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FI894066L - Depressionshaemmande n-substituerade nikotinamidfoereningar. - Google Patents

Depressionshaemmande n-substituerade nikotinamidfoereningar. Download PDF

Info

Publication number
FI894066L
FI894066L FI894066A FI894066A FI894066L FI 894066 L FI894066 L FI 894066L FI 894066 A FI894066 A FI 894066A FI 894066 A FI894066 A FI 894066A FI 894066 L FI894066 L FI 894066L
Authority
FI
Finland
Prior art keywords
nicotinamidfoereningar
depressionshaemmande
substituerade
substituerade nicotinamidfoereningar
Prior art date
Application number
FI894066A
Other languages
English (en)
Other versions
FI894066A0 (fi
FI894066A7 (fi
Inventor
Nicholas Alex Saccomano
Fredric James Vinick
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI894066A0 publication Critical patent/FI894066A0/fi
Publication of FI894066L publication Critical patent/FI894066L/fi
Publication of FI894066A7 publication Critical patent/FI894066A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Compounds Of Unknown Constitution (AREA)
FI894066A 1988-08-31 1989-08-30 Masennustiloja ehkäiseviä N-substituoituja nikotiiniaminiyhdisteitä FI894066A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/238,951 US4861891A (en) 1988-08-31 1988-08-31 Antidepressant N-substituted nicotinamide compounds

Publications (3)

Publication Number Publication Date
FI894066A0 FI894066A0 (fi) 1989-08-30
FI894066L true FI894066L (fi) 1990-03-01
FI894066A7 FI894066A7 (fi) 1990-03-01

Family

ID=22899998

Family Applications (1)

Application Number Title Priority Date Filing Date
FI894066A FI894066A7 (fi) 1988-08-31 1989-08-30 Masennustiloja ehkäiseviä N-substituoituja nikotiiniaminiyhdisteitä

Country Status (18)

Country Link
US (1) US4861891A (fi)
EP (1) EP0357316B1 (fi)
JP (1) JPH02115168A (fi)
KR (1) KR920000760B1 (fi)
AT (1) ATE88182T1 (fi)
AU (1) AU609329B2 (fi)
CA (1) CA1329605C (fi)
DE (1) DE68905979T2 (fi)
DK (1) DK426889A (fi)
FI (1) FI894066A7 (fi)
HU (1) HU208120B (fi)
IE (1) IE892775L (fi)
IL (1) IL91417A0 (fi)
MY (1) MY104179A (fi)
NO (1) NO893471L (fi)
NZ (1) NZ230493A (fi)
PT (1) PT91580B (fi)
ZA (1) ZA896626B (fi)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4973597A (en) * 1989-06-30 1990-11-27 Eli Lilly And Company Anticonvulsant agents
US5395935A (en) * 1992-05-08 1995-03-07 Pfizer Inc. Endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents
TW429148B (en) * 1995-10-27 2001-04-11 Pfizer Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
CN1254335A (zh) * 1997-04-04 2000-05-24 辉瑞产品公司 烟酰胺衍生物
GB9715584D0 (en) * 1997-07-23 1997-10-01 Eisai Co Ltd Compounds
SK10342002A3 (sk) 2000-01-31 2003-12-02 Pfizer Products Inc. Pyrimidínkarboxamidy užitočné ako selektívne inhibítory izozymov PDE4
BR0107964A (pt) * 2000-01-31 2002-10-29 Pfizer Prod Inc Derivados de nicotinamida benzofundida com heterociclica úteis como inibidores seletivos de isozimas pde4
KR100661081B1 (ko) * 2000-06-10 2006-12-26 동화약품공업주식회사 항바이러스제로 유용한 6-메틸니코틴아미드 유도체
US7250518B2 (en) * 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
PL365443A1 (en) * 2001-01-31 2005-01-10 Pfizer Products Inc. Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes
EA200300652A1 (ru) * 2001-01-31 2003-12-25 Пфайзер Продактс Инк. Эфирные производные, полезные в качестве ингибиторов изозимов pde4
EP1355884A1 (en) * 2001-01-31 2003-10-29 Pfizer Products Inc. Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
US20050079548A1 (en) * 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
GB0317472D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as PDE4 inhibitors
EP1742627A4 (en) 2004-05-06 2009-08-26 Plexxikon Inc PDE4B HEMMER AND ITS USE
CA2583428A1 (en) * 2004-09-03 2006-03-09 Plexxikon, Inc. Bicyclic heteroaryl pde4b inhibitors
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
CA2625153A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
CA2629935C (en) * 2005-11-24 2016-01-19 Dompe S.P.A. (r)-arylalkylamino derivatives and pharmaceutical compositions containing them
EP1987004A2 (en) * 2006-02-16 2008-11-05 Boehringer Ingelheim International GmbH Substituted pyridineamide compounds useful as soluble epoxide hydrolase inhibitors
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
DE102007057089B4 (de) * 2006-12-22 2010-04-29 Lg Display Co., Ltd. Flüssigkristallanzeige mit Photosensor und Herstellungsverfahren derselben
US20110105602A2 (en) * 2007-03-08 2011-05-05 Daria Mochly-Rosen Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof
CN102209541B (zh) 2008-09-08 2016-05-18 小利兰·斯坦福大学托管委员会 醛脱氢酶活性调节剂和其使用方法
JP2012506856A (ja) 2008-10-28 2012-03-22 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ アルデヒドデヒドロゲナーゼのモジュレーターおよびその使用方法
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US10457659B2 (en) 2011-04-29 2019-10-29 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
US9670162B2 (en) 2013-03-14 2017-06-06 The Board Of Trustees Of The Leland Stanford Junio Mitochondrial aldehyde dehyrogenase-2 modulators and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4251263A (en) * 1979-09-04 1981-02-17 Stauffer Chemical Company N-substituted, 2-phenoxynicotinamide compounds and the herbicidal use thereof
US4270946A (en) * 1979-10-01 1981-06-02 Stauffer Chemical Company N-Aryl,2-phenoxy nicotinamide compounds and the herbicidal use thereof
IL64220A (en) * 1980-11-21 1985-06-30 May & Baker Ltd Nicotinamide derivatives,their preparation and their use as herbicides
US4692185A (en) * 1986-01-13 1987-09-08 Stauffer Chemical Company N-(ortho-substituted) benzyl, 3-trifluoromethylphenoxy nicotinamides as herbicides

Also Published As

Publication number Publication date
PT91580B (pt) 1995-05-04
NZ230493A (en) 1991-03-26
ATE88182T1 (de) 1993-04-15
KR900003154A (ko) 1990-03-23
MY104179A (en) 1994-02-28
EP0357316B1 (en) 1993-04-14
PT91580A (pt) 1990-03-08
US4861891A (en) 1989-08-29
IL91417A0 (en) 1990-04-29
DE68905979T2 (de) 1993-07-22
IE892775L (en) 1990-02-28
CA1329605C (en) 1994-05-17
ZA896626B (en) 1991-04-24
DK426889D0 (da) 1989-08-30
KR920000760B1 (ko) 1992-01-21
DE68905979D1 (de) 1993-05-19
FI894066A0 (fi) 1989-08-30
DK426889A (da) 1990-03-01
AU609329B2 (en) 1991-04-26
NO893471D0 (no) 1989-08-30
EP0357316A1 (en) 1990-03-07
JPH02115168A (ja) 1990-04-27
HUT52058A (en) 1990-06-28
NO893471L (no) 1990-03-01
FI894066A7 (fi) 1990-03-01
AU4091389A (en) 1990-06-28
HU208120B (en) 1993-08-30

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Legal Events

Date Code Title Description
FD Application lapsed
MM Patent lapsed

Owner name: PFIZER INC.