PT632028E - Derivado opticamente activo do 2-nitroimidazole processo para a producao do mesmo e intermediario para a producao do mesmo - Google Patents
Derivado opticamente activo do 2-nitroimidazole processo para a producao do mesmo e intermediario para a producao do mesmoInfo
- Publication number
- PT632028E PT632028E PT93923039T PT93923039T PT632028E PT 632028 E PT632028 E PT 632028E PT 93923039 T PT93923039 T PT 93923039T PT 93923039 T PT93923039 T PT 93923039T PT 632028 E PT632028 E PT 632028E
- Authority
- PT
- Portugal
- Prior art keywords
- same
- production
- optically active
- nitroimidazole
- intermediary
- Prior art date
Links
- 150000004959 2-nitroimidazoles Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000000637 radiosensitizating effect Effects 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/63—Halogen-containing esters of saturated acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/78—Benzoic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33903592 | 1992-12-18 | ||
| JP1653093 | 1993-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT632028E true PT632028E (pt) | 2003-08-29 |
Family
ID=26352886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT93923039T PT632028E (pt) | 1992-12-18 | 1993-10-21 | Derivado opticamente activo do 2-nitroimidazole processo para a producao do mesmo e intermediario para a producao do mesmo |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5532380A (pt) |
| EP (1) | EP0632028B1 (pt) |
| JP (2) | JP3577079B2 (pt) |
| AT (1) | ATE236131T1 (pt) |
| DE (1) | DE69332821T2 (pt) |
| DK (1) | DK0632028T3 (pt) |
| ES (1) | ES2199221T3 (pt) |
| PT (1) | PT632028E (pt) |
| WO (1) | WO1994014778A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1838305A1 (en) * | 2005-01-21 | 2007-10-03 | Richard H. Matthews | Radiosensitizer formulations comprising nitrohistidine derivatives |
| JP5297815B2 (ja) | 2007-01-26 | 2013-09-25 | 株式会社ポーラファルマ | 医薬組成物 |
| WO2008152764A1 (ja) | 2007-06-14 | 2008-12-18 | Pola Pharma Inc. | 医薬組成物 |
| CN101642452B (zh) * | 2008-08-06 | 2014-05-28 | 株式会社宝丽制药 | 脑肿瘤用放射线敏化剂 |
| CN101805323B (zh) * | 2010-03-23 | 2012-09-26 | 深圳万乐药业有限公司 | 一种合成Doranidazole中间体的非对映异构体的方法 |
| JP6071715B2 (ja) * | 2013-03-22 | 2017-02-01 | 株式会社ポーラファルマ | ドラニダゾール構成光学異性体の製造方法 |
| EP3692990A4 (en) | 2017-10-02 | 2021-06-30 | Keio University | Cancer stem cell inhibitor |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2314454A (en) * | 1938-08-19 | 1943-03-23 | Gen Aniline & Film Corp | Production of esters of halogen alcohols |
| US2377878A (en) * | 1941-12-24 | 1945-06-12 | Du Pont | Dioxolane-acid halide reaction and product |
| US2901506A (en) * | 1956-12-06 | 1959-08-25 | American Cyanamid Co | Pyrolysis of substituted carbonyloxyalkyl halides |
| NL292912A (pt) * | 1962-05-18 | |||
| US3468902A (en) * | 1966-06-10 | 1969-09-23 | Hoffmann La Roche | 1-substituted-2-nitroimidazole derivatives |
| CH526506A (de) * | 1970-05-27 | 1972-08-15 | Sandoz Ag | Verfahren zur Herstellung von 2,2-Bis-(brommethyl)-propandiol-1,3-diacetat |
| ZW8781A1 (en) * | 1980-05-23 | 1981-12-16 | Hoffmann La Roche | 2-nitroimidazoles and preparation thereof |
| US4462992A (en) * | 1982-02-08 | 1984-07-31 | Research Corporation | Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof |
| JPS58170725A (ja) * | 1982-03-31 | 1983-10-07 | Ono Pharmaceut Co Ltd | グリセリン誘導体 |
| JPS59139363A (ja) * | 1983-01-31 | 1984-08-10 | Kayaku:Kk | ２−ニトロイミダゾ−ル誘導体およびその製造法 |
| JPS62283943A (ja) * | 1986-05-30 | 1987-12-09 | Taisho Pharmaceut Co Ltd | スレイト−ル化合物およびその製造方法 |
| JPS6330491A (ja) * | 1986-07-22 | 1988-02-09 | Sankyo Co Ltd | 環状ウレタン構造を有する燐酸エステル誘導体 |
| JPH0819111B2 (ja) * | 1987-10-22 | 1996-02-28 | ポーラ化成工業株式会社 | ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤 |
| KR927003539A (ko) * | 1990-01-26 | 1992-12-18 | 스즈끼 쯔네시 | 2-니트로 이미다졸 유도체, 그의 제조방법 및 이를 유효성분으로 하는 방사선 증감제 |
| JP2683613B2 (ja) * | 1990-01-30 | 1997-12-03 | 出光石油化学株式会社 | スチレン系樹脂から成る射出成形品 |
-
1993
- 1993-10-21 EP EP93923039A patent/EP0632028B1/en not_active Expired - Lifetime
- 1993-10-21 AT AT93923039T patent/ATE236131T1/de active
- 1993-10-21 DE DE69332821T patent/DE69332821T2/de not_active Expired - Lifetime
- 1993-10-21 PT PT93923039T patent/PT632028E/pt unknown
- 1993-10-21 DK DK93923039T patent/DK0632028T3/da active
- 1993-10-21 JP JP51458594A patent/JP3577079B2/ja not_active Expired - Lifetime
- 1993-10-21 ES ES93923039T patent/ES2199221T3/es not_active Expired - Lifetime
- 1993-10-21 WO PCT/JP1993/001519 patent/WO1994014778A1/ja not_active Ceased
- 1993-10-21 US US08/256,354 patent/US5532380A/en not_active Expired - Lifetime
-
2003
- 2003-05-29 JP JP2003152888A patent/JP2003321459A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994014778A1 (fr) | 1994-07-07 |
| US5532380A (en) | 1996-07-02 |
| EP0632028A4 (en) | 1995-03-29 |
| JP2003321459A (ja) | 2003-11-11 |
| DE69332821T2 (de) | 2003-11-13 |
| EP0632028A1 (en) | 1995-01-04 |
| DE69332821D1 (de) | 2003-05-08 |
| ES2199221T3 (es) | 2004-02-16 |
| JP3577079B2 (ja) | 2004-10-13 |
| DK0632028T3 (da) | 2003-07-21 |
| EP0632028B1 (en) | 2003-04-02 |
| ATE236131T1 (de) | 2003-04-15 |
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