PT3390367T - Método para prevenir e/ou tratar enfraquecimento cognitivo e neuroinflamação associados ao envelhecimento - Google Patents
Método para prevenir e/ou tratar enfraquecimento cognitivo e neuroinflamação associados ao envelhecimentoInfo
- Publication number
- PT3390367T PT3390367T PT168764272T PT16876427T PT3390367T PT 3390367 T PT3390367 T PT 3390367T PT 168764272 T PT168764272 T PT 168764272T PT 16876427 T PT16876427 T PT 16876427T PT 3390367 T PT3390367 T PT 3390367T
- Authority
- PT
- Portugal
- Prior art keywords
- neuroinflammation
- preventing
- cognitive impairment
- associated cognitive
- treating aging
- Prior art date
Links
- 208000028698 Cognitive impairment Diseases 0.000 title 1
- 208000036110 Neuroinflammatory disease Diseases 0.000 title 1
- 230000032683 aging Effects 0.000 title 1
- 208000010877 cognitive disease Diseases 0.000 title 1
- 230000003959 neuroinflammation Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562267437P | 2015-12-15 | 2015-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3390367T true PT3390367T (pt) | 2020-09-23 |
Family
ID=59057428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT168764272T PT3390367T (pt) | 2015-12-15 | 2016-12-09 | Método para prevenir e/ou tratar enfraquecimento cognitivo e neuroinflamação associados ao envelhecimento |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US10653669B2 (pt) |
| EP (2) | EP3390367B1 (pt) |
| JP (1) | JP6837486B2 (pt) |
| KR (1) | KR20180094989A (pt) |
| CN (1) | CN108884053B (pt) |
| AU (1) | AU2016371598B2 (pt) |
| CA (1) | CA3008019A1 (pt) |
| DK (1) | DK3390367T3 (pt) |
| ES (1) | ES2830447T3 (pt) |
| HR (1) | HRP20201652T1 (pt) |
| HU (1) | HUE051771T2 (pt) |
| IL (2) | IL285248B2 (pt) |
| MX (1) | MX379086B (pt) |
| PL (1) | PL3390367T3 (pt) |
| PT (1) | PT3390367T (pt) |
| RS (1) | RS61053B1 (pt) |
| SM (1) | SMT202000601T1 (pt) |
| WO (1) | WO2017106050A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10272070B2 (en) | 2014-10-14 | 2019-04-30 | The Board of Trustees of the Leland Stanford Junio r University | Method for treating neurodegenerative diseases |
| SMT202000601T1 (it) * | 2015-12-15 | 2021-01-05 | Univ Leland Stanford Junior | Metodo per prevenire e/o trattare il deterioramento cognitivo e la neuroinfiammazione associati all’invecchiamento |
| EP3833344A4 (en) * | 2018-08-06 | 2022-07-06 | The Board of Trustees of the Leland Stanford Junior University | 2-ARYLBENZIMIDAZOLES USEFUL AS PPARGC1A ACTIVATORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
| EP4171551A1 (en) | 2020-06-22 | 2023-05-03 | Tranquis Therapeutics, Inc. | Treatment of systemic immune activation syndromes |
| CN112933232A (zh) * | 2021-02-02 | 2021-06-11 | 袁玉佳 | PGC-1α激活TFEB介导的自噬在制备治疗急性肾损伤的药物中的应用 |
| JP2024522820A (ja) * | 2021-06-17 | 2024-06-21 | トランクイス セラピューティクス， インコーポレイテッド | ２－アリールベンゾイミダゾールの治療上有効な経口投与 |
| CN118541152A (zh) | 2021-11-02 | 2024-08-23 | 特朗奎斯治疗股份有限公司 | 具有循环髓样细胞炎性表型的受试者的选择和治疗 |
| TW202415372A (zh) | 2022-06-14 | 2024-04-16 | 美商特朗奎斯治療股份有限公司 | 老化相關改變及疾病之治療 |
| TW202416960A (zh) | 2022-06-17 | 2024-05-01 | 美商特朗奎斯治療股份有限公司 | 2-芳基苯并咪唑化合物之調配物 |
| JP2025537881A (ja) * | 2022-11-18 | 2025-11-20 | 理志 五條 | Ｚｌｎ－００５および関連化合物の使用 |
| WO2024118936A1 (en) | 2022-12-02 | 2024-06-06 | Tranquis Therapeutics, Inc. | 2-arylbenzimidazole compounds for the treatment of hemoglobinopathies |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53127475A (en) * | 1977-04-07 | 1978-11-07 | Kanebo Ltd | Novel benzimidazole compound and its preparation |
| GB1584296A (en) | 1976-12-07 | 1981-02-11 | Kanebo Ltd | 2-substituted benzimidazole compounds |
| NZ234564A (en) | 1986-11-21 | 1991-04-26 | Haessle Ab | 1-substituted benzimidazoles and pharmaceutical compositions |
| US5552426A (en) * | 1994-04-29 | 1996-09-03 | Eli Lilly And Company | Methods for treating a physiological disorder associated with β-amyloid peptide |
| CZ20011546A3 (cs) | 1998-11-03 | 2001-08-15 | Basf Aktiengesellschaft | Derivát substituovaného 2-fenylbenzimidazolu, způsob jeho přípravy a jeho použití |
| TWI287005B (en) * | 2000-01-14 | 2007-09-21 | Schering Ag | 1,2-diaylbenzimidazoles and their pharmaceutical use |
| DE10134775A1 (de) * | 2001-07-06 | 2003-01-30 | Schering Ag | 1-Alkyl-2.aryl-benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate |
| DE10207843A1 (de) * | 2002-02-15 | 2003-09-04 | Schering Ag | Mikrolia-Inhibitoren zur Unterbrechung von Interleukin 12 und IFN-gamma vermittelten Immunreaktionen |
| US20040002524A1 (en) * | 2002-06-24 | 2004-01-01 | Richard Chesworth | Benzimidazole compounds and their use as estrogen agonists/antagonists |
| SE0301371D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | New Compounds |
| BRPI0512239A (pt) | 2004-06-17 | 2008-02-19 | Wyeth Corp | processos para preparação de antagonistas de receptores de hormÈnios liberadores de gonatropina |
| KR20070057965A (ko) * | 2004-09-21 | 2007-06-07 | 신타 파마슈티칼스 코프. | 염증 및 면역 관련 용도를 위한 화합물 |
| US7689227B2 (en) * | 2005-03-02 | 2010-03-30 | Qualcomm Incorporated | Method and apparatus for hashing over multiple frequency bands in a communication system |
| US7893267B2 (en) * | 2005-03-14 | 2011-02-22 | High Point Pharmaceuticals, Llc | Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors |
| AU2006278504B2 (en) | 2005-08-04 | 2013-01-17 | Sirtris Pharmaceuticals, Inc. | Imidazopyridine derivatives as sirtuin modulating agents |
| GB0807103D0 (en) | 2008-04-18 | 2008-05-21 | Univ Bradford The | Compounds |
| GB201009656D0 (en) | 2010-06-09 | 2010-07-21 | Univ St Andrews | Carboxylation catalysts |
| CA2869954C (en) | 2012-04-20 | 2023-01-03 | Advinus Therapeutics Limited | Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof in medical conditions related to modulation of bruton's tyrosine kinase activity |
| KR101435496B1 (ko) | 2012-10-22 | 2014-08-28 | 한국과학기술연구원 | 미토콘드리아 기능 조절제로서의 벤즈이미다졸 유도체 |
| US10022357B2 (en) * | 2013-04-29 | 2018-07-17 | The General Hospital Corporation | Amyloid precursor protein MRNA blockers for treating Down syndrome and Alzheimer's disease |
| ES2830352T3 (es) * | 2013-09-18 | 2021-06-03 | Univ Georgetown | Tratamiento de enfermedad neurodegenerativa con fenofibrato y análogos del mismo |
| US10272070B2 (en) * | 2014-10-14 | 2019-04-30 | The Board of Trustees of the Leland Stanford Junio r University | Method for treating neurodegenerative diseases |
| CN104873500A (zh) | 2015-04-29 | 2015-09-02 | 中国人民解放军第四军医大学 | 化合物zln005的用途 |
| CA2984645C (en) * | 2015-05-18 | 2023-01-10 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating aging-associated impairments |
| SMT202000601T1 (it) * | 2015-12-15 | 2021-01-05 | Univ Leland Stanford Junior | Metodo per prevenire e/o trattare il deterioramento cognitivo e la neuroinfiammazione associati all’invecchiamento |
| EP4171551A1 (en) * | 2020-06-22 | 2023-05-03 | Tranquis Therapeutics, Inc. | Treatment of systemic immune activation syndromes |
-
2016
- 2016-12-09 SM SM20200601T patent/SMT202000601T1/it unknown
- 2016-12-09 EP EP16876427.2A patent/EP3390367B1/en active Active
- 2016-12-09 AU AU2016371598A patent/AU2016371598B2/en active Active
- 2016-12-09 MX MX2018007147A patent/MX379086B/es unknown
- 2016-12-09 DK DK16876427.2T patent/DK3390367T3/da active
- 2016-12-09 EP EP20185530.1A patent/EP3741747B1/en active Active
- 2016-12-09 CA CA3008019A patent/CA3008019A1/en active Pending
- 2016-12-09 PT PT168764272T patent/PT3390367T/pt unknown
- 2016-12-09 IL IL285248A patent/IL285248B2/en unknown
- 2016-12-09 PL PL16876427T patent/PL3390367T3/pl unknown
- 2016-12-09 ES ES16876427T patent/ES2830447T3/es active Active
- 2016-12-09 RS RS20201363A patent/RS61053B1/sr unknown
- 2016-12-09 US US15/781,756 patent/US10653669B2/en active Active
- 2016-12-09 HR HRP20201652TT patent/HRP20201652T1/hr unknown
- 2016-12-09 CN CN201680079142.9A patent/CN108884053B/zh active Active
- 2016-12-09 JP JP2018531575A patent/JP6837486B2/ja active Active
- 2016-12-09 HU HUE16876427A patent/HUE051771T2/hu unknown
- 2016-12-09 KR KR1020187020017A patent/KR20180094989A/ko not_active Ceased
- 2016-12-09 WO PCT/US2016/065972 patent/WO2017106050A1/en not_active Ceased
-
2018
- 2018-06-07 IL IL259902A patent/IL259902B/en unknown
-
2020
- 2020-04-09 US US16/844,414 patent/US20210059985A1/en not_active Abandoned
-
2023
- 2023-11-29 US US18/522,503 patent/US20240245646A1/en active Pending
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