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PT89778A - Processo para a preparacao de um derivado de hirudina - Google Patents

Processo para a preparacao de um derivado de hirudina

Info

Publication number
PT89778A
PT89778A PT89778A PT8977889A PT89778A PT 89778 A PT89778 A PT 89778A PT 89778 A PT89778 A PT 89778A PT 8977889 A PT8977889 A PT 8977889A PT 89778 A PT89778 A PT 89778A
Authority
PT
Portugal
Prior art keywords
hydrudine
derivatives
preparation
hydrudine derivatives
Prior art date
Application number
PT89778A
Other languages
English (en)
Other versions
PT89778B (pt
Inventor
Paul Habermann
Dominique Tripier
Peter Crausse
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of PT89778A publication Critical patent/PT89778A/pt
Publication of PT89778B publication Critical patent/PT89778B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
PT89778A 1988-02-23 1989-02-22 Processo para a preparacao de um derivado de hirudina PT89778B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3805540 1988-02-23

Publications (2)

Publication Number Publication Date
PT89778A true PT89778A (pt) 1989-10-04
PT89778B PT89778B (pt) 1994-03-31

Family

ID=6347932

Family Applications (1)

Application Number Title Priority Date Filing Date
PT89778A PT89778B (pt) 1988-02-23 1989-02-22 Processo para a preparacao de um derivado de hirudina

Country Status (11)

Country Link
US (1) US5180668A (pt)
JP (1) JPH0649719B2 (pt)
KR (1) KR970009950B1 (pt)
AU (1) AU604925B2 (pt)
CA (1) CA1339104C (pt)
HU (2) HU210439B (pt)
IE (1) IE65354B1 (pt)
NO (2) NO176915C (pt)
NZ (1) NZ228064A (pt)
PH (1) PH25937A (pt)
PT (1) PT89778B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3835815A1 (de) * 1988-10-21 1990-04-26 Hoechst Ag Neue isohirudine
DE4009268A1 (de) * 1990-03-22 1991-09-26 Consortium Elektrochem Ind Sekretion von hirudinderivaten
CA2072375C (en) * 1990-11-08 2000-01-11 Satoru Misawa Hirudin analog, method of manufacturing thereof and anti-coagulant composition, and secretion vector, transformed microorganisms containing saidvector and manufacturing method of products which is produced from said microorganism
DE4140381A1 (de) * 1991-12-07 1993-06-09 Hoechst Ag, 6230 Frankfurt, De Neue synthetische isohirudine mit verbesserter stabilitaet
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
DE19543737A1 (de) * 1995-11-24 1997-05-28 Hoechst Ag Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices
DE19544233A1 (de) * 1995-11-28 1997-06-05 Hoechst Ag Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten
DE19944870A1 (de) * 1999-09-18 2001-03-29 Aventis Pharma Gmbh Signalsequenzen zur Herstellung von Leu-Hirudin über Sekretion durch E. coli in das Kulturmedium
US7795205B2 (en) * 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
DE3445517C2 (de) * 1984-12-13 1993-11-18 Ciba Geigy Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins

Also Published As

Publication number Publication date
NO890758D0 (no) 1989-02-22
KR970009950B1 (en) 1997-06-19
HUT50502A (en) 1990-02-28
AU1828488A (en) 1989-08-24
HU211828A9 (en) 1995-12-28
AU604925B2 (en) 1991-01-03
PT89778B (pt) 1994-03-31
PH25937A (en) 1991-12-19
CA1339104C (en) 1997-07-29
IE65354B1 (en) 1995-10-18
NO1998016I1 (no) 1998-05-26
NZ228064A (en) 1990-12-21
JPH025891A (ja) 1990-01-10
NO176915C (no) 1995-06-21
NO176915B (no) 1995-03-13
JPH0649719B2 (ja) 1994-06-29
HU210439B (en) 1995-04-28
IE890559L (en) 1989-08-23
US5180668A (en) 1993-01-19
NO890758L (no) 1989-08-24

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19930913

PC3A Transfer or assignment

Free format text: 20010322 AVENTIS PHARMA DEUTSCHLAND GMBH DE

PC3A Transfer or assignment

Free format text: SCHERING AKTIENGESELLSCHAFT DE

Effective date: 20021128

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

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Effective date: 20090222