PT758328E - Compostos anti-cancro contendo um anel de ciclopentaquinazolina - Google Patents
Compostos anti-cancro contendo um anel de ciclopentaquinazolinaInfo
- Publication number
- PT758328E PT758328E PT95917433T PT95917433T PT758328E PT 758328 E PT758328 E PT 758328E PT 95917433 T PT95917433 T PT 95917433T PT 95917433 T PT95917433 T PT 95917433T PT 758328 E PT758328 E PT 758328E
- Authority
- PT
- Portugal
- Prior art keywords
- pct
- alkyl
- compounds containing
- hydroxyalkyl
- alkoxy
- Prior art date
Links
- RPNFBQFWFAHQAT-UHFFFAOYSA-N 1h-cyclopenta[h]quinazoline Chemical group C1=CC2=CN=CNC2=C2C1=CC=C2 RPNFBQFWFAHQAT-UHFFFAOYSA-N 0.000 title 1
- 230000001093 anti-cancer Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- -1 phenylene, thiophenediyl Chemical group 0.000 abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9408936A GB9408936D0 (en) | 1994-05-05 | 1994-05-05 | Anti-cancer compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT758328E true PT758328E (pt) | 2003-11-28 |
Family
ID=10754612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT95917433T PT758328E (pt) | 1994-05-05 | 1995-05-04 | Compostos anti-cancro contendo um anel de ciclopentaquinazolina |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5747499A (pt) |
| EP (1) | EP0758328B1 (pt) |
| JP (1) | JP4173911B2 (pt) |
| AT (1) | ATE245154T1 (pt) |
| CA (1) | CA2187449C (pt) |
| DE (1) | DE69531296T2 (pt) |
| DK (1) | DK0758328T3 (pt) |
| ES (1) | ES2203639T3 (pt) |
| GB (2) | GB9408936D0 (pt) |
| PT (1) | PT758328E (pt) |
| WO (1) | WO1995030673A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100471838C (zh) | 2000-12-28 | 2009-03-25 | 第一制药株式会社 | Vla-4抑制剂 |
| PT1421105E (pt) * | 2001-08-31 | 2010-12-07 | Btg Int Ltd | Compostos anticancerígenos de ciclopenta-g quinazolina |
| PT1420809E (pt) | 2001-08-31 | 2012-01-03 | Btg Int Ltd | Utilização de derivados de ciclopenta[g]quinazolina para tratamento de cancro |
| GB0121214D0 (en) | 2001-08-31 | 2001-10-24 | Btg Int Ltd | Synthetic method |
| EP2161254B1 (en) | 2002-03-05 | 2014-08-13 | Sumitomo Chemical Company, Limited | Intermediate for preparing a biaryl compound |
| WO2005009992A1 (ja) | 2003-07-24 | 2005-02-03 | Daiichi Pharmaceutical Co., Ltd. | シクロヘキサンカルボン酸類 |
| ES2387334T3 (es) * | 2008-03-18 | 2012-09-20 | Btg International Limited | Derivados de ciclopenta[g]quinazolina para el tratamiento de la artritis reumatoide o la leucemia mielocítica aguda |
| AU2011280235A1 (en) * | 2010-07-19 | 2013-03-07 | Onyx Pharmaceuticals, Inc. | Synthesis of cyclopentaquinazolines |
| EP2655398B1 (en) * | 2010-12-22 | 2016-08-24 | BTG International Limited | Efficient peptide couplings and their use in the synthesis and isolation of a cyclopenta (g) quinazoline trisodium salt |
| US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
| JP7399846B2 (ja) | 2017-08-21 | 2023-12-18 | セルジーン コーポレイション | （ｓ）－ｔｅｒｔ－ブチル４，５－ジアミノ－５－オキソペンタノエートの調製プロセス |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4925939A (en) * | 1989-01-05 | 1990-05-15 | Sloan-Kettering Institute For Cancer Research | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives |
| CA2021042A1 (en) * | 1989-07-21 | 1991-01-22 | Fabrizio Marazza | Salts of n ,n -methylene-5,6,7,8-tetrahydrofolic acid |
| US5077404A (en) * | 1989-08-29 | 1991-12-31 | Piper James R | Cyclized 5,10-dideazaaminopterin compounds |
| EP0438261A3 (en) * | 1990-01-16 | 1992-02-26 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic glutamic acid derivatives, their production and use |
| FR2659330B1 (fr) * | 1990-03-09 | 1994-02-11 | Sapec Sa | Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits. |
| GB9013615D0 (en) * | 1990-06-19 | 1990-08-08 | Wellcome Found | Pharmaceutical compounds |
| ZA917355B (en) * | 1990-09-17 | 1992-08-26 | Agouron Pharma | Antiproliferative substituted naphthalene compounds |
| YU155791A (sh) * | 1990-09-25 | 1994-01-20 | Agouron Pharmaceuticals Inc. | Antiproliferativna supstituisana triciklična jedinjenja |
| GB9105771D0 (en) * | 1991-03-19 | 1991-05-01 | Cancer Res Inst Royal | Anti-cancer compounds |
| GB9205320D0 (en) * | 1992-03-11 | 1992-04-22 | Ici Plc | Anti-tumour compounds |
| WO1994003439A1 (en) * | 1992-07-29 | 1994-02-17 | Agouron Pharmaceuticals, Inc. | Antiproliferative tricyclic compounds |
| GB9220571D0 (en) * | 1992-09-30 | 1992-11-11 | Ici Plc | Quinazoline derivatives |
| GB2272217B (en) * | 1992-11-06 | 1996-07-31 | Zeneca Ltd | Anti-cancer cyclopentaquinazoline tricyclic derivatives |
| GB9320113D0 (en) * | 1993-09-29 | 1993-11-17 | Zeneca Ltd | Tricyclic derivatives |
-
1994
- 1994-05-05 GB GB9408936A patent/GB9408936D0/en active Pending
-
1995
- 1995-05-04 DK DK95917433T patent/DK0758328T3/da active
- 1995-05-04 JP JP52877095A patent/JP4173911B2/ja not_active Expired - Lifetime
- 1995-05-04 PT PT95917433T patent/PT758328E/pt unknown
- 1995-05-04 EP EP95917433A patent/EP0758328B1/en not_active Expired - Lifetime
- 1995-05-04 US US08/732,273 patent/US5747499A/en not_active Expired - Lifetime
- 1995-05-04 WO PCT/GB1995/001016 patent/WO1995030673A1/en not_active Ceased
- 1995-05-04 AT AT95917433T patent/ATE245154T1/de active
- 1995-05-04 GB GB9509261A patent/GB2290082B/en not_active Expired - Lifetime
- 1995-05-04 ES ES95917433T patent/ES2203639T3/es not_active Expired - Lifetime
- 1995-05-04 DE DE69531296T patent/DE69531296T2/de not_active Expired - Lifetime
- 1995-05-04 CA CA002187449A patent/CA2187449C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2187449C (en) | 2006-01-03 |
| GB9509261D0 (en) | 1995-06-28 |
| EP0758328B1 (en) | 2003-07-16 |
| GB2290082A (en) | 1995-12-13 |
| ATE245154T1 (de) | 2003-08-15 |
| GB2290082B (en) | 1997-10-29 |
| WO1995030673A1 (en) | 1995-11-16 |
| DE69531296D1 (de) | 2003-08-21 |
| EP0758328A1 (en) | 1997-02-19 |
| DE69531296T2 (de) | 2004-04-22 |
| US5747499A (en) | 1998-05-05 |
| GB9408936D0 (en) | 1994-06-22 |
| CA2187449A1 (en) | 1995-11-16 |
| ES2203639T3 (es) | 2004-04-16 |
| JP4173911B2 (ja) | 2008-10-29 |
| JPH09512812A (ja) | 1997-12-22 |
| DK0758328T3 (da) | 2003-11-03 |
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