[go: up one dir, main page]

PT937054E - Derivados novos do acido 4-(1-piperazinil)benzoico processo para prepara-los e suas aplicacoes terapeuticas - Google Patents

Derivados novos do acido 4-(1-piperazinil)benzoico processo para prepara-los e suas aplicacoes terapeuticas

Info

Publication number
PT937054E
PT937054E PT97953824T PT97953824T PT937054E PT 937054 E PT937054 E PT 937054E PT 97953824 T PT97953824 T PT 97953824T PT 97953824 T PT97953824 T PT 97953824T PT 937054 E PT937054 E PT 937054E
Authority
PT
Portugal
Prior art keywords
piperazinyl
preparing
benzoic acid
therapeutic applications
acid process
Prior art date
Application number
PT97953824T
Other languages
English (en)
Inventor
Gerard Moinet
Micheline Kergoat
Gerard Botton
Liliane Doare
Didiaer Messangeau
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PT937054E publication Critical patent/PT937054E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/08Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
PT97953824T 1996-12-18 1997-12-15 Derivados novos do acido 4-(1-piperazinil)benzoico processo para prepara-los e suas aplicacoes terapeuticas PT937054E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9615588A FR2757158B1 (fr) 1996-12-18 1996-12-18 Nouveaux derives d'acide 4-(1-piperazinyl) benzoique, leur procede de preparation et leurs applications therapeutiques

Publications (1)

Publication Number Publication Date
PT937054E true PT937054E (pt) 2002-11-29

Family

ID=9498818

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97953824T PT937054E (pt) 1996-12-18 1997-12-15 Derivados novos do acido 4-(1-piperazinil)benzoico processo para prepara-los e suas aplicacoes terapeuticas

Country Status (26)

Country Link
US (1) US6281215B1 (pt)
EP (1) EP0937054B1 (pt)
JP (1) JP2001506645A (pt)
KR (1) KR20000069544A (pt)
CN (1) CN1073102C (pt)
AR (1) AR013889A1 (pt)
AT (1) ATE218558T1 (pt)
AU (1) AU726640B2 (pt)
BR (1) BR9713587A (pt)
CA (1) CA2275346A1 (pt)
CZ (1) CZ218999A3 (pt)
DE (1) DE69713128T2 (pt)
DK (1) DK0937054T3 (pt)
ES (1) ES2178039T3 (pt)
FR (1) FR2757158B1 (pt)
HU (1) HUP0000586A3 (pt)
ID (1) ID23671A (pt)
NO (1) NO312896B1 (pt)
PL (1) PL334187A1 (pt)
PT (1) PT937054E (pt)
RU (1) RU2178786C2 (pt)
SK (1) SK282841B6 (pt)
TR (1) TR199901367T2 (pt)
UA (1) UA56206C2 (pt)
WO (1) WO1998027078A1 (pt)
ZA (1) ZA9711329B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2763334A1 (fr) * 1997-05-13 1998-11-20 Lipha Derives anthraniliques
GB0013346D0 (en) * 2000-06-01 2000-07-26 Glaxo Group Ltd Therapeutic benzamide derivatives
US6476046B1 (en) 2000-12-04 2002-11-05 Sepracor, Inc. Diazabicyclo[4.3.0]nonanes, and methods of use thereof
CN101417988B (zh) * 2007-10-24 2011-04-27 山东轩竹医药科技有限公司 双胍哌嗪类二肽酰肽酶ⅳ抑制剂
CN101781273B (zh) * 2009-01-21 2012-07-04 山东轩竹医药科技有限公司 含有胍基的二肽酰肽酶ⅳ抑制剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2346011A1 (fr) * 1976-02-02 1977-10-28 Orsymonde Acetanilido-piperazines
DE3139970A1 (de) * 1981-10-08 1983-04-28 Boehringer Mannheim Gmbh, 6800 Mannheim Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
US5364849A (en) * 1989-04-22 1994-11-15 John Wyeth & Brother, Limited 1-[3 or 4-[1-[4-piperazinyl]]-2 arylpropionyl or butryl]-heterocyclic derivatives
FR2693722B1 (fr) 1992-07-16 1994-10-14 Meram Lab Dérivés de la N-cycloalkylpipérazine, procédé d'obtention et compositions pharmaceutiques les contenant.
GB9221931D0 (en) * 1992-10-17 1992-12-02 Wyeth John & Brother Ltd Piperazine derivatives
FR2707984B1 (fr) * 1993-07-23 1995-09-01 Adir Nouvelles pipérazines substituées, leur procédé de préparation et les compositions les contenant.
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
IT1278960B1 (it) * 1995-02-24 1997-12-02 Elitas S N C Di Belluzzi Lino Macchina tamponatrice per impregnare superficialmente pelli o simili.
KR100502229B1 (ko) * 1995-02-28 2005-11-08 다이이찌 산토리 파마 가부시키가이샤 아릴피페리딘및아릴피페라진유도체,및이를함유하는약제

Also Published As

Publication number Publication date
DK0937054T3 (da) 2002-09-16
AR013889A1 (es) 2001-01-31
AU726640B2 (en) 2000-11-16
CN1073102C (zh) 2001-10-17
CZ218999A3 (cs) 1999-09-15
DE69713128T2 (de) 2003-03-20
FR2757158A1 (fr) 1998-06-19
NO312896B1 (no) 2002-07-15
EP0937054A1 (en) 1999-08-25
UA56206C2 (uk) 2003-05-15
NO992968D0 (no) 1999-06-17
TR199901367T2 (xx) 1999-10-21
ES2178039T3 (es) 2002-12-16
JP2001506645A (ja) 2001-05-22
CN1245494A (zh) 2000-02-23
CA2275346A1 (en) 1998-06-25
US6281215B1 (en) 2001-08-28
EP0937054B1 (en) 2002-06-05
KR20000069544A (ko) 2000-11-25
HUP0000586A3 (en) 2002-10-28
ID23671A (id) 2000-05-11
ZA9711329B (en) 1998-06-24
HUP0000586A2 (hu) 2001-04-28
RU2178786C2 (ru) 2002-01-27
SK282841B6 (sk) 2002-12-03
NO992968L (no) 1999-08-17
WO1998027078A1 (en) 1998-06-25
ATE218558T1 (de) 2002-06-15
AU5758298A (en) 1998-07-15
DE69713128D1 (de) 2002-07-11
FR2757158B1 (fr) 1999-04-02
PL334187A1 (en) 2000-02-14
SK78599A3 (en) 2000-03-13
BR9713587A (pt) 2000-04-04

Similar Documents

Publication Publication Date Title
BR9708312A (pt) Derivados de 4-amino-pirimidina medicamentos contendo esses compostos sua aplicação e processo para sua fabricação
IT8948426A0 (it) Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico
PT850948E (pt) Derivados propiofenona e processo para a preparacao dos mesmos
PT826673E (pt) Derivados acetamida processo para a producao dos mesmos e composicao medicamentosa contendo os mesmos
BR9203816A (pt) Processo para purificacao de acido carboxilico,e processo para producao de anidrido acetico
BR9006868A (pt) Processo para producao de ester de acido carboxilico e catalisador
PT1150961E (pt) Derivados do acido pirazolecarboxilico processo para a sua preparacao e as composicoes farmaceuticas que os contem
BR8905857A (pt) Processo e aparelho para producao de compositos absorventes e os compositos assim obtidos
BR8603582A (pt) Processo para o tratamento de silica e silica assim obtida
BR8907463A (pt) Aparelho e processo para fabricacao de acido sulfurico
BR9102050A (pt) Processo e solucao de eletrolise para desalogenacao parcial de acido tri-e/ou dicloroacetico
BR9504463A (pt) Processo para preparaçao de lipossomas de quetoprofeno e preparaçoes farmacêuticas
PT937054E (pt) Derivados novos do acido 4-(1-piperazinil)benzoico processo para prepara-los e suas aplicacoes terapeuticas
BR9408340A (pt) Acido 5-acetamido-2,3,4,5-tetradeoxi-4-guanidino-d-glicero-d-glacto-não-2-enotiranosonico forma critalina processo para a preparação dos mesmos e formulação farmacêutica
BR9600149A (pt) 2-(2-N-alcoxifenil)-purin-6-onas 9-substituídas processo para sua preparação medicamantos e uso
FI964901L (fi) Menetelmä alfa-metoksi-iminokarboksyylihappometyyliamidien valmistamiseksi ja menetelmässä käytettyjä välituotteita
MX9205434A (es) Derivados del acido imidazolil-propenico substituidos ciclicamente y procedimiento para su fabricacion.
BR8806821A (pt) Processo para purificacao e para preparacao de acido acetico
MX9205436A (es) Derivados del acido imidazolil-propenico y procedimiento para su fabricacion
BR9605046A (pt) Compostos preparação farmacêutica uso dos compostos e processo para a fabricação dos mesmos
BR8904628A (pt) Processo para producao de acido clorico
BR9509367A (pt) Processo para preparar amidas ácidas
BR9202293A (pt) Processo para preparacao de acido 5-hidroxipirazinocarboxilico
BR9101958A (pt) Processo para a preparacao de cetonas e composicao de catalisador acido
BR9006443A (pt) Processo para preparacao de acido 2-(4-clorofenil)-3-metilbutirico