C1/ru active
-
1995
- 1995-06-22 HU HU95P/P00375P patent/HU211557A9/hu unknown
-
1996
- 1996-02-15 GR GR960400408T patent/GR3019009T3/el unknown
- 1996-08-08 HK HK151596A patent/HK151596A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69025104D1 (de) | 1996-03-14 |
| NO903438D0 (no) | 1990-08-06 |
| IL95281A0 (en) | 1991-06-30 |
| AU635758B2 (en) | 1993-04-01 |
| IE902679A1 (en) | 1991-02-27 |
| KR910004582A (ko) | 1991-03-29 |
| EP0412404B1 (en) | 1996-01-31 |
| NO903438L (no) | 1991-02-08 |
| CA2022731A1 (en) | 1991-02-08 |
| PT94925B (pt) | 1997-04-30 |
| HU904912D0 (en) | 1991-01-28 |
| TW205041B (pt) | 1993-05-01 |
| CN1027370C (zh) | 1995-01-11 |
| ATE133667T1 (de) | 1996-02-15 |
| FI903879A0 (fi) | 1990-08-06 |
| RU2010026C1 (ru) | 1994-03-30 |
| PH26766A (en) | 1992-09-28 |
| DK0412404T3 (da) | 1996-02-26 |
| FI96857B (fi) | 1996-05-31 |
| CN1049337A (zh) | 1991-02-20 |
| NO179638B (no) | 1996-08-12 |
| JPH0368567A (ja) | 1991-03-25 |
| AU6004590A (en) | 1991-02-07 |
| NO179638C (no) | 1996-11-20 |
| HK151596A (en) | 1996-08-16 |
| RU2048468C1 (ru) | 1995-11-20 |
| IL95281A (en) | 1996-06-18 |
| EP0412404A2 (en) | 1991-02-13 |
| HU211557A9 (en) | 1995-12-28 |
| ES2082805T3 (es) | 1996-04-01 |
| FI96857C (fi) | 1996-09-10 |
| GR3019009T3 (en) | 1996-05-31 |
| HUT57752A (en) | 1991-12-30 |
| EP0412404A3 (en) | 1991-06-12 |
| DE69025104T2 (de) | 1996-07-04 |
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