PT91580A - Processo para a preparacao de compostos de nicotinamida n-substituida antidepressivos - Google Patents
Processo para a preparacao de compostos de nicotinamida n-substituida antidepressivosInfo
- Publication number
- PT91580A PT91580A PT91580A PT9158089A PT91580A PT 91580 A PT91580 A PT 91580A PT 91580 A PT91580 A PT 91580A PT 9158089 A PT9158089 A PT 9158089A PT 91580 A PT91580 A PT 91580A
- Authority
- PT
- Portugal
- Prior art keywords
- substitute
- fluoro
- chloro
- preparation
- nicotinamide compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/238,951 US4861891A (en) | 1988-08-31 | 1988-08-31 | Antidepressant N-substituted nicotinamide compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT91580A true PT91580A (pt) | 1990-03-08 |
| PT91580B PT91580B (pt) | 1995-05-04 |
Family
ID=22899998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT91580A PT91580B (pt) | 1988-08-31 | 1989-08-30 | Processo para a preparacao de compostos de nicotinamida n-substituida antidepressivos |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4861891A (pt) |
| EP (1) | EP0357316B1 (pt) |
| JP (1) | JPH02115168A (pt) |
| KR (1) | KR920000760B1 (pt) |
| AT (1) | ATE88182T1 (pt) |
| AU (1) | AU609329B2 (pt) |
| CA (1) | CA1329605C (pt) |
| DE (1) | DE68905979T2 (pt) |
| DK (1) | DK426889A (pt) |
| FI (1) | FI894066L (pt) |
| HU (1) | HU208120B (pt) |
| IE (1) | IE892775L (pt) |
| IL (1) | IL91417A0 (pt) |
| MY (1) | MY104179A (pt) |
| NO (1) | NO893471L (pt) |
| NZ (1) | NZ230493A (pt) |
| PT (1) | PT91580B (pt) |
| ZA (1) | ZA896626B (pt) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4973597A (en) * | 1989-06-30 | 1990-11-27 | Eli Lilly And Company | Anticonvulsant agents |
| US5395935A (en) * | 1992-05-08 | 1995-03-07 | Pfizer Inc. | Endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents |
| TW429148B (en) * | 1995-10-27 | 2001-04-11 | Pfizer | Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases |
| GB9602166D0 (en) * | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US6380218B1 (en) * | 1997-04-04 | 2002-04-30 | Pfizer Inc | Nicotinamide derivatives |
| GB9715584D0 (en) * | 1997-07-23 | 1997-10-01 | Eisai Co Ltd | Compounds |
| ES2223772T3 (es) * | 2000-01-31 | 2005-03-01 | Pfizer Products Inc. | Pirimidincarboxamidas utiles como inhibidores de las isozimas pde4. |
| KR20020072299A (ko) * | 2000-01-31 | 2002-09-14 | 화이자 프로덕츠 인코포레이티드 | Ｐｄｅ4 이소자임의 선택적 억제제로서 유용한니코틴아미드 벤조접합된-헤테로사이클릴 유도체 |
| KR100661081B1 (ko) * | 2000-06-10 | 2006-12-26 | 동화약품공업주식회사 | 항바이러스제로 유용한 6-메틸니코틴아미드 유도체 |
| PL364135A1 (en) * | 2001-01-31 | 2004-12-13 | Pfizer Products Inc. | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
| DE60113731T2 (de) | 2001-01-31 | 2006-06-29 | Pfizer Products Inc., Groton | Als inhibitoren von pde4-isozymen geeignete etherderivate |
| EA200300622A1 (ru) * | 2001-01-31 | 2003-12-25 | Пфайзер Продактс Инк. | Производные амидов тиазолил-, оксазолил, пирролил- и имидазолилкислот, полезные в качестве ингибиторов изоферментов pde4 |
| US7250518B2 (en) * | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
| US20050079548A1 (en) * | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
| GB0317472D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
| CN101031293A (zh) * | 2004-05-06 | 2007-09-05 | 普莱希科公司 | Pde4b抑制剂及其应用 |
| CN101048407A (zh) * | 2004-09-03 | 2007-10-03 | 普莱希科公司 | 双环杂芳基pde4b抑制剂 |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| EP1942879A1 (en) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| RU2458051C2 (ru) * | 2005-11-24 | 2012-08-10 | ДОМПЕ ФА.Р.МА С.п.А. | (r)-арилалкиламинопроизводные и содержащие их фармацевтические композиции |
| EP1987004A2 (en) * | 2006-02-16 | 2008-11-05 | Boehringer Ingelheim International GmbH | Substituted pyridineamide compounds useful as soluble epoxide hydrolase inhibitors |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | アンジオテンシン調節による神経新生 |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| KR20090064418A (ko) | 2006-09-08 | 2009-06-18 | 브레인셀즈 인코퍼레이션 | 4-아실아미노피리딘 유도체 포함 조합물 |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| DE102007057089B4 (de) * | 2006-12-22 | 2010-04-29 | Lg Display Co., Ltd. | Flüssigkristallanzeige mit Photosensor und Herstellungsverfahren derselben |
| EP2126574B1 (en) * | 2007-03-08 | 2015-12-23 | The Board of Trustees of the Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
| EP2337563B1 (en) | 2008-09-08 | 2014-04-09 | The Board of Trustees of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
| CN102202669A (zh) | 2008-10-28 | 2011-09-28 | 利兰·斯坦福青年大学托管委员会 | 醛脱氢酶调节剂及其使用方法 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| WO2014160185A2 (en) * | 2013-03-14 | 2014-10-02 | The Board Of Trustees Of The Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4251263A (en) * | 1979-09-04 | 1981-02-17 | Stauffer Chemical Company | N-substituted, 2-phenoxynicotinamide compounds and the herbicidal use thereof |
| US4270946A (en) * | 1979-10-01 | 1981-06-02 | Stauffer Chemical Company | N-Aryl,2-phenoxy nicotinamide compounds and the herbicidal use thereof |
| IL64220A (en) * | 1980-11-21 | 1985-06-30 | May & Baker Ltd | Nicotinamide derivatives,their preparation and their use as herbicides |
| US4692185A (en) * | 1986-01-13 | 1987-09-08 | Stauffer Chemical Company | N-(ortho-substituted) benzyl, 3-trifluoromethylphenoxy nicotinamides as herbicides |
-
1988
- 1988-08-31 US US07/238,951 patent/US4861891A/en not_active Expired - Fee Related
-
1989
- 1989-08-22 DE DE8989308481T patent/DE68905979T2/de not_active Expired - Fee Related
- 1989-08-22 EP EP89308481A patent/EP0357316B1/en not_active Expired - Lifetime
- 1989-08-22 AT AT89308481T patent/ATE88182T1/de active
- 1989-08-24 IL IL91417A patent/IL91417A0/xx unknown
- 1989-08-25 MY MYPI89001168A patent/MY104179A/en unknown
- 1989-08-29 CA CA000609655A patent/CA1329605C/en not_active Expired - Fee Related
- 1989-08-30 NZ NZ230493A patent/NZ230493A/en unknown
- 1989-08-30 FI FI894066A patent/FI894066L/fi not_active IP Right Cessation
- 1989-08-30 ZA ZA896626A patent/ZA896626B/xx unknown
- 1989-08-30 HU HU894507A patent/HU208120B/hu not_active IP Right Cessation
- 1989-08-30 KR KR1019890012412A patent/KR920000760B1/ko not_active Expired
- 1989-08-30 NO NO89893471A patent/NO893471L/no unknown
- 1989-08-30 PT PT91580A patent/PT91580B/pt not_active IP Right Cessation
- 1989-08-30 JP JP1224342A patent/JPH02115168A/ja active Pending
- 1989-08-30 AU AU40913/89A patent/AU609329B2/en not_active Ceased
- 1989-08-30 IE IE892775A patent/IE892775L/xx unknown
- 1989-08-30 DK DK426889A patent/DK426889A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR920000760B1 (ko) | 1992-01-21 |
| PT91580B (pt) | 1995-05-04 |
| IE892775L (en) | 1990-02-28 |
| AU609329B2 (en) | 1991-04-26 |
| HUT52058A (en) | 1990-06-28 |
| DK426889A (da) | 1990-03-01 |
| NO893471D0 (no) | 1989-08-30 |
| FI894066A0 (fi) | 1989-08-30 |
| DK426889D0 (da) | 1989-08-30 |
| JPH02115168A (ja) | 1990-04-27 |
| HU208120B (en) | 1993-08-30 |
| ATE88182T1 (de) | 1993-04-15 |
| DE68905979T2 (de) | 1993-07-22 |
| AU4091389A (en) | 1990-06-28 |
| US4861891A (en) | 1989-08-29 |
| MY104179A (en) | 1994-02-28 |
| NZ230493A (en) | 1991-03-26 |
| EP0357316B1 (en) | 1993-04-14 |
| EP0357316A1 (en) | 1990-03-07 |
| KR900003154A (ko) | 1990-03-23 |
| CA1329605C (en) | 1994-05-17 |
| ZA896626B (en) | 1991-04-24 |
| IL91417A0 (en) | 1990-04-29 |
| NO893471L (no) | 1990-03-01 |
| FI894066A7 (fi) | 1990-03-01 |
| FI894066L (fi) | 1990-03-01 |
| DE68905979D1 (de) | 1993-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19941017 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19960430 |