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PT89769A - Processo para a preparacao de derivados do acido 3-alcenil-1-azabiciclo-{3,2,0}hept-2-eno-2-carboxilico - Google Patents

Processo para a preparacao de derivados do acido 3-alcenil-1-azabiciclo-{3,2,0}hept-2-eno-2-carboxilico

Info

Publication number
PT89769A
PT89769A PT89769A PT8976989A PT89769A PT 89769 A PT89769 A PT 89769A PT 89769 A PT89769 A PT 89769A PT 8976989 A PT8976989 A PT 8976989A PT 89769 A PT89769 A PT 89769A
Authority
PT
Portugal
Prior art keywords
preparation
alcenyl
eno
azabicyclo
hept
Prior art date
Application number
PT89769A
Other languages
English (en)
Other versions
PT89769B (pt
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of PT89769A publication Critical patent/PT89769A/pt
Publication of PT89769B publication Critical patent/PT89769B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
PT89769A 1988-02-22 1989-02-21 Processo para a preparacao de derivados do acido 3-alcenil-1-azabiciclo-{3,2,0}hept-2-eno-2-carboxilico PT89769B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888804058A GB8804058D0 (en) 1988-02-22 1988-02-22 3-alkenyl-1-azabicyclo(3 2 0)hept-2-ene-2-carboxylic acid compounds

Publications (2)

Publication Number Publication Date
PT89769A true PT89769A (pt) 1989-10-04
PT89769B PT89769B (pt) 1994-03-31

Family

ID=10632122

Family Applications (1)

Application Number Title Priority Date Filing Date
PT89769A PT89769B (pt) 1988-02-22 1989-02-21 Processo para a preparacao de derivados do acido 3-alcenil-1-azabiciclo-{3,2,0}hept-2-eno-2-carboxilico

Country Status (18)

Country Link
US (2) US4923857A (pt)
EP (1) EP0330108B1 (pt)
JP (1) JP2748500B2 (pt)
KR (1) KR890013020A (pt)
CN (1) CN1037149A (pt)
AT (1) ATE132150T1 (pt)
AU (1) AU2983889A (pt)
DE (1) DE68925223T2 (pt)
DK (1) DK66789A (pt)
FI (1) FI890689A7 (pt)
GB (1) GB8804058D0 (pt)
HU (1) HUT49612A (pt)
IE (1) IE890500L (pt)
IL (1) IL89354A0 (pt)
NO (1) NO890723L (pt)
OA (1) OA09039A (pt)
PT (1) PT89769B (pt)
ZA (1) ZA89986B (pt)

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DE2937911A1 (de) * 1978-09-19 1980-03-27 Daikin Ind Ltd Fluor enthaltende phenylbenzoatverbindungen, verfahren zu ihrer herstellung und ihre verwendung
US5102877A (en) * 1989-04-28 1992-04-07 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
CA2030342A1 (en) * 1989-11-21 1991-05-22 Susumu Nakagawa Process for producing 2-carbon-substituted carbapenem derivatives
US5258509A (en) * 1989-11-21 1993-11-02 Banyu Pharmaceutical Co., Ltd. Process for producing 2-carbon-substituted carbapenem derivatives
EP0465126A3 (en) * 1990-06-29 1992-03-11 Merck & Co. Inc. Carbapenem antibacterial agents
JPH06503803A (ja) * 1990-07-27 1994-04-28 藤沢薬品工業株式会社 １―アザビシクロ［３．２．０］ヘプト―２―エン―２―カルボン酸化合物
US5189158A (en) * 1991-03-20 1993-02-23 American Cyanamid Company 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them
US5371215A (en) * 1991-03-20 1994-12-06 American Cyanamid Company 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them
US6005138A (en) 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
WO1999052908A1 (en) * 1998-04-16 1999-10-21 Merck & Co., Inc. Titanium catalyzed preparation of carbapenem intermediates
US6395894B2 (en) 1998-04-16 2002-05-28 Philip J. Pye Process for the synthesis of carbapenem intermidiates, and compounds produced
US6489471B1 (en) 1998-06-17 2002-12-03 Merck & Co., Inc. Process for the synthesis of carbapenem intermediates, and compounds produced
US6194568B1 (en) 1998-07-13 2001-02-27 Merck & Co., Inc. Process for synthesizing carbapenem intermediates
KR100351660B1 (ko) * 2000-07-14 2002-09-05 한국화학연구원 2-아릴에테닐 카바페넴 유도체 및 그의 제조방법
CN100334061C (zh) * 2002-11-05 2007-08-29 立德化学株式会社 紫外线防御化合物
CN101365446B (zh) 2005-07-29 2013-05-22 雷斯弗洛吉克斯公司 预防和治疗复杂疾病的药物组合物及其经由可植入医药装置的递送
DK2118074T3 (en) 2007-02-01 2014-03-10 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular diseases
ES2532402T3 (es) 2008-06-26 2015-03-26 Resverlogix Corporation Métodos de preparación de derivados de quinazolinona
JP5635535B2 (ja) 2009-01-08 2014-12-03 レスバーロジックス コーポレイション 心血管疾患の予防および治療のための化合物
CN105859639A (zh) 2009-03-18 2016-08-17 雷斯韦洛吉克斯公司 新的抗炎剂
CN107252429B (zh) 2009-04-22 2023-06-16 雷斯韦洛吉克斯公司 新抗炎剂
EP3616695B1 (en) 2011-09-09 2024-10-23 Merck Sharp & Dohme LLC Ceftolozane/tazobactam for treating intrapulmonary infections
JP5992049B2 (ja) 2011-11-01 2016-09-14 レスバーロジックス コーポレイション 置換されたキナゾリノンのための経口速放性製剤
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
AU2013365926B9 (en) 2012-12-21 2019-01-17 Zenith Epigenetics Ltd. Novel heterocyclic compounds as bromodomain inhibitors
US9320740B2 (en) 2013-03-15 2016-04-26 Merck Sharp & Dohme Corp. Ceftolozane-tazobactam pharmaceutical compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
EP2893929B1 (en) 2013-03-15 2025-04-16 Merck Sharp & Dohme LLC Ceftolozane antibiotic compositions
US10376496B2 (en) 2013-09-09 2019-08-13 Merck, Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane
CN114984016A (zh) 2015-03-13 2022-09-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法

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US4543257A (en) * 1977-10-19 1985-09-24 Merck & Co., Inc. 1-Carba-2-penem-3-carboxylic acid
US4348320A (en) * 1976-11-19 1982-09-07 Merck & Co., Inc. Substituted azetidiones
US4465632A (en) * 1978-10-24 1984-08-14 Merck & Co., Inc. Process for preparing 1-6-and 2-substituted-1-carba-2-penem-3-carboxylic acids
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
EP0010317B1 (en) * 1978-10-24 1983-12-21 Merck & Co. Inc. 6-, 1- and 2-substituted-1-carbapen-2-em-3-carboxylic acids, processes for the preparation of such compounds and pharmaceutical composition comprising such compounds
US4267188A (en) * 1979-08-09 1981-05-12 Merck & Co., Inc. 5-Substituted-1-carba-pen-2-em-3-carboxylic acid
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
US4729993A (en) * 1984-12-13 1988-03-08 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent
EP0213610A1 (en) * 1985-08-31 1987-03-11 Lederle (Japan) Ltd. Azetidin-2-one derivatives and process for production thereof

Also Published As

Publication number Publication date
DK66789D0 (da) 1989-02-13
ZA89986B (en) 1989-10-25
GB8804058D0 (en) 1988-03-23
DK66789A (da) 1989-08-23
PT89769B (pt) 1994-03-31
JPH021490A (ja) 1990-01-05
NO890723D0 (no) 1989-02-21
DE68925223D1 (de) 1996-02-08
AU2983889A (en) 1989-08-24
US5081237A (en) 1992-01-14
US4923857A (en) 1990-05-08
IE890500L (en) 1989-08-22
EP0330108A1 (en) 1989-08-30
OA09039A (fr) 1991-03-31
FI890689L (fi) 1989-08-23
JP2748500B2 (ja) 1998-05-06
DE68925223T2 (de) 1996-06-13
FI890689A7 (fi) 1989-08-23
EP0330108B1 (en) 1995-12-27
IL89354A0 (en) 1989-09-10
KR890013020A (ko) 1989-09-20
NO890723L (no) 1989-08-23
HUT49612A (en) 1989-10-30
FI890689A0 (fi) 1989-02-14
CN1037149A (zh) 1989-11-15
ATE132150T1 (de) 1996-01-15

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19930913

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19950331