[go: up one dir, main page]

PT90248A - Metodo para a utilizacao de 2-oxindole-1-carboxamidas 3-substituidas como inibidores da biossintese da interleucina-1 - Google Patents

Metodo para a utilizacao de 2-oxindole-1-carboxamidas 3-substituidas como inibidores da biossintese da interleucina-1

Info

Publication number
PT90248A
PT90248A PT90248A PT9024889A PT90248A PT 90248 A PT90248 A PT 90248A PT 90248 A PT90248 A PT 90248A PT 9024889 A PT9024889 A PT 9024889A PT 90248 A PT90248 A PT 90248A
Authority
PT
Portugal
Prior art keywords
oxindole
carboxamides
substituted
mammal
interleukin
Prior art date
Application number
PT90248A
Other languages
English (en)
Other versions
PT90248B (pt
Inventor
Ivan George Otterness
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT90248A publication Critical patent/PT90248A/pt
Publication of PT90248B publication Critical patent/PT90248B/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT90248A 1988-04-13 1989-04-11 Metodo para a inibicao da interleucina-1 num mamifero PT90248B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/181,131 US4861794A (en) 1988-04-13 1988-04-13 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis

Publications (2)

Publication Number Publication Date
PT90248A true PT90248A (pt) 1989-11-10
PT90248B PT90248B (pt) 1994-11-30

Family

ID=22663029

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90248A PT90248B (pt) 1988-04-13 1989-04-11 Metodo para a inibicao da interleucina-1 num mamifero

Country Status (17)

Country Link
US (1) US4861794A (pt)
EP (1) EP0337627B1 (pt)
JP (1) JPH01305028A (pt)
KR (1) KR920002327B1 (pt)
AT (1) ATE89724T1 (pt)
AU (1) AU601325B2 (pt)
CA (1) CA1324761C (pt)
DE (1) DE68906706T2 (pt)
DK (1) DK174389A (pt)
HU (1) HU203970B (pt)
IE (1) IE63458B1 (pt)
IL (1) IL89871A (pt)
MY (1) MY103871A (pt)
NZ (1) NZ228711A (pt)
PH (1) PH25884A (pt)
PT (1) PT90248B (pt)
ZA (1) ZA892623B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
US5300655A (en) * 1989-04-18 1994-04-05 Pfizer Inc. 2-carboxy-thiophene derivatives
IL95880A (en) * 1989-10-13 1995-12-31 Pfizer Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis
US5006547A (en) * 1990-03-19 1991-04-09 Pfizer Inc. Tenidap as an inhibitor of the release of elastase by neutrophils
US5008283A (en) * 1990-03-19 1991-04-16 Pfizer Inc. Use of tenidap to inhibit activation of collagenase and to inhibit the activity of myeloperoxidase
US5064851A (en) * 1990-07-24 1991-11-12 Pfizer Inc. 3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
ATE157355T1 (de) * 1991-01-21 1997-09-15 Shionogi & Co 3-benzyliden-1-carbamoyl-2-pyrrolidon-analoga
US5122534A (en) * 1991-02-08 1992-06-16 Pfizer Inc. Use of tenidap to reduce total serum cholesterol, ldl cholesterol and triglycerides
WO1992016226A1 (en) * 1991-03-19 1992-10-01 Smithkline Beecham Corporation Il-1 inhibitors
DE4111305C2 (de) * 1991-04-08 1994-12-01 Mack Chem Pharm Pharmazeutische Zubereitung zur rektalen Applikation, die ein 2-Oxindol-l-carboxamid-derivat enthält
US5298522A (en) * 1993-01-22 1994-03-29 Pfizer Inc. 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
US5545656A (en) * 1995-04-05 1996-08-13 Pfizer Inc. 2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4569942A (en) * 1984-05-04 1986-02-11 Pfizer Inc. N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
US4678802A (en) * 1985-07-09 1987-07-07 Pfizer Inc. 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
GB8517958D0 (en) * 1985-07-16 1985-08-21 Cellena Cell Eng Ag Compositions containing melatonin/homologues
EP0284612B1 (en) * 1986-01-30 1991-07-24 University of Utah Treatment of bone loss
US4677132A (en) * 1986-03-12 1987-06-30 American Home Products Corporation Inhibition of bone resorption by etodolac
WO1988005656A1 (en) * 1987-02-02 1988-08-11 Pfizer Inc. Anhydrous, crystalline sodium salt of 5-chloro-3-(2-thenoyl)-2-oxindole-1-carboxamide

Also Published As

Publication number Publication date
ZA892623B (en) 1990-11-28
NZ228711A (en) 1997-02-24
KR890015739A (ko) 1989-11-25
DE68906706D1 (de) 1993-07-01
EP0337627B1 (en) 1993-05-26
HUT52377A (en) 1990-07-28
EP0337627A3 (en) 1991-01-02
IL89871A (en) 1994-11-11
PH25884A (en) 1991-12-02
AU3271189A (en) 1989-10-19
JPH01305028A (ja) 1989-12-08
DK174389A (da) 1989-10-16
CA1324761C (en) 1993-11-30
EP0337627A2 (en) 1989-10-18
KR920002327B1 (ko) 1992-03-21
AU601325B2 (en) 1990-09-06
IL89871A0 (en) 1989-12-15
ATE89724T1 (de) 1993-06-15
US4861794A (en) 1989-08-29
DK174389D0 (da) 1989-04-12
PT90248B (pt) 1994-11-30
HU203970B (en) 1991-11-28
MY103871A (en) 1993-09-30
IE63458B1 (en) 1995-04-19
DE68906706T2 (de) 1993-09-16
IE891172L (en) 1989-10-13

Similar Documents

Publication Publication Date Title
SE9803710D0 (sv) Use of certain drugs for treating nerve root injury
AU7321598A (en) Use of cholinesterase inhibitors to treat disorders of attention
PT90248A (pt) Metodo para a utilizacao de 2-oxindole-1-carboxamidas 3-substituidas como inibidores da biossintese da interleucina-1
BRPI0314308B8 (pt) antagonistas de opióide, seus usos, e composição farmacêutica
DE69427704D1 (de) Neue (r)-5-carbamoyl-8-fluor-3-n,n-disubstituierte-amino-3,4-dihydro-2h-1-benzopyrane
IL81887A0 (en) Dihydroisoxazole derivatives,their preparation and pharmaceutical compositions containing them
DE69805973D1 (de) Behandlung von herzrythmusstörungen durch hemmung einer multifunktionalen calcium/calmodulin-abhängigen protein kinase
BR9713178A (pt) Inbidores espirocìclicos da metaloprotease.
DE69210654D1 (de) Verwendung von Tomoxetine zur Behandlung von Funktionsstörungen der niedrigen Harnwege
BR0110396A (pt) Métodos para prevenir e tratar alopecia induzida por quimioterapia ou radioterapia
NO982863L (no) Nye forbindelser med analgetisk effekt
DK0425109T3 (da) 3-substitueret-2-oxindolderivater som inhibitorer for interleukin-1-biosyntese
DK1025101T3 (da) Naphtho-imidazo[1,2-a]pyridinderivater, deres fremstilling og deres anvendelse ved behandlingen af sygdomme i centralnervesystemet
BR0313922A (pt) Compostos de piperidina de benzoìla
ATE283269T1 (de) 5-(heteroaryl)alkyl)-3-oxo-pyrido(1,2- a)benzimidazol-4-carboxamid (pbi) derivate zur behandlung von störungen des zentralen nervensystems
DE69941134D1 (de) Verwendung von R (+)- g(a)-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol zur Behandlung von Schlafstörungen

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19940526

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20001130