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PT2884999T - Método e composições para imunoterapêutica celular - Google Patents

Método e composições para imunoterapêutica celular

Info

Publication number
PT2884999T
PT2884999T PT137534954T PT13753495T PT2884999T PT 2884999 T PT2884999 T PT 2884999T PT 137534954 T PT137534954 T PT 137534954T PT 13753495 T PT13753495 T PT 13753495T PT 2884999 T PT2884999 T PT 2884999T
Authority
PT
Portugal
Prior art keywords
compositions
cellular immunotherapy
immunotherapy
cellular
Prior art date
Application number
PT137534954T
Other languages
English (en)
Original Assignee
Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Hutchinson Fred Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49054932&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2884999(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Seattle Childrens Hospital Dba Seattle Childrens Res Inst, Hutchinson Fred Cancer Res filed Critical Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Publication of PT2884999T publication Critical patent/PT2884999T/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C—CHEMISTRY; METALLURGY
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    • C07—ORGANIC CHEMISTRY
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
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  • Oncology (AREA)
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  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
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  • Endocrinology (AREA)
  • Reproductive Health (AREA)
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PT137534954T 2012-08-20 2013-08-20 Método e composições para imunoterapêutica celular PT2884999T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261691117P 2012-08-20 2012-08-20

Publications (1)

Publication Number Publication Date
PT2884999T true PT2884999T (pt) 2021-01-05

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PT137534954T PT2884999T (pt) 2012-08-20 2013-08-20 Método e composições para imunoterapêutica celular
PT202014973T PT3824905T (pt) 2012-08-20 2013-08-20 Método e composições para imunoterapêutica celular

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PT202014973T PT3824905T (pt) 2012-08-20 2013-08-20 Método e composições para imunoterapêutica celular

Country Status (26)

Country Link
US (5) US10780118B2 (pt)
EP (3) EP4537839B1 (pt)
JP (4) JP6574381B2 (pt)
KR (4) KR102362240B1 (pt)
CN (1) CN104780939B (pt)
AU (4) AU2013305838A1 (pt)
BR (3) BR112015002816A8 (pt)
CA (2) CA2881981A1 (pt)
CY (1) CY1123959T1 (pt)
DK (2) DK3824905T3 (pt)
ES (2) ES2842102T3 (pt)
FI (2) FI3824905T3 (pt)
HR (2) HRP20250397T1 (pt)
HU (2) HUE053439T2 (pt)
IL (3) IL293944A (pt)
LT (2) LT2884999T (pt)
MX (3) MX380109B (pt)
PH (2) PH12019550223A1 (pt)
PL (2) PL3824905T3 (pt)
PT (2) PT2884999T (pt)
RS (2) RS61345B1 (pt)
RU (2) RU2700765C2 (pt)
SG (2) SG10201701339RA (pt)
SI (2) SI2884999T1 (pt)
SM (2) SMT202100005T1 (pt)
WO (1) WO2014031687A1 (pt)

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RU2636503C2 (ru) 2011-09-08 2017-11-23 Иеда Рисеч Энд Девелопмент Ко. Лтд. Т-клетки центральной памяти против третьей стороны, способы их получения и их применение в трансплантации и лечении заболеваний
RU2746407C1 (ru) 2012-02-23 2021-04-13 Стейдж Селл Терапеутикс Гмбх Хроматографическое выделение клеток и других сложных биологических материалов
IL293944A (en) 2012-08-20 2022-08-01 Hutchinson Fred Cancer Res Method and preparations for cellular immunotherapy
WO2014100615A1 (en) 2012-12-20 2014-06-26 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
CN111139256A (zh) 2013-02-20 2020-05-12 诺华股份有限公司 使用人源化抗EGFRvIII嵌合抗原受体治疗癌症
US9573988B2 (en) 2013-02-20 2017-02-21 Novartis Ag Effective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells
US9745368B2 (en) 2013-03-15 2017-08-29 The Trustees Of The University Of Pennsylvania Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
US10640569B2 (en) 2013-12-19 2020-05-05 Novartis Ag Human mesothelin chimeric antigen receptors and uses thereof
EP4420663A3 (en) 2013-12-20 2024-10-30 Novartis AG Regulatable chimeric antigen receptor
MX386422B (es) 2013-12-20 2025-03-18 Fred Hutchinson Cancer Center Moléculas efectoras químericas etiquetadas y receptores de las mismas.
ES2963718T3 (es) 2014-01-21 2024-04-01 Novartis Ag Capacidad presentadora de antígenos de células CAR-T potenciada mediante introducción conjunta de moléculas co-estimuladoras
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